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1. 发明申请

WO2011060295A8 KINASE INHIBITORS 审中-公开
标题翻译：激酶抑制剂
公开(公告)号：WO2011060295A8
公开(公告)日：2011-10-27
申请号：PCT/US2010056583
申请日：2010-11-12
申请人： GENOSCO , OSCOTEC INC , LEE JAEKYOO , SONG HO-JUHN , KOH JONG SUNG , LEE HEE KYU , KIM YOUNGSAM , KIM HONG WOO , CHANG SUNHWA , LIM SUN-HEE , CHOI JANG-SIK , KIM JUNG-HO , KIM SE-WON
发明人： LEE JAEKYOO , SONG HO-JUHN , KOH JONG SUNG , LEE HEE KYU , KIM YOUNGSAM , KIM HONG WOO , CHANG SUNHWA , LIM SUN-HEE , CHOI JANG-SIK , KIM JUNG-HO , KIM SE-WON
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： A61K31/505 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14 , C07D487/08
摘要： The present invention provides a new group of protein kinase inhibitors, pyrropyrimidine and pyrazolopyrimidine derivatives, and pharmaceutically acceptable salts and prodrugs thereof that are useful for treating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrropyrimidine and pyrazolopyrimidine derivatives.
摘要翻译：本发明提供了一组新的蛋白激酶抑制剂，吡咯嘧啶和吡唑并嘧啶衍生物及其药学上可接受的盐和前药，其可用于治疗细胞增殖性疾病和病症如癌症，自身免疫性疾病，感染，心血管疾病和神经变性疾病和病症。本发明提供了合成和施用蛋白激酶抑制剂化合物的方法。本发明还提供了药物制剂，其包含至少一种蛋白激酶抑制剂化合物以及药学上可接受的载体，稀释剂或赋形剂。本发明还提供了在合成pyrropyrimidine和吡唑并嘧啶衍生物期间产生的有用中间体。

2. 发明申请

WO2011053861A8 KINASE INHIBITORS 审中-公开
标题翻译：激酶抑制剂
公开(公告)号：WO2011053861A8
公开(公告)日：2011-10-27
申请号：PCT/US2010054853
申请日：2010-10-29
申请人： GENOSCO , OSCOTEC INC , KIM HONG WOO , KOH JONG SUNG , LEE JAEKYOO , SONG HO-JUHN , KIM YOUNGSAM , LEE HEE KYU , CHOI JANG-SIK , LIM SUN-HEE , CHANG SUNHWA
发明人： KIM HONG WOO , KOH JONG SUNG , LEE JAEKYOO , SONG HO-JUHN , KIM YOUNGSAM , LEE HEE KYU , CHOI JANG-SIK , LIM SUN-HEE , CHANG SUNHWA
IPC分类号： A01N43/90 , A61K31/519
CPC分类号： A61K31/519 , C07D471/04
摘要： The present invention provides a new group of protein kinase inhibitors, pyrido[4,3,-d]pyrimidin-5-one derivatives, and pharmaceutically acceptable salts thereof that are useful for intreating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrido[4,3,-d]pyrimidin-5-one derivatives.
摘要翻译：本发明提供了一组新的蛋白激酶抑制剂，吡啶并[4,3-d]嘧啶-5-酮衍生物及其药学上可接受的盐，其可用于治疗细胞增殖性疾病和病症如癌症，自身免疫性疾病，感染，心血管疾病和神经退行性疾病和病症。本发明提供了合成和施用蛋白激酶抑制剂化合物的方法。本发明还提供了药物制剂，其包含至少一种蛋白激酶抑制剂化合物以及药学上可接受的载体，稀释剂或赋形剂。本发明还提供了在合成吡啶并[4,3，-d]嘧啶-5-酮衍生物期间产生的有用中间体。

3. 发明专利

MY184858A SUBSTITUTED PYRIDOPYRIMIDINE COMPOUNDS AND THEIR USE AS FLT3 INHIBITORS 未知
公开(公告)号：MY184858A
公开(公告)日：2021-04-27
申请号：MYPI2014702705
申请日：2013-03-15
申请人： GENOSCO , OSCOTEC INC , OSCOTEC INC
发明人： KIM YOUNGSAM , KIM HONG-WOO , LEE HEE KYU , SONG HO-JUHN , LEE JAEKYOO , KOH JONG SUNG , KIM JUNG-HO , KIM SE WON , LEE IN YONG
IPC分类号： C07D471/04 , A01N43/90 , A61K31/31 , A61K31/519 , A61K45/06 , C07D239/00 , C07D487/04
摘要： Compounds of Formula (I) and methods for inhibiting kinases,including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I). Formula (I)

4. 发明公开

EP2804861A4 SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE AS SYK INHIBITORS 有权转让
标题翻译：替代品PYRIMIDINVERBINDUNGEN UND DEREN VERWENDUNG ALS SYK-INHIBITOREN
公开(公告)号：EP2804861A4
公开(公告)日：2015-07-22
申请号：EP13738382
申请日：2013-01-18
申请人： GENOSCO , OSCOTEC INC
发明人： CHOI JANG-SIK , HWANG HAE-JUN , LEE EUNHO , LEE JAEKYOO , SONG HO-JUHN , KIM SE WON , KIM JUNG-HO , KOH JONG SUNG , LEE TAE-IM , CHOI YUNG-GEUN , HAN IK-HWAN , LEE JAESANG , LEE IN YONG , JUNG DONG SIK
IPC分类号： C07D403/14 , A61K31/506 , A61P11/00 , A61P29/00 , C07D405/14
CPC分类号： A61K31/5377 , A61K31/506 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I).
摘要翻译：公开了式（I）的化合物和抑制激酶的方法，包括脾脏酪氨酸激酶。还公开了通过向受试者施用治疗有效量的式（I）化合物来治疗激酶介导的疾病或病症的方法。

5. 发明公开

EP2498607A4 KINASE INHIBITORS 有权
公开(公告)号：EP2498607A4
公开(公告)日：2013-06-19
申请号：EP10830814
申请日：2010-11-12
申请人： GENOSCO , OSCOTEC INC
发明人： LEE JAEKYOO , SONG HO-JUHN , KOH JONG SUNG , LEE HEE KYU , KIM YOUNGSAM , KIM HONG WOO , CHANG SUNHWA , LIM SUN-HEE , CHOI JANG-SIK , KIM JUNG-HO , KIM SE-WON
IPC分类号： A01N43/54 , A61K31/505 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14
CPC分类号： A61K31/505 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14 , C07D487/08

6. 发明公开

EP2493313A4 KINASE INHIBITORS 有权转让
标题翻译：激酶INHIBITOREN
公开(公告)号：EP2493313A4
公开(公告)日：2013-05-15
申请号：EP10827573
申请日：2010-10-29
申请人： GENOSCO , OSCOTEC INC
发明人： KIM HONG WOO , KOH JONG SUNG , LEE JAEKYOO , SONG HO-JUHN , KIM YOUNGSAM , LEE HEE KYU , CHOI JANG-SIK , LIM SUN-HEE , CHANG SUNHWA
IPC分类号： A61K31/519 , A61P25/28 , A61P29/00 , A61P35/00 , C07D471/04
CPC分类号： A61K31/519 , C07D471/04
摘要： The present invention provides a new group of protein kinase inhibitors, pyrido[4,3,-d]pyrimidin-5-one derivatives, and pharmaceutically acceptable salts thereof that are useful for intreating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrido[4,3,-d]pyrimidin-5-one derivatives.
摘要翻译：本发明提供了一组新的蛋白激酶抑制剂，吡啶并[4,3，-d]嘧啶-5-酮衍生物及其药学上可接受的盐，其可用于促进细胞增殖性疾病和病症如癌症，自身免疫性疾病，感染，心血管疾病和神经变性疾病和障碍。本发明提供了合成和施用蛋白激酶抑制剂化合物的方法。本发明还提供了包含至少一种蛋白激酶抑制剂化合物以及药学上可接受的载体，稀释剂或赋形剂的药物制剂。本发明还提供了在吡啶并[4,3， - d]嘧啶-5-酮衍生物的合成过程中产生的有用的中间体。

7. 发明专利

PL2804861T3 Podstawione związki pirymidyny i ich zastosowanie jako inhibitory SYK 未知
公开(公告)号：PL2804861T3
公开(公告)日：2018-08-31
申请号：PL13738382
申请日：2013-01-18
申请人： GENOSCO , OSCOTEC INC
发明人： CHOI JANG-SIK , HWANG HAE-JUN , LEE EUNHO , LEE JAEKYOO , SONG HO-JUHN , KIM SE WON , KIM JUNG-HO , KOH JONG SUNG , LEE TAE-IM , CHOI YUNG-GEUN , HAN IK-HWAN , LEE JAESANG , LEE IN YONG , JUNG DONG SIK
IPC分类号： C07D403/14 , A61K31/506 , A61P11/00 , A61P29/00 , C07D405/14

8. 发明专利

CA2779105C KINASE INHIBITORS 未知
公开(公告)号：CA2779105C
公开(公告)日：2016-08-16
申请号：CA2779105
申请日：2010-10-29
申请人： GENOSCO , OSCOTEC INC
发明人： KIM HONG WOO , LEE JAEKYOO , SONG HO-JUHN , KIM YOUNGSAM , LEE HEE KYU , CHOI JANG-SIK , LIM SUN-HEE , CHANG SUNHWA , KOH JONG SUNG
IPC分类号： C07D471/04 , A61K31/519 , C07D519/00
摘要： The present invention provides a new group of protein kinase inhibitors, pyrido[4,3,-d]pyrimidin-5-one derivatives, and pharmaceutically acceptable salts thereof that are useful for intreating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrido[4,3,-d]pyrimidin-5-one derivatives.

9. 发明专利

HK1205106A1 SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE AS SYK INHIBITORS SYK 未知
公开(公告)号：HK1205106A1
公开(公告)日：2015-12-11
申请号：HK15105445
申请日：2015-06-08
申请人： GENOSCO , OSCOTEC INC
发明人： CHOI JANG-SIK , HWANG HAE JUN , LEE EUNHO , LEE JAEKYOO , SONG HO-JUHN , KIM SE WON , KIM JUNG-HO , KOH JONG SUNG , LEE TAE-IM , CHOI YUNG-GEUN , HAN IK-HWAN , LEE JAESANG , LEE IN YONG , JUNG DONG SIK
IPC分类号： C07D20060101 , A61K20060101 , A61P20060101

10. 发明专利

IN2082MUN2014A SUBSTITUTED PYRIDOPYRIMIDINE COMPOUNDS AND THEIR USE AS FLT3 INHIBITORS 未知
公开(公告)号：IN2082MUN2014A
公开(公告)日：2015-08-21
申请号：IN2082MUN2014
申请日：2014-10-17
申请人： GENOSCO , OSCOTEC INC
发明人： KIM HONG WOO , LEE HEE KYU , SONG HO JUHN , LEE JAEKYOO , KOH JONG SUNG , KIM JUNG HO , KIM SE WON , LEE IN YONG
IPC分类号： A61K31/519 , C07D471/04 , A61P35/00
摘要： Compounds of Formula (I) and methods for inhibiting kinases including spleen tyrosine kinases are disclosed. Also disclosed are methods for treating a kinase mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I).

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