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1. 发明申请

WO2011088201A1 VOLTAGE-GATED SODIUM CHANNEL BLOCKERS 审中-公开
标题翻译：电压门控通道阻塞器
公开(公告)号：WO2011088201A1
公开(公告)日：2011-07-21
申请号：PCT/US2011/021114
申请日：2011-01-13
申请人： GLAXO GROUP LIMITED , BOEHM, Jeffrey, Charles , DAVIS, Roderick, S. , KERNS, Jeffrey, K. , LIN, Guoliang , NIE, Hong
发明人： BOEHM, Jeffrey, Charles , DAVIS, Roderick, S. , KERNS, Jeffrey, K. , LIN, Guoliang , NIE, Hong
IPC分类号： A61K31/497
CPC分类号： C07D213/80 , C07D213/74 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present invention relates to voltage-gated sodium channel blocker intermediates, compounds and dimers, corresponding pharmaceutical compositions, compound preparation and treatment methods for respiratory or respiratory tract diseases.
摘要翻译：本发明涉及电压门控钠通道阻断剂中间体，化合物和二聚体，相应的药物组合物，用于呼吸或呼吸道疾病的化合物制备和治疗方法。

2. 发明申请

WO2013006596A1 VOLTAGE-GATED SODIUM CHANNEL BLOCKERS 审中-公开
标题翻译：电压门控通道阻塞器
公开(公告)号：WO2013006596A1
公开(公告)日：2013-01-10
申请号：PCT/US2012/045350
申请日：2012-07-03
申请人： GLAXO GROUP LIMITED , BOEHM, Jeffrey, Charles , DAVIS, Roderick, S. , KERNS, Jeffrey , LIN, Guoliang , MURDOCH, Robert, D. , NIE, Hong
发明人： BOEHM, Jeffrey, Charles , DAVIS, Roderick, S. , KERNS, Jeffrey , LIN, Guoliang , MURDOCH, Robert, D. , NIE, Hong
IPC分类号： A61K31/497
CPC分类号： C07D409/14 , A61K31/497 , C07D213/80 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/12
摘要： In general, the present invention relates to uses of voltage-gated sodium channel blocker compounds,, which include corresponding precursors, intermediates, monomers and dimers, corresponding pharmaceutical compositions, compound preparation and treatment methods for respiratory and respiratory tract diseases. In particular, the present invention also relates to methods and uses for treatment of respiratory or respiratory tract diseases, which comprises administering to a subject in need thereof an effective amount of a compound of the present invention.
摘要翻译：通常，本发明涉及电压门控钠通道阻断剂化合物的用途，其包括相应的前体，中间体，单体和二聚体，相应的药物组合物，用于呼吸和呼吸道疾病的化合物制备和治疗方法。特别地，本发明还涉及治疗呼吸道或呼吸道疾病的方法和用途，其包括向有需要的受试者施用有效量的本发明化合物。

3. 发明申请

WO2007062318A3 CHEMICAL COMPOUNDS 审中-公开
公开(公告)号：WO2007062318A3
公开(公告)日：2007-05-31
申请号：PCT/US2006/061018
申请日：2006-11-17
申请人： SMITHKLINE BEECHAM CORPORATION , KERNS, Jeffrey, K. , BUSCH-PETERSEN, Jakob , LI, Huijie , BOEHM, Jeffrey, Charles , NIE, Hong , TAGGART, John, J.
发明人： KERNS, Jeffrey, K. , BUSCH-PETERSEN, Jakob , LI, Huijie , BOEHM, Jeffrey, Charles , NIE, Hong , TAGGART, John, J.
IPC分类号： A61K31/54
摘要： The invention is directed to novel indolecarboxamide derivatives, Specifically, the invention is directed to compounds according to formula (I), where R1 , R2, R3 and X are defined below. These compounds are useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, in particular in the treatment and prevention of disorders mediated by IKK2 mechanisms including inflammatory and tissue repair disorders. Such disorders include rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease).

4. 发明申请

WO2007005534A2 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：WO2007005534A2
公开(公告)日：2007-01-11
申请号：PCT/US2006/025402
申请日：2006-06-28
申请人： SMITHKLINE BEECHAM CORPORATION , DENG, Jianghe , KERNS, Jeffrey, K. , JIN, Qi , LIN, Guoliang , LIN, Xichen , LINDENMUTH, Michael , NEIPP, Christopher, E. , NIE, Hong , THOMAS, Sonia, M. , WIDDOWSON, Katherine, L.
发明人： DENG, Jianghe , KERNS, Jeffrey, K. , JIN, Qi , LIN, Guoliang , LIN, Xichen , LINDENMUTH, Michael , NEIPP, Christopher, E. , NIE, Hong , THOMAS, Sonia, M. , WIDDOWSON, Katherine, L.
IPC分类号： C07C15/02
CPC分类号： C07D409/14 , C07D209/14 , C07D401/04 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I: Formula (I) where R1 , R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
摘要翻译：本发明涉及新的吲哚甲酰胺衍生物。具体地，本发明涉及式I化合物：式（I）其中R 1，R 2，R 3，U和V定义如下，及其药学上可接受的盐。本发明的化合物是IKK2的抑制剂，并且可用于治疗与不适当的IKK2（也称为IKKβ）活性相关的疾病，例如类风湿性关节炎，哮喘和COPD（慢性阻塞性肺疾病）。因此，本发明进一步涉及包含本发明化合物的药物组合物。本发明还涉及使用本发明化合物或包含本发明化合物的药物组合物来抑制IKK2活性和与之相关疾病的治疗方法。

5. 发明申请

WO2006034317A2 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：WO2006034317A2
公开(公告)日：2006-03-30
申请号：PCT/US2005/033752
申请日：2005-09-21
申请人： GLAXO GROUP LIMITED , KERNS, Jeffrey, K. , LINDENMUTH, Michael , LIN, Xichen , NIE, Hong , THOMAS, Sonia, M.
发明人： KERNS, Jeffrey, K. , LINDENMUTH, Michael , LIN, Xichen , NIE, Hong , THOMAS, Sonia, M.
IPC分类号： A61K31/4439
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula (1): where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKß) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
摘要翻译：本发明涉及新的吲哚甲酰胺衍生物。具体地说，本发明涉及式（1）化合物：其中R1，R2，R3，U和V定义如下，及其药学上可接受的盐。本发明的化合物是IKK2的抑制剂，并且可用于治疗与不适当的IKK2（也称为IKKβ）活性相关的疾病，例如类风湿性关节炎，哮喘和COPD（慢性阻塞性肺疾病）。因此，本发明进一步涉及包含本发明化合物的药物组合物。本发明还涉及使用本发明化合物或包含本发明化合物的药物组合物来抑制IKK2活性和与之相关疾病的治疗方法。

6. 发明申请

WO2004017911A2 PROTEASE INHIBITORS 审中-公开
标题翻译：蛋白酶抑制剂
公开(公告)号：WO2004017911A2
公开(公告)日：2004-03-04
申请号：PCT/US2003/026358
申请日：2003-08-22
申请人： SMITHKLINE BEECHAM CORPORATION , BONDINELL, William, E. , HALL, Ralph, F. , JIN, Qi , KERNS, Jeffrey, K. , NIE, Hong , WIDDOWSON, Katherine, L.
发明人： BONDINELL, William, E. , HALL, Ralph, F. , JIN, Qi , KERNS, Jeffrey, K. , NIE, Hong , WIDDOWSON, Katherine, L.
IPC分类号： A61K
CPC分类号： H04L27/2601 , C07D223/08 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04
摘要： This invention relates 4-amino-azepan-3-ones of formula (1) which are useful as protease inhibitors, particularly of cathepsin S, and as such are useful for preventing a number of diseases amongst which are atherosclerotic lesions and pulmonary diseases such as asthma and allergic reactions.
摘要翻译：本发明涉及式（1）的4-氨基 - 氮杂环庚烷-3-酮，其可用作蛋白酶抑制剂，特别是组织蛋白酶S，并因此可用于预防许多疾病，其中是动脉粥样硬化病变和肺部疾病，如哮喘和过敏反应。

7. 发明申请

WO2005000247A3 4-CARBOXAMIDO QUINOLINE DERIVATIVES FOR USE AS NK-2 AND NK-3 审中-公开
公开(公告)号：WO2005000247A3
公开(公告)日：2005-01-06
申请号：PCT/US2004/020333
申请日：2004-06-23
申请人： SMITHKLINE BEECHAM CORPORATION , KERNS, Jeffrey, K. , NIE, Hong
发明人： KERNS, Jeffrey, K. , NIE, Hong
IPC分类号： A61K31/496
摘要： Compounds of the formula (I) are disclosed which are NK2 and NK3 receptor antagonists and are useful in the treatment of respiratory diseases: or a pharmaceutically acceptable salt thereof.

8. 发明申请

WO2009127036A1 IMPULSE ULTRA-WIDEBAND RADIO COMMUNICATION SYSTEM 审中-公开
标题翻译： IMPULSE ULTRA-WIDEBAND无线电通信系统
公开(公告)号：WO2009127036A1
公开(公告)日：2009-10-22
申请号：PCT/CA2008/001335
申请日：2008-07-23
申请人： NIE, Hong , CHEN, Zhizhang
发明人： NIE, Hong , CHEN, Zhizhang
IPC分类号： H04L25/49 , H03K7/02 , H04B7/005 , H04L29/02
CPC分类号： H04B1/719 , H04B1/71637
摘要： A method and apparatus are provided for implementing an impulse ultra-wideband communications system which combines the technique of transmitted reference (TR) with a code-sifted reference scheme that separates the reference and the data pulses with a sequence of codes such as a subset of Walsh codes. The joint use of shifting codes (at the transmitter) and detection codes (at the receiver) enable correct detection of information bits from the reference pulse sequence and data pulse sequences which are transmitted simultaneously. The combination of the two techniques in ultra-wideband (UWB) radio systems removes the wideband delay elements required by conventional TR UWB systems. The invention provides a system with no analog carriers and lower complexities than other UWB systems, and which has better performances, higher tolerance to nonlinearity, and larger capacities.
摘要翻译：提供了一种用于实现脉冲超宽带通信系统的方法和装置，该脉冲超宽带通信系统将传输参考（TR）的技术与使用诸如子集的子序列分离参考和数据脉冲的代码筛选参考方案进行组合沃尔什码联合使用移位代码（在发送器处）和检测代码（在接收器处）使得能够从参考脉冲序列和同时传输的数据脉冲序列中正确检测信息位。超宽带（UWB）无线电系统中的两种技术的组合消除了传统TR UWB系统所需的宽带延迟元件。本发明提供了一种没有模拟载波和比其他UWB系统更低复杂度的系统，其具有更好的性能，更高的对非线性的容忍性和更大的容量。

9. 发明申请

WO2004066950A2 QUINOLINE DERIVATIVES AS NK-2 AND NK-3 RECEPTOR ANTAGONISTS 审中-公开
标题翻译：作为NK-2和NK-3受体拮抗剂的喹啉衍生物
公开(公告)号：WO2004066950A2
公开(公告)日：2004-08-12
申请号：PCT/US2004/002366
申请日：2004-01-29
申请人： SMITHKLINE BEECHAM CORPORATION , KERNS, Jeffrey , JIN, Qi , WAN, Zehong , NIE, Hong , ZHU, Chongjie
发明人： KERNS, Jeffrey , JIN, Qi , WAN, Zehong , NIE, Hong , ZHU, Chongjie
IPC分类号： A61K
CPC分类号： C07D409/14
摘要： Compounds of formula (I) are disclosed which are NK2 and NK3 receptor antagonists and are useful in the treatment of respiratory diseases, or a pharmaceutically acceptable salt thereof.
摘要翻译：公开了式（I）化合物，它们是NK 2和NK 3受体拮抗剂并且可用于治疗呼吸系统疾病或其药学上可接受的盐。

10. 发明申请

WO2008002996A2 RHEUMATOID ARTHRITIS T CELL VACCINE 审中-公开
公开(公告)号：WO2008002996A2
公开(公告)日：2008-01-03
申请号：PCT/US2007/072277
申请日：2007-06-27
申请人： SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES , ZHANG, Jingwu, Zang , CHEN, Guangjie , NIE, Hong , LI, Ningli
发明人： ZHANG, Jingwu, Zang , CHEN, Guangjie , NIE, Hong , LI, Ningli
IPC分类号： C12N5/08
CPC分类号： C12N5/0636 , A61K39/0008 , A61K2039/515
摘要： Described herein is an activated synovial autoreactive T cell and compositions thereof. Methods or preparing T cell compositions that may be used for treating rheumatoid arthritis are also described.
摘要翻译：本文描述了活化的滑膜自体反应性T细胞及其组合物。还描述了可用于治疗类风湿性关节炎的方法或制备T细胞组合物。

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