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1. 发明申请

WO2008076960A2 ANTAGONIST ANTI-NOTCH3 ANTIBODIES AND THEIR USE IN THE PREVENTION AND TREATMENT OF NOTCH3-RELATED DISEASES 审中-公开
标题翻译：拮抗剂抗NOTCH3抗体及其在预防和治疗NOTCH3相关疾病中的用途
公开(公告)号：WO2008076960A2
公开(公告)日：2008-06-26
申请号：PCT/US2007087723
申请日：2007-12-17
申请人： GENENTECH INC , LI KANG , ZHOU BIN-BING STEPHEN , LI YUCHENG , FUNG SEK CHUNG , SINGH SANJAYA
发明人： LI KANG , ZHOU BIN-BING STEPHEN , LI YUCHENG , FUNG SEK CHUNG , SINGH SANJAYA
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , C12N5/12 , C12N15/13
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/705 , C07K16/28 , C07K2317/56 , C07K2317/76 , C07K2319/30
摘要： The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.
摘要翻译：本发明涉及与Notch3特异性结合并抑制其活化的拮抗剂抗体。本发明包括与包含第一Lin12结构域和第二二聚化结构域的构象表位结合的抗体。本发明还包括这些抗体用于治疗或预防Notch3相关疾病或病症的用途。

2. 发明申请

WO2008051797A3 ANTI-NOTCH3 AGONIST ANTIBODIES AND THEIR USE IN THE TREATMENT OF NOTCH3-RELATED DISEASES 审中-公开
标题翻译：抗坏血酸激动剂抗体及其在治疗缺血性相关疾病中的应用
公开(公告)号：WO2008051797A3
公开(公告)日：2008-07-31
申请号：PCT/US2007081797
申请日：2007-10-18
申请人： GENENTECH INC , LI KANG , ZHOU BIN-BING STEPHEN , WU WENJUAN , FUNG SEK CHUNG , SINGH SANJAYA
发明人： LI KANG , ZHOU BIN-BING STEPHEN , WU WENJUAN , FUNG SEK CHUNG , SINGH SANJAYA
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , C12N5/12 , C12N15/13
CPC分类号： C07K16/30 , A61K39/00 , A61K39/39558 , A61K2039/505 , A61K2039/5152 , C07K16/00 , C07K16/28 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/75 , C07K2319/30 , G01N33/57492 , G01N33/6893
摘要： The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.
摘要翻译：本发明涉及特异性结合Notch 3并激活信号传导的激动剂抗体。本发明包括与包含第一Lin12结构域的表位结合的抗体。本发明还包括这些抗体治疗或预防Notch 3相关疾病或病症的用途。

3. 发明申请

WO03057252A8 HUMAN MAST CELL-EXPRESSED MEMBRANE PROTEINS 审中-公开
标题翻译：人类细胞表达的蛋白质
公开(公告)号：WO03057252A8
公开(公告)日：2003-10-23
申请号：PCT/US0300307
申请日：2003-01-03
申请人： TANOX INC , LI KANG , LI YUCHENG , WANG SHEN-WU , HU GUANGHUI , YAO ZHENGBIN
发明人： LI KANG , LI YUCHENG , WANG SHEN-WU , HU GUANGHUI , YAO ZHENGBIN
IPC分类号： A01K67/027 , A61K31/7088 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/04 , A61P7/06 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/04 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/02 , A61P29/00 , A61P31/12 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07H21/04 , C07K14/47 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/00 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/567 , G01N33/569 , C12N15/00 , C12P15/00 , C12P21/06
CPC分类号： C07K16/28 , A01K2217/075 , A61K39/00 , A61K2039/505 , C07K14/705 , C12Q1/6886 , C12Q2600/136 , G01N33/56972 , G01N2500/00
摘要： Mast cell-expressed membrane proteins that are highly expressed in human mast cells and the lungs as compared to brain, heart, kidney, liver, tracheal, and similar tissues. The proteins are transmembrane proteins involved in the regulation of mast cell and lung tissue function, including degranulation of mast cells. The preferred protein is a 187 amino acid transmembrane protein having an intercellular domain comprising amino acids 1 through 82, a transmembrane domain comprising amino acids 83 through 105, and an extracellular domain comprising amino acids 106 through 187 (SEQ ID NO:2).
摘要翻译：与大脑，心脏，肾脏，肝脏，气管和类似组织相比，肥大细胞表达的膜蛋白在人类肥大细胞和肺中高度表达。蛋白质是涉及肥大细胞和肺组织功能调节的跨膜蛋白，包括肥大细胞的脱颗粒。优选的蛋白质是187氨基酸跨膜蛋白，其具有包含氨基酸1至82的细胞间结构域，包含氨基酸83至105的跨膜结构域和包含氨基酸106至187（SEQ ID NO：2）的细胞外结构域。

4. 发明申请

WO2006023226A2 THYMIC STROMAL LYMPHOPOIETIN PROMOTER AND USES THEREFOR 审中-公开
标题翻译：胸腺基质淋巴因子促进剂并用于此
公开(公告)号：WO2006023226A2
公开(公告)日：2006-03-02
申请号：PCT/US2005026633
申请日：2005-07-27
申请人： TANOX INC , YAO ZHENGBIN , HU GUANGHUI , YUCHENG LI , LI KANG
发明人： YAO ZHENGBIN , HU GUANGHUI , YUCHENG LI , LI KANG
IPC分类号： C12P21/06 , C07K14/705
CPC分类号： C07K14/5418 , A61K48/0058 , C07K14/475 , C07K2319/61 , C12N2830/008 , C12Q1/37 , G01N2333/81 , G01N2800/00
摘要： A promoter comprising the isolated promoter region of the human Thymic Stromal Lymphopoietin (TSLP) gene and functional portions of the promoter region having TSLP promoter activity. The promoters are useful for identifying promoter agonists and antagonists that can be used to prevent or treat allergic conditions and autoimmune diseases.
摘要翻译：包含人胸腺基质淋巴细胞生成素（TSLP）基因的分离的启动子区域的启动子和具有TSLP启动子活性的启动子区域的功能部分。该启动子可用于鉴定可用于预防或治疗过敏性疾病和自身免疫性疾病的启动子激动剂和拮抗剂。

5. 发明申请

WO2005010152A3 HUMAN MAST CELL-EXPRESSED MEMBRANE PROTEIN 审中-公开
标题翻译：人类肥大细胞表达的膜蛋白
公开(公告)号：WO2005010152A3
公开(公告)日：2005-05-12
申请号：PCT/US2004020296
申请日：2004-06-25
申请人： TANOX INC , LI KANG , WANG SHEN-WU , HU GUANGHUI , YAO ZHENGBIN
发明人： LI KANG , WANG SHEN-WU , HU GUANGHUI , YAO ZHENGBIN
IPC分类号： A61K38/00 , A61K39/395 , C07K14/705 , C12N20060101 , G01N33/567
CPC分类号： C07K14/705 , A61K2039/505
摘要： The present invention relates to GPR91, a purinergic receptor-like polypeptide, its expression in mast cells, and its use in the diagnosis and/or treatment of mast cell mediated diseases, including allergic and nonallergic asthma, chronic obstructive pulmonary disease (COPD), allergic rhinitis, anaphylaxis, allergic gastrointestinal disease, atopic dermatitis, rheumatoid arthritis, and other allergic, autoimmune and inflammatory diseases. The invention also includes methods of screening of agonists and/or antagonists of the GPR91 receptor.
摘要翻译：本发明涉及GPR91，嘌呤能受体样多肽，其在肥大细胞中的表达，及其在肥大细胞介导的疾病（包括过敏性和非过敏性哮喘，慢性阻塞性肺病（COPD））中的诊断和/或治疗中的用途。过敏性鼻炎，过敏性胃肠疾病，特应性皮炎，类风湿性关节炎和其他过敏性，自身免疫性和炎性疾病。本发明还包括筛选GPR91受体的激动剂和/或拮抗剂的方法。

6. 发明申请

WO2004027079A2 NUCLEAR FACTOR OF ACTIVATED T CELLS RECEPTOR 审中-公开
标题翻译：活化T细胞受体的核因子
公开(公告)号：WO2004027079A2
公开(公告)日：2004-04-01
申请号：PCT/US0329643
申请日：2003-09-19
申请人： TANOX INC , YAO ZHENGBIN , HU GUANGHUI , LI KANG , YANG JIANHUA
发明人： YAO ZHENGBIN , HU GUANGHUI , LI KANG , YANG JIANHUA
IPC分类号： A61K38/00 , C07K14/47 , C12Q1/00 , C12Q
CPC分类号： C07K14/4702 , A61K38/00
摘要： Novel nuclear factor of activated T cells ("NFAT") activating receptor useful for producing agonist and antagonist antibodies that regulate the cellular production and expression of cytokines and cellular receptors. The receptor is a 270 amino acid type I transmembrane protein with a calculated molecular mass of about 30 kD. The receptor has a putative signal peptide at the N-terminal (amino acids 1-42), an Ig-domain (amino acids 43-150) in the extracellular region, a predicted transmembrane domain (amino acids 164-186), and an predicted ITAM motif (amino acids 220-235) in the cytoplasmic region. The receptor activates NFAT, IL-13 and TNF alpha promoter reporter activities.
摘要翻译：活化的T细胞（“NFAT”）激活受体的新核因子可用于产生调节细胞因子和细胞受体的细胞产生和表达的激动剂和拮抗剂抗体。该受体是270个氨基酸的I型跨膜蛋白，其计算分子量约为30kD。受体在N-末端（氨基酸1-42），细胞外区域中的Ig结构域（氨基酸43-150），预测的跨膜结构域（氨基酸164-186）和在细胞质区域预测ITAM基序（氨基酸220-235）。受体激活NFAT，IL-13和TNFα启动子记录活性。

7. 发明专利

CA2670992C ANTAGONIST ANTI-NOTCH3 ANTIBODIES AND THEIR USE IN THE PREVENTION AND TREATMENT OF NOTCH3-RELATED DISEASES 未知
公开(公告)号：CA2670992C
公开(公告)日：2017-11-21
申请号：CA2670992
申请日：2007-12-17
申请人： GENENTECH INC
发明人： LI KANG , ZHOU BIN-BING STEPHEN , LI YUCHENG , FUNG SEK CHUNG , SINGH SANJAYA
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , C12N5/12 , C12N15/13
摘要： The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

8. 发明专利

AU2007333805B2 Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases 未知
公开(公告)号：AU2007333805B2
公开(公告)日：2013-07-25
申请号：AU2007333805
申请日：2007-12-17
申请人： GENENTECH INC
发明人： ZHOU BIN-BING STEPHEN , FUNG SEK CHUNG , LI KANG , LI YUCHENG , SINGH SANJAYA
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , C12N5/12 , C12N15/13
摘要： The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

9. 发明专利

NZ577274A ANTAGONIST ANTI-NOTCH3 ANTIBODIES AND THEIR USE IN THE PREVENTION AND TREATMENT OF NOTCH3-RELATED DISEASES 未知
公开(公告)号：NZ577274A
公开(公告)日：2012-10-26
申请号：NZ57727407
申请日：2007-12-17
申请人： GENENTECH INC
发明人： LI KANG , ZHOU BIN-BING STEPHEN , LI YUCHENG , FUNG SEK CHUNG , SINGH SANJAYA
IPC分类号： A61K39/395 , A61P35/00 , C07K16/28 , C12N5/12 , C12N15/13
摘要： Disclosed is an antibody that binds to a Notch 3 conformational epitope comprising amino acid residues 1395-1396, 1402-1404 and 1420-1422 of the L1 LIN12 domain of Notch3 (SEQ ID NO:1) and amino acid residues 1576-1578 and 1626-1628 of the D2 dimerization domain of Notch3 (SEQ ID NO:1). Also disclosed is the use of the antibody the manufacture of a medicament for the treatment of a Notch 3 related disease or disorder.

10. 发明专利

CO6230996A2 ANTICUERPOS ANTAGONISTAS ANTI-NOTCH3 Y SU USO EN LA PREVENCION Y EL TRATAMIENTO DE ENFERMEDADES RELACIONADAS CON EL RECEPTOR NOTCH3 未知
公开(公告)号：CO6230996A2
公开(公告)日：2010-12-20
申请号：CO09070744
申请日：2009-07-08
申请人： GENENTECH INC
发明人： LI KANG , ZHOU BIN-BING STEPHEN , FUNG SEK CHUNG , SINGH SANJAYA
IPC分类号： A61K39/395 , A61P35/00 , C07K16/28 , C12N5/12 , C12N15/13
摘要： 1.- Una región de cadena pesada variable ("VH") que comprende una secuencia amino con al menos un 95% de la identidad establecida en SEQ ID n° 2. 2.- La región de cadena VH de la reivindicación 1, comprendiendo además una región constante. 3.- La región de cadena VH de la reivindicación 2, comprendiendo además los dominios CH1, CH2 y CH3 de una región constante. 4.- La región de cadena VH de la reivindicación 2, donde la región constante es de un anticuerpo de lgG. 5.- La región de cadena VH de la reivindicación 4, donde el anticuerpo de IgG es de lgG1, lgG2, lgG3 o IgG4. 6.- Una región de cadena ligera variable ("VL") que comprende una secuencia amino con al menos un 95% de la identidad establecida en SEQ ID n°3. 7.- La región de cadena VL de la reivindicación 6, comprendiendo además una región constante. 8.- Una región de cadena pesada variable ('VH") que comprende una secuencia amino con al menos un 95% de la identidad establecida en SEQ ID n°4. 9.- La región de cadena VH de la reivindicación 8, comprendiendo además una región constante. 10.- La región de cadena VH de la reivindicación 9, comprendiendo además los dominios CH1, CH2 y CH3 de una región constante. 11.- La región de cadena VH de la reivindicación 9, donde la región constante es de un anticuerpo de IgG. 12.- La región de cadena VH de la reivindicación 11, donde el anticuerpo de IgG es de lgG1, lgG2, lgG3 o IgG4.13.- Una región de cadena ligera variable ("VL") que comprende una secuencia amino con al menos un 95% de la identidad establecida en SEQ ID n° 5.14.- La región de cadena VL de la reivindicación 13, comprendiendo además una región constante.

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