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1. 发明申请

WO02087792A8 METHODS AND APPARATUS FOR USE OF OPTICAL FORCES FOR IDENTIFICATION, CHARACTERIZATION AND/OR SORTING OF PARTICLES 审中-公开
标题翻译：用于识别，表征和/或分配颗粒的光学强度的方法和装置
公开(公告)号：WO02087792A8
公开(公告)日：2003-11-20
申请号：PCT/US0151001
申请日：2001-11-09
申请人： GENOPTIX INC , WANG MARK M , TU EUGENE , PESTANA LUIS M , SENYEI ANFREW E , O'CONNELL JAMES P , NOVA TINA S , LYKSTAD KRISTIE L , HALL JEFFREY M , BUTLER WILLIAM F
发明人： WANG MARK M , TU EUGENE , PESTANA LUIS M , SENYEI ANFREW E , O'CONNELL JAMES P , NOVA TINA S , LYKSTAD KRISTIE L , HALL JEFFREY M , BUTLER WILLIAM F
IPC分类号： G01N15/00 , B07C5/34 , C12Q1/04 , G01N15/14 , G01N30/02 , G21K1/00 , B07C5/02
CPC分类号： G01N15/1463 , B07C5/34 , G01N15/1459 , G01N30/02 , G01N2015/1486 , G01N2015/149 , H05H3/04 , B01D2015/3895
摘要： Apparatus and methods are provided for interacting light with particles, including but not limited to biological matter such as cells in unique and highly useful ways. Optophoresis consists of subjecting particles to various optical forces, especially optical gradient forces, and more particularly moving optical gradient forces, so as to obtain useful results. In biology, this technology represents a practical approach to probing the inner workings of a living cell, preferably without any dyes, labels or other markers. In one aspect, a particle may be characterized by determining its optophoretic constant or signature. For example, a diseased cell has a different optophoretic constant from a healthy cell, thereby providing information, or the basis for sorting. In the event of physical sorting, various forces may be used for separation, including fluidic forces, such as through the use of laminar flow, or optical forces, or mechanical forces, such as through adhesion. Various techniques for measuring the dielectric constant of particles are provided.
摘要翻译：提供了用于使光与颗粒相互作用的装置和方法，包括但不限于生物物质如细胞，其独特且非常有用的方式。电渗疗法包括使颗粒经受各种光学力，特别是光学梯度力，尤其是移动的光学梯度力，从而获得有用的结果。在生物学中，该技术是探测活细胞内部运作的实际方法，优选没有任何染料，标签或其他标记物。在一个方面，粒子的特征可以在于确定其荧光特性常数或特征。例如，患病细胞与健康细胞具有不同的视觉波动常数，从而提供信息或分选的基础。在物理分选的情况下，各种力可以用于分离，包括流体力，例如通过使用层流，或光学力，或机械力，例如通过粘附。提供了用于测量颗粒的介电常数的各种技术。

2. 发明申请

WO2004033059A3 METHODS AND APPARATUS FOR OPTOPHORETIC DIAGNOSIS OF CELLS AND PARTICLES 审中-公开
标题翻译：细胞和颗粒的OPTOPHORETIC诊断的方法和装置
公开(公告)号：WO2004033059A3
公开(公告)日：2006-01-26
申请号：PCT/US0330975
申请日：2003-09-30
申请人： GENOPTIX INC , ZHANG HAICHUAN , CHUNG THOMAS D Y , HALL JEFF , SOOHOO WILLIAM , KOHRUMEL JOSH , TU EUGENE , WANG MARK , RAYMOND DANIEL EDWARD , MARCHAND PHILIPPE , DIVER JONATHAN , BUTLER WILLIAM F , NGUYEN PHAN , CHACHISVILIS MIRIANAS , KATZ ANDREW , HAGEN NORBERT , LYKSTAD KRIS , PESTANA LUIS
发明人： ZHANG HAICHUAN , CHUNG THOMAS D Y , HALL JEFF , SOOHOO WILLIAM , KOHRUMEL JOSH , TU EUGENE , WANG MARK , RAYMOND DANIEL EDWARD , MARCHAND PHILIPPE , DIVER JONATHAN , BUTLER WILLIAM F , NGUYEN PHAN , CHACHISVILIS MIRIANAS , KATZ ANDREW , HAGEN NORBERT , LYKSTAD KRIS , PESTANA LUIS
IPC分类号： G01N33/48 , G01N33/569 , G21K1/00 , C12Q1/00 , C12M1/00 , G01F23/00 , G01N33/558
CPC分类号： G01N33/56966 , G01N15/147 , G01N15/1484 , G01N2015/1006 , G01N2015/1075 , G01N2015/145
摘要： A device for characterizing a cell or particle includes a channel having an inlet and an outlet, the channel containing a moving fluid therein for carrying the cell or particle from the inlet to the outlet. The device includes detectors for monitorng the position of the cell or particle along the channel. The device further comprises a light source to provide an optical gradient and a control system to receive and process signals from the detector.The device can be used to characterize and sort cells based on a biological property.
摘要翻译：用于表征细胞或颗粒的装置包括具有入口和出口的通道，所述通道在其中包含运动流体，用于将细胞或颗粒从入口运送到出口。该装置包括用于监测细胞或颗粒沿着通道的位置的检测器。该装置还包括提供光学梯度的光源和用于接收和处理来自检测器的信号的控制系统。该装置可用于基于生物特性来表征和分类细胞。

3. 发明申请

WO2008130871A3 CELL SORTING SYSTEM AND METHODS 审中-公开
标题翻译：细胞分选系统和方法
公开(公告)号：WO2008130871A3
公开(公告)日：2008-12-18
申请号：PCT/US2008060015
申请日：2008-04-11
申请人： CELLULA INC , BUTLER WILLIAM F , ZHANG HAICHUAN , MARCHAND PHILLIPPE , AHN KEUNHO , ZHANG YI , FRANCIS JOHN , LAI BENJAMIN , TU EUGENE
发明人： BUTLER WILLIAM F , ZHANG HAICHUAN , MARCHAND PHILLIPPE , AHN KEUNHO , ZHANG YI , FRANCIS JOHN , LAI BENJAMIN , TU EUGENE
IPC分类号： C12M1/34 , G01N33/48
CPC分类号： G01N33/5005 , B01L3/502761 , B01L3/502776 , B01L3/5088 , B01L2200/0652 , B01L2300/0864 , B01L2300/0874 , B01L2400/0454 , B01L2400/0487 , C12M47/04 , G01N15/1459 , G01N15/1484 , G01N2015/149 , Y10T137/86509 , Y10T137/87161 , Y10T436/118339 , Y10T436/2575
摘要： Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on a switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000 - 100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format. Optical and/or fluidic switching forces are used alone or in combination to effect switching.
摘要翻译：基于用于通过微流体通道网络的细胞路由的快速，主动控制的开关为微制造的荧光激活细胞分选器提供装置和方法。该分选机能够对小数量细胞群进行低应激，高效分选（即1000-100,000个细胞）。本发明包括将微流体通道网络包装在独立的塑料盒中，使得微流体通道网络能够以无菌的一次性格式进行大规模的仪器互连。光学和/或流体开关力单独使用或组合使用以实现切换。

4. 发明公开

EP0597063A4 METHOD AND APPARATUS FOR ELECTRICALLY DESTROYING A SYRINGE NEEDLE. 失效
标题翻译：装置和方法销毁注射器针头。
公开(公告)号：EP0597063A4
公开(公告)日：1994-12-07
申请号：EP93911101
申请日：1993-05-04
申请人： BUTLER WILLIAM F
发明人： BUTLER WILLIAM F
IPC分类号： A61G12/00 , A61M5/32 , B23H9/00 , B23H9/10
CPC分类号： B23H9/005 , A61M5/3278 , A61M2005/3283
摘要： This invention is directed to a method and apparatus for electrically destroying a syringe needle. The apparatus includes a housing (12) having a burn chamber (14) with a first electrical contact (33) with a conical shaped port (40) mounted on a front face wall (32) of the burn chamber (14) and a second electrical contact (53) made of a block secured to the burn chamber (14) is used to destroy a hypodermic needle (50). The conical shaped port (40) and an opening (37) are sized to receive the metal needle portion (42), the neck portion (44), shoulder portion (46) and body portion (48) of the hypodermic needle (50). A battery (78) is used to energize the contacts (33, 53). When the hypodermic needle (50) is in the opening (37) the length of the needle (50) is in contact with the second contact (53) melting of at least most of the needle's length, with the resulting melted waste falling into a tray (70).

5. 发明专利

CA2061839C METHOD AND APPARATUS FOR DESTROYING A SYRINGE NEEDLE 未知
公开(公告)号：CA2061839C
公开(公告)日：2001-06-05
申请号：CA2061839
申请日：1992-02-25
申请人： BUTLER WILLIAM F
发明人： BUTLER WILLIAM F
IPC分类号： F27D11/04 , H05B3/66
摘要： A method and apparatus for destroying a syringe needle, having a housing, first and second walls in opposed relationship in the housing and defining therebetween a needle burn chamber, the distance between the first and second surfaces being at least the length of the needle, the first surface defining a first opening therethrough, needle receiving means in the chamber movable between the first and second surfaces and defining a second opening therethrough which is coaxial with the first opening, a first electrical contact on the needle receiving means, a second electrical contact on the second surface and being in registry with the second opening, power means connected to the first and second contacts, a waste collecting means disposed in the housing beneath and in communication with the burn chamber, the waste collecting means being removable from the housing, and means for normally biasing the needle receiving means toward the first opening; so that when the needle is inserted through the first and second openings to be in contacting relationship to the needle receiving means and the needle receiving means is moved toward the second surface, the tip of the needle engages the second contact closing the circuit between the contacts and melting the needle along at least most of its length with the resultant melted waste falling into the waste collecting means.

6. 发明专利

CA2061839A1 METHOD AND APPARATUS FOR DESTROYING A SYRINGE NEEDLE 未知
公开(公告)号：CA2061839A1
公开(公告)日：1993-08-26
申请号：CA2061839
申请日：1992-02-25
申请人： BUTLER WILLIAM F
发明人： BUTLER WILLIAM F
IPC分类号： F27D11/04 , H05B3/66
摘要： A method and apparatus for destroying a syringe needle, having a housing, first and second walls in opposed relationship in the housing and defining therebetween a needle burn chamber, the distance between the first and second surfaces being at least the length of the needle, the first surface defining a first opening therethrough, needle receiving means in the chamber movable between the first and second surfaces and defining a second opening therethrough which is coaxial with the first opening, a first electrical contact on the needle receiving means, a second electrical contact on the second surface and being in registry with the second opening, power means connected to the first and second contacts, a waste collecting means disposed in the housing beneath and in communication with the burn chamber, the waste collecting means being removable from the housing, and means for normally biasing the needle receiving means toward the first opening; so that when the needle is inserted through the first and second openings to be in contacting relationship to the needle receiving means and the needle receiving means is moved toward the second surface, the tip of the needle engages the second contact closing the circuit between the contacts and melting the needle along at least most of its length with the resultant melted waste falling into the waste collecting means.

7. 发明专利

CA670034A CLAMPING DEVICE 未知
公开(公告)号：CA670034A
公开(公告)日：1963-09-10
申请号：CA670034D
申请人： BUTLER WILLIAM F
发明人： BUTLER WILLIAM F

8. 发明专利

CA238633A TRAP 未知
公开(公告)号：CA238633A
公开(公告)日：1924-03-18
申请号：CA238633D
申请人： BUTLER WILLIAM F
发明人： BUTLER WILLIAM F

9. 发明授权

US1119572A Flexible shafting. 失效
公开(公告)号：US1119572A
公开(公告)日：1914-12-01
申请号：US1912676563
申请日：1912-02-09
申请人： BUTLER WILLIAM F
发明人： BUTLER WILLIAM F
CPC分类号： F16D3/20 , Y10T279/17017

10. 发明授权

US1022464A Can-flanging machine. 失效
标题翻译： CAN-FLANGING MACHINE。
公开(公告)号：US1022464A
公开(公告)日：1912-04-09
申请号：US1908456260
申请日：1908-10-05
申请人： BUTLER WILLIAM F
发明人： BUTLER WILLIAM F
CPC分类号： B21D51/2615

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