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1. 发明申请

WO2010097386A1 ANTIGEN-BINDING CONSTRUCTS 审中-公开
标题翻译：抗原结构
公开(公告)号：WO2010097386A1
公开(公告)日：2010-09-02
申请号：PCT/EP2010/052284
申请日：2010-02-23
申请人： GLAXO GROUP LIMITED , HAMBLIN, Paul Andrew , PARMAR, Radha Shah , WHITE, John
发明人： HAMBLIN, Paul Andrew , PARMAR, Radha Shah , WHITE, John
IPC分类号： C07K16/24 , C07K16/28 , C07K16/46
CPC分类号： C07K16/2875 , C07K16/248 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/569 , C07K2319/00
摘要： The invention relates to a combination of RANKL antagonists with OSM antagonists, and provides antigen-binding constructs which bind to RANKL comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof.
摘要翻译：本发明涉及RANKL拮抗剂与OSM拮抗剂的组合，并提供与RANKL结合的抗原结合构建体，其包含与一个或多个表位结合结构域连接的蛋白质支架，其中所述抗原结合构建体具有至少两个抗原结合其中至少一个来自表位结合结构域并且其中至少一个来自配对的VH / VL结构域的位点，制备此类构建体的方法及其用途。

2. 发明申请

WO2010097394A1 MULTIVALENT AND/OR MULTISPECIFIC RANKL-BINDING CONSTRUCTS 审中-公开
标题翻译：多重和/或多重RANKL绑定结构
公开(公告)号：WO2010097394A1
公开(公告)日：2010-09-02
申请号：PCT/EP2010/052304
申请日：2010-02-23
申请人： GLAXO GROUP LIMITED , HAMBLIN, Paul, Andrew , PARMAR, Radha, Shah , WHITE, John
发明人： HAMBLIN, Paul, Andrew , PARMAR, Radha, Shah , WHITE, John
IPC分类号： C07K16/22 , C07K16/28 , C07K16/46
CPC分类号： C07K16/22 , C07K16/2875 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/569 , C07K2319/00
摘要： The invention relates to combinations of RANKL antagonists with VEGF antagonists, and provides antigen-binding constructs which bind to RANKL comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof.
摘要翻译：本发明涉及RANKL拮抗剂与VEGF拮抗剂的组合，并提供与RANKL结合的抗原结合构建体，其包含与一个或多个表位结合结构域连接的蛋白质支架，其中所述抗原结合构建体具有至少两个抗原结合位点其中至少一个来自表位结合结构域，并且其中至少一个来自配对的VH / VL结构域，制备此类构建体的方法及其用途。

3. 发明申请

WO2010097385A1 ANTIGEN-BINDING CONSTRUCTS 审中-公开
标题翻译：抗原结构
公开(公告)号：WO2010097385A1
公开(公告)日：2010-09-02
申请号：PCT/EP2010/052283
申请日：2010-02-23
申请人： GLAXO GROUP LIMITED , HAMBLIN, Paul Andrew , PARMAR, Radha Shah , WHITE, John
发明人： HAMBLIN, Paul Andrew , PARMAR, Radha Shah , WHITE, John
IPC分类号： C07K16/24 , C07K16/28 , C07K16/46
CPC分类号： C07K16/2875 , C07K16/241 , C07K16/2878 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/569 , C07K2319/00
摘要： The invention relates to combinations of RANKL antagonists with TNF-alpha antagonists and provides antigen-binding constructs which bind to RANKL comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof.
摘要翻译：本发明涉及RANKL拮抗剂与TNF-α拮抗剂的组合，并提供与RANKL结合的抗原结合构建体，其包含与一个或多个表位结合结构域连接的蛋白质支架，其中所述抗原结合构建体具有至少两个抗原结合其中至少一个来自表位结合结构域并且其中至少一个来自配对的VH / VL结构域的位点，制备此类构建体的方法及其用途。

4. 发明公开

EP2401298A1 ANTIGEN-BINDING CONSTRUCTS 审中-公开
标题翻译：抗原结合构建
公开(公告)号：EP2401298A1
公开(公告)日：2012-01-04
申请号：EP10711861.4
申请日：2010-02-23
申请人： Glaxo Group Limited
发明人： HAMBLIN, Paul Andrew , PARMAR, Radha Shah , WHITE, John
IPC分类号： C07K16/24 , C07K16/28 , C07K16/46
CPC分类号： C07K16/2875 , C07K16/241 , C07K16/2878 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/569 , C07K2319/00
摘要： The invention relates to combinations of RANKL antagonists with TNF-alpha antagonists and provides antigen-binding constructs which bind to RANKL comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof.

5. 发明公开

EP2401296A1 MULTIVALENT AND/OR MULTISPECIFIC RANKL-BINDING CONSTRUCTS 审中-公开
标题翻译： MULTI VALENTE和/或您特定的RANKL结合构建
公开(公告)号：EP2401296A1
公开(公告)日：2012-01-04
申请号：EP10704580.9
申请日：2010-02-23
申请人： Glaxo Group Limited
发明人： HAMBLIN, Paul, Andrew , PARMAR, Radha, Shah , WHITE, John
IPC分类号： C07K16/22 , C07K16/28 , C07K16/46
CPC分类号： C07K16/22 , C07K16/2875 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/569 , C07K2319/00
摘要： The invention relates to combinations of RANKL antagonists with VEGF antagonists, and provides antigen-binding constructs which bind to RANKL comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof.

6. 发明公开

EP2401297A1 ANTIGEN-BINDING CONSTRUCTS 审中-公开
标题翻译：抗原结合构建体
公开(公告)号：EP2401297A1
公开(公告)日：2012-01-04
申请号：EP10704579.1
申请日：2010-02-23
申请人： Glaxo Group Limited
发明人： HAMBLIN, Paul Andrew , PARMAR, Radha Shah , WHITE, John
IPC分类号： C07K16/24 , C07K16/28 , C07K16/46
CPC分类号： C07K16/2875 , C07K16/248 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/569 , C07K2319/00
摘要： The invention relates to a combination of RANKL antagonists with OSM antagonists, and provides antigen-binding constructs which bind to RANKL comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof.
摘要翻译：本发明涉及RANKL拮抗剂与OSM拮抗剂的组合，并提供与RANKL结合的抗原结合构建体，其包含与一个或多个表位结合结构域连接的蛋白质支架，其中抗原结合构建体具有至少两个抗原结合其中至少一个来自表位结合结构域且其中至少一个来自配对的VH / VL结构域的位点，制备这种构建体的方法及其用途。

7. 发明申请

WO2006124238A3 TISSUE PUNCTURE CLOSURE SYSTEM WITH RETRACTABLE SHEATH 审中-公开
公开(公告)号：WO2006124238A3
公开(公告)日：2006-11-23
申请号：PCT/US2006/016224
申请日：2006-04-28
申请人： ST. JUDE MEDICAL PUERTO RICO B.V. , WHITE, John , FIEHLER, William , FORSBERG, Andrew, T.
发明人： WHITE, John , FIEHLER, William , FORSBERG, Andrew, T.
IPC分类号： A61B17/08 , A61B17/02 , A61B17/04 , A61B17/12 , A61D1/00
摘要： Methods and apparatus are disclosed for sealing a puncture or incision formed percutaneously in tissue separating two internal portions of the body of a living being with an anchor, a sealing plug and a filament connecting the anchor and sealing plug, The methods and apparatus provide for automatic tamping and/or cinching of the sealing plug when the apparatus is withdrawn from the puncture site. The automatic tamping and/or cinching may be facilitated by retracting a procedure sheath without moving the sealing plug or a tamping assembly.

8. 发明申请

WO2002098972A1 SYSTEME SILICONE MODULATEUR D'ADHERENCE ET SON UTILISATION POUR LA PREPARATION DE COMPOSITIONS ANTI-ADHERENTES DURCISSABLES 审中-公开
标题翻译：释放调节硅酮体系及其用于制备可固化释放组合物
公开(公告)号：WO2002098972A1
公开(公告)日：2002-12-12
申请号：PCT/FR2002/001892
申请日：2002-06-04
申请人： RHODIA CHIMIE , DHALER, Didier , WHITE, John
发明人： DHALER, Didier , WHITE, John
IPC分类号： C08L83/04
CPC分类号： C09D183/06 , C08G77/12 , C08G77/14 , C08G77/16 , C08G77/20 , C08G77/80 , C08L83/04 , C08L83/06 , C09D183/04 , C08L83/00
摘要： La présente invention a pour objet un nouveau système silicone modulateur d'adhérence, et son utilisation pour la préparation de compositions silicones antiadhérentes, durcissables (Si-H/Si-Vi), et applicables sur des supports, de manière à faciliter l'enlèvement de matières adhésives collées de manière réversible sur ces supports. On recherche des modulateurs très efficaces en terme de pouvoir modulant, très réactifs et sans effet négatif sur les propriétés d'adhérence instantanée ("tack") des matières adhésives contrecollées sur le revêtement silicone anti-adhérent. Pour atteindre ce but, on a mis au point un système modulateur d'adhérence à base de 96 à 85 parties en poids d'au moins une résine polyorganosiloxane (A) réactive de type: MDViQ, MMViQ, MDViT, MMHéxénylQ, ou MMAllyloxypropylQ,o de 4 à 15 parties en poids d'au moins une résine (B) non réactive de type: MD'Q, MDD'Q, MDT', MQ, ou MDQ. Utilisation dudit système modulateur pour la préparation de compositions durcissables anti-adhérentes renfermant un polydiorganosiloxane linéaire, ledit système modulateur, un inhibiteur d'hydrosilylation, un polyorgano-hydrogénosiloxane linéaire réticulant et un catalyseur d'hydrosilylation.
摘要翻译：本发明涉及新型释放调节硅酮组合物及其用于制备适用于基材上的可固化脱模组合物（Si-H / Si-Vi）的用途，以便于去除可逆粘合在所述基材上的粘合剂材料。本发明的目的是在调节功率方面提供高效的粘合改性剂，并且不会对层压在剥离硅氧烷涂层上的粘合剂材料的瞬时粘合性产生不利影响。因此，本发明提供一种释放调节系统，其基于：96至85重量份的至少一种以下类型的反应性聚有机硅氧烷树脂（A）：MDViQ，MDViT，MMHexenylQ或MMAllyloxypropyl Q; 4至15重量份至少一种类型为MD'Q，MDD'Q，MDT'，MQ或MDQ的非反应性树脂（B）。本发明还涉及调节系统用于制备含有线性聚有机硅氧烷，所述调节系统，氢化硅烷化抑制剂，线性交联聚有机卤代硅氧烷和氢化硅烷化催化剂的释放组合物的用途。

9. 发明申请

WO2007064908A2 A SYSTEM TO PREVENT AIRWAY OBSTRUCTION 审中-公开
标题翻译：一种防止空中障碍的系统
公开(公告)号：WO2007064908A2
公开(公告)日：2007-06-07
申请号：PCT/US2006/046028
申请日：2006-11-30
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , MERY, Carlos , SHAFI, Bilal , BINYAMIN, Gary , CONNOR, Jessica Anne , WHITE, John
发明人： MERY, Carlos , SHAFI, Bilal , BINYAMIN, Gary , CONNOR, Jessica Anne , WHITE, John
IPC分类号： A61F5/56
CPC分类号： A61F5/566 , A61F2/02 , A61F5/56
摘要： Devices and methods are provided for the treatment of obstructive sleep apnea. An implantable device is inserted into the tongue. The implantable device is a flexible elongated structure, which may be a curved or jointed filament; of a sufficient length and diameter to provide support, when implanted, sufficient to restrain obstructive movement of the tongue during sleep.
摘要翻译：提供了用于治疗阻塞性睡眠呼吸暂停的装置和方法。将可植入装置插入到舌头中。可植入装置是柔性细长结构，其可以是弯曲或接合的细丝; 足够的长度和直径以在植入时提供足以在睡眠期间抑制舌头的阻塞运动的支撑。

10. 发明申请

WO2006073568A2 MULTI-LAYER HIGH QUALITY GATE DIELECTRIC FOR LOW-TEMPERATURE POLY-SILICON TFTs 审中-公开
标题翻译：用于低温聚硅薄膜的多层高质量栅介质
公开(公告)号：WO2006073568A2
公开(公告)日：2006-07-13
申请号：PCT/US2005/041231
申请日：2005-11-15
申请人： APPLIED MATERIALS, INC. , WHITE, John
发明人： WHITE, John
IPC分类号： C23C16/00 , H05H1/24
CPC分类号： C23C8/36 , C23C16/0218 , C23C16/402
摘要： A method and apparatus that is useful for forming a high quality gate dielectric layer in MOS TFT devices using a high density plasma oxidation (HDPO) process. In one embodiment a HDPO process layer is formed over the channel, source and drain regions to form a dielectric interface and then one or more dielectric layers are deposited on the HDPO layer to form a high quality gate dielectric layer. The HDPO process generally uses an inductively and/or capacitively coupled RF transmitting device to generate and control the plasma generated over the substrate and injecting a gas containing an oxidizing source to grow the interfacial layer. A second dielectric layer may then be deposited on the substrate using a CVD or PECVD deposition process. Aspects of the invention also provide a cluster tool that contains at least one specialized plasma processing chamber that is capable of depositing a high quality gate dielectric layer.
摘要翻译：一种用于在使用高密度等离子体氧化（HDPO）工艺的MOS TFT器件中形成高质量栅极电介质层的方法和装置。在一个实施例中，在沟道，源极和漏极区域上形成HDPO处理层以形成电介质界面，然后将一个或多个电介质层沉积在HDPO层上以形成高质量的栅极电介质层。 HDPO工艺通常使用感应和/或电容耦合的RF传输装置来产生和控制在衬底上产生的等离子体，并且注入含有氧化源的气体以生长界面层。然后可以使用CVD或PECVD沉积工艺将第二电介质层沉积在衬底上。本发明的各方面还提供了一种集群工具，其包含能够沉积高质量栅极电介质层的至少一个专用等离子体处理室。

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