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1. 发明申请

WO2013014208A2 ANTIGEN BINDING CONSTRUCTS 审中-公开
标题翻译：抗原结合结构
公开(公告)号：WO2013014208A2
公开(公告)日：2013-01-31
申请号：PCT/EP2012/064632
申请日：2012-07-25
申请人： GLAXO GROUP LIMITED , ASHMAN, Claire , CATCHPOLE, Ian Richard , HUGHES-THOMAS, Zoe , LEWIS, Alan Peter , STEWARD, Michael
发明人： ASHMAN, Claire , CATCHPOLE, Ian Richard , HUGHES-THOMAS, Zoe , LEWIS, Alan Peter , STEWARD, Michael
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/54 , A61K2039/70 , C07K16/46 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/52 , C07K2317/565 , C07K2317/569 , C07K2317/60 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain Fc region of an antibody, wherein each epitope binding domain in capable of binding to VEGF, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with VEGF signalling, such as diabetic macular edema (DME), wet age-related macular degeneration (Wet AMD), diabetic retinopathy, retinal vein occlusion (RVO), and corneal neovascularisation, and polynucleotide sequences encoding said antigen binding constructs.
摘要翻译：本发明涉及包含通过抗体的单链Fc区分离的一个或两个表位结合结构域的抗原结合构建体，其中能够结合VEGF的每个表位结合域与包含本发明的两个抗原结合构建体的二聚体，包含所述二聚体的药物组合物及其用于治疗与VEGF信号传导相关的疾病，例如糖尿病性黄斑水肿（DME），湿性年龄相关性黄斑变性（湿性AMD），糖尿病性视网膜病变，视网膜静脉阻塞（RVO）和角膜新血管形成和编码所述抗原结合构建体的多核苷酸序列。

2. 发明申请

WO2013024059A2 MODIFIED PROTEINS AND PEPTIDES 审中-公开
标题翻译：改性蛋白和肽
公开(公告)号：WO2013024059A2
公开(公告)日：2013-02-21
申请号：PCT/EP2012/065782
申请日：2012-08-13
申请人： GLAXO GROUP LIMITED , ASHMAN, Claire , BIRCHLER, Mary , DE WILDT, Rudolf M T , HOLLAND, Claire , LEWIS, Alan Peter , MORLEY, Peter , SANDAL, Thomas , STEWARD, Michael
发明人： ASHMAN, Claire , BIRCHLER, Mary , DE WILDT, Rudolf M T , HOLLAND, Claire , LEWIS, Alan Peter , MORLEY, Peter , SANDAL, Thomas , STEWARD, Michael
IPC分类号： C07K16/00
CPC分类号： C07K16/42 , C07K16/00 , C07K16/22 , C07K16/2878 , C07K2317/40 , C07K2317/567 , C07K2317/569 , C07K2317/60 , C07K2317/64 , C07K2319/00
摘要： The present invention relates to modified proteins and peptides that have reduced ability to bind to pre-existing antibodies. Such modified protein/peptide molecules can comprise C-terminal additions, extensions or tags and/or certain amino acid substitutions. Such modified molecules (e.g. fusions and conjugates) comprise proteins, peptides, antigen binding molecules, antibodies or antibody fragments such as single variable domains e.g. human immunoglobulin (antibody) single variable domains, and also single variable domains derived from non-human sources such as a llama or camel, e.g. a VHH including a nanobody TM (described in e.g. WO 94/04678 and WO 95/04079 inter alia). The invention further relates to uses, formulations, compositions comprising such modified C terminally extended and/or amino acid substituted molecules and also to methods of production and expression of these molecules.
摘要翻译：本发明涉及具有降低与先前存在的抗体结合的能力的修饰的蛋白质和肽。这种修饰的蛋白质/肽分子可以包含C-末端添加，延伸或标签和/或某些氨基酸取代。这样的修饰分子（例如融合物和缀合物）包括蛋白质，肽，抗原结合分子，抗体或抗体片段，例如单个可变结构域，例如，人免疫球蛋白（抗体）单可变结构域，以及衍生自非人来源的单可变结构域，例如美洲驼或骆驼，例如。包括纳米体系的VHH（例如WO 94/04678和WO 95/04079等）。本发明还涉及包含这种修饰的C末端延伸和/或氨基酸取代分子的用途，制剂，组合物，以及这些分子的生产和表达方法。

3. 发明申请

WO2002070711A1 VACCINE 审中-公开
标题翻译：疫苗
公开(公告)号：WO2002070711A1
公开(公告)日：2002-09-12
申请号：PCT/GB2002/000900
申请日：2002-03-01
申请人： GLAXO GROUP LIMITED , ASHMAN, Claire , CROWE, James, Scott , ELLIS, Jonathan, Henry , LEWIS, Alan, Peter
发明人： ASHMAN, Claire , CROWE, James, Scott , ELLIS, Jonathan, Henry , LEWIS, Alan, Peter
IPC分类号： C12N15/24
CPC分类号： C07K14/5406 , A61K39/00 , A61K2039/55561 , C07K14/5437 , C07K2319/00
摘要： The present invention relates to an isolated polypeptide useful for immunisation against self-antigens. In particular the invention relates to a self-protein that is capable of raising auto-antibodies when administered in vivo. The invention particularly relates to rendering human cytokines immunogenic in humans. The invention further relates to pharmaceutical compositions comprising such compounds and their use in medicine and to methods for their production.
摘要翻译：本发明涉及用于免疫抗自身抗原的分离的多肽。特别地，本发明涉及当在体内施用时能够引发自身抗体的自身蛋白质。本发明特别涉及在人体中呈递免疫原性的人类细胞因子。本发明还涉及包含这些化合物的药物组合物及其在医药中的用途及其生产方法。

4. 发明申请

WO2011151432A1 HUMANISED ANTIGEN BINDING PROTEINS TO MYOSTATIN6 审中-公开
标题翻译：人类抗原结合蛋白到MYOSTATIN6
公开(公告)号：WO2011151432A1
公开(公告)日：2011-12-08
申请号：PCT/EP2011/059173
申请日：2011-06-02
申请人： GLAXO GROUP LIMITED , ASHMAN, Claire , ASHMAN, Stephen , HAMBLIN, Paul Andrew , LEWIS, Alan Peter , ORECCHIA, Martin, Anibal
发明人： ASHMAN, Claire , ASHMAN, Stephen , HAMBLIN, Paul Andrew , LEWIS, Alan Peter , ORECCHIA, Martin, Anibal
IPC分类号： C07K16/22 , A61K39/395 , A61P21/06
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to humanised antigen binding proteins, such as antibodies, which bind to myostatin, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present invention also concerns the use of such humanised antigen binding proteins in the treatment or prophylaxis of diseases associated with any one or a combination of decreased muscle mass, muscle strength and muscle function.
摘要翻译：本发明涉及结合肌生成抑制素的人源化抗原结合蛋白，例如抗体，编码这种抗原结合蛋白的多核苷酸，包含所述抗原结合蛋白的药物组合物及其制备方法。本发明还涉及这样的人源化抗原结合蛋白在治疗或预防与肌肉量，肌肉力量和肌肉功能降低的任何一种或组合相关的疾病中的用途。

5. 发明申请

WO2010136481A1 IL-13 BINDING PROTEIN 审中-公开
标题翻译： IL-13结合蛋白
公开(公告)号：WO2010136481A1
公开(公告)日：2010-12-02
申请号：PCT/EP2010/057228
申请日：2010-05-26
申请人： GLAXO GROUP LIMITED , ASHMAN, Claire , ELLIS, Jonathan, Henry , HAMBLIN, Paul Andrew , LEWIS, Alan Peter , ORECCHIA, Martin, Anibal
发明人： ASHMAN, Claire , ELLIS, Jonathan, Henry , HAMBLIN, Paul Andrew , LEWIS, Alan Peter , ORECCHIA, Martin, Anibal
IPC分类号： C07K16/24 , C07K16/46 , A61P11/06
CPC分类号： C07K16/244 , A61K2039/505 , C07K16/247 , C07K16/468 , C07K2317/24 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/76 , Y02A50/41
摘要： The present invention relates to antigen binding proteins to human IL-13, including anti-IL-13 antibodies and anti-IL-3/anti-IL-4 mAbdAbs, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as asthma or IPF.
摘要翻译：本发明涉及抗人IL-13的抗原结合蛋白，包括抗IL-13抗体和抗IL-3 /抗-IL-4mAbdAb，含有它们的药物制剂以及该抗原结合蛋白在治疗和/或预防炎性疾病如哮喘或IPF。

6. 发明申请

WO2009068649A3 ANTIGEN-BINDING CONSTRUCTS 审中-公开
公开(公告)号：WO2009068649A3
公开(公告)日：2009-06-04
申请号：PCT/EP2008/066438
申请日：2008-11-28
申请人： GLAXO GROUP LIMITED , ASHMAN, Claire , BATUWANGALA, Thil , BURDEN, Michael, Neil , CLEGG, Stephanie, Jane , DE WILDT, Rudolf, Maria , ELLIS, Jonathan, Henry , HAMBLIN, Paul, Andrew , HUSSAIN, Farhana , JESPERS, Laurent , LEWIS, Alan , ORECCHIA, Martin, Anibal , SHAH, Radha , STEWARD, Michael
发明人： ASHMAN, Claire , BATUWANGALA, Thil , BURDEN, Michael, Neil , CLEGG, Stephanie, Jane , DE WILDT, Rudolf, Maria , ELLIS, Jonathan, Henry , HAMBLIN, Paul, Andrew , HUSSAIN, Farhana , JESPERS, Laurent , LEWIS, Alan , ORECCHIA, Martin, Anibal , SHAH, Radha , STEWARD, Michael
IPC分类号： C07K16/46 , A61K39/395 , A61P35/00 , A61P29/00 , C12N15/13 , C12N5/10 , C07K16/22 , C07K16/24 , C07K16/28 , C07K16/32
摘要： The invention relates to antigen-binding constructs comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen- binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof.

7. 发明申请

WO2004019974A2 VACCINE 审中-公开
标题翻译：疫苗
公开(公告)号：WO2004019974A2
公开(公告)日：2004-03-11
申请号：PCT/GB2003/003703
申请日：2003-08-28
申请人： GLAXO GROUP LIMITED , ASHMAN, Claire , ELLIS, Jonathan, Henry
发明人： ASHMAN, Claire , ELLIS, Jonathan, Henry
IPC分类号： A61K39/00
CPC分类号： A61K39/0005 , A61K39/00 , A61K39/0008 , A61K2039/55572 , A61K2039/55577 , A61K2039/6037 , C07K14/5437
摘要： The present invention relates to isolated immunogens and their use in the treatment of diseases that are treatable with neutralisation of IL-13, such as COPD, asthma and atopic disorders such as hayfever, contact allergies and atopic dermatitis. In particular the invention relates to the neutralisation of the biological effects of IL-13 by raising an immune response against the IL-13 by vaccination of a mammal with immunogens comprising the native or mutated amino acid sequence of IL-13, and foreign T-helper epitopes either inserted in, or attached to the IL-13 sequence or present in carrier polypeptides. Also provided by the present invention are DNA vaccines that comprise a polynucleotide sequence that encodes the immunogens of the present invention. The invention further relates to pharmaceutical compositions comprising such immunogens and their use in medicine and to methods for their production.
摘要翻译：本发明涉及分离的免疫原及其用于治疗可以通过中和IL-13治疗的疾病，例如COPD，哮喘和特应性疾病如过敏，接触性过敏和特应性皮炎。特别地，本发明涉及通过用包含IL-13的天然或突变的氨基酸序列的免疫原接种哺乳动物和外来T-细胞的免疫原，通过提高对IL-13的免疫应答来中和IL-13的生物学效应，插入或附着于IL-13序列或存在于载体多肽中的辅助表位。本发明还提供了包含编码本发明的免疫原的多核苷酸序列的DNA疫苗。本发明还涉及包含这种免疫原的药物组合物及其在医药中的用途及其生产方法。

8. 发明申请

WO2004019975A2 VACCINE 审中-公开
标题翻译：疫苗
公开(公告)号：WO2004019975A2
公开(公告)日：2004-03-11
申请号：PCT/GB2003/003729
申请日：2003-08-28
申请人： GLAXO GROUP LIMITED , ELLIS, Jonathan, Henry , ASHMAN, Claire
发明人： ELLIS, Jonathan, Henry , ASHMAN, Claire
IPC分类号： A61K39/00
CPC分类号： A61K39/0005 , A61K39/0008 , A61K2039/55561 , A61K2039/55572 , A61K2039/55577 , A61K2039/6037
摘要： The present invention relates to IL-13 vaccines and their use in the treatment of diseases that are treatable with neutralisation of IL-13, such as COPD, asthma and atopic disorders such as hayfever, contact allergies and atopic dermatitis. The vaccines of the present invention comprise an IL-13 immunogen and an adjuvant composition which is a combination of a saponin and a non-toxic derivative of LPS. The invention further relates to pharmaceutical compositions comprising such immunogens and their use in medicine and to methods for their production.
摘要翻译：本发明涉及IL-13疫苗及其用于治疗可以通过中和IL-13治疗的疾病，例如COPD，哮喘和特应性疾病如过敏，接触性过敏和特应性皮炎。本发明的疫苗包含IL-13免疫原和作为皂苷和LPS的无毒性衍生物的组合的佐剂组合物。本发明还涉及包含这种免疫原的药物组合物及其在医药中的用途及其生产方法。

9. 发明申请

WO2007080174A2 IMMUNOGLOBULINS 审中-公开
标题翻译：免疫球蛋白
公开(公告)号：WO2007080174A2
公开(公告)日：2007-07-19
申请号：PCT/EP2007/050219
申请日：2007-01-10
申请人： GLAXO GROUP LIMITED , ASHMAN, Claire , CASSIDY, Martin, John , CLARKSON, Jane, Elizabeth , ELLIS, Jonathan, Henry , WATTAM, Trevor, Anthony, Kenneth
发明人： ASHMAN, Claire , CASSIDY, Martin, John , CLARKSON, Jane, Elizabeth , ELLIS, Jonathan, Henry , WATTAM, Trevor, Anthony, Kenneth
IPC分类号： C07K16/00
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y02A50/41
摘要： The present invention concerns immunoglobulins, particularly antibodies which specifically bind human lnterleukin 13 (hlL-13). Antibodies of the invention may be used in the treatment of a variety of diseases or disorders responsive to modulation of the interaction between hlL-13 and the human IL-13 receptor. Such diseases include severe asthma, atopic dermatitis, COPD and various fibrotic diseases. Pharmaceutical compositions comprising said antibodies and methods of manufacture are also disclosed.
摘要翻译：本发明涉及免疫球蛋白，特别是特异性结合人白细胞介素13（hIL-13）的抗体。本发明的抗体可用于治疗响应于调节hIL-13与人IL-13受体之间相互作用的各种疾病或病症。这些疾病包括严重哮喘，特应性皮炎，COPD和各种纤维化疾病。还公开了包含所述抗体和制备方法的药物组合物。

10. 发明申请

WO2006003407A2 IMMUNOGLOBULINS 审中-公开
标题翻译：免疫球蛋白
公开(公告)号：WO2006003407A2
公开(公告)日：2006-01-12
申请号：PCT/GB2005/002581
申请日：2005-06-30
申请人： GLAXO GROUP LIMITED , ASHMAN, Claire , CASSIDY, Martin, John , ELLIS, Jonathan, Henry , WATTAM, Trevor, Anthony, Kenneth
发明人： ASHMAN, Claire , CASSIDY, Martin, John , ELLIS, Jonathan, Henry , WATTAM, Trevor, Anthony, Kenneth
IPC分类号： C07K16/00
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , Y02A50/41
摘要： The present invention concerns immunoglobulins, particularly antibodies which specifically bind human Interleukin 13 (hIL-13). Antibodies of the invention may be used in the treatment of a variety of diseases or disorders responsive to modulation of the interaction between hIL-13 and the human IL-13 receptor. Such diseases include severe asthma, atopic dermatitis, COPD and various fibrotic diseases. Pharmaceutical compositions comprising said antibodies and methods of manufacture are also disclosed.
摘要翻译：本发明涉及免疫球蛋白，特别是特异性结合人白细胞介素13（hIL-13）的抗体。本发明的抗体可用于治疗响应调节hIL-13与人IL-13受体之间的相互作用的各种疾病或病症。这些疾病包括严重哮喘，特应性皮炎，COPD和各种纤维化疾病。还公开了包含所述抗体和制备方法的药物组合物。

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