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1. 发明专利

CH689672A9 Katalytische Untereinheit menschlicher Telomerase. 未知
公开(公告)号：CH689672A9
公开(公告)日：2000-02-29
申请号：CH231297
申请日：1997-10-01
申请人： GERON CORP , UNIV TECHNOLOGY CORP
发明人： CECH THOMAS R , HARLEY CALVIN BRUCE , ANDREWS WILLIAM H , LIGNER JOACHIM , NAKAMURA TORU , CHAPMAN KAREN B , MORIN GREGG B
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C12N9/12 , C12N15/113 , C07K14/435 , A61K38/17 , C07H21/02 , C07K16/18 , C12N15/11

2. 发明专利

JPH11243998A ASSAY FOR TELOMERASE ACTIVITY 失效
公开(公告)号：JPH11243998A
公开(公告)日：1999-09-14
申请号：JP27368998
申请日：1998-09-28
申请人： GERON CORP
发明人： HARLEY CALVIN BRUCE , KIM NAM WOO , WEINRICH SCOTT LAWRENCE
IPC分类号： C12N15/09 , A61K38/00 , C12N9/12 , C12N15/10 , C12N15/54 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To highly sensitively judge the telomerase activity of a specimen at a high speed by adding a telomere repeating sequence to elongate a substrate in the presence of a telomerase, duplicating the elongated substrate and subsequently showing interrelation between the presence of the telomerase activity and the absence of the telomerase activity. SOLUTION: This method for judging whether a specimen (for example, a cell specimen) contains the activity of telomerase or not comprises incubating a specimen in a reaction mixture containing a telomerase substrate under such a condition that the telomerase can catalyze the elongation of the telomerase substrate by the addition of a telomere repeating sequence, replicating the elongated telomerase substrate, and subsequently showing an interrelation between the presence of telomerase activity in a specimen containing the replicated elongated telomerase substrate and the absence of the telomerase activity in a specimen not containing the replicated elongated telomerase substrate. By the assay method, the telomerase activity in a specimen in improved detection sensitivity, speed and efficiency in comparison with conventional assay methods can be judged.

3. 发明专利

PT728207E 未知
公开(公告)号：PT728207E
公开(公告)日：2000-11-30
申请号：PT95903110
申请日：1994-11-10
申请人： GERON CORP
发明人： HARLEY CALVIN BRUCE , KIM NAM WOO , WEINRICH SCOTT LAWRENCE
IPC分类号： A61K38/00 , C12N9/12 , C12N15/10 , C12N15/54 , C12Q1/68 , C12N15/09 , C12Q1/48
摘要： Telomerase activity in a sample can be measured using a two reaction protocol involving telomerase substrate and primer extension steps.

4. 发明专利

DE69424797T2 未知
公开(公告)号：DE69424797T2
公开(公告)日：2000-12-28
申请号：DE69424797
申请日：1994-11-10
申请人： GERON CORP
发明人： HARLEY CALVIN BRUCE , KIM NAM WOO , WEINRICH SCOTT LAWRENCE
IPC分类号： A61K38/00 , C12N9/12 , C12N15/10 , C12N15/54 , C12N15/09 , C12Q1/68 , C12Q1/48
摘要： Telomerase activity in a sample can be measured using a two reaction protocol involving telomerase substrate and primer extension steps.

5. 发明专利

ES2147602T3 未知
公开(公告)号：ES2147602T3
公开(公告)日：2000-09-16
申请号：ES95903110
申请日：1994-11-10
申请人： GERON CORP
发明人： HARLEY CALVIN BRUCE , KIM NAM WOO , WEINRICH SCOTT LAWRENCE
IPC分类号： A61K38/00 , C12N9/12 , C12N15/10 , C12N15/54 , C12N15/09 , C12Q1/68 , C12Q1/48
摘要： Telomerase activity in a sample can be measured using a two reaction protocol involving telomerase substrate and primer extension steps.

6. 发明专利

HK1011384A1 TELOMERASE ACTIVITY ASSAYS 未知
公开(公告)号：HK1011384A1
公开(公告)日：1999-07-09
申请号：HK98112561
申请日：1998-11-30
申请人： GERON CORP
发明人： HARLEY CALVIN BRUCE , KIM NAM WOO , WEINRICH SCOTT LAWRENCE
IPC分类号： A61K38/00 , C12N9/12 , C12N15/09 , C12N15/10 , C12N15/54 , C12Q1/68 , C12N , C12Q
摘要： Telomerase activity in a sample can be measured using a two reaction protocol involving telomerase substrate and primer extension steps.

7. 发明专利

DK0728207T3 未知
公开(公告)号：DK0728207T3
公开(公告)日：2000-10-02
申请号：DK95903110
申请日：1994-11-10
申请人： GERON CORP
发明人： HARLEY CALVIN BRUCE , KIM NAM WOO , WEINRICH SCOTT LAWRENCE
IPC分类号： A61K38/00 , C12N9/12 , C12N15/10 , C12N15/54 , C12Q1/68 , C12N15/09 , C12Q1/48
摘要： Telomerase activity in a sample can be measured using a two reaction protocol involving telomerase substrate and primer extension steps.

8. 发明专利

DE69424797D1 未知
公开(公告)号：DE69424797D1
公开(公告)日：2000-07-06
申请号：DE69424797
申请日：1994-11-10
申请人： GERON CORP
发明人： HARLEY CALVIN BRUCE , KIM NAM WOO , WEINRICH SCOTT LAWRENCE
IPC分类号： A61K38/00 , C12N9/12 , C12N15/10 , C12N15/54 , C12N15/09 , C12Q1/68 , C12Q1/48
摘要： Telomerase activity in a sample can be measured using a two reaction protocol involving telomerase substrate and primer extension steps.

9. 发明专利

AT193554T 未知
公开(公告)号：AT193554T
公开(公告)日：2000-06-15
申请号：AT95903110
申请日：1994-11-10
申请人： GERON CORP
发明人： HARLEY CALVIN BRUCE , KIM NAM WOO , WEINRICH SCOTT LAWRENCE
IPC分类号： C12N15/09 , A61K38/00 , C12N9/12 , C12N15/10 , C12N15/54 , C12Q1/68 , C12Q1/48
摘要： Telomerase activity in a sample can be measured using a two reaction protocol involving telomerase substrate and primer extension steps.

10. 发明专利

CA2173872A1 TELOMERASE ACTIVITY ASSAYS 未知
公开(公告)号：CA2173872A1
公开(公告)日：1995-05-18
申请号：CA2173872
申请日：1994-11-10
申请人： GERON CORP
发明人： HARLEY CALVIN BRUCE , KIM NAM WOO , WEINRICH SCOTT LAWRENCE
IPC分类号： C12N15/09 , A61K38/00 , C12N9/12 , C12N15/10 , C12N15/54 , C12Q1/68 , C12Q1/48
摘要： Telomerase activity in a sample can be measured using a two reaction protoco l involving telomerase substrate and primer extension steps.

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