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1. 发明申请

WO2016205520A1 HUMANIZED AND AFFINITY MATURED ANTIBODIES TO FCRH5 AND METHODS OF USE 审中-公开
标题翻译： FCRH5的人类和亲属成熟抗体及其使用方法
公开(公告)号：WO2016205520A1
公开(公告)日：2016-12-22
申请号：PCT/US2016/037879
申请日：2016-06-16
申请人： GENENTECH, INC. , F. HOFFMAN-LA ROCHE AG
发明人： HOTZEL, Isidro , JUNTTILA, Teemu, T. , LI, Ji , SCHEER, Justin , DICARA, Danielle , ELLERMAN, Diego , SPIESS, Christoph , CARTER, Paul
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/283 , A61K39/39558 , A61K45/06 , A61K47/6849 , A61K47/6851 , A61K2039/505 , A61K2039/507 , C07K16/2809 , C07K16/2827 , C07K16/30 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/62 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/57492 , G01N2333/70535
摘要： The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.
摘要翻译：本发明涉及抗FcRH5抗体，包括抗FcRH5抗体，其包含FcRH5结合结构域和CD3结合结构域（例如，FcRH5T细胞依赖性双特异性（TDB）抗体）及其使用方法。

2. 发明申请

WO2015171822A1 PRODUCTION OF HETEROMULTIMERIC PROTEINS USING MAMMALIAN CELLS 审中-公开
标题翻译：使用马马里亚细胞生产异源蛋白
公开(公告)号：WO2015171822A1
公开(公告)日：2015-11-12
申请号：PCT/US2015/029546
申请日：2015-05-06
申请人： GENENTECH, INC. , F. HOFFMANN-LA ROCHE AG
发明人： SCHEER, Justin , SHATZ, Whitney , NG, Domingos
IPC分类号： C12N5/07 , C12P21/04 , C12P21/08 , A61K39/00
CPC分类号： C07K16/00 , C07K16/468 , C07K2317/14 , C07K2317/31 , C07K2317/52 , C07K2317/526 , C07K2317/53
摘要： Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes located on a single molecule or located on different molecules.
摘要翻译：本文描述了有效制备能够特异性结合多于一种靶的抗体和其它多聚体蛋白复合物（统称为异多聚体蛋白质）的方法。靶可以是例如位于单个分子上或位于不同分子上的不同表位。

3. 发明申请

WO2016205520A8 HUMANIZED AND AFFINITY MATURED ANTIBODIES TO FCRH5 AND METHODS OF USE 审中-公开
公开(公告)号：WO2016205520A8
公开(公告)日：2016-12-22
申请号：PCT/US2016/037879
申请日：2016-06-16
申请人： GENENTECH, INC. , F. HOFFMANN-LA ROCHE AG
发明人： HOTZEL, Isidro , JUNTTILA, Teemu, T. , LI, Ji , SCHEER, Justin , DICARA, Danielle , ELLERMAN, Diego , SPIESS, Christoph , CARTER, Paul
IPC分类号： C07K16/28 , A61K39/395
摘要： The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.

4. 发明申请

WO2017062407A1 SYSTEMS AND METHODS FOR PREDICTING VITREAL HALF-LIFE OF THERAPEUTIC AGENT-POLYMER CONJUGATES 审中-公开
标题翻译：用于预测治疗剂 - 聚合物结合物的维生素HALF生命的系统和方法
公开(公告)号：WO2017062407A1
公开(公告)日：2017-04-13
申请号：PCT/US2016/055421
申请日：2016-10-05
申请人： GENENTECH, INC.
发明人： KELLEY, Robert , SCHEER, Justin , SHATZ, Whitney
IPC分类号： G06F19/00
CPC分类号： G06F19/704
摘要： Disclosed are systems and methods for estimating the vitreal half-life of a therapeutic agent. In particular, systems and methods are disclosed for predicting the vitreal half-life of a therapeutic agent conjugated to a polymer that make use of an empirically-derived relationship of vitreal half-life to the hydrodynamic radius of a candidate therapeutic agent-polymer conjugate. The present disclosure is further directed to the use of the systems and methods disclosed herein to design a candidate therapeutic agent-polymer conjugate with a preselected vitreal half-life.
摘要翻译：公开了用于估计治疗剂的玻璃体半衰期的系统和方法。特别地，公开了用于预测与聚合物缀合的治疗剂的玻璃体半衰期的系统和方法，其利用经验导出的玻璃体半衰期与候选治疗剂 - 聚合物缀合物的流体动力学半径的关系。本公开进一步涉及本文公开的系统和方法用于设计具有预选的玻璃体半衰期的候选治疗剂 - 聚合物缀合物。

5. 发明申请

WO2014145016A3 IL-22 POLYPEPTIDES AND IL-22 FC FUSION PROTEINS AND METHODS OF USE 审中-公开
公开(公告)号：WO2014145016A3
公开(公告)日：2014-09-18
申请号：PCT/US2014/029652
申请日：2014-03-14
申请人： GENENTECH, INC. , F. HOFFMANN-LA ROCHE AG
发明人： SCHEER, Justin , OUYANG, Wenjun , STEFANICH, Eric, Gary , VANDLEN, Richard , HAAS, Philip, E. , KOLUMAM, Ganesh, A. , WANG, Xiaoting , ROSS, Jed , VAN BRUGGEN, Nicholas , LEE, Wyne, P.
IPC分类号： C07K14/54 , A61K38/20 , C07K16/28
摘要： The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.

6. 发明申请

WO2011133886A3 PRODUCTION OF HETEROMULTIMERIC PROTEINS 审中-公开
公开(公告)号：WO2011133886A3
公开(公告)日：2011-10-27
申请号：PCT/US2011/033610
申请日：2011-04-22
申请人： GENENTECH, INC. , F. HOFFMANN-LA ROCHE AG , SCHEER, Justin , SPIESS, Christoph , YANSURA, Daniel G.
发明人： SCHEER, Justin , SPIESS, Christoph , YANSURA, Daniel G.
IPC分类号： A61K39/395 , A61P35/00 , C07K16/24 , C07K16/28 , C07K16/30 , C07K16/46
摘要： Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.

7. 发明申请

WO2013055958A1 IMPROVED ASSEMBLY OF BISPECIFIC ANTIBODIES 审中-公开
标题翻译：改进的双歧杆菌抗体组装
公开(公告)号：WO2013055958A1
公开(公告)日：2013-04-18
申请号：PCT/US2012/059810
申请日：2012-10-11
申请人： GENENTECH, INC. , F. HOFFMANN-LA ROCHE AG
发明人： GIESE, Glen , PERSSON, Josefine , WILLIAMS, Ambrose , LIM, Amy , SCHEER, Justin
IPC分类号： C07K16/46
CPC分类号： C07K16/468 , C07K2317/31 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/56 , C07K2317/622
摘要： Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding to more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins at higher yield and efficiency than otherwise possible. Also described are compositions comprising a hinge-containing polypeptide, such as a half-antibody.
摘要翻译：本文描述了有效制备异源多聚体蛋白质如双特异性抗体的方法。异源多聚体蛋白质可能能够特异性结合单个靶分子上的多于一个靶分子或不同表位。该方法调节参数以改善异源多聚体蛋白的组装，以更高的产率和效率比其他可能的方式。还描述了包含含铰链的多肽，例如半抗体的组合物。

8. 发明申请

WO2012106587A1 Fc VARIANTS AND METHODS FOR THEIR PRODUCTION 审中-公开
标题翻译： Fc变种及其生产方法
公开(公告)号：WO2012106587A1
公开(公告)日：2012-08-09
申请号：PCT/US2012/023749
申请日：2012-02-03
申请人： GENENTECH, INC. , ELLIOTT, J. Michael , SCHEER, Justin
发明人： ELLIOTT, J. Michael , SCHEER, Justin
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , C07K2317/52
摘要： Described herein are Fc variants and methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins). Heteromultimeric proteins may be capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.
摘要翻译：本文描述了用于有效产生抗体和其它多聚体蛋白复合物（本文统称为异源多聚体蛋白质）的Fc变体和方法。异源多聚体蛋白质可能能够特异性结合多于一个靶标。靶可以是例如在单个分子上或位于不同分子上的不同表位。该方法结合有效，高基因表达水平，合适的装配和异源多聚体蛋白的纯化方便。本发明还提供了使用这些异源多聚体蛋白质的方法，以及包含这些抗体的组合物，试剂盒和制品。

9. 发明申请

WO2011069104A2 MULTISPECIFIC ANTIBODIES, ANTIBODY ANALOGS, COMPOSITIONS, AND METHODS 审中-公开
标题翻译：多特异性抗体，抗体类似物，组合物和方法
公开(公告)号：WO2011069104A2
公开(公告)日：2011-06-09
申请号：PCT/US2010/058958
申请日：2010-12-03
申请人： GENENTECH, INC. , F. HOFFMANN-LA ROCHE AG , SCHEER, Justin , VANDLEN, Richard L.
发明人： SCHEER, Justin , VANDLEN, Richard L.
IPC分类号： A61K39/395 , C12P21/06
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/283 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/55 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/90
摘要： Multispecific antibodies that specifically bind at least two different epitopes are provided. Structural variants of native antibodies (antibody analogs) are also provided. Also provided are multispecific antibodies and antibody analogs having a range of biological activities. Agonist and antagonist multispecific antibodies and agonist and antagonist antibody analogs are provided. Multispecific antibodies and antibody analogs conjugated with therapeutic and/or diagnostic agents are also provided, as are multispecific antibodies and antibody analogs conjugated with agents to increase in vivo half-life compared to multispecific antibodies and antibody analogs lacking such agents. In addition, methods of making multispecific antibodies and antibody analogs and compositions comprising multispecific antibodies and antibody analogs are provided. Therapeutic, research, and diagnostic uses of multispecific antibodies and antibody analogs are also provided.
摘要翻译：提供了特异性结合至少两个不同表位的多特异性抗体。还提供了天然抗体的结构变体（抗体类似物）。还提供了具有一系列生物学活性的多特异性抗体和抗体类似物。提供了激动剂和拮抗剂多特异性抗体和激动剂和拮抗剂抗体类似物。还提供了与治疗剂和/或诊断剂缀合的多特异性抗体和抗体类似物，多特异性抗体和与试剂缀合的抗体类似物与增加体内半衰期的多特异性抗体和缺乏这些试剂的抗体类似物相比。另外，提供了制备包含多特异性抗体和抗体类似物的多特异性抗体和抗体类似物和组合物的方法。还提供了多特异性抗体和抗体类似物的治疗，研究和诊断用途。

10. 发明公开

EP2670776A1 Fc VARIANTS AND METHODS FOR THEIR PRODUCTION 有权转让
标题翻译： FC-VARIANTEN UND VERFAHREN ZU IHRER HERSTELLUNG
公开(公告)号：EP2670776A1
公开(公告)日：2013-12-11
申请号：EP12704198.6
申请日：2012-02-03
申请人： Genentech, Inc.
发明人： ELLIOTT, J. Michael , SCHEER, Justin
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , C07K2317/52
摘要： Described herein are Fc variants and methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins). Heteromultimeric proteins may be capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.
摘要翻译：本文描述了用于有效产生抗体和其他多聚体蛋白复合物（本文统称为异源多聚体蛋白质）的Fc变体和方法。异源多聚体蛋白质可能能够特异性结合多于一个靶标。靶可以是例如在单个分子上或位于不同分子上的不同表位。该方法结合了有效，高基因表达水平，合适的组装和异源多聚体蛋白质的纯化方便。本发明还提供使用这些异源多聚体蛋白质的方法，以及包含这些抗体的组合物，试剂盒和制品。

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