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1. 发明申请

WO2014130617A1 METHOD OF PREDICTING BREAST CANCER PROGNOSIS 审中-公开
标题翻译：预测乳腺癌预后的方法
公开(公告)号：WO2014130617A1
公开(公告)日：2014-08-28
申请号：PCT/US2014/017279
申请日：2014-02-20
申请人： GENOMIC HEALTH, INC. , CRAGER, Michael R. , QU, Kunbin , WATSON, George Andrew , LEVY, Samuel
发明人： CRAGER, Michael R. , QU, Kunbin , WATSON, George Andrew , LEVY, Samuel
IPC分类号： C40B30/00 , C12Q1/68 , G01N33/574 , A61K39/385 , A61K39/00
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/112 , G01N2800/52
摘要： The present invention relates to biomarkers associated with breast cancer prognosis. These biomarkers include coding transcripts and their expression products, as well as non-coding transcripts, and are useful for predicting the likelihood of breast cancer recurrence in a breast cancer patient.
摘要翻译：本发明涉及与乳腺癌预后相关的生物标志物。这些生物标志物包括编码转录物及其表达产物，以及非编码转录物，并且可用于预测乳腺癌患者乳腺癌复发的可能性。

2. 发明申请

WO2015066068A1 METHODS OF INCORPORATION OF TRANSCRIPT CHROMOSOMAL LOCUS INFORMATION FOR IDENTIFICATION OF BIOMARKERS OF DISEASE RECURRENCE RISK 审中-公开
标题翻译：用于鉴定疾病复发风险的生物标志物的转录色谱位置信息的方法
公开(公告)号：WO2015066068A1
公开(公告)日：2015-05-07
申请号：PCT/US2014/062715
申请日：2014-10-28
申请人： GENOMIC HEALTH, INC.
发明人： KIEFER, Michael C. , BAKER, Joffre B. , CRAGER, Michael R. , SEGAL, Mark R. , COLLIN, Francois , LEVY, Samuel
IPC分类号： G06F19/26
CPC分类号： G06F19/18 , C12Q1/6886 , C12Q2600/158 , G06F19/20 , G06F19/22 , G06F19/26
摘要： The present invention provides methods for incorporating transcript chromosomal locus information for identification of biomarkers of disease recurrence risk.
摘要翻译：本发明提供了用于鉴定疾病复发风险生物标志物的转录染色体基因座信息的方法。

3. 发明公开

EP3063689A1 METHODS OF INCORPORATION OF TRANSCRIPT CHROMOSOMAL LOCUS INFORMATION FOR IDENTIFICATION OF BIOMARKERS OF DISEASE RECURRENCE RISK 审中-公开
标题翻译：法团轨迹音信息用于识别生物标志物的疾病复发风险的方法
公开(公告)号：EP3063689A1
公开(公告)日：2016-09-07
申请号：EP14858957.5
申请日：2014-10-28
申请人： Genomic Health, Inc.
发明人： KIEFER, Michael C. , BAKER, Joffre B. , CRAGER, Michael R. , SEGAL, Mark R. , COLLIN, Francois , LEVY, Samuel
IPC分类号： G06F19/26
CPC分类号： G06F19/18 , C12Q1/6886 , C12Q2600/158 , G06F19/20 , G06F19/22 , G06F19/26
摘要： The present invention provides methods for incorporating transcript chromosomal locus information for identification of biomarkers of disease recurrence risk.

4. 发明申请

WO2011109520A1 GASTRIC VOLUME FILLING CONSTRUCT 审中-公开
标题翻译：气体填充结构
公开(公告)号：WO2011109520A1
公开(公告)日：2011-09-09
申请号：PCT/US2011/026871
申请日：2011-03-02
申请人： BRAITHWAITE, Gavin , VAN BUREN, Martin , SPIEGELBERG, Stephen , GAUR, Shantanu , LEVY, Samuel , WECKER, Jonathan , CHUTTANI, Ram
发明人： BRAITHWAITE, Gavin , VAN BUREN, Martin , SPIEGELBERG, Stephen , GAUR, Shantanu , LEVY, Samuel , WECKER, Jonathan , CHUTTANI, Ram
IPC分类号： A61F2/02
CPC分类号： A61F5/0036 , A61F5/003 , A61F2210/0004 , A61F2210/0061
摘要： The technology described herein provides methods for addressing obesity by introducing a device into the stomach. Embodiments of a device for treating obesity may comprise a shaped membrane construct that contains a swellable material. The construct may be contained within a capsule which is ingested by a patient. When the capsule dissolves in the stomach, the gastric secretions may diffuse through the membrane and spontaneously swell the internal material, which swells and stiffens the construct sufficiently to create a sensation of satiety by both filling gastric volume and by distending the walls of the stomach. The volume of the construct may be sufficient to prevent passage through the pyloric sphincter. After a set period of time or after the administration of a degradation formulation, the device may structurally degrade to allow passage through the pyloric sphincter and eventual passage from the body.
摘要翻译：本文所述的技术提供了通过将装置引入胃来解决肥胖症的方法。用于治疗肥胖症的装置的实施方案可以包含含有可溶胀材料的成形膜构造。构建体可以包含在被患者摄取的胶囊内。当胶囊溶解在胃中时，胃分泌物可以扩散通过膜并自发地膨胀内部材料，其膨胀并使构造物充分膨胀，从而通过充满胃体积和膨胀胃壁来增加饱腹感。构建体的体积可能足以防止通过幽门括约肌。在一段时间之后或在施用降解制剂后，该装置可在结构上降解以允许通过幽门括约肌并最终从身体通过。

5. 发明申请

WO2008045575A3 SEQUENCING METHOD 审中-公开
公开(公告)号：WO2008045575A3
公开(公告)日：2008-04-17
申请号：PCT/US2007/021981
申请日：2007-10-15
申请人： J. CRAIG VENTER INSTITUTE, INC. , LEVY, Samuel , GOLDBERG, Susanne , BEESON, Karen
发明人： LEVY, Samuel , GOLDBERG, Susanne , BEESON, Karen
IPC分类号： C12Q1/68
摘要： The present invention relates, e.g., to a method for isolating a DNA molecule of interest in a form suitable for sequencing at least a portion of the DNA by a high throughput sequencing method, comprising (a) digesting a double-stranded (ds) DNA molecule with two different restriction enzymes, A and B, to generate a ds form of the DNA molecule of interest, which is bounded by the two restriction enzyme cleavage products, and (b) attaching to each end of the DNA molecule of interest an adaptor molecule which comprises at one end a restriction enzyme cleavage site that is compatible with the restriction enzyme A or the r estriction enzyme B cleavage product, and which also comprises a sequence and/or element that allows the DNA of interest to be sequenced with a high throughput sequencing apparatus. The method can be adapted for sequencing DNA with a variety of high throughput sequencing apparatuses, including machines manufactured by the 454, Illumina (Solexa Sequencing technology) and ABI (SOLiD TM Sequencing technology) companies. A method is also described for sequencing regulatory elements within a cell, comprising subjecting a collection of ds DNA molecules that are enriched for regulatory elements and that are generated by digestion with two restriction enzymes, A and B, which generate sticky ends, to an isolation method of the invention, and sequencing the collection of ds DNA molecules with a high throughput sequencing apparatus.

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