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1. 发明申请

WO2012175675A9 METHOD OF PRODUCING BIOLOGICAL NETWORKS 审中-公开
标题翻译：生物生物网络的生产方法
公开(公告)号：WO2012175675A9
公开(公告)日：2013-02-14
申请号：PCT/EP2012062092
申请日：2012-06-22
申请人： GENOMATIX SOFTWARE GMBH , WERNER THOMAS , HAHN ALEXANDER , SUPPER JOCHEN
发明人： WERNER THOMAS , HAHN ALEXANDER , SUPPER JOCHEN
IPC分类号： G06F19/12
CPC分类号： G06F19/12
摘要： Method of producing a network comprising: (1) receiving a list of molecules; (2) identifying all pathways, among a list of pathways stored in a pathway database, associated with the molecules contained in the received list of molecules; (3) merging all associated pathways forming pathway families; (4) identifying molecules from the received list of (1) that are statistically significantly cocited, with at least two molecules from two different pathways, thereby providing pathway pairs; (5) calculating a statistical association score for pathway pairs; (6) ranking pathway pairs by their pathway pair score; (7) defining the pathway pair having the most significant association score as the initial network; (8) identifying additional pathway pairs; (9) joining the pathway pair to the network; (10) calculating a statistical association network score for the network, preserving the network if the score is higher, otherwise discarding the pathway pair joined; (11) repeating steps (8) to (10) until no more pathway pairs can be added to the network; (12) reporting the resulting network.
摘要翻译：生产网络的方法，包括：（1）接收分子列表; （2）鉴定与存储在通路数据库中的途径相关联的途径，所述途径与包含在分子接收列表中的分子相关联; （3）合并形成途径家族的所有相关途径; （4）从来自两个不同途径的至少两个分子的统计学上显着地排列来自（1）的所接收的列表中的分子，由此提供通路对; （5）计算路径对的统计学关联得分; （6）通过路线对得分排名; （7）将具有最高关联分数的路径对定义为初始网络; （8）鉴定其他途径对; （9）将路径对加入网络; （10）计算网络的统计关联网络分数，如果分数较高则保留网络，否则丢弃路由对连接; （11）重复步骤（8）至（10），直到不再有通路对可以添加到网络中; （12）报告结果网络。

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