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1. 发明申请

WO1994019020A1 EXCIPIENT STABILIZATION OF POLYPEPTIDES TREATED WITH ORGANIC SOLVENTS 审中-公开
标题翻译：用有机溶剂处理的聚醚的特殊稳定性
公开(公告)号：WO1994019020A1
公开(公告)日：1994-09-01
申请号：PCT/US1994001666
申请日：1994-02-17
申请人： GENENTECH, INC. , CLELAND, Jeffrey, L. , JONES, Andrew, J., S.
发明人： GENENTECH, INC.
IPC分类号： A61K47/26
CPC分类号： A61K47/26 , A61K9/1694 , A61K47/10
摘要： Methods and compositions for excipient stabilization of dry or aqueous polypeptides treated with organic solvents are disclosed, wherein the polypeptide is admixed with a polyol having a molecular weight less than about 70,000 kD.
摘要翻译：公开了用有机溶剂处理的干燥或含水多肽的赋形剂稳定化方法和组合物，其中多肽与分子量小于约70,000kD的多元醇混合。

2. 发明申请

WO1998023645A1 AFFINITY PURIFICATION OF POLYPEPTIDE ON PROTEIN A MATRIX 审中-公开
标题翻译：多肽对蛋白A基质的亲和纯化
公开(公告)号：WO1998023645A1
公开(公告)日：1998-06-04
申请号：PCT/US1997019994
申请日：1997-10-29
申请人： GENENTECH, INC.
发明人： GENENTECH, INC. , BLANK, Greg, S.
IPC分类号： C07K16/06
CPC分类号： C07K16/32 , C07K16/065 , Y10S436/824 , Y10S436/828
摘要： A method for purifying proteins by Protein A chromatography is described which comprises the steps of: (a) adsorbing the protein to Protein A immobilized on a solid phase comprising silica or glass; (b) removing contaminants bound to the solid phase by washing the solid phase with a hydrophobic electrolyte solvent; and (c) recovering the protein from the solid phase.
摘要翻译：描述了通过蛋白A层析纯化蛋白质的方法，其包括以下步骤：（a）将蛋白质吸附到固定在包含二氧化硅或玻璃的固相上的蛋白A中; （b）通过用疏水性电解质溶剂洗涤固相来除去结合固相的污染物; 和（c）从固相中回收蛋白质。

3. 发明申请

WO1998020036A1 CONSTRAINED HELICAL PEPTIDES AND METHODS OF MAKING SAME 审中-公开
标题翻译：受约束的绷带及其制造方法
公开(公告)号：WO1998020036A1
公开(公告)日：1998-05-14
申请号：PCT/US1997020069
申请日：1997-11-05
申请人： GENENTECH, INC.
发明人： GENENTECH, INC. , BRAISTED, Andrew , JUDICE, J., Kevin , MCDOWELL, Robert, S. , PHELAN, J., Christopher , STAROVASNIK, Melissa, A. , WELLS, James, A.
IPC分类号： C07K14/16
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2740/16122
摘要： Provided are cyclized peptides with a constrained region(s) having an alpha -helical conformation. Constrained helical peptides having amino acid sequences from HIV gp41 are provided, as is their use in preparing antibodies that prevent viral membrane fusion. Also provided are methods for making such cyclized peptides.
摘要翻译：提供具有具有α-螺旋构象的约束区域的环化肽。提供了具有来自HIV gp41的氨基酸序列的约束螺旋肽，以及它们在制备防止病毒膜融合的抗体中的用途。还提供了制备这种环化肽的方法。

4. 发明申请

WO1998018946A1 PROCESS FOR BACTERIAL PRODUCTION OF POLYPEPTIDES 审中-公开
标题翻译：多肽生产细菌的方法
公开(公告)号：WO1998018946A1
公开(公告)日：1998-05-07
申请号：PCT/US1997018383
申请日：1997-10-09
申请人： GENENTECH, INC.
发明人： GENENTECH, INC. , JOLY, John, C. , SWARTZ, James, R.
IPC分类号： C12N15/70
CPC分类号： C12N9/0051 , C07K1/1133 , C07K14/245 , C07K14/65 , C07K2319/00 , C12N9/90 , C12N15/70 , C12P21/02
摘要： A process is provided for producing a heterologous polypeptide in bacteria. This process comprises, in a first step, culturing bacterial cells that lack their native pstS gene and comprise nucleic acid encoding a PstS variant having an amino acid variation within the phosphate-binding region of the corresponding native PstS, nucleic acid encoding a DsbA or DsbC protein, nucleic acid encoding the heterologous polypeptide, a signal sequence for secretion of both the DsbA or DsbC protein and the heterologous polypeptide, an inducible promoter for the nucleic acid encoding the DsbA or DsbC protein, and an alkaline phosphatase promoter for the nucleic acid encoding the heterologous polypeptide. The nucleic acid encoding a PstS variant is under the transcriptional control of the wild-type pstS gene promoter. The culturing step is conducted under conditions whereby expression of the nucleic acid encoding the DsbA or DsbC protein is induced prior to induction of the expression of the nucleic acid encoding the heterologous polypeptide, whereby the culturing takes place in a culture medium at a concentration of inorganic phosphate in the medium that during all phases of cell growth is above the level at which the cells are starved for phosphate, and whereby either both the heterologous polypeptide and the DsbA or DsbC protein are secreted into the periplasm of the bacteria or the heterologous polypeptide is secreted into the medium in which the bacterial cells are cultured. The second step of the process involves recovering the heterologous polypeptide from the periplasm or the culture medium.
摘要翻译：提供了用于在细菌中产生异源多肽的方法。该方法在第一步中包括培养缺乏其天然pstS基因的细菌细胞，并且包含编码在相应天然PstS的磷酸结合区域内具有氨基酸变异的PstS变体的核酸，编码DsbA或DsbC的核酸蛋白质，编码异源多肽的核酸，用于分泌DsbA或DsbC蛋白质和异源多肽的信号序列，用于编码DsbA或DsbC蛋白质的核酸的诱导型启动子，以及用于核酸编码的碱性磷酸酶启动子异源多肽。编码PstS变体的核酸在野生型pstS基因启动子的转录控制下。培养步骤是在诱导编码异源多肽的核酸表达之前诱导编码DsbA或DsbC蛋白的核酸的表达的条件下进行的，由此培养在培养基中以无机的浓度进行在培养基中，在细胞生长的所有阶段都高于细胞饥饿磷酸盐的水平，并且由此异源多肽和DsbA或DsbC蛋白质分泌到细菌的周质或异源多肽中的是分泌到培养细菌细胞的培养基中。该方法的第二步包括从周质或培养基中回收异源多肽。

5. 发明申请

WO1998016551A3 VARIANTS OF VASCULAR ENDOTHELIAL CELL GROWTH FACTOR HAVING ANTAGONISTIC PROPERTIES 审中-公开
公开(公告)号：WO1998016551A3
公开(公告)日：1998-04-23
申请号：PCT/US1997019471
申请日：1997-10-10
申请人： GENENTECH, INC. , KEYT, Bruce, A. , NGUYEN, Francis, Hung , FERRARA, Napoleone
发明人： GENENTECH, INC.
IPC分类号： C07K14/52

6. 发明申请

WO1998002540A1 CHIMERIC HETEROMULTIMER ADHESINS 审中-公开
标题翻译： CHIMERIC HETERMULTIMER ADHESINS
公开(公告)号：WO1998002540A1
公开(公告)日：1998-01-22
申请号：PCT/US1997011825
申请日：1997-07-08
申请人： GENENTECH, INC.
发明人： GENENTECH, INC. , FIZPATRICK, Vincent, Danial , SLIWKOWSKI, Mark , VANDLEN, Richard, L.
IPC分类号： C12N15/12
CPC分类号： C07K14/4705 , A61K38/00 , C07K14/4756 , C07K14/71 , C07K19/00 , C07K2319/30
摘要： Chimeric heteromultimer adhesins that bind the ligand of natural heteromultimeric receptors and uses therefor are disclosed. The chimeric molecules of the heteromultimer adhesins comprise an extracellular domain of a heteromultimeric receptor monomer and a multimerization domain for the stable interaction of the chimeric mollecules in the adhesin. Specifically disclosed are heteromultimeric adhesins comprising the extracellular domains of ErbB2 and ErbB3 or ErbB2 and ErbB4. The chimeric ErbB heteromultimer adhesins of the present invention are useful as competitive antagonists or agonists of a neuregulin for the treatment of diseases such as various cancers.
摘要翻译：公开了结合天然异源多聚体受体的配体的嵌合异源多聚体粘附素及其用途。杂多聚体粘附素的嵌合分子包含异源多聚体受体单体的细胞外结构域和用于粘附素中嵌合分子的稳定相互作用的多聚化结构域。具体公开的是包含ErbB2和ErbB3或ErbB2和ErbB4的细胞外结构域的异源多聚体粘附素。本发明的嵌合ErbB异源多聚体粘附素可用作神经调节蛋白的竞争性拮抗剂或激动剂用于治疗各种癌症等疾病。

7. 发明申请

WO1997030146A2 CARDIOTROPHIN AND USES THEREFOR 审中-公开
标题翻译： CARDIOTROPHIN及其用途
公开(公告)号：WO1997030146A2
公开(公告)日：1997-08-21
申请号：PCT/US1997002675
申请日：1997-02-11
申请人： GENENTECH, INC. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： GENENTECH, INC. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BAKER, Joffre , CHIEN, Kenneth , KING, Kathleen , PENNICA, Diane , WOOD, William
IPC分类号： C12N05/06
CPC分类号： C12N5/0606 , A61K35/34 , A61K38/204 , C12N2501/115 , C12N2501/125 , C12N2501/175
摘要： Isolated CT-1, isolated DNA encoding CT-1, and recombinant or synthetic methods of preparing CT-1 are disclosed. CT-1 is shown to bind to and activate the receptor, LIFR beta . These CT-1 molecules are shown to influence hypertrophic activity, neurological activity, and other activities associated with receptor LIFR beta . Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, neurological disorders, and other disorders associated with the LIFR beta .
摘要翻译：公开了分离的CT-1，编码CT-1的分离的DNA，以及制备CT-1的重组或合成方法。显示CT-1结合并激活受体LIFRβ。显示这些CT-1分子影响与受体LIFRβ相关的肥大活性，神经活性和其它活性。因此，这些化合物或其拮抗剂可用于治疗心力衰竭，心律不齐症，肌力障碍，神经障碍和与LIFRβ相关的其它障碍。

8. 发明申请

WO1997025425A1 WSX RECEPTOR AND LIGANDS 审中-公开
标题翻译： WSX受体和配偶
公开(公告)号：WO1997025425A1
公开(公告)日：1997-07-17
申请号：PCT/US1997000325
申请日：1997-01-07
申请人： GENENTECH, INC.
发明人： GENENTECH, INC. , BENNETT, Brian , CARTER, Paul, J. , CHIANG, Nancy, Y. , KIM, Kyung, Jin , MATTHEWS, William , RODRIGUES, Maria, L.
IPC分类号： C12N15/12
CPC分类号： C07K16/2866 , A01K2217/05 , A01K2227/105 , A61K38/00 , C07K14/715 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/622 , C07K2317/75 , C07K2319/00 , C07K2319/02 , C07K2319/30 , G01N33/6863 , G01N2500/00
摘要： The WSX receptor and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed, including various uses therefor. Uses for WSX ligands (e.g., anti-WSX receptor agonist antibodies or OB protein) in hematopoiesis are also disclosed.
摘要翻译：公开了与其结合的WSX受体和抗体（包括激动剂和中和抗体），包括其各种用途。还公开了在造血作用中用于WSX配体（例如抗WSX受体激动剂抗体或OB蛋白）。

9. 发明申请

WO1997009997A1 CYSTIC FIBROSIS THERAPY 审中-公开
公开(公告)号：WO1997009997A1
公开(公告)日：1997-03-20
申请号：PCT/US1996014588
申请日：1996-09-12
申请人： GENENTECH, INC. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CHILDREN'S HOSPITAL MEDICAL CENTER OF NORTHERN CALIFORNIA
发明人： GENENTECH, INC. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CHILDREN'S HOSPITAL MEDICAL CENTER OF NORTHERN CALIFORNIA , MRSNY, Randall, J. , SHEN, Ben-Quan , WIDDICOMBE, Jonathan, H.
IPC分类号： A61K38/18
CPC分类号： A61K38/1833
摘要： The invention provides methods for treating cystic fibrosis and other pathological conditions in mammals using hepatocyte growth factor ("HGF"). The invention also provides articles of manufacture and kits containing HGF.
摘要翻译：本发明提供使用肝细胞生长因子（“HGF”）治疗哺乳动物囊状纤维化和其它病理状况的方法。本发明还提供了含有HGF的制品和试剂盒。

10. 发明申请

WO1996037216A1 METHOD OF ADMINISTRATION OF IGF-I 审中-公开
标题翻译： IGF-I的施用方法
公开(公告)号：WO1996037216A1
公开(公告)日：1996-11-28
申请号：PCT/US1996006704
申请日：1996-05-09
申请人： GENENTECH, INC. , WASHINGTON UNIVERSITY
发明人： GENENTECH, INC. , WASHINGTON UNIVERSITY , CLARK, Ross, G. , GESUNDHEIT, Neil , HAMMERMAN, Marc, R. , MILLER, Steven, B.
IPC分类号： A61K38/30
CPC分类号： A61K38/30 , A61K38/556 , A61K38/2242 , A61K38/27 , A61K2300/00
摘要： A method is disclosed that comprises administering insulin-like growth factor-I (IGF-I) to a mammal so as to sustain its biological activity in the mammal comprising administering a therapeutically effective amount of IGF-I to the mammal to provide an exposure to IGF-I for a period of time that stimulates the maximum biological response in the mammal, then discontinuing said administration for a period of time equal to or less than the time period used for administration, and repeating this pattern of administration and discontinuance of administration for a period as long as necessary to achieve or maintain the desired biological response in the mammal.
摘要翻译：公开了一种方法，其包括向哺乳动物施用胰岛素样生长因子-I（IGF-I）以维持其在哺乳动物中的生物学活性，包括向哺乳动物施用治疗有效量的IGF-1以提供暴露于 IGF-I刺激哺乳动物最大生物反应的一段时间，然后停止所述施用一段时间等于或小于用于给药的时间段，并重复这种给药方式和中断给药方式只要在哺乳动物中达到或维持所需生物反应所必需的时间。

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