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1. 发明申请

WO0236792A3 DNA EXPRESSION VECTORS 审中-公开
标题翻译： DNA表达载体
公开(公告)号：WO0236792A3
公开(公告)日：2002-09-06
申请号：PCT/GB0104912
申请日：2001-11-02
申请人： GLAXO GROUP LTD , CATCHPOLE IAN RICHARD , ELLIS JONATHAN HENRY , ERTL PETER FRANZ , RHODES JOHN RICHARD
发明人： CATCHPOLE IAN RICHARD , ELLIS JONATHAN HENRY , ERTL PETER FRANZ , RHODES JOHN RICHARD
IPC分类号： C12N15/09 , A61K9/16 , A61K39/00 , A61K39/21 , A61K39/39 , A61P9/10 , A61P11/06 , A61P15/00 , A61P25/28 , A61P31/06 , A61P31/12 , A61P31/18 , A61P31/20 , A61P35/00 , A61P37/06 , A61P37/08 , C07K14/045 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/85 , C12P21/02 , A61K48/00
CPC分类号： C12N15/85 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/545 , A61K2039/555 , A61K2039/57 , C07K14/005 , C12N2710/16122 , C12N2740/16034 , C12N2830/42
摘要： The invention relates to DNA vectors containing a transcription regulatory sequence derived from Human Cytomegalovirus major immediate early gene that includes exon 1, but not intron A. Vectors, host cells, pharmaceutical and vaccine compositions comprising such host cells and vectors are contemplated.
摘要翻译：本发明涉及含有源自人巨细胞病毒主要即时早期基因的转录调控序列的DNA载体，其包括外显子1但不包括内含子A.考虑载体，宿主细胞，包含这种宿主细胞和载体的药物和疫苗组合物。

2. 发明申请

WO2006136460A3 NEW ADJUVANT 审中-公开
标题翻译：新ADJUVANT
公开(公告)号：WO2006136460A3
公开(公告)日：2007-06-14
申请号：PCT/EP2006006264
申请日：2006-06-20
申请人： GLAXO GROUP LTD , CATCHPOLE IAN RICHARD , PAPANICOLAOU IRENE
发明人： CATCHPOLE IAN RICHARD , PAPANICOLAOU IRENE
IPC分类号： A61K39/21 , A61P31/14
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55577 , C12N2710/10343 , C12N2740/16034
摘要： The present invention provides a novel adjuvant for polynucleotide vaccines, and in particular the present invention provides immunogenic compositions comprising a polynucleotide encoding an antigen capable of eliciting an immune response and an adjuvant comprising an immunostimulatory quantity of a gemini surfactant, or a derivative thereof. The invention further comprises polynucleotide vaccines that comprise, or are administered in association with, a composition that comprises a gemini surfactant compound. The polynucleotide vaccines of the present invention are vaccines that encode an antigen against which it is desired to generate an immune response, and in particular the polynucleotide vaccine may be a DNA vaccine. Also provided by the present invention is the use of gemini surfactants in the manufacture of a polynucleotide vaccine composition for the purpose of enhancing the immune response against the specific antigen that is encoded by the polynucleotide vaccine. Vaccine compositions, kits comprising separate polynucleotide composition and adjuvant compositions for separate or simultaneous administration, methods of manufacture of the vaccines and kits, and methods of treatment of individuals with the immunogencic compositions and vaccines of the present invention, are provided.
摘要翻译：本发明提供了用于多核苷酸疫苗的新型佐剂，特别是本发明提供了包含编码能引发免疫应答的抗原的多核苷酸的免疫原性组合物和包含免疫刺激量的双子表面活性剂或其衍生物的佐剂。本发明还包括包含或与包含双子表面活性剂化合物的组合物结合施用的多核苷酸疫苗。本发明的多核苷酸疫苗是编码希望产生免疫应答的抗原的疫苗，特别是多核苷酸疫苗可以是DNA疫苗。本发明还提供了双子座表面活性剂在制造多核苷酸疫苗组合物中的用途，以增强针对由多核苷酸疫苗编码的特异性抗原的免疫应答。提供疫苗组合物，包含单独的多核苷酸组合物和用于单独或同时施用的佐剂组合物的试剂盒，疫苗和试剂盒的制备方法以及用本发明的免疫原性组合物和疫苗处理个体的方法。

3. 发明申请

WO2009135853A3 ENCAPSULATION OF BIOLOGICALLY ACTIVE AGENTS 审中-公开
标题翻译：生物活性剂的包埋
公开(公告)号：WO2009135853A3
公开(公告)日：2011-05-12
申请号：PCT/EP2009055436
申请日：2009-05-05
申请人： GLAXO GROUP LTD , CATCHPOLE IAN RICHARD , GOUGH GERALD WAYNE , PAPANICOLAOU IRENE
发明人： CATCHPOLE IAN RICHARD , GOUGH GERALD WAYNE , PAPANICOLAOU IRENE
IPC分类号： A61K9/51
CPC分类号： A61K9/5138 , A61K9/0051 , A61K9/1647 , A61K9/5153 , A61K9/5192 , A61K2039/505
摘要： The present invention provides particulate carriers comprising encapsulated biologically active agents such as proteins for ocular delivery. Also provided are methods of delivery of proteins to the eye in nanoparticles, and uses of compositions comprising such particulate carriers in treatment.
摘要翻译：本发明提供了包含包封的生物活性剂如用于眼睛递送的蛋白质的颗粒载体。还提供了在纳米颗粒中将蛋白递送到眼睛的方法，以及在治疗中使用包含这种颗粒载体的组合物。

4. 发明申请

WO03061636A2 DNA DOSAGE FORMS 审中-公开
标题翻译： DNA剂型
公开(公告)号：WO03061636A2
公开(公告)日：2003-07-31
申请号：PCT/GB0300282
申请日：2003-01-23
申请人： GLAXO GROUP LTD , CATCHPOLE IAN RICHARD
发明人： CATCHPOLE IAN RICHARD
IPC分类号： A61K9/70 , A61K9/14 , A61K9/16 , A61K31/7088 , A61K39/00 , A61K47/04 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/42 , A61M37/00 , C12N15/89
CPC分类号： A61K9/1676 , A61K9/0014 , A61K9/0021 , A61K9/145 , A61K47/183 , A61K47/26
摘要： The present invention relates to efficient devices for administration of DNA based pharmaceutical agents into mammalian skin. In a particularly preferred aspect of the present invention there is provided devices for administration of DNA vaccines into the skin of the mammal, and preferably into human skin. The present invention provides a microneedle DNA pharmaceutical agent delivery device having at least one skin-piercing element which comprises a support member coated with a solid reservoir medium containing, in solid solution or suspension within it, the DNA pharmaceutical agent, and a stabilising agent that inhibits the degradative effects of free radicals. Preferably the solid pharmaceutical reservoir medium coated onto such devices is a polyol, preferably being a polyol in an amorphous state such as a glass.
摘要翻译：本发明涉及用于向哺乳动物皮肤中施用基于DNA的药剂的有效装置。在本发明的一个特别优选的方面，提供了用于将DNA疫苗施用于哺乳动物皮肤，优选进入人体皮肤的装置。本发明提供了一种具有至少一个皮肤刺穿元件的微针DNA药剂递送装置，其包括涂覆有固体储存介质的支撑构件，该固体储存介质在其中具有固体溶液或悬浮液中的DNA药剂和稳定剂，抑制自由基的降解作用。优选地，涂覆在这种装置上的固体药物储存介质是多元醇，优选是非晶状态的多元醇，例如玻璃。

5. 发明申请

WO0102594A3 DNA CONSTRUCTS BASED ON THE eIF4A GENE PROMOTER 审中-公开
标题翻译：基于eIF4A基因启动子的DNA构建体
公开(公告)号：WO0102594A3
公开(公告)日：2001-11-15
申请号：PCT/GB0002569
申请日：2000-07-05
申请人： GLAXO GROUP LTD , GREAVES DAVID ROBERT , THOMSEN LINDY , CATCHPOLE IAN RICHARD , FORD MARTIN JAMES
发明人： GREAVES DAVID ROBERT , THOMSEN LINDY , CATCHPOLE IAN RICHARD , FORD MARTIN JAMES
IPC分类号： C12N15/09 , A61K35/76 , A61K38/00 , A61K39/395 , A61K48/00 , A61P35/00 , A61P43/00 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/85 , C12P21/00 , A61K31/17
CPC分类号： C07K14/4705 , A61K48/00 , A61K2039/51 , C12N15/85 , C12N2830/00 , C12N2830/42 , C12N2830/46 , C12N2830/85
摘要： The present invention provides novel DNA constructs comprising a transcriptional regulatory sequence comprising a polynucleotide derivable from the eIF4A1 gene promoter. In preferred embodiments, the polynucleotide further comprises a polynucleotide derivable from the eIF4A gene introns, particularly intron 1. Host cells harbouring the constructs are also provided. These novel constructs have applications in gene therapy, DNA vaccines and in the commercial production of proteins.
摘要翻译：本发明提供了包含转录调节序列的新型DNA构建体，所述转录调节序列包含可得自eIF4A1基因启动子的多核苷酸。在优选的实施方案中，多核苷酸还包含衍生自eIF4A基因内含子的多核苷酸，特别是内含子1.还提供了携带该构建体的宿主细胞。这些新型构建体在基因治疗，DNA疫苗和蛋白质的商业化生产中都有应用。

6. 发明申请

WO2009135852A3 ENCAPSULATION OF BIOLOGICALLY ACTIVE AGENTS 审中-公开
标题翻译：生物活性剂的包埋
公开(公告)号：WO2009135852A3
公开(公告)日：2010-01-14
申请号：PCT/EP2009055435
申请日：2009-05-05
申请人： GLAXO GROUP LTD , BEATON ANDREW , CATCHPOLE IAN RICHARD , GOUGH GERALD WAYNE , PAPANICOLAOU IRENE
发明人： BEATON ANDREW , CATCHPOLE IAN RICHARD , GOUGH GERALD WAYNE , PAPANICOLAOU IRENE
IPC分类号： A61K9/50 , A61K9/51 , A61K47/34
CPC分类号： A61K9/5138 , A61K9/0019 , A61K9/0051 , A61K9/0085 , A61K9/1647 , A61K9/5153 , A61K9/5192 , A61K2039/505
摘要： The present invention provides particulate carriers comprising encapsulated biologically active agents such as proteins for delivery across the blood brain barrier. Also provided are methods of delivery of proteins across the blood brain barrier in nanoparticles, and uses of such compositions in treatment.
摘要翻译：本发明提供了包含包封的生物活性剂如颗粒载体，例如通过血脑屏障递送的蛋白质。还提供了在纳米颗粒中通过血脑屏障传递蛋白质的方法，以及这些组合物在治疗中的用途。

7. 发明申请

WO2006136460A8 NEW ADJUVANT 审中-公开
标题翻译：新的佐剂
公开(公告)号：WO2006136460A8
公开(公告)日：2007-04-19
申请号：PCT/EP2006006264
申请日：2006-06-20
申请人： GLAXO GROUP LTD , CATCHPOLE IAN RICHARD , PAPANICOLAOU IRENE
发明人： CATCHPOLE IAN RICHARD , PAPANICOLAOU IRENE
IPC分类号： A61K39/21 , A61P31/14
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55577 , C12N2710/10343 , C12N2740/16034
摘要： The present invention provides a novel adjuvant for polynucleotide vaccines, and in particular the present invention provides immunogenic compositions comprising a polynucleotide encoding an antigen capable of eliciting an immune response and an adjuvant comprising an immunostimulatory quantity of a gemini surfactant, or a derivative thereof. The invention further comprises polynucleotide vaccines that comprise, or are administered in association with, a composition that comprises a gemini surfactant compound. The polynucleotide vaccines of the present invention are vaccines that encode an antigen against which it is desired to generate an immune response, and in particular the polynucleotide vaccine may be a DNA vaccine. Also provided by the present invention is the use of gemini surfactants in the manufacture of a polynucleotide vaccine composition for the purpose of enhancing the immune response against the specific antigen that is encoded by the polynucleotide vaccine. Vaccine compositions, kits comprising separate polynucleotide composition and adjuvant compositions for separate or simultaneous administration, methods of manufacture of the vaccines and kits, and methods of treatment of individuals with the immunogencic compositions and vaccines of the present invention, are provided.
摘要翻译：本发明提供了一种用于多核苷酸疫苗的新佐剂，具体地说，本发明提供了包含编码能够引发免疫应答的抗原的多核苷酸的免疫原性组合物和包含免疫刺激量的双子表面活性剂或其衍生物的佐剂。本发明进一步包含多核苷酸疫苗，其包含包含双子表面活性剂化合物或与包含双子表面活性剂化合物的组合物联合施用。本发明的多核苷酸疫苗是编码希望产生免疫应答的抗原的疫苗，特别是多核苷酸疫苗可以是DNA疫苗。本发明还提供了双子表面活性剂在制备多核苷酸疫苗组合物中的用途，所述多核苷酸疫苗组合物用于增强针对由多核苷酸疫苗编码的特异性抗原的免疫应答。提供了疫苗组合物，包含用于单独或同时施用的单独的多核苷酸组合物和佐剂组合物的试剂盒，制备疫苗和试剂盒的方法以及用本发明的免疫原性组合物和疫苗治疗个体的方法。

8. 发明申请

WO2004052909A3 LNA-CPG CONJUGATES 审中-公开
标题翻译： LNA-CPG结合
公开(公告)号：WO2004052909A3
公开(公告)日：2004-09-10
申请号：PCT/EP0313803
申请日：2003-12-04
申请人： GLAXO GROUP LTD , CATCHPOLE IAN RICHARD
发明人： CATCHPOLE IAN RICHARD
IPC分类号： C12N15/117 , C07H21/00
CPC分类号： C12N15/117 , A61K2039/55561 , C12N2310/315 , C12N2310/3231 , C12N2310/346
摘要： The present invention relates to compositions comprising DNA attached to an immunostimulatory oligonucleotide (CpG) via a locked nucleic acid oligonucleotide of a defined sequence. In particular the present invention provides compositions comprising a plasmid containing a gene encoding a protein of interest, wherein said plasmid may be introduced to a tissue or cell and the gene expressed, complexed to the LNA -CpG. Also provided is a method of co-synthesis of CpG and LNA to form compositions for use as adjuvants with DNA plasmid vaccines.
摘要翻译：本发明涉及通过经定义的序列的锁定核酸寡核苷酸连接到免疫刺激性寡核苷酸（CpG）上的DNA的组合物。特别地，本发明提供包含含有编码目的蛋白质的基因的质粒的组合物，其中所述质粒可以被引入到组织或细胞中，并且所述基因与LNA -CpG复合。还提供了共同合成CpG和LNA以形成用作DNA质粒疫苗佐剂的组合物的方法。

9. 发明申请

WO2013014208A3 ANTI-VEGF SINGLE VARIABLE DOMAINS FUSED TO FC DOMAINS 审中-公开
标题翻译：抗体单克隆抗体单链可变域融合到FC域
公开(公告)号：WO2013014208A3
公开(公告)日：2013-05-10
申请号：PCT/EP2012064632
申请日：2012-07-25
申请人： GLAXO GROUP LTD , ASHMAN CLAIRE , CATCHPOLE IAN RICHARD , HUGHES-THOMAS ZOE , LEWIS ALAN PETER , STEWARD MICHAEL
发明人： ASHMAN CLAIRE , CATCHPOLE IAN RICHARD , HUGHES-THOMAS ZOE , LEWIS ALAN PETER , STEWARD MICHAEL
IPC分类号： C07K16/22 , A61P27/02
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/54 , A61K2039/70 , C07K16/46 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/52 , C07K2317/565 , C07K2317/569 , C07K2317/60 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain Fc region of an antibody, wherein each epitope binding domain in capable of binding to VEGF, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with VEGF signalling, such as diabetic macular edema (DME), wet age-related macular degeneration (Wet AMD), diabetic retinopathy, retinal vein occlusion (RVO), and corneal neovascularisation, and polynucleotide sequences encoding said antigen binding constructs.
摘要翻译：本发明涉及包含通过抗体的单链Fc区分离的一个或两个表位结合结构域的抗原结合构建体，其中能够结合VEGF的每个表位结合域与包含本发明的两个抗原结合构建体的二聚体，包含所述二聚体的药物组合物及其用于治疗与VEGF信号传导相关的疾病，例如糖尿病性黄斑水肿（DME），湿性年龄相关性黄斑变性（湿性AMD），糖尿病性视网膜病变，视网膜静脉阻塞（RVO）和角膜新血管形成和编码所述抗原结合构建体的多核苷酸序列。

10. 发明申请

WO03061629A3 DNA DOSAGE FORMS 审中-公开
标题翻译： DNA剂型
公开(公告)号：WO03061629A3
公开(公告)日：2003-10-02
申请号：PCT/GB0300336
申请日：2003-01-23
申请人： GLAXO GROUP LTD , CATCHPOLE IAN RICHARD
发明人： CATCHPOLE IAN RICHARD
IPC分类号： A61K9/22 , A61K9/14 , A61K9/16 , A61K31/711 , A61K39/00 , A61K39/39 , A61K47/04 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/20 , A61K47/24 , A61K47/26 , A61K47/36 , A61K48/00 , A61P37/04 , C12N15/89
CPC分类号： A61K9/0021 , A61K9/145 , A61K9/1676 , A61K47/183 , A61K47/26
摘要： The present invention relates to DNA formulations suitable for ballistic delivery into the skin of the human body. In particular the present invention provides DNA formulations suitable for ballistic administration of DNA vaccines into the skin. The present invention provides a novel DNA pharmaceutical agent dosage form, having a dense core element which is coated with an amorphous solid reservoir medium containing the DNA pharmaceutical agent.
摘要翻译：本发明涉及适合于弹道输送到人体皮肤中的DNA制剂。特别地，本发明提供适合于将DNA疫苗弹性施用到皮肤中的DNA制剂。本发明提供了一种新颖的DNA药剂剂型，其具有被包含含有DNA药剂的无定形固体储存介质的致密核心元件。

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