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1. 发明专利

JP2009219499A Gene disruption, composition and method relating thereto 审中-公开
标题翻译：基因破坏，组合物和方法相关
公开(公告)号：JP2009219499A
公开(公告)日：2009-10-01
申请号：JP2009129694
申请日：2009-05-28
申请人： Genentech Inc , Lexicon Pharmaceuticals Inc , ジェネンテック・インコーポレーテッドGenentech,Inc. , レキシコンファーマシューティカルズ, インコーポレイテッド
发明人： HORNER ALLISON ANNE BYERS , COMBS KATHERIN E , CULBERTSON LING LING , DELMAS-MATA JUAN , DESAUVAGE FREDERIC , FAN LIANGFEN , FRANTZ GRETCHEN , GREEN LESLIE JANE , MASSEY ERIN MARIE , MCLAIN DINA REBECCA , MONTGOMERY CHARLES A , PAYNE BOBBY JOE , PEALE FRANKLIN JR , PHILLIPS HEIDI , ROHRER MICHELLE , SHI ZHENG-ZHENG , SPARKS MARY JEAN , STALA JOY ANNE , TANG TRACY TSU-LING , VOGEL PETER , WANG CHING-YUN , WILLIS-SEVAUX TRACY ELLEN , XIONG WEN
IPC分类号： C12N15/09 , A01K67/027 , A61K39/395 , A61K45/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/06 , A61P27/12 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07K14/705 , C07K16/28 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50
CPC分类号： C12N15/8509 , A01K2217/075 , A01K2267/0306 , A01K2267/0362 , A01K2267/0375
摘要： PROBLEM TO BE SOLVED: To provide transgenic animals, as well as compositions and methods relating to the characterization of gene function. SOLUTION: Provided is transgenic mice comprising disruptions in various genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions (such as neurological disorders, cardiovascular, endothelial or angiogenic disorders, eye abnormalities, immunological disorders, oncological disorders, bone metabolic abnormalities or disorders, lipid metabolic disorders, or developmental abnormalities). COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供转基因动物，以及与基因功能表征相关的组合物和方法。解决方案：提供包含各种基因中断的转基因小鼠。这样的体内研究和表征可以提供有用的识别和发现用于预防，改善或矫正与基因中断相关的疾病或功能障碍（例如神经系统疾病，心血管，内皮或血管发生性疾病，眼睛异常，免疫学障碍，肿瘤疾病，骨代谢异常或病症，脂代谢紊乱或发育异常）。版权所有（C）2010，JPO＆INPIT

2. 发明申请

WO2007021423A3 GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO 审中-公开
标题翻译：基因破坏，组合物和方法相关
公开(公告)号：WO2007021423A3
公开(公告)日：2007-06-28
申请号：PCT/US2006027777
申请日：2006-07-18
申请人： GENENTECH INC , LEXICON PHARMACEUTICALS INC , HORNER ALLISON ANNE BYERS , COMBS KATHERINE E , CULBERTSON LING LING , DELMAS-MATA JUAN , DESAUVAGE FREDERIC , FAN LIANGFEN , FRANTZ GRETCHEN , GREEN LESLIE JANE , MASSEY ERIN MARIE , MCLAIN DINA REBECCA , MONTGOMERY CHARLES A , PAYNE BOBBY JOE , PEALE FRANKLIN JR , PHILLIPS HEIDI , ROHRER MICHELLE , SHI ZHENG-ZHENG , SPARKS MARY JEAN , STALA JOY , TANG TRACY TZU-LING , VOGEL PETER , WANG CHING-YUN , SEVAUX TRACY ELLEN WILLIS , XIONG WEI
发明人： HORNER ALLISON ANNE BYERS , COMBS KATHERINE E , CULBERTSON LING LING , DELMAS-MATA JUAN , DESAUVAGE FREDERIC , FAN LIANGFEN , FRANTZ GRETCHEN , GREEN LESLIE JANE , MASSEY ERIN MARIE , MCLAIN DINA REBECCA , MONTGOMERY CHARLES A , PAYNE BOBBY JOE , PEALE FRANKLIN JR , PHILLIPS HEIDI , ROHRER MICHELLE , SHI ZHENG-ZHENG , SPARKS MARY JEAN , STALA JOY , TANG TRACY TZU-LING , VOGEL PETER , WANG CHING-YUN , SEVAUX TRACY ELLEN WILLIS , XIONG WEI
IPC分类号： C12N15/85 , A01K67/027 , A61K38/00 , A61K49/00 , C12N5/06
CPC分类号： C12N15/8509 , A01K2217/075 , A01K2267/0306 , A01K2267/0362 , A01K2267/0375
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译：本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。具体地说，本发明提供转基因小鼠，其包括在PRO226，PRO257，PRO268，PRO290，PRO36006，PRO363，PRO365，PRO382，PRO444，PRO705，PRO1071，PRO1125，PRO1134，PRO1155，PRO1281，PRO1343，PRO1379，PRO1380，PRO1387，PRO1419中的中断，PRO1433，PRO1474，PRO1550，PRO1571，PRO1572，PRO1759，PRO1904，PRO35193，PRO4341，PRO4348，PRO4369，PRO4381，PRO4407，PRO4425，PRO4985，PRO4989，PRO5737，PRO5800，PRO5993，PRO6017，PRO7174，PRO9744，PRO9821，PRO9852，PRO9873 ，PRO10196，PRO34778，PRO20233，PRO21956，PRO57290，PRO38465，PRO38683或PRO85161基因。这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱或发育异常。

4. 发明专利

CA2619577A1 GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO 未知
公开(公告)号：CA2619577A1
公开(公告)日：2007-02-22
申请号：CA2619577
申请日：2006-07-18
申请人： GENENTECH INC , LEXICON PHARMACEUTICALS INC
发明人： FAN LIANGFEN , STALA JOY ANNE , TANG TRACY TZU-LING , DESAUVAGE FREDERIC , SEVAUX TRACY ELLEN WILLIS , XIONG WEN , DELMAS-MATA JUAN , CULBERTSON LING LING , SHI ZHENG-ZHENG , HORNER ALLISON ANNE BYERS , SPARKS MARY JEAN , COMBS KATHERINE E , VOGEL PETER , MCLAIN DINA REBECCA , MONTGOMERY CHARLES A , MASSEY ERIN MARIE , GREEN LESLIE JANE , PAYNE BOBBY JOE , PEALE FRANKLIN JR , ROHRER MICHELLE , WANG CHING-YUN , FRANTZ GRETCHEN , PHILLIPS HEIDI
IPC分类号： C12N15/85 , A01K67/027 , A61K38/00 , A61K49/00 , C12N5/06
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders ; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

5. 发明专利

AU2006280321A1 Gene disruptions, compositions and methods relating thereto 未知
公开(公告)号：AU2006280321A1
公开(公告)日：2007-02-22
申请号：AU2006280321
申请日：2006-07-18
申请人： GENENTECH INC , LEXICON PHARMACEUTICALS INC
发明人： MASSEY ERIN MARIE , STALA JOY ANNE , TANG TRACY TZU-LING , FAN LIANGFEN , WILLIS-SEVAUX TRACY ELLEN , SHI ZHENG-ZHENG , CULBERTSON LING LING , WANG CHING-YUN , BYERS-HORNER ALLISON ANNE , VOGEL PETER , PHILLIPS HEIDI , SPARKS MARY JEAN , DELMAS-MATA JUAN , DESAUVAGE FREDERIC , FRANTZ GRETCHEN , MONTGOMERY CHUCK , PEALE FRANKLIN JR , COMBS KATHERIN , GREEN LESLIE JANE , PAYNE BOBBY JOE , ROHRER MICHELLE , XIONG WEN , MCLAIN DINA REBECCA
IPC分类号： C12N15/85 , A01K67/027 , A61K38/00 , A61K49/00 , C12N5/06
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO112 PRO1134 PRO115 PRO1281 PRO1343 PRO1379 PRO1380 PRO1387 PRO1419 PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196 PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

6. 发明专利

CA2562482A1 NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO 未知
公开(公告)号：CA2562482A1
公开(公告)日：2005-12-01
申请号：CA2562482
申请日：2005-04-12
申请人： GENENTECH INC , LEXICON GENETICS INC
发明人： PHILLIPS HEIDI , MONTGOMERY CHUCK , EDWARDS JOEL , PEALE FRANKLIN JR , SPARKS MARY JEAN , FILVAROFF ELLEN , STALA JOY , YE WEILAN , PAYNE BOBBY JOE , KIRCHHOFER DANIEL J , SHI ZHENG-ZHENG , VOGEL PETER , WICKRAMASINGHE DINELI , JUNUTULA JAGATH REDDY , BRENNAN JANE , QIAN NI NANCY , GREWAL IQBAL , DESAUVAGE FREDERIC , HUANG WENHU , TANG TRACY TZU-LING , IRVING BRYAN
IPC分类号： A01K67/027 , A61K49/00 , C07K14/47 , C07K14/705 , C07K14/71 , C07K14/715 , C07K14/72 , C07K14/78 , C07K14/81 , C12N5/10 , C12N9/00 , C12N9/16 , C12N9/64 , C12N15/12 , C12N15/15 , C12N15/24 , C12N15/52 , C12N15/55 , C12N15/57 , C12N15/85 , G01N33/50
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO256, PRO34421, PRO334, PRO770, PRO983, PRO1009, PRO1107, PRO1158, PRO1250 , PRO1317, PRO4334, PRO4395, PRO49192, PRO9799, PRO21175, PRO19837, PRO21331, PRO23949, PRO697 or PRO1480 genes. Such in vivo studies and characterization s may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders ; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

7. 发明专利

CO6220835A2 ANTICUERPOS ANTI-ROBO4 Y SUS USOS 未知
公开(公告)号：CO6220835A2
公开(公告)日：2010-11-19
申请号：CO09082361
申请日：2009-08-06
申请人： GENENTECH INC
发明人： PEALE FRANKLIN JR , WATTS RYAN J , KOCH ALEXANDER W , WU YAN , STAWICKI SCOTT , CARANO RICHARD
IPC分类号： A61K39/395 , A61P35/00 , C07K16/30
摘要： 1.- Un anticuerpo anti-Robo4 que comprende: al menos una, dos, tres, cuatro, cinco o seis secuencias de la región hipervariable (HVR) seleccionadas entre el grupo formado por: (i) HVR-L1 que comprende la secuencia A1-A11, donde A1-A11 es RASQDVSTAVA (identificador de secuencia n.°:1) (ii) HVR-L2 que comprende la secuencia B1-B7, donde B1-B7 es SASFLYS (identificador de secuencia n.°: 2) (iii) HVR-L3 que comprende la secuencia C1-C9, donde C1-C9 es QQSYTTPPT (identificador de secuencia n.°:3) (iv) HVR-H1 que comprende la secuencia D1-D10, donde D1-D10 es GFTINGYYIH (identificador de secuencia n.°: 17) (v) HVR-H2 que comprende la secuencia E1-E18, donde E1-E18 es GFIYPAGGDTDYADSVKG (identificador de secuencia n.°: 18); (vi) HVR-H3 que comprende la secuencia F1-F17, donde F1-F17 es ARLIGNKFGWSSYGMDY (identificador de secuencia n.°:19); y (vii) al menos una variante de la HVR, donde la variante de la HVR comprende una inserción, deleción o sustitución de al menos un residuo aminoacídico de la secuencia mostrada en el identificador de secuencia n.°: 1, 2, 3, 17, 18 ó 19. 2.- El anticuerpo de la reivindicación 1, que comprende un dominio variable de la cadena ligera que incluye una secuencia de aminoácidos seleccionada en el grupo formado por: identificadores de secuencia n.°:72-97 como se muestra en la Figura 1A y 2A. 3.- El anticuerpo de la reivindicación 1, que comprende un dominio variable de la cadena pesada que incluye una secuencia de aminoácidos seleccionada en el grupo formado por: identificadores de secuencia n.°:140-165 como se muestra en la Figura 1B y 2B.

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