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1. 发明申请

WO2009052830A1 NOVEL ANTIBODY THERAPIES 审中-公开
标题翻译：新型抗生素治疗
公开(公告)号：WO2009052830A1
公开(公告)日：2009-04-30
申请号：PCT/DK2008/050256
申请日：2008-10-22
申请人： GENMAB A/S , MEDICAL UNIVERSITY OF WARSAW , GOLAB, Jakub , WINIARSKA, Magdalena , PARREN, Paul , MACKUS, Wendy , ENGELBERTS, Patrick
发明人： GOLAB, Jakub , WINIARSKA, Magdalena , PARREN, Paul , MACKUS, Wendy , ENGELBERTS, Patrick
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2887 , A61K39/39558 , A61K45/06 , C07K2317/732 , C07K2317/734 , A61K2300/00
摘要： Antibody capable of mediating effector function which specifically binds to a multiple membrane spanning antigen or to an antigen which forms dimers or multimers (i) for use in combination with a cholesterol-increasing agent in the treatment of a disease or disorder associated with said antigen, wherein antibody-induced effector function has a beneficial effect on said disease ordisorder or (ii) for use in the treatment of such disease or disorder, wherein the antibody is to be administered to a subject undergoing therapy with a cholesterol-lowering agent, such as a statin, and wherein the subject is withdrawn from treatment with the cholesterol-lowering agent prior to the administration of the antibody. Furthermore, a kit of parts comprising such antibody as well as a cholesterol-increasing agent.
摘要翻译：能够介导效应子功能的抗体，其特异性结合跨越抗原的多重膜或形成二聚体或多聚体的抗原（i）与胆固醇增加剂组合用于治疗与所述抗原相关的疾病或病症，其中抗体诱导的效应子功能对所述疾病秩序具有有益作用或（ii）用于治疗这种疾病或病症，其中抗体将被施用于经历降胆固醇药物治疗的受试者，例如他汀类，并且其中所述受试者在施用所述抗体之前用所述胆固醇降低剂从所述治疗中撤出。此外，还包含一些包含这种抗体的部分试剂盒以及一种胆固醇增加剂。

2. 发明公开

EP2205277A1 NOVEL ANTIBODY THERAPIES 有权转让
标题翻译： NEUARTIGEANTIKÖRPERTHERAPIEN
公开(公告)号：EP2205277A1
公开(公告)日：2010-07-14
申请号：EP08841962.7
申请日：2008-10-22
申请人： Genmab A/S
发明人： GOLAB, Jakub , WINIARSKA, Magdalena , PARREN, Paul , MACKUS, Wendy , ENGELBERTS, Patrick
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2887 , A61K39/39558 , A61K45/06 , C07K2317/732 , C07K2317/734 , A61K2300/00
摘要： Antibody capable of mediating effector function which specifically binds to a multiple membrane spanning antigen or to an antigen which forms dimers or multimers (i) for use in combination with a cholesterol-increasing agent in the treatment of a disease or disorder associated with said antigen, wherein antibody-induced effector function has a beneficial effect on said disease ordisorder or (ii) for use in the treatment of such disease or disorder, wherein the antibody is to be administered to a subject undergoing therapy with a cholesterol-lowering agent, such as a statin, and wherein the subject is withdrawn from treatment with the cholesterol-lowering agent prior to the administration of the antibody. Furthermore, a kit of parts comprising such antibody as well as a cholesterol-increasing agent.
摘要翻译：能够介导效应子功能的抗体，其特异性结合跨越抗原的多重膜或形成二聚体或多聚体的抗原（i）与胆固醇增加剂组合用于治疗与所述抗原相关的疾病或病症，其中抗体诱导的效应子功能对所述疾病或病症具有有益作用，或（ii）用于治疗这种疾病或病症，其中抗体将被施用于经历降胆固醇药物治疗的受试者，例如作为他汀类，并且其中所述受试者在施用所述抗体之前用所述胆固醇降低剂从所述治疗中撤出。此外，还包括一种包含这种抗体以及胆固醇增加剂的试剂盒。

3. 发明授权

EP2205277B1 NOVEL ANTIBODY THERAPIES 有权转让
标题翻译：新型抗体治疗
公开(公告)号：EP2205277B1
公开(公告)日：2017-07-26
申请号：EP08841962.7
申请日：2008-10-22
申请人： Genmab A/S
发明人： GOLAB, Jakub , WINIARSKA, Magdalena , PARREN, Paul , MACKUS, Wendy , ENGELBERTS, Patrick
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2887 , A61K39/39558 , A61K45/06 , C07K2317/732 , C07K2317/734 , A61K2300/00

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