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1. 发明申请

WO0014222A3 GABAB RECEPTOR SUBTYPES GABAB-R1C AND GABAB-R2 AND HETERODIMERS THEREOF 审中-公开
标题翻译： GABAB受体亚型GABAB-R1C和GABAB-R2及其偶联剂
公开(公告)号：WO0014222A3
公开(公告)日：2000-07-06
申请号：PCT/GB9902918
申请日：1999-09-03
申请人： GLAXO GROUP LTD , BARNES ASHLEY ANTONY , WISE ALAN , MARSHALL FIONA HAMILTON , FRASER NEIL JAMES , WHITE JULIA HELEN MARGARET , FOORD STEVEN MICHAEL
发明人： BARNES ASHLEY ANTONY , WISE ALAN , MARSHALL FIONA HAMILTON , FRASER NEIL JAMES , WHITE JULIA HELEN MARGARET , FOORD STEVEN MICHAEL
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61K45/00 , A61P1/00 , A61P1/14 , A61P11/00 , A61P13/10 , A61P25/00 , A61P25/08 , A61P25/18 , A61P25/28 , A61P29/00 , A61P43/00 , C07K14/705 , C07K16/28 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/91 , G01N33/15 , A61K49/00
CPC分类号： C07K14/70571 , A61K38/00
摘要： The present invention relates to the novel GABAB receptor subtypes GABAB-R1c and GABAB-R2 as well as to a novel, functional GABAB receptor which comprises a heterodimer of GABAB-R1 and GABAB-R2 receptor subunits. The present invention also relates to variant of the receptors, nucleotide sequences encoding the receptors and variants thereof and novel vectors, stable cell lines, antibodies, screening methods, methods of treatment and methods of receptor production.
摘要翻译：本发明涉及新型GABAB受体亚型GABAB-R1c和GABAB-R2，以及一种新的功能性GABA B受体，其包含GABAB-R1和GABAB-R2受体亚基的异源二聚体。本发明还涉及受体的变体，编码受体及其变体的核苷酸序列和新载体，稳定细胞系，抗体，筛选方法，治疗方法和受体产生方法。

2. 发明申请

WO02084298A2 MEDICAMENTS 审中-公开
标题翻译：药物
公开(公告)号：WO02084298A2
公开(公告)日：2002-10-24
申请号：PCT/GB0201671
申请日：2002-04-10
申请人： GLAXO GROUP LTD , FOORD STEVEN MICHAEL , PIKE NICHOLAS BRIAN , WISE ALAN
发明人： FOORD STEVEN MICHAEL , PIKE NICHOLAS BRIAN , WISE ALAN
IPC分类号： A61P3/10 , A61P7/02 , A61P9/10 , A61P13/12 , A61P29/00 , G01N33/566 , G01N33/68
CPC分类号： G01N33/566
摘要： A method of treating HM74A and/or HM74 mediated disease in an individual which comprises administering to the individual a therapeutic amount of a modulator of HM74A and/or HM74 activity.
摘要翻译：一种在个体中治疗HM74A和/或HM74介导的疾病的方法，其包括向个体施用治疗量的HM74A和/或HM74活性的调节剂。

3. 发明申请

WO0186305A3 IDENTIFICATION OF MODULATORS OF GPR55 ACTIVITY 审中-公开
标题翻译： GPR55活性调节剂的鉴定
公开(公告)号：WO0186305A3
公开(公告)日：2002-03-28
申请号：PCT/GB0101969
申请日：2001-05-04
申请人： GLAXO GROUP LTD , WISE ALAN , BROWN ANDREW JAMES
发明人： WISE ALAN , BROWN ANDREW JAMES
IPC分类号： G01N33/566 , A61P3/04 , A61P3/06 , A61P3/10 , C07K14/72
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/00
摘要： A method for identification of an agent that modulates activity of G-protein coupled receptor 55 (GPR 55), which method comprises: (i) contacting a test agent with GPR 55 or a variant thereof which is capable of coupling to a G-protein; and (ii) monitoring for GPR 55 activity in the presence of a G-protein; thereby determining whether the test agent modulates GPR 55 activity.
摘要翻译：用于鉴定调节G蛋白偶联受体55（GPR 55）的活性的试剂的方法，该方法包括：（i）使测试试剂与能够偶联于G蛋白的GPR55或其变体接触 ; 和（ii）在G蛋白存在下监测GPR 55活性; 从而确定测试剂是否调节GPR 55活性。

4. 发明申请

WO0161360A3 IDENTIFICATION OF MODULATORS OF GPR31 ACTIVITY 审中-公开
标题翻译： GPR31活性调节剂的鉴定
公开(公告)号：WO0161360A3
公开(公告)日：2002-03-28
申请号：PCT/GB0100693
申请日：2001-02-19
申请人： GLAXO GROUP LTD , WISE ALAN
发明人： WISE ALAN
IPC分类号： G01N33/566 , C07K14/72 , A61P3/04 , A61P3/06 , A61P3/10
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/00
摘要： The present invention provides a method for identification of an agent that modulates activity of G-protein coupled receptor 31 (GPR 31). The method comprises: (i) contacting a test agent with GPR 31 or a variant thereof which is capable of coupling to a G-protein; and (ii) monitoring for GPR 31 activity in the presence of a G-protein; thereby determining whether the test agent modulates GPR 31 activity. The invention also provides activators of GPR 31, inhibitors of lipolysis and GPR 31 polynucleotides which can be used in the treatment of dyslipidaemia, coronary heart disease, atheroscloresis, thrombosis or obesity, angina, chronic renal failure, peripheral vascular disease, stroke, type I diabetes or metabolic syndrome (syndrome X).
摘要翻译：本发明提供了一种鉴定调节G蛋白偶联受体31（GPR 31）活性的试剂的方法。该方法包括：（i）使测试试剂与GPR31或其能够与G蛋白偶联的变体接触; 和（ii）在G蛋白存在下监测GPR 31活性; 从而确定测试剂是否调节GPR 31活性。本发明还提供了可用于治疗血脂异常，冠心病，动脉粥样硬化，血栓形成或肥胖，心绞痛，慢性肾功能衰竭，外周血管疾病，中风，I型的GPR31激动剂，脂解作用抑制剂和GPR 31多核苷酸糖尿病或代谢综合症（X综合症）。

5. 发明申请

WO0161359A2 NOVEL ASSAY 审中-公开
标题翻译：新的测定
公开(公告)号：WO0161359A2
公开(公告)日：2001-08-23
申请号：PCT/GB0100684
申请日：2001-02-19
申请人： GLAXO GROUP LTD , WISE ALAN , BROWN ANDREW JAMES
发明人： WISE ALAN , BROWN ANDREW JAMES
IPC分类号： A61P3/04 , A61P3/06 , A61P3/10 , G01N33/566 , G01N33/68
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/10
摘要： This invention relates to a method for identification of an agent that modulates activity of G-protein coupled receptor 41 (GPR 41), or G-protein coupled receptor 42 (GPR 42) which method comprises: (i) contacting a test agent with GPR 41, GPR42 or a variant of either thereof which is capable of coupling to a G-protein; and (ii) monitoring for GPR 41 or GPR 42 activity in the presence of a G-protein; thereby determining whether the test agent modulates GPR 41 or GPR 42 activity. An agent identifiable by this method is provided for use in the treatment of dyslipidaemia, coronary heart disease, atheroselerosis, thrombosis or obesity, angina, chronic renal failure, peripheral vascular disease, stroke, type II diabetes or metabolic syndrome (syndrome X).
摘要翻译：本发明涉及一种用于鉴定调节G蛋白偶联受体41（GPR 41）或G蛋白偶联受体42（GPR 42）的活性的试剂的方法，该方法包括：（i）将测试试剂与GPR 41，GPR42或其能够与G蛋白偶联的任一种的变体; 和（ii）在G蛋白存在下监测GPR 41或GPR 42活性; 从而确定测试剂是否调节GPR 41或GPR 42活性。通过该方法识别的药剂可用于治疗血脂异常，冠心病，动脉粥样硬化，血栓形成或肥胖，心绞痛，慢性肾功能衰竭，外周血管疾病，中风，II型糖尿病或代谢综合征（综合征X）。

6. 发明申请

WO0116596A3 SCREENING FOR MODULATORS OF GABA B RECEPTOR ACTIVITY 审中-公开
标题翻译： GABA B受体活性调节剂筛选
公开(公告)号：WO0116596A3
公开(公告)日：2001-05-03
申请号：PCT/GB0003361
申请日：2000-08-31
申请人： GLAXO GROUP LTD , WHITE JULIA , WISE ALAN , MARSHALL FIONA
发明人： WHITE JULIA , WISE ALAN , MARSHALL FIONA
IPC分类号： A61K38/00 , C07K14/47 , G01N33/94
CPC分类号： G01N33/9426 , A61K38/00 , C07K14/4702 , G01N2333/726 , G01N2500/00
摘要： A method of identifying a modulator of GABAB receptor-mediated activity, the method comprising: (i) providing (a) a transcription factor of the CREB/ATF family, or fragment thereof capable of binding to a GABAB receptor subunit; and (b) a GABAB receptor subunit, or fragment thereof capable of binding to CREB2 or ATFx; and (c) a test substance under conditions that would permit binding of (a) to (b) in the absence of (c); (ii) monitoring the interaction between (a) and (b); and (iii) determining whether (c) modulates the binding of (a) and (b) and thereby whether the test substance is a modulator of GABAB receptor-mediated activity.
摘要翻译：一种鉴定GABA B受体介导活性的调节剂的方法，所述方法包括：（i）提供（a）可结合GABA B受体亚基的CREB / ATF家族或其片段的转录因子; 和（b）能够结合CREB2或ATFx的GABA B受体亚基或其片段; （c）在没有（c）条件下允许（a）至（b）的约束的条件下的测试物质; （ii）监测（a）和（b）之间的相互作用; （iii）确定（c）调节（a）和（b）的结合，从而是否测试物质是GABA B受体介导的活性的调节剂。

7. 发明专利

DE69933776T2 未知
公开(公告)号：DE69933776T2
公开(公告)日：2008-01-03
申请号：DE69933776
申请日：1999-09-03
申请人： GLAXO GROUP LTD
发明人： BARNES ANTONY , WISE ALAN , MARSHALL HAMILTON , FRASER JAMES , WHITE HELEN , FOORD MICHAEL
IPC分类号： C12N15/12 , G01N33/50 , A61K38/00 , A61K39/395 , A61K45/00 , A61K49/00 , A61P1/00 , A61P1/14 , A61P11/00 , A61P13/10 , A61P25/00 , A61P25/08 , A61P25/18 , A61P25/28 , A61P29/00 , A61P43/00 , C07K14/705 , C07K16/28 , C12N5/10 , C12N15/09 , C12P21/02 , C12R1/91 , G01N33/15

8. 发明专利

AU6904301A Modified chemokine receptor ccr-3 and assay 未知
公开(公告)号：AU6904301A
公开(公告)日：2001-12-11
申请号：AU6904301
申请日：2001-05-31
申请人： GLAXO GROUP LTD
发明人： BARNES ASHLEY ANTONY , FRASER NEIL JAMES , O'SHAUGHNESSY CELESTINE THERES , WISE ALAN
IPC分类号： C12N15/09 , C07K14/705 , C07K14/715 , C12N5/10 , C12N15/12 , C12Q1/02 , C12N5/06 , G01N33/68
摘要： The present invention relates to the modification of the CC chemokine receptor 3 to stabilise or enhance surface expression, for example, to reduce internalization and/or kinase-mediated phosphorylation. The invention also relates to assays for CCR3 receptor activity in which internalization and/or kinase mediated phosphorylation of the receptor is reduced.

9. 发明专利

DE69933776D1 未知
公开(公告)号：DE69933776D1
公开(公告)日：2006-12-07
申请号：DE69933776
申请日：1999-09-03
申请人： GLAXO GROUP LTD
发明人： BARNES ANTONY , WISE ALAN , MARSHALL HAMILTON , FRASER JAMES , WHITE HELEN , FOORD MICHAEL
IPC分类号： C12N15/12 , G01N33/50 , A61K38/00 , A61K39/395 , A61K45/00 , A61K49/00 , A61P1/00 , A61P1/14 , A61P11/00 , A61P13/10 , A61P25/00 , A61P25/08 , A61P25/18 , A61P25/28 , A61P29/00 , A61P43/00 , C07K14/705 , C07K16/28 , C12N5/10 , C12N15/09 , C12P21/02 , C12R1/91 , G01N33/15

10. 发明专利

AU6857600A Screen 未知
公开(公告)号：AU6857600A
公开(公告)日：2001-03-26
申请号：AU6857600
申请日：2000-08-31
申请人： GLAXO GROUP LTD
发明人： WHITE JULIA , WISE ALAN , MARSHALL FIONA
IPC分类号： A61K38/00 , C07K14/47 , G01N33/94 , G01N33/50

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