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1. 发明授权

US11007285B2 Microbubble tether for diagnostic and therapeutic applications 有权
公开(公告)号：US11007285B2
公开(公告)日：2021-05-18
申请号：US16935998
申请日：2020-07-22
申请人： General Electric Company
发明人： Matthew David Butts , Jason William Castle , Andrew Soliz Torres , Jeannette Christine Roberts , Binil Itty Ipe Kandapallil
IPC分类号： A61K49/22 , A61K9/00 , A61K9/50
摘要： The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.

2. 发明授权

US10751429B2 Microbubble tether for diagnostic and therapeutic applications 有权
公开(公告)号：US10751429B2
公开(公告)日：2020-08-25
申请号：US16102368
申请日：2018-08-13
申请人： GENERAL ELECTRIC COMPANY
发明人： Matthew David Butts , Jason William Castle , Andrew Soliz Torres , Jeannette Christine Roberts , Binil Itty Ipe Kandapallil
IPC分类号： A61K49/22 , A61K9/00 , A61K9/50
摘要： The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.

3. 发明授权

US10052394B2 Microbubble tether for diagnostic and therapeutic applications 有权
公开(公告)号：US10052394B2
公开(公告)日：2018-08-21
申请号：US14550689
申请日：2014-11-21
申请人： GENERAL ELECTRIC COMPANY
发明人： Matthew David Butts , Jason William Castle , Andrew Soliz Torres , Jeannette Christine Roberts , Binil Itty Ipe Kandapallil
IPC分类号： A61K49/22 , A61K9/00 , A61K9/50
CPC分类号： A61K49/223 , A61K9/0009 , A61K9/5052
摘要： The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.

4. 发明授权

US09155804B2 Contrast enhancement agents and method of use thereof 有权
标题翻译：对比增强剂及其使用方法
公开(公告)号：US09155804B2
公开(公告)日：2015-10-13
申请号：US13626942
申请日：2012-09-26
申请人： General Electric Company
发明人： Brian James Grimmond , Michael James Rishel , Jeannette Christine Roberts
IPC分类号： A61K51/00 , A61M36/14 , A61K49/12
CPC分类号： A61K49/126
摘要： A contrast agent composition and a method of diagnostic imaging are provided. The composition comprises a pharmaceutically acceptable carrier and a metal-complex comprising a ligand having structure (XXX): wherein R1, R2, R3, R7, R8, R′1, R′2, R′3, R7′ and R8′ are selected form hydrogen, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group; R4, R′4 are selected from a hydrogen, a hydroxyl, a protected hydroxyl group, a protected C1-C3 hydroxyalkyl group, a C1-C3 alkyl group; n is an integer between 0 and 4; R5, R′5 are selected from a hydrogen, a protecting group comprising C1-C30 aliphatic radicals, C3-C30 cycloaliphatic radicals, C2-C30 aromatic radicals, m is an integer between 1 and 10; at least one of R7 and R′7 is acidic groups or protected acidic groups; Y comprises a protein or peptide moiety, a particle, a micelle, a liposome, an organic molecule, oligomer, polymer or a hydrophilic moiety.
摘要翻译：提供造影剂组合物和诊断成像方法。该组合物包含药学上可接受的载体和包含具有结构（XXX）的配体的金属络合物：其中R1，R2，R3，R7，R8，R'1，R'2，R'3，R7'和R8'是选自氢，受保护的C1-C3羟烷基或C1-C3烷基; R 4，R'4选自氢，羟基，被保护的羟基，保护的C 1 -C 3羟烷基，C 1 -C 3烷基; n是0和4之间的整数; R5，R'5选自氢，包含C1-C30脂族基团，C3-C30脂环族基团，C2-C30芳族基团的保护基，m是1-10之间的整数; R 7和R 7中的至少一个是酸性基团或被保护的酸性基团; Y包括蛋白质或肽部分，颗粒，胶束，脂质体，有机分子，低聚物，聚合物或亲水部分。

5. 发明申请

US20160144059A1 MICROBUBBLE TETHER FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS 审中-公开
标题翻译：用于诊断和治疗应用的MICROBUBBLE TETHER
公开(公告)号：US20160144059A1
公开(公告)日：2016-05-26
申请号：US14550689
申请日：2014-11-21
申请人： GENERAL ELECTRIC COMPANY
发明人： Matthew David Butts , Jason William Castle , Andrew Soliz Torres , Jeannette Christine Roberts , Binil Itty Ipe Kandapallil
IPC分类号： A61K49/22
CPC分类号： A61K49/223 , A61K9/0009 , A61K9/5052
摘要： The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.
摘要翻译：本公开内容涉及白蛋白微泡的组合物，其结合了相对于游离的天然HSA显示白蛋白微泡的结合偏好的一个或多个部分。还讨论了白蛋白微泡组合物的生产和白蛋白微泡组合物在超声介导的递送治疗剂或诊断剂中的用途。

6. 发明申请

US20140086846A1 CONTRAST ENHANCEMENT AGENTS AND METHOD OF USE THEREOF 有权
标题翻译：对比增强剂及其使用方法
公开(公告)号：US20140086846A1
公开(公告)日：2014-03-27
申请号：US13626942
申请日：2012-09-26
申请人： GENERAL ELECTRIC COMPANY
发明人： Brian James Grimmond , Michael James Rishel , Jeannette Christine Roberts
IPC分类号： A61K49/00 , A61K49/14 , C07H21/00 , C07K14/00 , C07K16/00 , C07H99/00 , A61K49/10 , A61K49/16
CPC分类号： A61K49/126
摘要： A contrast agent composition and a method of diagnostic imaging are provided. The composition comprises a pharmaceutically acceptable carrier and a metal-complex comprising a ligand having structure (XXX): wherein R1, R2, R3, R7, R8, R′1, R′2, R′3, R7′ and R8′ are selected form hydrogen, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group; R4, R′4 are selected from a hydrogen, a hydroxyl, a protected hydroxyl group, a protected C1-C3 hydroxyalkyl group, a C1-C3 alkyl group; n is an integer between 0 and 4; R5, R′5 are selected from a hydrogen, a protecting group comprising C1-C30 aliphatic radicals, C3-C30 cycloaliphatic radicals, C2-C30 aromatic radicals, m is an integer between 1 and 10; at least one of R7 and R′7 is acidic groups or protected acidic groups; Y comprises a protein or peptide moiety, a particle, a micelle, a liposome, an organic molecule, oligomer, polymer or a hydrophilic moiety.
摘要翻译：提供造影剂组合物和诊断成像方法。该组合物包含药学上可接受的载体和包含具有结构（XXX）的配体的金属络合物：其中R1，R2，R3，R7，R8，R'1，R'2，R'3，R7'和R8'是选自氢，受保护的C1-C3羟烷基或C1-C3烷基; R 4，R'4选自氢，羟基，被保护的羟基，保护的C 1 -C 3羟烷基，C 1 -C 3烷基; n是0和4之间的整数; R5，R'5选自氢，包含C1-C30脂族基团，C3-C30脂环族基团，C2-C30芳族基团的保护基，m是1-10之间的整数; R 7和R 7中的至少一个是酸性基团或被保护的酸性基团; Y包括蛋白质或肽部分，颗粒，胶束，脂质体，有机分子，低聚物，聚合物或亲水部分。

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