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1. 发明申请

WO2005059181A1 CARBON ELECTRODE SURFACE FOR ATTACHMENT OF DNA AND PROTEIN MOLECULES 审中-公开
标题翻译：用于连接DNA和蛋白质分子的碳电极表面
公开(公告)号：WO2005059181A1
公开(公告)日：2005-06-30
申请号：PCT/US2004/042039
申请日：2004-12-13
申请人： GENEOHM SCIENCES, INC. , CHEN, Ting , YANG, Xing , HOLMLIN, R. Erik
发明人： CHEN, Ting , YANG, Xing , HOLMLIN, R. Erik
IPC分类号： C12Q1/68
CPC分类号： G01N33/5438 , B01J19/0046 , B01J2219/00432 , B01J2219/00441 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , C12Q1/6825 , C12Q1/6837 , C12Q2565/501 , C12Q2565/607
摘要： Methods for conducting an assay to detect nucleic acid hybridization are disclosed. In particular, the fabrication of a carbon electrode suited to nucleic acid hybridization detection is described. In some preferred embodiments, a micro array of carbon electrodes is constructed using photolithography. The final step in the photolithography process involves developing a solder mask 306 with an alkaline solution. The alkaline solution oxidizes the carbon surface 304 producing surface carboxylic acid groups. The surface carboxylic acid groups are reacted with EDC or DCC and NHS to produce NHS esters. Immobilization of NeutrAvidinTM onto the electrode surface is effected by reaction with the surface NHS ester groups. A biotinylated probe DNA molecule is then attached to the electrode via binding between the biotin group and the immobilized NeutrAvidinTM. The resulting electrode can be used to detect hybridization between the probe DNA and complementary target DNA.
摘要翻译：公开了用于进行测定以检测核酸杂交的方法。特别地，描述了适合于核酸杂交检测的碳电极的制造。在一些优选实施例中，使用光刻法构建微电极阵列的碳电极。光刻工艺的最后一步包括用碱性溶液开发焊接掩模306。碱性溶液氧化形成表面羧酸基团的碳表面304。表面羧酸基团与EDC或DCC和NHS反应生成NHS酯。通过与表面NHS酯基团的反应来实现将NeutrAvidin TM固定在电极表面上。然后通过生物素基团和固定化的NeutrAvidinTM之间的结合将生物素化的探针DNA分子连接到电极上。所得电极可用于检测探针DNA和互补靶DNA之间的杂交。

2. 发明授权

EP1694867B1 CARBON ELECTRODE SURFACE FOR ATTACHMENT OF DNA AND PROTEIN MOLECULES 有权
标题翻译：碳电极表面的DNA和蛋白质分子的约束力REMEMBER
公开(公告)号：EP1694867B1
公开(公告)日：2009-10-28
申请号：EP04814245.9
申请日：2004-12-13
申请人： Geneohm Sciences, Inc.
发明人： CHEN, Ting , YANG, Xing , HOLMLIN, R. Erik
IPC分类号： C12Q1/68 , G01N33/543
CPC分类号： G01N33/5438 , B01J19/0046 , B01J2219/00432 , B01J2219/00441 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , C12Q1/6825 , C12Q1/6837 , C12Q2565/501 , C12Q2565/607

3. 发明公开

EP1694867A1 CARBON ELECTRODE SURFACE FOR ATTACHMENT OF DNA AND PROTEIN MOLECULES 有权
标题翻译：碳电极表面的DNA和蛋白质分子的约束力REMEMBER
公开(公告)号：EP1694867A1
公开(公告)日：2006-08-30
申请号：EP04814245.9
申请日：2004-12-13
申请人： Geneohm Sciences, Inc.
发明人： CHEN, Ting , YANG, Xing , HOLMLIN, R. Erik
IPC分类号： C12Q1/68 , G01N33/543
CPC分类号： G01N33/5438 , B01J19/0046 , B01J2219/00432 , B01J2219/00441 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , C12Q1/6825 , C12Q1/6837 , C12Q2565/501 , C12Q2565/607
摘要： Methods for conducting an assay to detect nucleic acid hybridization are disclosed. In particular, the fabrication of a carbon electrode suited to nucleic acid hybridization detection is described. In some preferred embodiments, a micro array of carbon electrodes is constructed using photolithography. The final step in the photolithography process involves developing a solder mask 306 with an alkaline solution. The alkaline solution oxidizes the carbon surface 304 producing surface carboxylic acid groups. The surface carboxylic acid groups are reacted with EDC or DCC and NHS to produce NHS esters. Immobilization of NeutrAvidinTM onto the electrode surface is effected by reaction with the surface NHS ester groups. A biotinylated probe DNA molecule is then attached to the electrode via binding between the biotin group and the immobilized NeutrAvidinTM. The resulting electrode can be used to detect hybridization between the probe DNA and complementary target DNA.

4. 发明申请

WO2011143318A2 ANTI-FGFR2 ANTIBODIES 审中-公开
标题翻译：抗FGFR2抗体
公开(公告)号：WO2011143318A2
公开(公告)日：2011-11-17
申请号：PCT/US2011/036085
申请日：2011-05-11
申请人： AVEO PHARMACEUTICALS, INC. , WENG, Zhigang , WINSTON, William, M., Jr. , BAI, Ailin , MEETZE, Kristan , WEILER, Solly , CHEN, Ting , GYURIS, Jeno
发明人： WENG, Zhigang , WINSTON, William, M., Jr. , BAI, Ailin , MEETZE, Kristan , WEILER, Solly , CHEN, Ting , GYURIS, Jeno
IPC分类号： A61K39/395 , C07H21/00 , C12N15/63 , C12P21/02 , C12N5/09 , C07K16/40 , C12N5/10 , C12N1/21 , A61P35/00
CPC分类号： C07K16/2863 , A61K2039/505 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that bind and inhibit biological activities of human FGFR2 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation or overexpression of FGFR2.
摘要翻译：公开了结合和抑制人FGFR2的生物学活性的单克隆抗体。抗体可用于治疗与FGFR2的活化或过表达相关的细胞增殖性疾病和病症，包括某些形式的癌症。

5. 发明申请

WO2011156617A2 ANTI-EGFR ANTIBODIES 审中-公开
标题翻译：抗EGFR抗体
公开(公告)号：WO2011156617A2
公开(公告)日：2011-12-15
申请号：PCT/US2011/039821
申请日：2011-06-09
申请人： AVEO PHARMACEUTICALS, INC. , WANG, Fang , VINCENT, Sylvie , WINSTON, William, M., Jr. , BOTEGA, Steve , MCINTOSH, Donna , CHEN, Ting , TYLER, Steven , GYURIS, Jeno
发明人： WANG, Fang , VINCENT, Sylvie , WINSTON, William, M., Jr. , BOTEGA, Steve , MCINTOSH, Donna , CHEN, Ting , TYLER, Steven , GYURIS, Jeno
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/30 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member EGFR L858R/T790M are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of EGFR L858R/T790M , EGFRvIII or wild-type EGFR amplification.
摘要翻译：公开了结合并抑制表皮生长因子受体相关成员EGFRL858R / T790M活化的单克隆抗体。抗体可用于治疗与激活EGFRL858R / T790M，EGFRvIII或野生型EGFR扩增相关的细胞增殖性疾病和障碍，包括某些形式的癌症。

6. 发明申请

WO2011136911A2 ANTI-ERBB3 ANTIBODIES 审中-公开
标题翻译：抗ERBB3抗体
公开(公告)号：WO2011136911A2
公开(公告)日：2011-11-03
申请号：PCT/US2011/031829
申请日：2011-04-08
申请人： AVEO PHARMACEUTICALS, INC. , VINCENT, Sylvie , WINSTON, William, M., Jr. , WANG, Fang , WEILER, Solly , MEETZE, Kristan , BREAULT, Lyne , BOTEGA, Steve , CHEN, Ting , DEPRIMA, Michael , FLEET, Christina , TYLER, Steven , WOO, Jin-Kyeung , GYURIS, Jeno
发明人： VINCENT, Sylvie , WINSTON, William, M., Jr. , WANG, Fang , WEILER, Solly , MEETZE, Kristan , BREAULT, Lyne , BOTEGA, Steve , CHEN, Ting , DEPRIMA, Michael , FLEET, Christina , TYLER, Steven , WOO, Jin-Kyeung , GYURIS, Jeno
IPC分类号： C07K16/32
CPC分类号： C07K16/32 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of ErbB 3/HER3.
摘要翻译：公开了结合并抑制表皮生长因子受体相关成分ErbB3 / HER3活化的单克隆抗体。抗体可用于治疗与ErbB 3 / HER3的激活相关的细胞增殖性疾病和病症，包括某些形式的癌症。

7. 发明申请

WO2008054608A1 ANALYTE SENSORS AND METHODS 审中-公开
标题翻译：分析传感器和方法
公开(公告)号：WO2008054608A1
公开(公告)日：2008-05-08
申请号：PCT/US2007/021229
申请日：2007-10-03
申请人： ABBOTT DIABETES CARE INC. , CHEN, Ting , FELDMAN, Benjamin, J.
发明人： CHEN, Ting , FELDMAN, Benjamin, J.
IPC分类号： G01N33/487 , C12Q1/00 , G01N27/42 , G01N27/49
CPC分类号： G01N27/26 , C12Q1/006 , G01N27/3273
摘要： Methods of determining analyte concentration. The methods use a fraction of the predicted total charge, from analyte electrolysis, instead of using time, for determination of a data collection endpoint. The total charge is then extrapolated from the data collection endpoint. The analyte concentration is determined from the total charge.
摘要翻译：测定分析物浓度的方法。该方法使用分析物电解的预计总电荷的一部分，而不是使用时间来确定数据收集终点。然后从数据收集端点外推总费用。分析物浓度由总电荷确定。

8. 发明申请

WO2013048757A1 DEVICE ORIENTATION DEPENDENT AUTOFOCUS OPERATIONS 审中-公开
标题翻译：设备方向依赖自动操作
公开(公告)号：WO2013048757A1
公开(公告)日：2013-04-04
申请号：PCT/US2012/055109
申请日：2012-09-13
申请人： APPLE INC. , BRUNNER, Ralph , CHEN, Ting
发明人： BRUNNER, Ralph , CHEN, Ting
IPC分类号： H04N1/21 , H04N5/232
CPC分类号： H04N1/2112 , H04N5/23212 , H04N2101/00 , H04N2201/0084 , H04N2201/0096
摘要： Systems, methods, and computer readable media for dynamically adjusting an image capture device's autofocus (AF) operation based, at least in part, on the device's orientation are described. In general, information about an image capture device's orientation may be used to either increase the speed or improve the resolution of autofocus operations. More particularly, orientation information such as that available from an accelerometer may be used to reduce the number of lens positions (points-of-interest) used during an autofocus operation, thereby improving the operation's speed. Alternatively, orientation information may be used to reduce the lens' range of motion while maintaining the number of points-of-interest, thereby improving the operation's resolution.
摘要翻译：描述了至少部分地基于设备的取向来动态地调整图像捕获设备的自动对焦（AF）操作的系统，方法和计算机可读介质。通常，可以使用关于图像捕获装置的取向的信息来提高速度或提高自动对焦操作的分辨率。更具体地，可以使用诸如从加速度计获得的定向信息来减少在自动对焦操作期间使用的透镜位置（兴趣点）的数量，从而提高操作的速度。或者，可以使用取向信息来减少透镜的运动范围，同时保持感兴趣点的数量，从而改善操作的分辨率。

9. 发明申请

WO2011152848A1 ADAPTIVE LENS SHADING CORRECTION 审中-公开
标题翻译：自适应镜头调整校正
公开(公告)号：WO2011152848A1
公开(公告)日：2011-12-08
申请号：PCT/US2010/049512
申请日：2010-09-20
申请人： APPLE INC. , KUO, David Daming , GUO, Haitao , ZIPNICK, Jay David , CHEN, Ting , CHAWLA, Sumit
发明人： KUO, David Daming , GUO, Haitao , ZIPNICK, Jay David , CHEN, Ting , CHAWLA, Sumit
IPC分类号： H04N9/73
CPC分类号： H04N9/045 , H04N5/3572
摘要： Systems, methods, and devices for applying lens shading correction to image data captured by an image sensor are provided. In one embodiment, multiple lens shading adaptation functions, each modeled based on the response of a color channel to a reference illuminant, are provided. An image frame from the image data may be analyzed to select a lens shading adaptation function corresponding to a reference illuminant that most closely matches a current illuminant. The selected lens shading function may then be used to adjust a set of lens shading parameters.
摘要翻译：提供了用于将图像传感器捕获的图像数据应用透镜阴影校正的系统，方法和装置。在一个实施例中，提供了基于颜色通道对参照光源的响应而建模的多个透镜遮蔽适应功能。可以分析来自图像数据的图像帧以选择对应于与当前光源最接近匹配的参考光源的透镜遮蔽适应功能。然后可以使用所选择的透镜遮蔽功能来调整一组透镜遮蔽参数。

10. 发明申请

WO2011008357A1 EXTRUDED ELECTRODE STRUCTURES AND METHODS OF USING SAME 审中-公开
标题翻译：挤出电极结构及其使用方法
公开(公告)号：WO2011008357A1
公开(公告)日：2011-01-20
申请号：PCT/US2010/036926
申请日：2010-06-01
申请人： ABBOTT DIABETES CARE INC. , MAZZA, John C. , ZHANG, Songbiao , HOSS, Udo , MOEIN, Mohammed , CHEN, Ting , THOMAS, Christopher
发明人： MAZZA, John C. , ZHANG, Songbiao , HOSS, Udo , MOEIN, Mohammed , CHEN, Ting , THOMAS, Christopher
IPC分类号： A61B5/05
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/14542 , A61B5/14546 , A61B5/150022 , A61B5/15003 , A61B5/150282 , A61B5/150389 , A61B5/150427 , A61B5/150435 , A61B5/150511 , A61B5/150519 , A61B5/150572 , A61B5/151 , A61B5/15153 , A61B5/15155 , A61B5/15174 , A61B5/157 , A61B5/6848 , A61B2562/0295 , A61B2562/125
摘要： The present disclosure provides electrode structures and integrated electrode structures having one or more conductive materials coextruded with one or more dielectric materials. The disclosed electrode structures can be configured for use as analyte sensors. Also provided, are methods of making and using the electrode structures and integrated electrode structures described herein.
摘要翻译：本公开提供具有一个或多个与一种或多种介电材料共挤出的导电材料的电极结构和集成电极结构。公开的电极结构可被配置为用作分析物传感器。还提供了制造和使用本文所述的电极结构和集成电极结构的方法。

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