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1. 发明专利

JP2011088897A Method for making apo-2 ligand using divalent metal ion 审中-公开
标题翻译：使用金属离子制备APO-2配体的方法
公开(公告)号：JP2011088897A
公开(公告)日：2011-05-06
申请号：JP2010253233
申请日：2010-11-11
申请人： Genentech Inc , ジェネンテック, インコーポレイテッド
发明人： ASHKENAZI AVI J , HYMOWITZ SARAH , KELLEY ROBERT F , KOUMENIS IPHIGENIA , LEUNG SUSAN , O'CONNELL MARK , PAI ROGER , SHAHROKH ZAHRA , SIMMONS LAURA
IPC分类号： A61K38/00 , B01J20/281 , A61K9/00 , A61K9/08 , A61K9/19 , A61K33/30 , A61K47/02 , A61P31/12 , A61P35/00 , A61P43/00 , B01J20/285 , C07K14/525 , C07K14/705 , C12N1/21 , C12N15/09 , C12N15/19 , C12P21/02 , C12R1/19 , G01N30/88 , G01N30/96
CPC分类号： A61K9/19 , A61K9/0019 , A61K38/00 , A61K47/02 , C07K14/525 , C07K14/70575
摘要： PROBLEM TO BE SOLVED: To provide a method for making Apo-2 ligand and Apo-2 ligand drug formulation, both of which are made by using divalent metal ion and are useful for inducing or irritating apoptosis of mammalian cancer cell; and to provide a method for using Apo-2L trimer drug formulation together with Apo-2 ligand and Apo-2 ligand drug formulation both having stability. SOLUTION: Apo-2L (114-281 configuration) is incubated at 5°C for 24 hours together with 20 mMTris, 8% trehalose, 0.01% Tween 20, and 5 mM of a specific metal salt (such as zinc acetate, or zinc sulfate) included in a pH 7.5 formulation. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供制备Apo-2配体和Apo-2配体药物制剂的方法，它们均通过使用二价金属离子制备并且可用于诱导或刺激哺乳动物癌细胞的凋亡; 并提供使用Apo-2L三聚体药物制剂以及具有稳定性的Apo-2配体和Apo-2配体药物制剂的方法。解决方案：将Apo-2L（114-281构型）与20mM Tris，8％海藻糖，0.01％吐温20和5mM特定金属盐（例如乙酸锌）一起在5℃下孵育24小时，或硫酸锌）。版权所有（C）2011，JPO＆INPIT

2. 发明申请

WO0100832A9 METHODS FOR MAKING APO-2 LIGAND USING DIVALENT METAL IONS 审中-公开
标题翻译：使用金属离子制备APO-2配体的方法
公开(公告)号：WO0100832A9
公开(公告)日：2012-03-08
申请号：PCT/US0017579
申请日：2000-06-26
申请人： GENENTECH INC
发明人： ASHKENAZI AVI J , HYMOWITZ SARAH , KELLEY ROBERT F , KOUMENIS IPHIGENIA , LEUNG SUSAN , O'CONNELL MARK , PAI ROGER , SHAHROKH ZAHRA , SIMMONS LAURA
IPC分类号： B01J20/281 , A61K9/00 , A61K9/08 , A61K9/19 , A61K38/00 , A61K47/02 , A61P31/12 , A61P35/00 , B01J20/285 , C07K14/525 , C07K14/705 , C12N1/21 , C12N15/09 , C12N15/19 , C12P21/02 , C12R1/19 , G01N30/88 , G01N30/96
CPC分类号： A61K9/19 , A61K9/0019 , A61K38/00 , A61K47/02 , C07K14/525 , C07K14/70575
摘要： Methods of making Apo-2 ligand and formulations of Apo-2 ligand using divalent metal ions are provided. Such divalent metal ions include zinc and cobalt which improve Apo-2 ligand trimer formation and stability. The crystal structure of Apo-2 ligand is also provided, along with Apo-2 ligand variant polypeptides identified using oligonucleotide-directed mutagenesis.
摘要翻译：提供使用二价金属离子制备Apo-2配体和Apo-2配体制剂的方法。这种二价金属离子包括改善Apo-2配体三聚体形成和稳定性的锌和钴。还提供了Apo-2配体的晶体结构，以及使用寡核苷酸定向突变鉴定的Apo-2配体变体多肽。

3. 发明申请

WO9837200A3 ANTIBODY FRAGMENT-POLYMER CONJUGATES AND HUMANIZED ANTI-IL-8 MONOCLONAL ANTIBODIES 审中-公开
标题翻译：抗体片段聚合物和人类抗IL-8单克隆抗体
公开(公告)号：WO9837200A3
公开(公告)日：1999-01-28
申请号：PCT/US9803337
申请日：1998-02-20
申请人： GENENTECH INC , HSEI VANESSA , KOUMENIS IPHIGENIA , LEONG STEVEN R , PRESTA LEONARD R , SHAHROKH ZAHRA , ZAPATA GERARDO A
发明人： HSEI VANESSA , KOUMENIS IPHIGENIA , LEONG STEVEN R , PRESTA LEONARD R , SHAHROKH ZAHRA , ZAPATA GERARDO A
IPC分类号： A61K38/00 , A61K47/48 , A61P37/00 , C07K16/24 , C12N15/13 , C07K19/00 , C12N5/10 , C12N15/85
CPC分类号： C07K16/244 , A61K38/00 , A61K47/60 , A61K47/6845 , A61K47/6883 , A61K2039/505 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： Humanized anti-IL-8 monoclonal antibodies and variants thereof are described for use in diagnostic applications and in the treatment of inflammatory disorders. Also described is a conjugate formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugate exhibits substantially improved half-life, mean residence time, and/or clearance rate in circulation as compared to the underivatized parental antibody fragment.

4. 发明专利

DE69821338T2 未知
公开(公告)号：DE69821338T2
公开(公告)日：2004-10-21
申请号：DE69821338
申请日：1998-02-20
申请人： GENENTECH INC
发明人： HSEI VANESSA , KOUMENIS IPHIGENIA , LEONG R , PRESTA G , SHAHROKH ZAHRA , ZAPATA A
IPC分类号： C12N15/09 , A61K38/00 , A61K47/48 , A61P37/00 , C07K16/24 , C07K16/46 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12N15/85
摘要： (A) A conjugate consisting of one or more antibody fragments covalently attached to one or more non-proteinaceous polymer molecules (NPPMs), where the apparent size of the conjugate is at least 500 kD.Also claimed are: (B) a conjugate formed by one or more antibody fragments covalently attached to one or more NPPMs, where the apparent size of the conjugate is at least 500 kD and where the molecular structure of the conjugate is free of other matter; (C) a conjugate formed by one or more antibody fragments covalently attached to one or more NPPMs, where the apparent size of the conjugate is at least 500 kD, where the antibody fragment incorporates a nonproteinaceous label free of any polymer, and where the molecular structure of the conjugate is free of other matter; (D) a polypeptide selected from a polypeptide that is an anti-IL-8 monoclonal antibody (MAb) or antibody fragment comprising a light chain amino acid sequence comprising the complementarity determining regions (CDRs) of the light chain polypeptide amino acid sequence shown; (E) a nucleic acid molecule that comprises a nucleic acid sequence encoding a polypeptide as in (D); (F) an expression vector comprising a nucleic acid molecule as in (E) operably linked to control sequences recognised by a host cell transfected with the vector; (G) a host cell comprising a vector as in (F).

5. 发明专利

AU6535798A Antibody fragment-polymer conjugates and humanized anti-il-8 monoclonal antibodies 未知
公开(公告)号：AU6535798A
公开(公告)日：1998-09-09
申请号：AU6535798
申请日：1998-02-20
申请人： GENENTECH INC
发明人： HSEI VANESSA , KOUMENIS IPHIGENIA , LEONG STEVEN R , PRESTA LEONARD R , SHAHROKH ZAHRA , ZAPATA GERARDO A
IPC分类号： C12N15/09 , A61K38/00 , A61K47/48 , A61P37/00 , C07K16/24 , C07K16/46 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12N15/85
摘要： (A) A conjugate consisting of one or more antibody fragments covalently attached to one or more non-proteinaceous polymer molecules (NPPMs), where the apparent size of the conjugate is at least 500 kD.Also claimed are: (B) a conjugate formed by one or more antibody fragments covalently attached to one or more NPPMs, where the apparent size of the conjugate is at least 500 kD and where the molecular structure of the conjugate is free of other matter; (C) a conjugate formed by one or more antibody fragments covalently attached to one or more NPPMs, where the apparent size of the conjugate is at least 500 kD, where the antibody fragment incorporates a nonproteinaceous label free of any polymer, and where the molecular structure of the conjugate is free of other matter; (D) a polypeptide selected from a polypeptide that is an anti-IL-8 monoclonal antibody (MAb) or antibody fragment comprising a light chain amino acid sequence comprising the complementarity determining regions (CDRs) of the light chain polypeptide amino acid sequence shown; (E) a nucleic acid molecule that comprises a nucleic acid sequence encoding a polypeptide as in (D); (F) an expression vector comprising a nucleic acid molecule as in (E) operably linked to control sequences recognised by a host cell transfected with the vector; (G) a host cell comprising a vector as in (F).

6. 发明专利

AU2008249162A1 Methods for making APO-2 ligand using divalent metal ions 未知
公开(公告)号：AU2008249162A1
公开(公告)日：2008-12-11
申请号：AU2008249162
申请日：2008-11-21
申请人： GENENTECH INC
发明人： O'CONNELL MARK , KOUMENIS IPHIGENIA , HYMOWITZ SARAH , SHAHROKH ZAHRA , KELLEY ROBERT F , LEUNG SUSAN , ASHKENAZI AVI J , PAI ROGER , SIMMONS LAURA
IPC分类号： A61K9/00 , B01J20/281 , A61K9/08 , A61K9/19 , A61K38/00 , A61K47/02 , A61P31/12 , A61P35/00 , B01J20/285 , C07K14/525 , C07K14/705 , C12N1/21 , C12N15/09 , C12N15/19 , C12P21/02 , C12R1/19 , G01N30/88 , G01N30/96
摘要： Methods of making Apo-2 ligand and formulations of Apo-2 ligand using divalent metal ions are provided. Such divalent metal ions include zinc and cobalt which improve Apo-2 ligand trimer formation and stability. The crystal structure of Apo-2 ligand is also provided, along with Apo-2 ligand variant polypeptides identified using oligonucleotide-directed mutagenesis.

7. 发明专利

AU2005211561B2 Methods for making APO-2 ligand using divalent metal ions 未知
公开(公告)号：AU2005211561B2
公开(公告)日：2008-08-21
申请号：AU2005211561
申请日：2005-09-16
申请人： GENENTECH INC
发明人： O'CONNELL MARK , LEUNG SUSAN , SHAHROKH ZAHRA , KELLEY ROBERT F , ASHKENAZI AVI J , PAI ROGER , SIMMONS LAURA , KOUMENIS IPHIGENIA , HYMOWITZ SARAH
IPC分类号： B01J20/281 , A61K9/00 , A61K9/08 , A61K9/19 , A61K38/00 , A61K47/02 , A61P31/12 , A61P35/00 , B01J20/285 , C07K14/525 , C07K14/705 , C12N1/21 , C12N15/09 , C12N15/19 , C12P21/02 , C12R1/19 , G01N30/88 , G01N30/96
摘要： Methods of making Apo-2 ligand and formulations of Apo-2 ligand using divalent metal ions are provided. Such divalent metal ions include zinc and cobalt which improve Apo-2 ligand trimer formation and stability. The crystal structure of Apo-2 ligand is also provided, along with Apo-2 ligand variant polypeptides identified using oligonucleotide-directed mutagenesis.

8. 发明专利

AU2005211561A1 Methods for making APO-2 ligand using divalent metal ions 未知
公开(公告)号：AU2005211561A1
公开(公告)日：2005-10-13
申请号：AU2005211561
申请日：2005-09-16
申请人： GENENTECH INC
发明人： O'CONNELL MARK , LEUNG SUSAN , SHAHROKH ZAHRA , KELLEY ROBERT F , ASHKENAZI AVI J , PAI ROGER , SIMMONS LAURA , KOUMENIS IPHIGENIA , HYMOWITZ SARAH
IPC分类号： B01J20/281 , A61K9/00 , A61K9/08 , A61K9/19 , A61K38/00 , A61K47/02 , A61P31/12 , A61P35/00 , B01J20/285 , C07K14/525 , C07K14/705 , C12N1/21 , C12N15/09 , C12N15/19 , C12P21/02 , C12R1/19 , G01N30/88 , G01N30/96 , C12N5/10 , A61K38/19
摘要： Methods of making Apo-2 ligand and formulations of Apo-2 ligand using divalent metal ions are provided. Such divalent metal ions include zinc and cobalt which improve Apo-2 ligand trimer formation and stability. The crystal structure of Apo-2 ligand is also provided, along with Apo-2 ligand variant polypeptides identified using oligonucleotide-directed mutagenesis.

9. 发明专利

BR9807464A 未知
公开(公告)号：BR9807464A
公开(公告)日：2000-05-09
申请号：BR9807464
申请日：1998-02-20
申请人： GENENTECH INC
发明人： HSEI VANESSA , KOUMENIS IPHIGENIA , LEONG STEVEN R , PRESTA LEONARD G
IPC分类号： C12N15/09 , A61K38/00 , A61K47/48 , A61P37/00 , C07K16/24 , C07K16/46 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12N15/85
摘要： (A) A conjugate consisting of one or more antibody fragments covalently attached to one or more non-proteinaceous polymer molecules (NPPMs), where the apparent size of the conjugate is at least 500 kD.Also claimed are: (B) a conjugate formed by one or more antibody fragments covalently attached to one or more NPPMs, where the apparent size of the conjugate is at least 500 kD and where the molecular structure of the conjugate is free of other matter; (C) a conjugate formed by one or more antibody fragments covalently attached to one or more NPPMs, where the apparent size of the conjugate is at least 500 kD, where the antibody fragment incorporates a nonproteinaceous label free of any polymer, and where the molecular structure of the conjugate is free of other matter; (D) a polypeptide selected from a polypeptide that is an anti-IL-8 monoclonal antibody (MAb) or antibody fragment comprising a light chain amino acid sequence comprising the complementarity determining regions (CDRs) of the light chain polypeptide amino acid sequence shown; (E) a nucleic acid molecule that comprises a nucleic acid sequence encoding a polypeptide as in (D); (F) an expression vector comprising a nucleic acid molecule as in (E) operably linked to control sequences recognised by a host cell transfected with the vector; (G) a host cell comprising a vector as in (F).

10. 发明专利

CA2615918C ANTIBODY FRAGMENT-POLYMER CONJUGATES AND HUMANIZED ANTI-IL-8 MONOCLONAL ANTIBODIES 未知
公开(公告)号：CA2615918C
公开(公告)日：2013-11-26
申请号：CA2615918
申请日：1998-02-20
申请人： GENENTECH INC
发明人： HSEI VANESSA , KOUMENIS IPHIGENIA , LEONG STEVEN R , PRESTA LEONARD G , SHAHROKH ZAHRA , ZAPATA GERARDO A
IPC分类号： C07K16/00 , C12N15/09 , A61K38/00 , A61K39/395 , A61K47/48 , A61K51/10 , A61P29/00 , A61P37/00 , C07K16/24 , C07K16/46 , C07K17/00 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12N15/85
摘要： Humanized anti-IL-8 monoclonal antibodies and variants thereof are described for use in diagnostic applications and in the treatment of inflammatory disorders. Also described is a conjugate formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugate exhibits substantially improved half-life, mean residence time, and/or clearance rate in circulation as compared to the underivatized parental antibody fragment.

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