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1. 发明申请

WO0032221A3 PROMOTION OR INHIBITION OF ANGIOGENESIS AND CARDIOVASCULARIZATION 审中-公开
标题翻译：促进或抑制血液生成和心血管化
公开(公告)号：WO0032221A3
公开(公告)日：2000-11-23
申请号：PCT/US9928313
申请日：1999-11-30
申请人： GENENTECH INC , ASHKENAZI AVI J , BAKER KEVIN P , FERRARA NAPOLEONE , GERBER HANSPETER , HILLAN KENNETH J , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , KLEIN ROBERT D , KUO SOPHIA S , PAONI NICHOLAS F , SMITH VICTORIA , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I
发明人： ASHKENAZI AVI J , BAKER KEVIN P , FERRARA NAPOLEONE , GERBER HANSPETER , HILLAN KENNETH J , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , KLEIN ROBERT D , KUO SOPHIA S , PAONI NICHOLAS F , SMITH VICTORIA , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I
IPC分类号： G01N33/50 , A61K20060101 , A61K31/7088 , A61K31/711 , A61K38/00 , A61K38/17 , A61K39/395 , A61K45/00 , A61K48/00 , A61P7/00 , A61P9/00 , A61P9/04 , A61P9/10 , A61P17/00 , A61P17/02 , A61P35/00 , C07K14/47 , C07K14/515 , C07K14/52 , C07K16/18 , C07K16/22 , C07K16/24 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/11 , C12N15/12 , C12N15/867 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/19 , C12R1/645 , C12R1/93 , G01N33/15 , G01N33/53 , G01N33/68 , C12N15/62
CPC分类号： C12N9/6408 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K16/18 , C12N2799/026 , C12Y304/21034 , G01N2800/32
摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：公开了用于刺激或抑制哺乳动物（包括人）中的血管发生和/或心血管化的组合物和方法。药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如创伤，各种癌症和血管障碍，包括动脉粥样硬化和心脏肥大。此外，本发明涉及新型多肽和编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

2. 发明申请

WO0053753A3 PROMOTION OR INHIBITION OF ANGIOGENESIS AND CARDIOVASCULARIZATION 审中-公开
标题翻译：血管发生和心血管化的促进或抑制
公开(公告)号：WO0053753A3
公开(公告)日：2001-04-19
申请号：PCT/US0000219
申请日：2000-01-05
申请人： GENENTECH INC , ASHKENAZI AVI J , BAKER KEVIN P , FERRARA NAPOLEONE , GERBER HANSPETER , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , HILLAN KENNETH J , KUO SOPHIA S , MARK MELANIE R , MARSTERS SCOT A , PAONI NICHOLAS F , PITTI ROBERT M , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I
发明人： ASHKENAZI AVI J , BAKER KEVIN P , FERRARA NAPOLEONE , GERBER HANSPETER , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , HILLAN KENNETH J , KUO SOPHIA S , MARK MELANIE R , MARSTERS SCOT A , PAONI NICHOLAS F , PITTI ROBERT M , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I
IPC分类号： A61K38/00 , A61K38/17 , C07K14/47 , C07K14/705 , C07K16/18 , C12N15/11 , C12N15/12 , C12N15/62 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4703 , C07K14/70578 , C07K16/18 , C07K2317/24 , C07K2319/00 , C12N2799/026 , C12N2799/027 , G01N2800/32
摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：公开了用于刺激或抑制包括人在内的哺乳动物的血管生成和/或心血管形成的组合物和方法。药物组合物基于已鉴定用于一种或多种这些用途的多肽或拮抗剂。可以被本文组合物诊断，预防或治疗的疾病包括创伤如伤口，各种癌症和血管疾病，包括动脉粥样硬化和心脏肥大。另外，本发明涉及新的多肽和编码这些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，结合本发明多肽的抗体以及产生本发明多肽的方法发明。

3. 发明申请

WO0073445A3 INTERLEUKIN-1-RECEPTOR ASSOCIATED KINASE-3 (IRAK3) 审中-公开
标题翻译：白细胞介素-1受体相关激酶-3（IRAK3）
公开(公告)号：WO0073445A3
公开(公告)日：2001-03-01
申请号：PCT/US0013705
申请日：2000-05-17
申请人： GENENTECH INC , ASHKENAZI AVI J , BAKER KEVIN P , FERRARA NAPOLEONE , GERBER HANSPETER , GERRITSEN MARY E , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , KUO SOPHIA S , MARK MELANIE R , MARSTERS SCOT A , PAONI NICHOLAS F , PITTI ROBERT M , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I
发明人： ASHKENAZI AVI J , BAKER KEVIN P , FERRARA NAPOLEONE , GERBER HANSPETER , GERRITSEN MARY E , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , KUO SOPHIA S , MARK MELANIE R , MARSTERS SCOT A , PAONI NICHOLAS F , PITTI ROBERT M , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I
IPC分类号： G01N33/50 , A61K38/00 , A61K38/17 , A61K39/395 , A61K45/00 , A61P9/00 , A61P9/10 , A61P17/02 , A61P27/02 , A61P35/00 , C07K14/47 , C07K14/52 , C07K16/18 , C07K16/46 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N9/99 , C12N15/09 , C12N15/11 , C12N15/12 , C12N15/86 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/91 , G01N33/15 , G01N33/53 , G01N33/577
CPC分类号： G01N33/5011 , A61K38/00 , C07K14/475 , C07K14/52 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , G01N2800/32
摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：公开了用于刺激或抑制哺乳动物（包括人）中的血管发生和/或心血管化的组合物和方法。药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如创伤，各种癌症和血管障碍，包括动脉粥样硬化和心脏肥大。此外，本发明涉及新型多肽和编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

4. 发明申请

WO0053757A3 PROMOTION OR INHIBITION OF ANGIOGENESIS AND CARDIOVASCULARIZATION 审中-公开
标题翻译：促进或抑制血液生成和心血管化
公开(公告)号：WO0053757A3
公开(公告)日：2001-11-01
申请号：PCT/US0005004
申请日：2000-02-24
申请人： GENENTECH INC , ASHKENAZI AVI J , BAKER KEVIN P , FERRARA NAPOLEONE , GERBER HANSPETER , GERRITSEN MARY E , GODDARD AUDREY , GURNEY AUSTIN L , HILLAN KENNETH J , MARSTERS SCOT A , PAONI NICHOLAS F , PITTI ROBERT M , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I
发明人： ASHKENAZI AVI J , BAKER KEVIN P , FERRARA NAPOLEONE , GERBER HANSPETER , GERRITSEN MARY E , GODDARD AUDREY , GURNEY AUSTIN L , HILLAN KENNETH J , MARSTERS SCOT A , PAONI NICHOLAS F , PITTI ROBERT M , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I
IPC分类号： G01N33/50 , A61K31/7088 , A61K38/00 , A61K38/17 , A61K39/395 , A61K45/00 , A61K45/06 , A61K48/00 , A61P9/00 , A61P9/04 , A61P9/10 , A61P17/00 , A61P17/02 , A61P27/02 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/12 , C12N15/62 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4703 , C07K14/70578 , C07K16/18 , C07K2317/24 , C07K2319/00 , C12N2799/026 , C12N2799/027 , G01N2800/32
摘要： Compositions and methods are disclosed for stimulting or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：公开了用于刺激或抑制哺乳动物（包括人）中的血管发生和/或心血管化的组合物和方法。药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如创伤，各种癌症和血管障碍，包括动脉粥样硬化和心脏肥大。此外，本发明涉及新型多肽和编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

5. 发明申请

WO0140464A8 INTERLEUKIN-1-RECEPTOR ASSOCIATED KINASE-3 (IRAK3) AND ITS USE IN PROMOTION OR INHIBITION OF ANGIOGENESIS AND CARDIOVASCULARIZATION 审中-公开
标题翻译：白介素-1受体相关激酶-3（IRAK3）及其在促进或抑制血管生成和心血管形成中的用途
公开(公告)号：WO0140464A8
公开(公告)日：2001-06-28
申请号：PCT/US0022031
申请日：2000-08-11
申请人： GENENTECH INC , ASHKENAZI AVI J , BAKER KEVIN P , FERRARA NAPOLEONE , GODOWSKI PAUL J , GURNEY AUSTIN L , HILLAN KENNETH J , MARK MELANIE R , MARSTERS SCOT A , PAONI NICHOLAS F , PITTI ROBERT M , WOOD WILLIAM I
发明人： ASHKENAZI AVI J , BAKER KEVIN P , FERRARA NAPOLEONE , GODOWSKI PAUL J , GURNEY AUSTIN L , HILLAN KENNETH J , MARK MELANIE R , MARSTERS SCOT A , PAONI NICHOLAS F , PITTI ROBERT M , WOOD WILLIAM I
IPC分类号： A61K38/17 , C07K14/47 , C07K14/52 , C07K16/18 , C12N15/11 , C12N15/12 , C12N15/86 , C12Q1/68 , G01N33/53
CPC分类号： A61K38/17 , C07K14/47 , C07K14/52 , C07K16/18 , C12N15/11 , C12N15/86 , C12Q1/68 , G01N33/53 , G01N2800/32
摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：公开了用于刺激或抑制包括人在内的哺乳动物的血管生成和/或心血管形成的组合物和方法。药物组合物基于已鉴定用于一种或多种这些用途的多肽或拮抗剂。可以被本文组合物诊断，预防或治疗的疾病包括创伤如伤口，各种癌症和血管疾病，包括动脉粥样硬化和心脏肥大。另外，本发明涉及新的多肽和编码这些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，结合本发明多肽的抗体以及产生本发明多肽的方法发明。

6. 发明申请

WO0073452A3 COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES 审中-公开
公开(公告)号：WO0073452A3
公开(公告)日：2001-06-28
申请号：PCT/US0015264
申请日：2000-06-02
申请人： GENENTECH INC , ASHKENAZI AVI J , BAKER KEVIN P , CHAN BETTY , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , HEBERT CAROLINE , HENZEL WILLIAM , KABAKOFF RHONA C , SHELTON DAVID L , TUMAS DANIEL , WATANABE COLIN K , WOOD WILLIAM I
发明人： ASHKENAZI AVI J , BAKER KEVIN P , CHAN BETTY , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , HEBERT CAROLINE , HENZEL WILLIAM , KABAKOFF RHONA C , SHELTON DAVID L , TUMAS DANIEL , WATANABE COLIN K , WOOD WILLIAM I
IPC分类号： A61K38/17 , A61K38/18 , A61K48/00 , C07K14/47 , C07K14/50 , C07K16/18 , C07K16/22 , C12N15/11 , C12N15/12 , C12N15/62 , C12N15/86 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/5023 , A61K38/00 , C07K14/47 , C07K14/50 , C12Q1/6886 , C12Q2600/158 , G01N2800/24
摘要： The present invention relates to a composition containing novel proteins and methods for the diagnosis and treatment of immune related diseases.

7. 发明申请

WO0053755A3 COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUMOR 审中-公开
公开(公告)号：WO0053755A3
公开(公告)日：2001-02-08
申请号：PCT/US0000376
申请日：2000-01-06
申请人： GENENTECH INC , ASHKENAZI AVI J , BAKER KEVIN P , GODDARD AUDREY , GURNEY AUSTIN L , HILLAN KENNETH J , ROY MARGARET ANN , WATANABE COLIN K , WOOD WILLIAM I
发明人： ASHKENAZI AVI J , BAKER KEVIN P , GODDARD AUDREY , GURNEY AUSTIN L , HILLAN KENNETH J , ROY MARGARET ANN , WATANABE COLIN K , WOOD WILLIAM I
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N15/12 , A61K39/395 , C12N15/11 , C12N15/62 , C12Q1/68 , G01N33/574
CPC分类号： C07K14/70578 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K16/18 , C07K2319/00 , C12N2799/026
摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

8. 发明申请

WO0109327A3 METHOD OF PREVENTING THE INJURY OR DEATH OF RETINAL CELLS AND TREATING OCULAR DISEASES 审中-公开
标题翻译：预防视网膜细胞损伤或死亡并治疗眼部疾病的方法
公开(公告)号：WO0109327A3
公开(公告)日：2001-08-02
申请号：PCT/US0020710
申请日：2000-07-28
申请人： GENENTECH INC , ASHKENAZI AVI J , BAKER KEVIN P , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , KLJAVIN IVAR J , LAFLEUR MONIQUE , MARK MELANIE R , MARSTERS SCOT A , PITTI ROBERT M , WATANABE COLIN K , WOOD WILLIAM I
发明人： ASHKENAZI AVI J , BAKER KEVIN P , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , KLJAVIN IVAR J , LAFLEUR MONIQUE , MARK MELANIE R , MARSTERS SCOT A , PITTI ROBERT M , WATANABE COLIN K , WOOD WILLIAM I
IPC分类号： A61K38/00 , A61K38/17 , C07K14/47 , C07K14/705 , C07K16/18 , C12N15/12 , C12N15/62
CPC分类号： C07K14/4703 , A61K38/00 , C07K14/70578 , G01N2800/164
摘要： The present invention relates to the use of PRO polypeptides to delay, prevent or rescue retinal neurons, including photoreceptors, other retinal cells or supportive cells (e.g. Müller cells or RPE cells) from injury and/or death. Conditions comprehended by treatment of the present PRO polypeptides (including variants), antibodies, compositions and articles of manufacture include: retinal detachment, age-related and other maculopathies, photic retinopathies, surgery-induced retinopathies (either mechanically or light-induced), toxic retinopathies including those resulting from foreign bodies in the eye, diabetic retinopathies, retinopathy of prematurity, viral retinopathies such as CMV or HIV retinopathy related to AIDS, uveitis, ischemic retinopathies due to venous or arterial occlusion or other vascular disorder, retinopathies due to trauma or penetrating lesions of the eye, peripheral vitreoretinopathy, and inherited retinal degenerations. Exemplary retinal degenerations include e.g., hereditary spastic paraplegia with retinal degeneration (Kjellin and Barnard-Scholz syndromes), retinitis pigmentosa, Stargardt disease, Usher syndrome (retinitis pigmentosa with congenital hearing loss), and Refsum syndrome (retinitis pigmentosa, hereditary hearing loss, and polyneuropathy). Additional disorders which result in death of retinal neurons include, retinal tears, detachment of the retina and pigment epithelium, degenerative myopia, acute retinal necrosis syndrome (ARN), traumatic chorioretinopathies or contusion (Purtscher's Retinopathy) and edema.
摘要翻译：本发明涉及PRO多肽用于延迟，预防或挽救视网膜神经元（包括光感受器，其他视网膜细胞或支持细胞（例如Müller细胞或RPE细胞）免受损伤和/或死亡）。通过治疗本发明的PRO多肽（包括变体），抗体，组合物和制造品而理解的病症包括：视网膜脱离，年龄相关性和其他黄斑病，光视网膜病，手术诱导的视网膜病（机械或光诱导），毒性视网膜病变，包括由眼内异物引起的视网膜病，糖尿病性视网膜病，早产儿视网膜病，病毒视网膜病如与AIDS有关的CMV或HIV视网膜病，葡萄膜炎，由于静脉或动脉闭塞或其他血管病导致的缺血性视网膜病，由创伤引起的视网膜病，穿透性眼部病变，外周玻璃体视网膜病变和遗传性视网膜变性。示例性视网膜变性包括例如具有视网膜变性（Kjellin和Barnard-Scholz综合征）的遗传性痉挛性截瘫，色素性视网膜炎，Stargardt病，Usher综合征（具有先天性听力丧失的视网膜色素变性）和Refsum综合征（视网膜色素变性，遗传性听力丧失和多发性神经病）。导致视网膜神经细胞死亡的其它疾病包括视网膜撕裂，视网膜和色素上皮脱离，退行性近视，急性视网膜坏死综合征（ARN），创伤性脉络膜视网膜病变或挫伤（Purtscher视网膜病变）和水肿。

9. 发明申请

WO0053758A3 COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES 审中-公开
标题翻译：用于治疗免疫相关疾病的组合物和方法
公开(公告)号：WO0053758A3
公开(公告)日：2001-02-08
申请号：PCT/US0005841
申请日：2000-03-02
申请人： GENENTECH INC , ASHKENAZI AVI J , BAKER KEVIN P , GODDARD AUDREY , GURNEY AUSTIN L , HEBERT CAROLINE , HENZEL WILLIAM , KABAKOFF RHONA C , LU YANMEI , PAN JAMES , PENNICA DIANE , SHELTON DAVID L , SMITH VICTORIA , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WOOD WILLIAM I , YAN MINHONG
发明人： ASHKENAZI AVI J , BAKER KEVIN P , GODDARD AUDREY , GURNEY AUSTIN L , HEBERT CAROLINE , HENZEL WILLIAM , KABAKOFF RHONA C , LU YANMEI , PAN JAMES , PENNICA DIANE , SHELTON DAVID L , SMITH VICTORIA , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WOOD WILLIAM I , YAN MINHONG
IPC分类号： G01N33/50 , A61K38/00 , A61K38/17 , A61K39/395 , A61K45/00 , A61P1/16 , A61P3/10 , A61P5/14 , A61P11/00 , A61P11/02 , A61P17/00 , A61P19/02 , A61P25/00 , A61P29/02 , A61P35/00 , A61P37/00 , A61P37/04 , A61P37/06 , C07K14/47 , C07K14/705 , C07K16/18 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/10 , C12N15/12 , C12N15/62 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/577
CPC分类号： C12N15/10 , A61K38/00 , C07K14/4703 , C07K14/70578 , C07K16/18 , C12N2799/026 , C12Q1/686 , C12Q2531/113 , C12Q2521/331
摘要： The present invention relates to a composition containing novel proteins and methods for the diagnosis and treatment of immune related diseases.
摘要翻译：本发明涉及包含用于诊断和治疗免疫相关疾病的新型蛋白质和方法的组合物。

10. 发明申请

WO0216602A3 COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR 审中-公开
公开(公告)号：WO0216602A3
公开(公告)日：2003-02-06
申请号：PCT/US0126626
申请日：2001-08-23
申请人： GENENTECH INC , ASHKENAZI AVI J , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , POLAKIS PAUL , WILLIAMS P MICKEY , WOOD WILLIAM I , WU THOMAS D , ZHANG ZEMIN
发明人： ASHKENAZI AVI J , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , POLAKIS PAUL , WILLIAMS P MICKEY , WOOD WILLIAM I , WU THOMAS D , ZHANG ZEMIN
IPC分类号： C12N15/09 , A61K31/537 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K47/48 , A61K48/00 , A61P35/00 , C07K16/30 , C07K16/32 , C12N15/00
CPC分类号： C07K16/30 , A61K47/6455
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

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