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1. 发明申请

WO2004108963A1 MULTI-HYBRIDIZATION SET FOR DNA MICROARRAY RELATED ASSAY 审中-公开
标题翻译：用于DNA微阵列相关测定的多重杂交
公开(公告)号：WO2004108963A1
公开(公告)日：2004-12-16
申请号：PCT/KR2003/001115
申请日：2003-06-07
申请人： GENOMICTREE INC. , AN, Sung Whan , YOON, Chi Wang , OH, Tae Jeong , YOON, Dae Kyoung , LEE, Sun Woo , KIM, Myung Soon , WOO, Suk Kyung
发明人： AN, Sung Whan , YOON, Chi Wang , OH, Tae Jeong , YOON, Dae Kyoung , LEE, Sun Woo , KIM, Myung Soon , WOO, Suk Kyung
IPC分类号： C12Q1/68
CPC分类号： B01L3/5085 , B01J2219/00533 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00628 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , B01L9/52 , B01L2200/0689 , B01L2300/0636 , B01L2300/0819 , B01L2300/0822
摘要： The present invention relates to a multi-hybridization set for DNA microarray assay, which comprises: a lower plate in which a DNA microarray is mounted; an upper plate which is coupled to the lower plate, and in which one or more O-rings are attached to the lower surface of the upper plate coming in contact with the DNA microarray such that separate spaces are formed when the upper and lower plates are coupled to each other, the upper plate having sample injection holes formed inside of the O-ring; and means for coupling the upper and lower plates to each other. The multi-hybridization set of the present invention allows the DNA microarray assay of several samples to be performed at once. In addition, according to this multi-hybridization set, the problem of contamination caused by oil and dust, which occurs due to the use of the existing cover glass, can be solved.
摘要翻译：本发明涉及用于DNA微阵列测定的多杂交组，其包括：安装有DNA微阵列的下板; 上板，其连接到下板，并且其中一个或多个O形环附接到与DNA微阵列接触的上板的下表面，使得当上板和下板为彼此耦合，上板具有形成在O形环内部的样品注入孔; 以及用于将上板和下板彼此连接的装置。本发明的多杂交组允许立即进行若干样品的DNA微阵列测定。此外，根据该多杂交组合，可以解决由于使用现有的盖玻璃而发生的由油和灰尘引起的污染的问题。

2. 发明申请

WO2009069984A2 DIAGNOSIS KIT AND CHIP FOR BLADDER CANCER USING BLADDER CANCER SPECIFIC METHYLATION MARKER GENE 审中-公开
标题翻译：使用刮刀癌特异性甲基标记基因的刀片诊断工具包和芯片
公开(公告)号：WO2009069984A2
公开(公告)日：2009-06-04
申请号：PCT/KR2008/007081
申请日：2008-12-01
申请人： GENOMICTREE, INC. , AN, Sung Whan , MOON, Young Ho , OH, Tae Jeong
发明人： AN, Sung Whan , MOON, Young Ho , OH, Tae Jeong
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/686 , C12Q2600/154 , C12Q2600/156
摘要： The present invention relates to a kit and nucleic acid chip for diagnosing bladder cancer using a bladder cancer-specific marker gene. More particularly, the invention relates to a kit and nucleic acid chip for diagnosing bladder cancer, which can detect the promoter methylation of a bladder cancer-specific gene, the promoter or exon region of which is methylated specifically in transformed cells of bladder cancer. The use of the diagnostic kit or nucleic acid chip of the invention enables diagnosis of bladder cancer at an early stage of transformation, thus enabling early diagnosis of bladder cancer, and can diagnose bladder cancer in a more accurate and rapid manner compared to a conventional method.
摘要翻译：本发明涉及一种用于使用膀胱癌特异性标志物基因诊断膀胱癌的试剂盒和核酸芯片。更具体地，本发明涉及用于诊断膀胱癌的试剂盒和核酸芯片，其可以检测膀胱癌特异性基因的启动子甲基化，其启动子或外显子区域在膀胱癌的转化细胞中特异性甲基化。使用本发明的诊断试剂盒或核酸芯片能够在转化的早期阶段诊断膀胱癌，从而能够早期诊断膀胱癌，并且可以以比传统方法更准确和更快速地诊断膀胱癌。

3. 发明公开

EP2253714A1 LUNG CANCER DETECTING METHOD USING LUNG CANCER SPECIFIC METHYLATION MARKER GENES 有权
标题翻译：方法肺癌检测中的应用肺癌特异的甲基化标记基因
公开(公告)号：EP2253714A1
公开(公告)日：2010-11-24
申请号：EP09720916.7
申请日：2009-02-18
申请人： Genomictree, Inc.
发明人： AN, Sung Whan , MOON, Young Ho , OH, Tae Jeong
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154 , C12Q2600/156
摘要： The present invention relates to a method for detecting lung cancer using a lung cancer-specific biomarker, and more particularly to a biomarker for lung cancer diagnosis, which can detect methylation of PCDHGA12 gene whose 5'UTR or exon 1 region is specifically methylated in lung cancer cells, and to a method of detecting lung cancer and the stage of its progression using the biomarker. The diagnostic kit according to the present invention makes it possible to diagnose lung cancer at an early stage in an accurate and rapid manner compared to conventional methods and can be used for prognosis and monitoring of lung cancer and the stage of its progression.
摘要翻译：本发明涉及一种方法用于使用肺癌特异性生物标记物检测肺癌，并且更具体地涉及用于肺癌诊断的生物标记物，其可检测PCDHGA12基因的5'UTR谁或外显子1个区域在肺癌是专门甲基化的甲基癌细胞，并检测肺癌和它的进展的使用生物标志物的阶段的方法。诊断试剂盒gemäß到本发明使得有可能在以准确和快速的方式诊断早期肺癌上相比于常规的方法和可用于预后和肺癌的监测和它的发展阶段。

4. 发明公开

EP2982762A1 NUCLEIC ACID AMPLIFICATION METHOD USING ALLELE-SPECIFIC REACTIVE PRIMER 有权
标题翻译： VERFAHREN ZURNUKLEINSÄUREAMPLIFIKATIONMITTELS EINES ALLELSPEZIFISCHEN REAKTIVEN PRIMERS
公开(公告)号：EP2982762A1
公开(公告)日：2016-02-10
申请号：EP13881318.3
申请日：2013-04-16
申请人： Genomictree, Inc.
发明人： AN, Sung Whan , OH, Tae Jeong
IPC分类号： C12Q1/68 , C12N15/11
CPC分类号： C12Q1/6858 , C12Q2521/101 , C12Q2523/125
摘要： The present invention relates to a nucleic acid amplification method using an allele-specific reactive primer (ASRP) which is designed to solve problems of conventional allele-specific PCR. More specifically, the present invention relates to a detection method of a target nucleic acid, comprising a DNA polymerase having proofreading activity and a base sequence complementary to the target nucleic acid, wherein the target nucleic acid is amplified in the presence of an ASRP which is modified in such a manner that one or more bases from the base immediately in front, in the 5'-end direction, of a base that is cut off by the proofreading activity of the DNA polymerase when a non-complementary base exists at the 3' end, to the base at the 5' end, cannot serve as a primer for polymerization. The detection method using an ASRP according to the present invention is a technique with very high specificity of amplification due to the characteristics of the ASRP and the proofreading DNA polymerase, and is capable of effectively detecting mutations (point mutation, insertion, and deletion) including single nucleotide polymorphism (SNP). Furthermore, the method can also be used for detecting the presence of CpG methylation after bisulfite treatment, or for amplifying and detecting a target DNA starting with a desired base sequence from a DNA library.
摘要翻译：本发明涉及使用等位基因特异性反应性引物（ASRP）的核酸扩增方法，其被设计用于解决常规等位基因特异性PCR的问题。更具体地，本发明涉及靶核酸的检测方法，其包含具有校正活性的DNA聚合酶和与靶核酸互补的碱基序列，其中靶核酸在ASRP存在下扩增，所述ASRP是以这样的方式进行修饰，即当碱基不存在于3位时被DNA聚合酶的校正活性所切断的碱的5'端方向的一个或多个碱基 '结束，在5'端的碱基，不能作为聚合的底漆。使用根据本发明的ASRP的检测方法是由于ASRP和校对DNA聚合酶的特征而具有非常高的扩增特异性的技术，并且能够有效地检测突变（点突变，插入和缺失），包括单核苷酸多态性（SNP）。此外，该方法还可以用于检测亚硫酸氢盐处理后CpG甲基化的存在，或者从DNA文库扩增和检测起始于所需碱基序列的靶DNA。

5. 发明公开

EP2586865A2 RECOMBINANT VECTOR FOR SUPPRESSING PROLIFERATION OF HUMAN PAPILLOMAVIRUS CELL INCLUDING ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE 1 (PITUITARY) GENE AND PHARMACEUTICAL COMPOSITION FOR TREATING HUMAN PAPILLOMAVIRUS 有权
标题翻译：人乳头瘤病毒包括腺苷酸环化酶激活多肽-1-（脑垂体）针对人乳头瘤病毒治疗基因和药物组合物的细胞的增殖的抑制的重组载体
公开(公告)号：EP2586865A2
公开(公告)日：2013-05-01
申请号：EP11798393.2
申请日：2011-06-23
申请人： Genomictree, Inc.
发明人： AN, Sung Whan , MOON, Young Ho , OH, Tae Jeong , LEE, Seng-Hoon
IPC分类号： C12N15/63 , C12N15/12 , A61K38/00 , A61P35/00
CPC分类号： A61K48/005 , A61K38/00 , C07K14/57563
摘要： The present invention relates to a cervical cancer therapeutic agent comprising a recombinant vector containing a gene that encodes adenylate cyclase activating polypeptide 1 (pituitary) ( ADCYAP1 ). The use of the recombinant vector and a pharmaceutical composition comprising the recombinant vector can prevent or treat cervical cancer by inhibiting the proliferation of cervical cancer cells.
摘要翻译：本发明涉及包含含有一个基因的重组载体宫颈癌治疗剂确实编码腺苷酸环化酶激活多肽1（垂体）（ADCYAP1）。使用该重组载体的，并且包括重组载体，可以防止或抑制宫颈癌细胞增殖治疗宫颈癌的药物组合物。

6. 发明公开

EP2217728A2 DIAGNOSIS KIT AND CHIP FOR BLADDER CANCER USING BLADDER CANCER SPECIFIC METHYLATION MARKER GENE 审中-公开
标题翻译： DIAGONSEKIT和芯片膀胱癌与膀胱癌特异性METHYLIERUNGSMARKERGEN
公开(公告)号：EP2217728A2
公开(公告)日：2010-08-18
申请号：EP08853388.0
申请日：2008-12-01
申请人： Genomictree, Inc.
发明人： AN, Sung Whan , MOON, Young Ho , OH, Tae Jeong
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/686 , C12Q2600/154 , C12Q2600/156
摘要： The present invention relates to a kit and nucleic acid chip for diagnosing bladder cancer using a bladder cancer-specific marker gene. More particularly, the invention relates to a kit and nucleic acid chip for diagnosing bladder cancer, which can detect the promoter methylation of a bladder cancer-specific gene, the promoter or exon region of which is methylated specifically in transformed cells of bladder cancer. The use of the diagnostic kit or nucleic acid chip of the invention enables diagnosis of bladder cancer at an early stage of transformation, thus enabling early diagnosis of bladder cancer, and can diagnose bladder cancer in a more accurate and rapid manner compared to a conventional method.

7. 发明授权

EP2497834B2 METHOD FOR DETECTING THE METHYLATION OF COLON-CANCER-SPECIFIC METHYLATION MARKER GENES FOR COLON CANCER DIAGNOSIS 有权
公开(公告)号：EP2497834B2
公开(公告)日：2018-09-12
申请号：EP10828451.4
申请日：2010-10-14
申请人： Genomictree, Inc.
发明人： AN, Sung Whan , MOON, Young Ho , OH, Tae Jeong , CHUNG, Hyun Cheol
IPC分类号： C12Q1/68 , C12N15/11
CPC分类号： C12Q1/686 , C12Q1/6886 , C12Q2600/154 , C12Q2523/125
摘要： The present invention relates to a method for detecting the methylation of colorectal cancer-specific marker genes for colorectal cancer diagnosis, and more particularly to a method of detecting colorectal cancer-specific marker genes, which are methylated specifically in colorectal cancer cells, to provide information for diagnosing colorectal cancer. The use of the inventive method for detecting methylation and the inventive composition, kit and nucleic chip for diagnosing colorectal cancer makes it possible to diagnose colorectal cancer at an early transformation stage, thus enabling the early diagnosis of colorectal cancer. In addition, the inventive method enables colorectal cancer to be effectively diagnosed in an accurate and rapid manner compared to conventional methods.

8. 发明授权

EP2497834B1 METHOD FOR DETECTING THE METHYLATION OF COLON-CANCER-SPECIFIC METHYLATION MARKER GENES FOR COLON CANCER DIAGNOSIS 有权
标题翻译：程序结肠癌特异的甲基化的甲基化标记基因的癌症诊断认证
公开(公告)号：EP2497834B1
公开(公告)日：2016-01-06
申请号：EP10828451.4
申请日：2010-10-14
申请人： Genomictree, Inc.
发明人： AN, Sung Whan , MOON, Young Ho , OH, Tae Jeong , CHUNG, Hyun Cheol
IPC分类号： C12Q1/68 , C12N15/11
CPC分类号： C12Q1/686 , C12Q1/6886 , C12Q2600/154 , C12Q2523/125
摘要： The present invention relates to a method for detecting the methylation of colorectal cancer-specific marker genes for colorectal cancer diagnosis, and more particularly to a method of detecting colorectal cancer-specific marker genes, which are methylated specifically in colorectal cancer cells, to provide information for diagnosing colorectal cancer. The use of the inventive method for detecting methylation and the inventive composition, kit and nucleic chip for diagnosing colorectal cancer makes it possible to diagnose colorectal cancer at an early transformation stage, thus enabling the early diagnosis of colorectal cancer. In addition, the inventive method enables colorectal cancer to be effectively diagnosed in an accurate and rapid manner compared to conventional methods.
摘要翻译：本发明涉及一种方法，用于检测结肠直肠癌症特异性标志物基因为结肠直肠癌诊断中的甲基化，和更具体地涉及检测结肠癌症特异性标记基因的方法，其特别是在结肠直肠癌细胞中的甲基化，以提供信息用于诊断结肠直肠癌。使用用于检测甲基化和本发明组合物，试剂盒和核酸芯片用于诊断结肠直肠癌的本发明方法使得有可能在早期阶段相变来诊断结肠直肠癌，从而使大肠癌的早期诊断。此外，本发明的方法允许结肠直肠癌被有效地诊断准确且快速的方式与常规方法相比。

9. 发明授权

EP2522741B1 GENOTYPING METHOD 有权
标题翻译：基因分型
公开(公告)号：EP2522741B1
公开(公告)日：2015-04-15
申请号：EP10830217.5
申请日：2010-11-15
申请人： Genomictree, Inc.
发明人： AN, Sung Whan , OH, Myung Sok
IPC分类号： C12Q1/68 , C12N15/11 , C12Q1/70
CPC分类号： C12Q1/6874 , C12Q1/68 , C12Q1/6869 , C12Q1/6886 , C12Q1/701 , C12Q1/708 , C12Q2525/185 , C12Q2535/122 , C12Q2537/143 , C12Q2563/179 , C12Q2565/301 , C12Q2600/156 , C12Q2600/16 , C12Q2525/155
摘要： The present invention relates to a genotyping method, and more particularly to an ID sequence, which is assigned to each genotype, and a multiplex genotyping method which uses the ID sequence. When pyrosequencing is performed using the ID sequence, a unique and simple pyrogram can be obtained for each genotype. Thus, the use of the ID sequence makes it possible to genotype viral genes, disease genes, bacterial genes and identification genes in a simple and efficient manner. In addition, a genotyping primer of the invention can be used in various genotyping methods which are performed using dispensation orders and sequencing methods.

10. 发明公开

EP2653547A2 METHOD FOR DETECTING METHYLATION OF THE BOWEL-CANCER-SPECIFIC METHYLATION MARKER GPM6A GENE IN ORDER TO DIAGNOSE BOWEL CANCER 有权
标题翻译：程序结肠癌特异的甲基化标记基因GPM6A甲基化来诊断结肠认证
公开(公告)号：EP2653547A2
公开(公告)日：2013-10-23
申请号：EP11849157.0
申请日：2011-12-16
申请人： Genomictree, Inc.
发明人： AN, Sung Whan , OH, Tae Jeong
IPC分类号： C12N15/12 , C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C07K14/705 , C12Q2600/154
摘要： The present invention relates to a method for detecting methylation of the bowel-cancer-specific methylation marker GPM6A (NM_201591, glycoprotein M6A) gene in order to diagnose bowel cancer, and more specifically relates to a method for providing information for diagnosing bowel cancer by detecting the methylation of a bowel-cancer-specific marker gene that is specifically methylated in bowel cancer cells. The method for detecting methylation and a diagnostic composition, kit and nucleic-acid chip according to the present invention can be used to advantage in diagnosing bowel cancer more accurately and quickly than by normal methods as they permit bowel cancer to be diagnosed at the initial genetic transformation step and so allow early diagnosis.
摘要翻译：本发明涉及一种方法，用于为了检测特定肠癌甲基化标记物GPM6A的甲基化（NM_201591，糖蛋白M6A）基因诊断肠癌症，更具体地涉及一种方法，用于通过检测诊断肠癌症提供信息一个特定的肠癌标志物基因的甲基化并在肠肿瘤细胞是专门甲基化。用于检测甲基化和一种诊断组合物，试剂盒和核酸芯片雅丁到本发明的方法可用于诊断肠癌更精确地设定和速度比通过常规方法，因为它们允许肠癌到在初始遗传诊断有利变换步骤，因此允许早期诊断。

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