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1. 发明公开

EP1962584A2 NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO 审中-公开
标题翻译：新基因的破坏，相关组合物和方法
公开(公告)号：EP1962584A2
公开(公告)日：2008-09-03
申请号：EP06849173.7
申请日：2006-11-16
申请人： GENENTECH, INC. , Lexicon Pharmaceuticals, Inc.
发明人： HORNER, Allison, Anne, Byers , COMBS, Katherin E. , DESAUVAGE, Frederic , FAN, Liangfen , FILVAROFF, Ellen , IRVING, Bryan , JUNUTULA, Jagath Reddy , MASSEY, Erin Marie , MCLAIN, Dina Rebecca , MINZE, Laurie Jeanette , MONTGOMERY, Charles, A. , PAYNE, Bobby Joe , PHILLIPS, Heidi , RANGEL, Carolina , SHI, Zheng-zheng , SPARKS, Mary Jean , STALA, Joy, Anne , TOWNSEND, Teresa Gail , VOGEL, Peter , SEVAUX, Tracy Ellen Willis
IPC分类号： A01K67/027 , A61K49/00
CPC分类号： C12Q1/6883 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K49/0008 , C12N15/8509 , C12Q2600/158
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO218, PRO228, PRO271, PRO273, PRO295, PRO302, PRO305, PRO326, PRO386, PRO655, PRO162, PRO788, PRO792, PRO940, PRO941, PRO1004, PRO1012, PRO1016, PRO474, PRO5238, PRO1069, PRO1111, PRO1113, PRO1130, PRO1195, PRO1271, PRO1865, PRO1879, PRO3446, PRO3543, PRO4329, PRO4352, PRO5733, PRO9859, PRO9864, PRO9904, PRO9907, PRO10013, PRO90948, PRO28694, PRO16089, PRO19563, PRO19675, PRO20084, PRO21434, PRO50332, PRO38465 or PRO346 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

2. 发明申请

WO2013181452A1 METHODS OF TREATING CANCER USING PD-L1 AXIS BINDING ANTAGONISTS AND VEGF ANTAGONISTS 审中-公开
标题翻译：使用PD-L1轴结合拮抗剂和VEGF拮抗剂治疗癌症的方法
公开(公告)号：WO2013181452A1
公开(公告)日：2013-12-05
申请号：PCT/US2013/043452
申请日：2013-05-30
申请人： GENENTECH, INC. , F. HOFFMANN-LA ROCHE AG
发明人： MAECKER, Heather , IRVING, Bryan
IPC分类号： C07K16/28 , C07K16/22 , A61K39/395
CPC分类号： A61K39/3955 , A61K31/282 , A61K31/513 , A61K31/519 , A61K39/39558 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K16/2827 , A61K2300/00
摘要： The present invention describes combination treatment comprising a PD-1 axis binding antagonist, chemotherapy and optionally a VEGF antagonist and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer.
摘要翻译：本发明描述了包含PD-1轴结合拮抗剂，化学疗法和任选的VEGF拮抗剂的组合治疗剂及其使用方法，包括治疗需要增强免疫原性的病症的方法，例如增加用于治疗癌症的肿瘤免疫原性。

3. 发明申请

WO2013019906A9 METHODS OF TREATING CANCER USING PD-1 AXIS BINDING ANTAGONISTS AND MEK INHIBITORS 审中-公开
公开(公告)号：WO2013019906A9
公开(公告)日：2013-02-07
申请号：PCT/US2012/049233
申请日：2012-08-01
申请人： GENENTECH, INC. , F. HOFFMANN-LA ROCHE AG , MAECKER, Heather , IRVING, Bryan
发明人： MAECKER, Heather , IRVING, Bryan
IPC分类号： A61P35/00 , A61K39/395 , C07K16/28 , C07K16/30
摘要： The present invention describes combination treatment comprising a PD-1 axis binding antagonist and a MEK inhibitor and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer.

4. 发明申请

WO2015095418A1 METHODS OF TREATING HER2-POSITIVE CANCERS USING PD-1 AXIS BINDING ANTAGONISTS AND ANTI-HER2 ANTIBODIES 审中-公开
标题翻译：使用PD-1轴结合拮抗剂和抗HER2抗体治疗HER2阳性癌症的方法
公开(公告)号：WO2015095418A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/070992
申请日：2014-12-17
申请人： GENENTECH, INC. , F. HOFFMANN-LA ROCHE AG
发明人： DENNIS, Mark, S. , EBENS, Allen , IRVING, Bryan , JUNTTILA, Teemu, T.
IPC分类号： C07K16/28 , A61K31/337
CPC分类号： C07K16/32 , A61K31/282 , A61K31/337 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/643 , A61K2039/505 , A61K2039/507 , C07K16/2803 , C07K16/2809 , C07K16/2818 , C07K16/2827 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3069 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94 , A61K2300/00
摘要： The invention provides compositions and methods for treating HER2-postitive cancers. The method comprising administering a PD-1 axis binding antagonist and an antibody that targets HER2.
摘要翻译：本发明提供用于治疗HER2-肿瘤的组合物和方法。该方法包括施用PD-1轴结合拮抗剂和靶向HER2的抗体。

5. 发明申请

WO2013019906A1 METHODS OF TREATING CANCER USING PD-1 AXIS BINDING ANTAGONISTS AND MEK INHIBITORS 审中-公开
标题翻译：使用PD-1轴结合拮抗剂和MEK抑制剂治疗癌症的方法
公开(公告)号：WO2013019906A1
公开(公告)日：2013-02-07
申请号：PCT/US2012/049233
申请日：2012-08-01
申请人： GENENTECH, INC. , F. HOFFMANN-LA ROCHE AG , MAECKER, Heather , IRVING, Bryan
发明人： MAECKER, Heather , IRVING, Bryan
IPC分类号： A61P35/00 , A61K39/395 , C07K16/28 , C07K16/30
CPC分类号： A61K39/39558 , A61K31/4184 , A61K31/4355 , A61K31/44 , A61K31/4523 , A61K31/519 , A61K47/62 , A61K47/64 , A61K2039/505 , C07K16/2827 , C07K16/3046 , C07K16/3053 , A61K2300/00
摘要： The present invention describes combination treatment comprising a PD-1 axis binding antagonist and a MEK inhibitor and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer.
摘要翻译：本发明描述了包含PD-1轴结合拮抗剂和MEK抑制剂的组合治疗剂及其使用方法，包括治疗需要增强免疫原性的病症的方法，例如增加用于治疗癌症的肿瘤免疫原性。

6. 发明申请

WO2007109052A2 METHODS OF TREATING LUPUS USING CD4 ANTIBODIES 审中-公开
标题翻译：使用CD4抗体治疗淋巴结的方法
公开(公告)号：WO2007109052A2
公开(公告)日：2007-09-27
申请号：PCT/US2007/006443
申请日：2007-03-14
申请人： GENENTECH, INC. , IRVING, Bryan
发明人： IRVING, Bryan
IPC分类号： A61K39/395 , A61K31/5375 , A61K31/66
CPC分类号： C07K16/2812 , A61K31/5375 , A61K31/66 , A61K39/395 , A61K39/39541 , A61K45/06 , A61K2039/505 , C07K2317/565 , A61K2300/00
摘要： Methods of treating lupus, including systemic lupus erythematosus, cutaneous lupus erythmetosus, and lupus nephritis, are provided. The methods involve administration of a combination of a non-depleting CD4 antibody and another compound used clinically or experimentally to treat lupus. Methods of treating lupus nephritis by administration of a non-depleting CD4 antibody that results in an improvement in renal function and/or a reduction in proteinuria or active urinary sediment are also provided. Methods of treating multiple sclerosis by administration of a non-depleting CD4 antibody, optionally in combination with another compound used clinically or experimentally to treat MS, are described. Methods of treating transplant recipients and subjects with rheumatoid arthritis, asthma, psoriasis, Crohn's disease, ulcerative colitis, and Sjogren's syndrome are also provided.
摘要翻译：提供了治疗狼疮的方法，包括系统性红斑狼疮，皮肤红斑狼疮和狼疮性肾炎。所述方法包括施用非消耗性CD4抗体和临床或实验用于治疗狼疮的另一种化合物的组合。还提供了通过施用导致肾功能改善和/或蛋白尿或活性尿沉渣降低的非消耗性CD4抗体来治疗狼疮肾炎的方法。描述了通过施用非消耗性CD4抗体治疗多发性硬化的方法，任选与临床或实验用于治疗MS的另一化合物组合使用。还提供了治疗类风湿关节炎，哮喘，牛皮癣，克罗恩病，溃疡性结肠炎和干燥综合征的移植受者和受试者的方法。

7. 发明申请

WO2015009856A2 METHODS OF TREATING CANCER USING PD-1 AXIS BINDING ANTAGONISTS AND TIGIT INHIBITORS 审中-公开
标题翻译：使用PD-1轴绑定拮抗剂和TIGIT抑制剂治疗癌症的方法
公开(公告)号：WO2015009856A2
公开(公告)日：2015-01-22
申请号：PCT/US2014/046896
申请日：2014-07-16
申请人： GENENTECH, INC. , F. HOFFMANN-LA ROCHE AG
发明人： GROGAN, Jane , JOHNSTON, Robert, J. , IRVING, Bryan , HACKNEY, Jason , YU, Xin , EATON, Dan , BOWLES, Kristin , COMPS-AGRAR, Laetitia
IPC分类号： A61K48/00 , A61K39/395
CPC分类号： C07K16/2803 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0331 , A01K2267/0387 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/507 , C07K14/70596 , C07K16/2818 , C07K16/2827 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3053 , C07K16/3061 , C07K16/3069 , C07K2319/30 , Y02A50/466
摘要： The present invention describes combination treatment comprising a PD-1 axis binding antagonist and an agent that decreases or inhibits TIGIT expression and/or activity and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer or chronic infection.
摘要翻译：本发明描述了包含PD-1轴结合拮抗剂和降低或抑制TIGIT表达和/或活性的试剂的组合治疗及其使用方法，包括治疗需要增强免疫原性的病症的方法，例如增加肿瘤免疫原性治疗癌症或慢性感染。

8. 发明申请

WO2010077634A1 ANTI-PD-L1 ANTIBODIES AND THEIR USE TO ENHANCE T-CELL FUNCTION 审中-公开
标题翻译：抗PD-L1抗体及其用于增强T细胞功能的用途
公开(公告)号：WO2010077634A1
公开(公告)日：2010-07-08
申请号：PCT/US2009/067104
申请日：2009-12-08
申请人： GENENTECH, INC. , IRVING, Bryan , CHEUNG, Jeanne , CHIU, Henry , LEHAR, Sophie, M. , MAECKER, Heather , MARIATHASAN, Sanjeev , WU, Yan
发明人： IRVING, Bryan , CHEUNG, Jeanne , CHIU, Henry , LEHAR, Sophie, M. , MAECKER, Heather , MARIATHASAN, Sanjeev , WU, Yan
IPC分类号： C07K16/28 , A61P35/00 , A61K39/395
CPC分类号： C07K16/2827 , A61K31/7068 , A61K39/00 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/1063 , C07K16/22 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K2317/14 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92 , Y02A50/41 , Y02A50/412 , Y02A50/423 , Y02A50/492 , A61K2300/00
摘要： The present application relates to anti-PD-L1 antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection ( e.g. , acute and chronic) and tumor immunity.
摘要翻译：本申请涉及抗PD-L1抗体，编码它的核酸，其治疗组合物及其用途增强T细胞功能以上调细胞介导的免疫应答和治疗T细胞功能障碍性疾病，包括感染（例如急性和慢性）和肿瘤免疫。

9. 发明申请

WO2007081608A2 NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO 审中-公开
标题翻译：新的基因破坏，组合物和方法相关
公开(公告)号：WO2007081608A2
公开(公告)日：2007-07-19
申请号：PCT/US2006/060990
申请日：2006-11-16
申请人： GENENTECH, INC. , LEXICON GENETICS INCORPORATED , BYERS-HORNER, Allison Anne , COMBS, Katherin , DESAUVAGE, Frederic , FAN, Liangfen , FILVAROFF, Ellen , IRVING, Bryan , JUNUTULA, Jagath Reddy , MASSEY, Erin Marie , MCLAIN, Dina Rebecca , MINZE, Laurie Jeanette , MONTGOMERY, Charles, A. , PAYNE, Bobby Joe , PHILLIPS, Heidi , RANGEL, Carolina , SHI, Zheng-zheng , SPARKS, Mary Jean , STALA, Joy , TOWNSEND, Teresa Gail , VOGEL, Peter , WILLIS-SEVAUX, Tracy Ellen
发明人： BYERS-HORNER, Allison Anne , COMBS, Katherin , DESAUVAGE, Frederic , FAN, Liangfen , FILVAROFF, Ellen , IRVING, Bryan , JUNUTULA, Jagath Reddy , MASSEY, Erin Marie , MCLAIN, Dina Rebecca , MINZE, Laurie Jeanette , MONTGOMERY, Charles, A. , PAYNE, Bobby Joe , PHILLIPS, Heidi , RANGEL, Carolina , SHI, Zheng-zheng , SPARKS, Mary Jean , STALA, Joy , TOWNSEND, Teresa Gail , VOGEL, Peter , WILLIS-SEVAUX, Tracy Ellen
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K49/0008 , C12N15/8509 , C12Q2600/158
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO218, PRO228, PRO271, PRO273, PRO295, PRO302, PRO305, PRO326, PRO386, PRO655, PRO162, PRO788, PRO792, PRO940, PRO941, PRO1004, PRO1012, PRO1016, PRO474, PRO5238, PRO1069, PRO1111, PRO1113, PRO1130, PRO1195, PRO1271, PRO1865, PRO1879, PRO3446, PRO3543, PRO4329, PRO4352, PRO5733, PRO9859, PRO9864, PRO9904, PRO9907, PRO10013, PRO90948, PRO28694, PRO16089, PRO19563, PRO19675, PRO20084, PRO21434, PRO50332, PRO38465 or PRO346 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译：本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。具体地说，本发明提供了包含PRO218，PRO228，PRO271，PRO273，PRO295，PRO302，PRO305，PRO326，PRO386，PRO655，PRO162，PRO788，PRO792，PRO940，PRO941，PRO1004，PRO1012，PRO1016，PRO474，PRO5238中的中断的转基因小鼠，PRO1069，PRO1111，PRO1113，PRO1130，PRO1195，PRO1271，PRO1865，PRO1879，PRO3446，PRO3543，PRO4329，PRO4352，PRO5733，PRO9859，PRO9864，PRO9904，PRO9907，PRO10013，PRO90948，PRO28694，PRO16089，PRO19563，PRO19675，PRO20084，PRO21434 ，PRO50332，PRO38465或PRO346基因。这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱或发育异常。

10. 发明授权

EP2855528B1 METHODS OF TREATING CANCER USING PD-L1 AXIS BINDING ANTAGONISTS AND VEGF ANTAGONISTS 有权
公开(公告)号：EP2855528B1
公开(公告)日：2019-06-19
申请号：EP13729174.6
申请日：2013-05-30
申请人： Genentech, Inc. , F. Hoffmann-La Roche AG
发明人： MAECKER, Heather , IRVING, Bryan
IPC分类号： A61K39/00 , A61K31/282 , A61K31/513 , A61K31/519 , C07K16/28 , C07K16/22 , A61K39/395

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