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1. 发明授权

EP0278173B1 Use of heterocyclic derivatives in the treatment of depressions 失效
标题翻译：使用用于治疗抑郁症的杂环化合物。
公开(公告)号：EP0278173B1
公开(公告)日：1993-11-03
申请号：EP87311077.9
申请日：1987-12-16
申请人： GLAXO GROUP LIMITED
发明人： Tyers, Michael Brian
IPC分类号： A61K31/415 , A61K31/445 , A61K31/46 , A61K31/50 , A61K31/55
CPC分类号： A61K31/46 , A61K31/415 , A61K31/445 , A61K31/50 , A61K31/55

2. 发明公开

EP0275668A3 Use of ketone derivatives in the treatment of cognitive disorders 失效
标题翻译：使用酮衍生物治疗认知障碍
公开(公告)号：EP0275668A3
公开(公告)日：1989-10-11
申请号：EP87311078.7
申请日：1987-12-16
申请人： GLAXO GROUP LIMITED
发明人： Tyers, Michael Brian
IPC分类号： A61K31/415
CPC分类号： A61K31/415
摘要： The invention relates to the use of 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1 H -imidazol-1-yl)methyl]-4 H -carbazol-4-one and physiologically acceptable salts and solvates thereof in the treatment of cognitive disorders such as attentional and memory deficits and dementia states.

3. 发明公开

EP0275668A2 Use of ketone derivatives in the treatment of cognitive disorders 失效
标题翻译： Verwendung von Ketonderivaten zur Behandlung vonBewusstseinsstörungen。
公开(公告)号：EP0275668A2
公开(公告)日：1988-07-27
申请号：EP87311078.7
申请日：1987-12-16
申请人： GLAXO GROUP LIMITED
发明人： Tyers, Michael Brian
IPC分类号： A61K31/415
CPC分类号： A61K31/415
摘要： The invention relates to the use of 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1 H -imidazol-1-yl)methyl]-4 H -carbazol-4-one and physiologically acceptable salts and solvates thereof in the treatment of cognitive disorders such as attentional and memory deficits and dementia states.
摘要翻译：本发明涉及1,2,3,9-四氢-9-甲基-3 - [（2-甲基-1H-咪唑-1-基）甲基] -4H - 咔唑-4-酮一种和其生理上可接受的盐和溶剂合物在治疗认知障碍如注意缺陷和记忆缺陷和痴呆状态。

4. 发明授权

EP0279990B1 Use of heterocyclic derivatives in the treatment of cognitive disorders 失效
标题翻译：对意识障碍的治疗中使用的杂环化合物。
公开(公告)号：EP0279990B1
公开(公告)日：1995-07-12
申请号：EP87311079.5
申请日：1987-12-16
申请人： GLAXO GROUP LIMITED
发明人： Tyers, Michael Brian
IPC分类号： A61K31/445 , A61K31/46
CPC分类号： A61K31/55 , A61K31/415 , A61K31/435 , A61K31/445 , A61K31/46 , A61K31/495 , A61K31/50

5. 发明公开

EP0559297A1 Use of heterocyclic derivatives for the manufacture of medicaments 失效
标题翻译：杂环衍生物用于制造药物的用途
公开(公告)号：EP0559297A1
公开(公告)日：1993-09-08
申请号：EP93201171.1
申请日：1987-12-16
申请人： GLAXO GROUP LIMITED
发明人： Tyers, Michael Brian
IPC分类号： A61K31/435
CPC分类号： A61K31/55 , A61K31/415 , A61K31/435 , A61K31/445 , A61K31/46 , A61K31/495 , A61K31/50
摘要： The invention relates to the use of certain compounds which act as antagonists of 5-hydroxytryptamine (5-HT) at 5-HT₃ receptors for the treatment of cognitive disorders such as attentional and memory deficits and dementia states.
摘要翻译：本发明涉及某些在5-HT 3受体上起5-羟色胺（5-HT）拮抗剂作用的化合物用于治疗认知障碍如注意力和记忆缺陷和痴呆状态的用途。

6. 发明公开

EP0357416A2 Use of serotonin antagonists in the treatment of drug addiction 失效
标题翻译： Verwendung von Serotonin-Antagonisten bei der Behandlung vonDrogenabhängigkeit。
公开(公告)号：EP0357416A2
公开(公告)日：1990-03-07
申请号：EP89308806.2
申请日：1989-08-31
申请人： GLAXO GROUP LIMITED
发明人： Coates, Ian Harold , Oxford, Alexander William , North, Peter Charles , Tyers, Michael Brian
IPC分类号： A61K31/00 , A61K31/445 , A61K31/55
CPC分类号： A61K31/00 , A61K31/445 , A61K31/55
摘要： The invention relates to the use of compounds of formula (I)
wherein Im represents an imidazolyl group of formula:
and R¹ represents a hydrogen atom or a group selected from C₁₋₆alkyl, C₃₋₆alkenyl, C₃₋₁₀alkynyl, C₃₋₇cycloalkyl, C₃₋₇cycloalkylC₁₋₄alkyl, phenyl, phenylC₁₋₃alkyl, phenylmethoxymethyl, phenoxyethyl, phenoxymethyl, -CO₂R⁵, -COR⁵, -CONR⁵R⁶ or -SO₂R⁵ (wherein R⁵ and R⁶, which may be the same or different, each represents a hydrogen atom, a C₁₋₆alkyl or C₃₋₇cycloalkyl group, or a phenyl or phenylC₁₋₄alkyl group, in which the phenyl group is optionally substituted by one or more C₁₋₄alkyl, C₁₋₄alkoxy or hydroxy groups or halogen atoms, with the proviso that R⁵ does not represent a hydrogen atom when R¹ represents a group -CO₂R⁵ or -SO₂R⁵);
one of the groups represented by R², R³ and R⁴ is a hydrogen atom or a C₁₋₆alkyl, C₃₋₇cycloalkyl, C₃₋₆alkenyl, phenyl or phenyl C₁₋₃alkyl group, and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C₁₋₆ alkyl group;
and n represents 2 or 3,
and physiologically acceptable salts and solvates thereof for the manufacture of a medicament for the relief or prevention of a withdrawal syndrome resulting from addiction to a drug of substance of abuse and/or for the suppression of dependence on drugs or substances of abuse.
摘要翻译：本发明涉及式（I）化合物的用途，其中Im表示下式的咪唑基：＆lt; CHEM＆gt; R 1表示氢原子或选自C 1-6烷基，C 3-6烯基， C 3-10炔基，C 3-7环烷基，C 3-7环烷基C 1-4烷基，苯基，苯基C 1-3烷基，苯基甲氧基甲基，苯氧基乙基，苯氧基甲基，-CO 2 R 5，-COR 5，-CONR 5 R 6或-SO 2 R <5>（其中R 5和R 6可以相同或不同，各自表示氢原子，C 1-6烷基或C 3-7环烷基或苯基或苯基C 1-4烷基，其中苯基任选被一个或多个C 1-4烷基，C 1-4烷氧基或羟基或卤素原子取代，条件是当R 1表示-CO 2 R 5基团时，R 5不表示氢原子 >或-SO 2 R 5）; 由R 2，R 3和R 4表示的基团之一是氢原子或C 1-6烷基，C 3-7环烷基，C 3-6烯基，苯基或苯基C 1-3烷基，可以相同或不同的其它两个基团表示氢原子或C1-6烷基; 和n表示2或3，以及其生理上可接受的盐和溶剂合物，用于制备用于缓解或预防由于滥用物质的药物成瘾引起的戒断综合征和/或抑制对药物的依赖或滥用物质

7. 发明公开

EP0278173A3 Use of heterocyclic derivatives in the treatment of depressions 失效
标题翻译：杂环衍生物在治疗抑郁症中的应用
公开(公告)号：EP0278173A3
公开(公告)日：1989-10-18
申请号：EP87311077.9
申请日：1987-12-16
申请人： GLAXO GROUP LIMITED
发明人： Tyers, Michael Brian
IPC分类号： A61K31/415 , A61K31/445 , A61K31/46 , A61K31/50 , A61K31/55
CPC分类号： A61K31/46 , A61K31/415 , A61K31/445 , A61K31/50 , A61K31/55
摘要： The invention relates to the use of compounds which act as antagonists of 5-hydroxytryptamine (5-HT) at 5-HT₃ receptors for the treatment of depression.

8. 发明公开

EP0279990A2 Use of heterocyclic derivatives in the treatment of cognitive disorders 失效
标题翻译： Verwendung von hybridlischen Verbindungen zur Behandlung vonBewusstseinsstörungen。
公开(公告)号：EP0279990A2
公开(公告)日：1988-08-31
申请号：EP87311079.5
申请日：1987-12-16
申请人： GLAXO GROUP LIMITED
发明人： Tyers, Michael Brian
IPC分类号： A61K31/445 , A61K31/46
CPC分类号： A61K31/55 , A61K31/415 , A61K31/435 , A61K31/445 , A61K31/46 , A61K31/495 , A61K31/50
摘要： The invention relates to the use of certain compounds which act as antagonists of 5-hydroxytryptamine (5-HT) at 5-HT₃ receptors for the treatment of cognitive disorders such as attentional and memory deficits and dementia states.
摘要翻译：本发明涉及在5-HT 3受体上作为5-羟色胺（5-HT）拮抗剂的某些化合物用于治疗认知障碍如注意力缺陷和记忆缺陷和痴呆状态的用途。

9. 发明公开

EP0272876A3 Use of heterocyclic derivatives for the manufacture of medicaments 失效
标题翻译：用于制造药物的杂环衍生物的使用
公开(公告)号：EP0272876A3
公开(公告)日：1988-07-27
申请号：EP87311081
申请日：1987-12-16
申请人： GLAXO GROUP LIMITED
发明人： Tyers, Michael Brian
IPC分类号： A61K45/06 , A61K31/44 , A61K31/415 , A61K31/46 , A61K31/55
CPC分类号： A61K31/44 , A61K31/415 , A61K31/46 , A61K31/55 , A61K2300/00
摘要： The invention relates to the use of a compound which is an antagonist of 5-HT at 5-HT₃ receptors and promotes gastric emptying in conjunction with an H⁺K⁺ATPase inhibitor in the treatment of gastrointestinal disorders.

10. 发明授权

EP0275669B1 Use of heterocyclic derivatives for the manufacture of medicaments 失效
标题翻译：用于制造药物的杂环衍生物的使用
公开(公告)号：EP0275669B1
公开(公告)日：1992-09-30
申请号：EP87311080.3
申请日：1987-12-16
申请人： GLAXO GROUP LIMITED
发明人： Tyers, Michael Brian
IPC分类号： A61K45/06 , A61K31/425 , A61K31/415 , A61K31/46 , A61K31/55
CPC分类号： A61K31/425 , A61K31/415 , A61K31/46 , A61K31/55 , A61K2300/00

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