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1. 发明专利

IL281979D0 Humanised anti-n-truncated amyloid beta monoclonal antibody field 未知
公开(公告)号：IL281979D0
公开(公告)日：2021-05-31
申请号：IL28197921
申请日：2021-04-01
申请人： GEORG AUGUST UNIVERSIT?T G?TTINGEN STIFTUNG ?FFENTLICHEN RECHTS UNIVERSIT?TSMEDIZIN , LIFEARC , BAYER THOMAS , BAKRANIA PREETI , DAVIES SARAH , BROWN ALEX , MPAMHANGA CHIDO , MATTHEWS DAVID , CARR MARK , HALL GARETH
发明人： BAYER THOMAS , BAKRANIA PREETI , DAVIES SARAH , BROWN ALEX , MPAMHANGA CHIDO , MATTHEWS DAVID , CARR MARK , HALL GARETH
IPC分类号： A61K39/00 , A61P25/28 , C07K16/18
摘要： The present invention relates to humanised antibodies that bind amyloid peptides, which antibodies comprise mutations in the heavy chain and/or light chain variable domains, which mutations improve the binding activity. The antibodies may be useful in the treatment of Alzheimer's disease (AD).

2. 发明申请

WO2008127594A3 COMBINATION THERAPIES COMPRISING QUINOXALINE INHIBITORS OF PI3K-ALPHA FOR USE IN THE TREATMENT OF CANCER 审中-公开
标题翻译：包含用于治疗癌症的PI3K-ALPHA的喹诺酮抑制剂的组合治疗
公开(公告)号：WO2008127594A3
公开(公告)日：2009-04-30
申请号：PCT/US2008004570
申请日：2008-04-08
申请人： EXELIXIS INC , LAMB PETER , MATTHEWS DAVID
发明人： LAMB PETER , MATTHEWS DAVID
IPC分类号： A61K31/337 , A61K31/436 , A61K31/497 , A61K31/498 , A61K31/4985 , A61K31/517 , A61K31/555 , A61K45/06 , A61P35/00
CPC分类号： A61K31/337 , A61K31/436 , A61K31/497 , A61K31/498 , A61K31/4985 , A61K31/517 , A61K31/555 , A61K45/06 , A61K2300/00
摘要： The present invention provides methods of treating cancer by administering a compound of Formula I, optionally as a pharmaceutically acceptable salt, solvate and/or hydrate thereof, in combination with other cancer treatments.
摘要翻译：本发明提供了通过与其它癌症治疗组合施用式I化合物，任选地作为其药学上可接受的盐，溶剂合物和/或水合物来治疗癌症的方法。

3. 发明申请

WO2011041304A3 ANTIMALARIAL AGENTS THAT ARE INHIBITORS OF DIHYDROOROTATE DEHYDROGENASE 审中-公开
标题翻译：作为DIHYDROOROTETE DEHYDROGENASE的抑制剂的抗菌药物
公开(公告)号：WO2011041304A3
公开(公告)日：2011-08-04
申请号：PCT/US2010050532
申请日：2010-09-28
申请人： UNIV TEXAS , UNIV MONASH , MEDICINES MALARIA VENTURE MMV , PHILLIPS MARGARET , RATHOD PRADIPSINH K , CHARMAN SUSAN A , FLOYD DAVID , BURROWS JEREMY , MATTHEWS DAVID , MARWAHA ALKA , GUJAR RAMESH , COTERON-LOPEZ JOSE
发明人： PHILLIPS MARGARET , RATHOD PRADIPSINH K , CHARMAN SUSAN A , FLOYD DAVID , BURROWS JEREMY , MATTHEWS DAVID , MARWAHA ALKA , GUJAR RAMESH , COTERON-LOPEZ JOSE
IPC分类号： C07D487/04 , A61K31/519 , A61P33/06
CPC分类号： C07D487/04
摘要： Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound: and a triazolopyrimidine class of compounds that conform to Formula (IX): and their solvates, stereoisomers, tautomers and pharmaceutically acceptable salts.
摘要翻译：寄生二氢乳清酸脱氢酶（DHOD）的抑制剂是治疗疟疾的候选治疗剂。这样的治疗剂的例子包括符合式（IX）的化合物和三唑并嘧啶类化合物及其溶剂合物，立体异构体，互变异构体和药学上可接受的盐。

4. 发明申请

WO2009048957A8 ANTIMALARIAL COMPOUNDS WITH FLEXIBLE SIDE-CHAINS 审中-公开
标题翻译：具有柔性侧链的抗微生物化合物
公开(公告)号：WO2009048957A8
公开(公告)日：2010-04-22
申请号：PCT/US2008079210
申请日：2008-10-08
申请人： MEDICINES MALARIA VENTURE MMV , YUTHAVONG YONGYUTH , VILAIVAN TIRAYUT , KAMCHONWONGPAISAN SUMALEE , TARNCHOMPOO BONGKOCH , THONGPANCHANG CHAWANEE , CHITNUMSUB PENCHIT , YUVANIYAMA JIRUNDON , MATTHEWS DAVID , CHARMAN SUSAN , CHARMAN WILLIAM , VIVAS LIVIA , KATIYAR SANJAY BABU
发明人： YUTHAVONG YONGYUTH , VILAIVAN TIRAYUT , KAMCHONWONGPAISAN SUMALEE , TARNCHOMPOO BONGKOCH , THONGPANCHANG CHAWANEE , CHITNUMSUB PENCHIT , YUVANIYAMA JIRUNDON , MATTHEWS DAVID , CHARMAN SUSAN , CHARMAN WILLIAM , VIVAS LIVIA , KATIYAR SANJAY BABU
IPC分类号： A61K31/495 , A61K31/496
CPC分类号： C07D401/04 , C07D239/48 , C07D401/12
摘要： The present invention relates to novel compounds that are inhibitors of wild type and mutant dihydrofolate reductase (DHFR) of Plasmodium falciparum, which are useful for the treatment of malaria. It also relates to processes of making and using such compounds. The antimalarial compounds of the present invention have low toxicity to a host infected with the malarial parasite, and are potent when administered in pharmaceutical compositions.
摘要翻译：本发明涉及可用于治疗疟疾的恶性疟原虫的野生型和突变型二氢叶酸还原酶（DHFR）的抑制剂的新化合物。它还涉及制备和使用这些化合物的方法。本发明的抗疟疾化合物对感染疟疾寄生虫的宿主具有低毒性，并且在药物组合物中施用时是有效的。

5. 发明申请

WO2012125981A3 RAF KINASE INHIBITORS 审中-公开
标题翻译： RAF激酶抑制剂
公开(公告)号：WO2012125981A3
公开(公告)日：2012-11-15
申请号：PCT/US2012029547
申请日：2012-03-16
申请人： SELEXAGEN THERAPEUTICS INC , VERNIER JEAN-MICHEL , HOPKINS STEPHANIE , BOUNAUD PIERRE-YVES , O'CONNOR PATRICK , MATTHEWS DAVID , BENDER STEVE
发明人： VERNIER JEAN-MICHEL , HOPKINS STEPHANIE , BOUNAUD PIERRE-YVES , O'CONNOR PATRICK , MATTHEWS DAVID , BENDER STEVE
IPC分类号： C07D417/04 , A61K31/427 , A61P35/00 , C07D401/04 , C07D403/04 , C07D417/14
CPC分类号： C07D417/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/04 , C07D471/04
摘要： Described herein are compounds, pharmaceutical compositions and methods for the inhibition of RAF kinae mediated signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human disease and disorders.
摘要翻译：本文描述了用于抑制RAF基因介导的信号传导的化合物，药物组合物和方法。所述化合物，药物组合物和方法可用于治疗人类疾病和病症。

6. 发明申请

WO2010045601A3 SYNERGISTIC COMBINATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS 审中-公开
标题翻译：丝氨酸1-磷酸酯受体拮抗剂和抗肿瘤药物的协同组合
公开(公告)号：WO2010045601A3
公开(公告)日：2010-06-10
申请号：PCT/US2009061071
申请日：2009-10-16
申请人： EXELIXIS INC , SHANKAR GEETHA , BENTZIEN FRAUKE , LAMB PETER , MATTHEWS DAVID
发明人： SHANKAR GEETHA , BENTZIEN FRAUKE , LAMB PETER , MATTHEWS DAVID
IPC分类号： A61K31/16 , A61K31/337 , A61K31/34 , A61K31/4192 , A61K31/4196 , A61K31/435 , A61K45/06 , A61P35/00
CPC分类号： A61K31/4196 , A61K31/16 , A61K31/337 , A61K31/34 , A61K31/4192 , A61K31/435 , A61K2300/00
摘要： This invention is based on the discovery that the administration of a sphingosine-1- phosphate receptor antagonist (SlP) and at least one chemotherapeutic agent selected from the the group of antimicrotubule agents provides an unexpectedly superior treatment for cancer. Antimicrobial agents such as the taxane compounds are known in the art, for example, paclitaxel (available as TAXOL® from Bristol-Myers Squibb, Princeton, NJ.), docetaxel (available as TAXOTERE® from Sanofi-aventis, Bridgewater, NJ.) and the like and other compounds that act as antimicrotubule agents, such as Vincristine (ONCOVIN®, VINCASAR PFS®, VCR), Vinblastin (VELBAN®, VELSAR®) and Vinorelbine, and similar compounds. The present invention also provides methods of modulating the growth of selected cell populations, such as cancer cells, by administering a therapeutically effective amount of at least one sphingosine-1 -phosphate 1 (SlPlR) receptor antagonists, and at least one antimicrotubule agent.
摘要翻译：本发明基于以下发现：施用鞘氨醇-1-磷酸受体拮抗剂（S1P）和选自抗微管剂组的至少一种化学治疗剂提供了意想不到的优异的癌症治疗。抗菌剂如紫杉烷化合物是本领域已知的，例如紫杉醇（可从Bristol-Myers Squibb，Princeton，NJ获得），多西紫杉醇（可从Sanofi-aventis，Bridgewater，NJ获得）和类似物以及用作抗微管剂的其它化合物，例如长春新碱（ONCVIN，VINCASAR PFS，VCR），长春花碱（VELBAN？VELSAR）和长春瑞滨（Vinorelbine）等类似化合物。本发明还提供了通过施用治疗有效量的至少一种鞘氨醇-1-磷酸1（S1P1R）受体拮抗剂和至少一种抗微管剂来调节所选细胞群体如癌细胞的生长的方法。

7. 发明专利

DE68902148D1 未知
公开(公告)号：DE68902148D1
公开(公告)日：1992-08-27
申请号：DE68902148
申请日：1989-01-11
申请人： MATTHEWS DAVID
发明人： MATTHEWS DAVID
IPC分类号： F04D29/26 , F16B5/02 , F16B9/02 , F16D1/06 , F04D29/20
摘要： A method and device for mounting and centering a thin wall hub of a driven member onto a drive shaft provides the shaft with a radial end face which projects an axially extending reduced diameter threaded stud which fits within a central aperture of the hub and secures a nut to clamp the hub between the end face and nut. A raised shaft embracing portion centered on the hub axis snugly embraces the outer periphery of the drive shaft and axially aligns the two members. The drive shaft may also incorporate a drive pin which extends axially from the end face and is seated in a second aperture in the hub to provide effective driving of the hub by the drive shaft.

8. 发明专利

AU2006100279A4 Backyard football 未知
公开(公告)号：AU2006100279A4
公开(公告)日：2006-05-11
申请号：AU2006100279
申请日：2006-04-11
申请人： MATTHEWS DAVID
发明人： MATTHEWS DAVID , SEDGWICK STEPHEN
IPC分类号： A63F7/20

9. 发明专利

DE68902148T2 未知
公开(公告)号：DE68902148T2
公开(公告)日：1993-01-07
申请号：DE68902148
申请日：1989-01-11
申请人： MATTHEWS DAVID
发明人： MATTHEWS DAVID
IPC分类号： F04D29/26 , F16B5/02 , F16B9/02 , F16D1/06 , F04D29/20
摘要： A method and device for mounting and centering a thin wall hub of a driven member onto a drive shaft provides the shaft with a radial end face which projects an axially extending reduced diameter threaded stud which fits within a central aperture of the hub and secures a nut to clamp the hub between the end face and nut. A raised shaft embracing portion centered on the hub axis snugly embraces the outer periphery of the drive shaft and axially aligns the two members. The drive shaft may also incorporate a drive pin which extends axially from the end face and is seated in a second aperture in the hub to provide effective driving of the hub by the drive shaft.

10. 发明专利

GB2457744A Six-stroke compressed air and internal combustion engine combination 未知
公开(公告)号：GB2457744A
公开(公告)日：2009-08-26
申请号：GB0813182
申请日：2008-07-18
申请人： MATTHEWS DAVID
发明人： MATTHEWS DAVID
IPC分类号： B60K6/12 , F02B75/02 , F02G5/02
摘要： A compressed air and combustion engine combination engine has alternate 4 stroke combustion cycles and 2 stroke compressed air cycles, making an overall six stroke cycle which creates additional power. The compressed air is best achieved from the otherwise wasted heat energy from the exhaust system to raise steam which drives a turbine-driven air compressor. This system is complemented with additional methods of creating the compressed air when the vehicle is cold through the use of the engine's power output to drive an air compressor that cuts in once the vehicle is moving above a certain speed, compressing the air into the tanks for use in the 6 stroke cycle. The compressed air may alternatively be obtained using an outside energy source, eg at a service station or the overnight use of an electrically driven compressor. If the tanks were low the compressed air would be used to drive the 6 stoke cycle only under the heavy engine loads when the combustion engine is least efficient. The compressed air is captured in cylinders / tanks or the framework of the vehicle which is then used in the 6 stroke cycle to create additional power strokes which in turn increase the efficiency of the engine and produce no harmful emissions.

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