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1. 发明申请

WO2015090863A1 DEVICES FOR SEPARATION OF PARTICULATES, ASSOCIATED METHODS AND SYSTEMS 审中-公开
标题翻译：用于分离颗粒物，相关方法和系统的装置
公开(公告)号：WO2015090863A1
公开(公告)日：2015-06-25
申请号：PCT/EP2014/075569
申请日：2014-11-25
申请人： GENERAL ELECTRIC COMPANY , GE HEALTHCARE UK LIMITED
发明人： PULEO, Christopher, Michael , KVAM, Erik, Leeming , GROSSMANN, Gregory, Andrew , GALLIGAN, Craig, Patrick , NICHOLS, Jason, Michael , WANG, Xuefeng , DAVIS, Jason, Louis
IPC分类号： B01L3/00
CPC分类号： B01D21/0087 , B01D17/02 , B01D21/0006 , B01D21/0042 , B01D21/02 , B01D21/10 , B01D21/2433 , B01D21/2444 , B01D21/245 , B01D2221/04 , B01L3/502753 , B01L3/502761 , B01L2200/0631 , B01L2200/0652 , B01L2200/0668 , B01L2300/0681 , B01L2300/0851 , B01L2400/0421 , B01L2400/043 , B01L2400/0457 , B01L2400/0469 , C02F1/00 , C02F1/24 , C02F1/444 , C02F1/48 , C02F2001/007 , C02F2101/32 , C02F2103/08 , C02F2103/10 , C02F2201/002 , C12M47/02 , C12N5/0641
摘要： A device is configured for separation of particulates dispersed within a base fluid, wherein the particulates have a relative density difference compared to the base fluid. The device comprises a microchannel of length 1 and height h comprising an inlet and an outlet; a microporous surface on one or more walls of the microchannel; a collection chamber on an opposing side of the microporous surface; and an applied force field across the height h of the microchannel to sediment the particles through the microporous surface into the collection chamber. The microporous body operationally generates a fluid flow regime comprising a first fluid flow having a first flow rate through the microchannel and a second fluid flow having a second flow rate through the collection chamber and the second flow rate is a fraction of the first flow rate.
摘要翻译：一种装置被配置用于分离分散在基础流体中的微粒，其中微粒与基础流体相比具有相对密度差。该装置包括长度为1的微通道和包括入口和出口的高度h; 在微通道的一个或多个壁上的微孔表面; 在微孔表面的相对侧上的收集室; 以及穿过微通道的高度h的施加的力场，以将颗粒通过微孔表面沉淀到收集室中。微孔体可操作地产生流体流动状态，其包括具有通过微通道的第一流量的第一流体流和具有通过收集室的第二流量的第二流体流，而第二流量是第一流量的一部分。

2. 发明申请

WO2016012394A1 SAMPLE COLLECTION AND TRANSFER DEVICE 审中-公开
标题翻译：样品收集和转移装置
公开(公告)号：WO2016012394A1
公开(公告)日：2016-01-28
申请号：PCT/EP2015/066532
申请日：2015-07-20
申请人： GENERAL ELECTRIC COMPANY , GE HEALTHCARE BIO-SCIENCES AB
发明人： LENIGK, Ralf , FINEHOUT, Erin, Jean , WANG, Xuefeng
IPC分类号： B01L3/02 , B01L3/00
CPC分类号： B01L3/5023 , A61B5/150343 , A61B5/150358 , B01L3/0258 , B01L3/0262 , B01L3/502715 , B01L3/561 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/16 , B01L2300/069 , B01L2300/0838 , B01L2300/0887 , B01L2300/161 , B01L2400/0406 , C12Q1/6806 , G01N1/14 , G01N2001/149
摘要： An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface and an outlet for driving out the sample fluid. The device further comprises an interface assembly comprising: a third layer, a fourth layer, a fifth layer, and a flow path. The interface assembly is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer of the interface assembly and the outlet is in contact with the flow path of the interface assembly for driving out the sample fluid from the integrated device.
摘要翻译：提供了一种用于样品收集和转移的集成设备。集成装置包括设置在第一层和第二层之间的毛细通道，其中第一层包括亲水层，该亲水层包括用于将样品流体接收到毛细通道的流体入口，其中毛细通道包括内表面和外表面表面和用于排出样品流体的出口。该装置还包括界面组件，其包括：第三层，第四层，第五层和流路。接口组件设置在毛细管的外表面上，在相对于出口的确定位置处，使得毛细管与接口组件的第三层接触并且出口与界面的流动路径接触用于从集成装置排出样品流体的组件。

3. 发明申请

WO2016012392A1 SAMPLE COLLECTION AND TRANSFER DEVICE 审中-公开
标题翻译：样品收集和转移装置
公开(公告)号：WO2016012392A1
公开(公告)日：2016-01-28
申请号：PCT/EP2015/066530
申请日：2015-07-20
申请人： GENERAL ELECTRIC COMPANY , GE HEALTHCARE BIO-SCIENCES AB
发明人： LENIGK, Ralf , FINEHOUT, Erin, Jean , WANG, Xuefeng
IPC分类号： B01L3/02
CPC分类号： B01L3/502715 , B01L3/0258 , B01L3/0262 , B01L3/5023 , B01L3/561 , B01L2200/027 , B01L2200/10 , B01L2300/069 , B01L2300/0838 , B01L2300/0887 , B01L2300/12 , B01L2300/161 , B01L2300/165 , B01L2400/0406
摘要： Anintegrateddevice for a sample collectionand transferis provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface; and an outlet for driving out the sample fluid. The device further comprisesa third layer comprising an adhesive materialsuch asa patterned adhesive material, and a flow path, wherein the third layer is disposed on the outer surface of the capillary, at a determining position relative to the outlet,such thatthe capillary is in contact with the third layer and the outlet is in contact with the flow path of the third layerfor allowing the sample fluid out from the integrated device.
摘要翻译：提供样品收集和转移的综合设备。集成装置包括设置在第一层和第二层之间的毛细通道，其中第一层包括亲水层，该亲水层包括用于将样品流体接收到毛细通道的流体入口，其中毛细通道包括内表面和外表面表面; 以及用于驱出样品流体的出口。该装置还包括第三层，其包括诸如图案化粘合剂材料的粘合材料，以及流路，其中第三层设置在毛细管的外表面上，在相对于出口的确定位置处，使得毛细管与第三层和出口与第三层的流动路径接触，以允许样品流体从集成装置中排出。

4. 发明授权

EP3171978B1 SAMPLE COLLECTION AND TRANSFER DEVICE 有权转让
公开(公告)号：EP3171978B1
公开(公告)日：2020-03-25
申请号：EP15739579.9
申请日：2015-07-20
申请人： General Electric Company
发明人： LENIGK, Ralf , FINEHOUT, Erin Jean , WANG, Xuefeng
IPC分类号： B01L3/02 , B01L3/00

5. 发明公开

EP3171978A1 SAMPLE COLLECTION AND TRANSFER DEVICE 有权转让
标题翻译：样品收集和转移设备
公开(公告)号：EP3171978A1
公开(公告)日：2017-05-31
申请号：EP15739579.9
申请日：2015-07-20
申请人： General Electric Company
发明人： LENIGK, Ralf , FINEHOUT, Erin Jean , WANG, Xuefeng
IPC分类号： B01L3/02 , B01L3/00
摘要： An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface and an outlet for driving out the sample fluid. The device further comprises an interface assembly comprising: a third layer, a fourth layer, a fifth layer, and a flow path. The interface assembly is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer of the interface assembly and the outlet is in contact with the flow path of the interface assembly for driving out the sample fluid from the integrated device.
摘要翻译：提供样品采集和转移的集成设备。集成装置包括设置在第一层和第二层之间的毛细管通道，其中第一层包括亲水层，该亲水层包括用于将样本流体接收到毛细通道的流体入口，其中毛细通道包括内表面和外层表面和用于驱出样品流体的出口。该装置还包括界面组件，该界面组件包括：第三层，第四层，第五层和流动路径。界面组件在相对于出口的确定位置处设置在毛细管的外表面上，使得毛细管与界面组件的第三层接触，并且出口与界面的流动路径接触用于从集成装置中排出样品流体的组件。

6. 发明公开

EP3083051A1 DEVICES FOR SEPARATION OF PARTICULATES, ASSOCIATED METHODS AND SYSTEMS 有权转让
标题翻译： VORRICHTUNGEN ZUM TRENNEN VON TEILCHEN，ZUGEHÖRIGEVERFAHREN UND SYSTEME
公开(公告)号：EP3083051A1
公开(公告)日：2016-10-26
申请号：EP14802472.2
申请日：2014-11-25
申请人： General Electric Company
发明人： PULEO, Christopher Michael , KVAM, Erik, Leeming , GROSSMANN, Gregory Andrew , GALLIGAN, Craig Patrick , NICHOLS, Jason Michael , WANG, Xuefeng , DAVIS, Jason Louis
IPC分类号： B01L3/00
CPC分类号： B01D21/0087 , B01D17/02 , B01D21/0006 , B01D21/0042 , B01D21/02 , B01D21/10 , B01D21/2433 , B01D21/2444 , B01D21/245 , B01D2221/04 , B01L3/502753 , B01L3/502761 , B01L2200/0631 , B01L2200/0652 , B01L2200/0668 , B01L2300/0681 , B01L2300/0851 , B01L2400/0421 , B01L2400/043 , B01L2400/0457 , B01L2400/0469 , C02F1/00 , C02F1/24 , C02F1/444 , C02F1/48 , C02F2001/007 , C02F2101/32 , C02F2103/08 , C02F2103/10 , C02F2201/002 , C12M47/02 , C12N5/0641
摘要： A device is configured for separation of particulates dispersed within a base fluid, wherein the particulates have a relative density difference compared to the base fluid. The device comprises a microchannel of length l and height h comprising an inlet and an outlet; a microporous surface on one or more walls of the microchannel; a collection chamber on an opposing side of the microporous surface; and an applied force field across the height h of the microchannel to sediment the particles through the microporous surface into the collection chamber. The microporous body operationally generates a fluid flow regime comprising a first fluid flow having a first flow rate through the microchannel and a second fluid flow having a second flow rate through the collection chamber and the second flow rate is a fraction of the first flow rate.
摘要翻译：一种装置被配置用于分离分散在基础流体中的微粒，其中微粒与基础流体相比具有相对密度差。该装置包括长度为l的微通道和包括入口和出口的高度h; 在微通道的一个或多个壁上的微孔表面; 在微孔表面的相对侧上的收集室; 以及穿过微通道的高度h的施加的力场，以将颗粒通过微孔表面沉淀到收集室中。微孔体可操作地产生流体流动状态，其包括具有通过微通道的第一流量的第一流体流和具有通过收集室的第二流速的第二流体流，第二流量是第一流量的一部分。

7. 发明公开

EP3032230A3 FLOW METER AND A METHOD OF CALIBRATION 有权转让
标题翻译：流量计和方法
公开(公告)号：EP3032230A3
公开(公告)日：2016-06-22
申请号：EP15197857.4
申请日：2015-12-03
申请人： General Electric Company
发明人： WANG, Xuefeng
IPC分类号： G01F25/00
CPC分类号： G01F25/0007
摘要： A system, comprising a first sensor 104 that generates a first output signal representative of a first flow rate measurement in a first flow rate range of a fluid 102, a second sensor 106 that generates a second output signal representative of a second flow rate measurement in a second flow rate range of the fluid that at least partially overlaps the first flow rate range of the fluid to form a partially overlapping region, a data repository 122 storing a first calibration relationship 124 corresponding to a first condition of the fluid and a second calibration relationship 126 corresponding to a second condition of the fluid, wherein the first calibration relationship and the second calibration relationship correspond to the first sensor, and a processing subsystem 120 that automatically generates a third calibration relationship when the second flow rate measurement falls in the partially overlapping region, wherein the third calibration relationship corresponds to a third condition of the fluid based at least on the first calibration relationship, the second calibration relationship, the first output signal and the second output signal.

8. 发明授权

EP3171979B1 SAMPLE COLLECTION AND TRANSFER DEVICE 有权转让
公开(公告)号：EP3171979B1
公开(公告)日：2020-04-01
申请号：EP15747763.9
申请日：2015-07-20
申请人： General Electric Company
发明人： LENIGK, Ralf , FINEHOUT, Erin Jean , WANG, Xuefeng
IPC分类号： B01L3/00 , B01L3/02

9. 发明公开

EP3032230A2 FLOW METER AND A METHOD OF CALIBRATION 有权转让
标题翻译：流量计和校准方法
公开(公告)号：EP3032230A2
公开(公告)日：2016-06-15
申请号：EP15197857.4
申请日：2015-12-03
申请人： General Electric Company
发明人： WANG, Xuefeng
IPC分类号： G01F25/00
CPC分类号： G01F25/0007
摘要： A system, comprising a first sensor 104 that generates a first output signal representative of a first flow rate measurement in a first flow rate range of a fluid 102, a second sensor 106 that generates a second output signal representative of a second flow rate measurement in a second flow rate range of the fluid that at least partially overlaps the first flow rate range of the fluid to form a partially overlapping region, a data repository 122 storing a first calibration relationship 124 corresponding to a first condition of the fluid and a second calibration relationship 126 corresponding to a second condition of the fluid, wherein the first calibration relationship and the second calibration relationship correspond to the first sensor, and a processing subsystem 120 that automatically generates a third calibration relationship when the second flow rate measurement falls in the partially overlapping region, wherein the third calibration relationship corresponds to a third condition of the fluid based at least on the first calibration relationship, the second calibration relationship, the first output signal and the second output signal.
摘要翻译：一种系统，包括：第一传感器104，其产生表示流体102的第一流速范围内的第一流速测量值的第一输出信号;第二传感器106，其产生表示第二流速测量值的第二输出信号至少部分地与流体的第一流速范围重叠以形成部分重叠区域的流体的第二流速范围，存储对应于流体的第一条件的第一校准关系124的数据储存库122，以及第二校准对应于流体的第二条件的关系126，其中第一校准关系和第二校准关系对应于第一传感器;以及处理子系统120，其在第二流速测量值落入部分重叠时自动产生第三校准关系区域，其中第三校准关系对应于第三条件至少基于第一校准关系，第二校准关系，第一输出信号和第二输出信号确定流体的流量。

10. 发明公开

EP3171979A1 SAMPLE COLLECTION AND TRANSFER DEVICE 有权转让
标题翻译：样品收集和转移设备
公开(公告)号：EP3171979A1
公开(公告)日：2017-05-31
申请号：EP15747763.9
申请日：2015-07-20
申请人： General Electric Company
发明人： LENIGK, Ralf , FINEHOUT, Erin Jean , WANG, Xuefeng
IPC分类号： B01L3/02
摘要： An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface; and an outlet for driving out the sample fluid. The device further comprises a third layer comprising an adhesive material such as a patterned adhesive material, and a flow path, wherein the third layer is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer and the outlet is in contact with the flow path of the third layer for allowing the sample fluid out from the integrated device.
摘要翻译：提供样品采集和转移的集成设备。集成装置包括设置在第一层和第二层之间的毛细管通道，其中第一层包括亲水层，该亲水层包括用于将样本流体接收到毛细通道的流体入口，其中毛细通道包括内表面和外层表面; 和用于驱出样品流体的出口。该装置还包括第三层，该第三层包括诸如图案化粘合剂材料的粘合材料和流动路径，其中第三层设置在毛细管的外表面上相对于出口的确定位置处，使得毛细管与第三层接触并且出口与第三层的流动路径接触以允许样品流体从集成装置中流出。

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