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1. 发明申请

WO9818925A3 MODIFIED GLUCOCORTICOID RECEPTORS, GLUCOCORTICOID RECEPTORS/PROGESTERONE RECEPTORS HYBRIDS 审中-公开
标题翻译：改性葡萄球菌受体，葡萄糖激素受体/孕激素受体杂交
公开(公告)号：WO9818925A3
公开(公告)日：1998-10-15
申请号：PCT/US9719607
申请日：1997-10-28
申请人： GENEMEDICINE INC , BAYLOR COLLEGE MEDICINE , MALLEY BERT O , TSAI MING JER , TSAI SOPHIA Y , KITTLE JOSEPH D JR , LEDEBUR HARRY C JR , WANG YAOLIN
发明人： O'MALLEY BERT , TSAI MING-JER , TSAI SOPHIA Y , KITTLE JOSEPH D JR , LEDEBUR HARRY C JR , WANG YAOLIN
IPC分类号： A01K67/027 , A61K38/00 , A61K48/00 , A61P11/06 , A61P19/02 , A61P25/28 , C07K14/72 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/63 , C12N15/82 , G01N33/566 , G01N33/74 , A61K38/17 , C12N15/62
CPC分类号： C12N15/63 , A01K2217/05 , A61K38/00 , C07K14/721 , C07K2319/00 , C12N15/8237 , C12N15/8238 , G01N33/566 , G01N33/743 , G01N2333/723 , G01N2500/10
摘要： The present invention provides modified proteins of steroid hormone receptors. These mutated proteins are useful as gene medicines. In particular, these mutated proteins are useful for regulating expression of genes in gene therapy. In addition, the present invention provides plasmids encoding for the desired mutated steroid hormone receptor proteins, as well as cells transfected with those plasmids.

2. 发明专利

CA2013389A1 ASSAYS OF COUP-TRANSCRIPTION FACTOR INTERACTIONS IN MAMALIAN SYSTEMS 未知
公开(公告)号：CA2013389A1
公开(公告)日：1990-10-10
申请号：CA2013389
申请日：1990-03-28
申请人： MALLEY BERT W O , TSAI MING JER , WANG LEE HO , TSAI SOPHIA Y
发明人： O'MALLEY BERT W , TSAI MING-JER , WANG LEE-HO , TSAI SOPHIA Y
IPC分类号： G01N33/53 , C07K14/00 , C07K14/47 , C07K16/00 , C07K16/18 , C12N15/85 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/564 , G01N33/577 , G01N33/68 , G01N33/74
摘要： ASSAYS OF COUP-TRANSCRIPTION FACTOR INTERACTIONS IN MAMMALIAN SYSTEMS Multiple methods for measuring the COUP-TF system, including: a method to measure the level of COUP-TF by combining antibodies with biological samples and measuring the resultant antibody/COUP-TF complex; the binding of COUP-TF to promoters by combining biological samples with COUP-TF binding oligonucleotides and measuring the resultant complex or gene synthesis; and a method to measure COUP-TF inducable promoters by combining native COUP-TF with nuclear extracts of biological samples and measuring the resultant complexes. The methods when applied to human biological samples can detect diabetes due to COUP-TF or promoter defects. In addition to the methods for measuring the COUP-TF system and associated diseases, there are also the polyclonal and monoclonal antibodies necessary for the methods. These bind to at least one immunoreactive site on COUP-TF. Furthermore, there is a DNA clone containing the genetic coding regions of the COUP-TF protein. 9000G

3. 发明专利

CA2223717A1 MODIFIED STEROID HORMONES FOR GENE THERAPY AND METHODS FOR THEIR USE 未知
公开(公告)号：CA2223717A1
公开(公告)日：1996-12-19
申请号：CA2223717
申请日：1996-03-29
申请人： GENEMEDICINE INC , BAYLOR COLLEGE MEDICINE
发明人： LEDEBUR HARRY C JR , TSAI MING-JER , O'MALLEY BERT W , KITTLE JOSEPH D JR
IPC分类号： A01K67/027 , A61K31/00 , A61K35/76 , A61K38/00 , A61K48/00 , A61P11/00 , A61P11/06 , A61P43/00 , C07K14/72 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/63 , C12N15/82 , C12P21/02 , C12R1/91 , G01N33/566 , G01N33/74
摘要： The present invention provides mutated proteins of steroid hormone receptors. These mutated proteins are useful as gene medicines. In particular, these mutated proteins are useful for regulating expression of genes in gene therapy. In addition, the present invention provides plasmids encoding for the desired mutated steroid hormone receptor proteins, as well as cells transfected with those plasmids.

4. 发明专利

AU5378196A Modified steroid hormones for gene therapy and methods for t heir use 未知
公开(公告)号：AU5378196A
公开(公告)日：1996-12-30
申请号：AU5378196
申请日：1996-03-29
申请人： BAYLOR COLLEGE MEDICINE , GENEMEDICINE INC
发明人： O'MALLEY BERT W , TSAI MING-JER , LEDEBUR HARRY C JR , KITTLE JOSEPH D JR
IPC分类号： A01K67/027 , A61K31/00 , A61K35/76 , A61K38/00 , A61K48/00 , A61P11/00 , A61P11/06 , A61P43/00 , C07K14/72 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/63 , C12N15/82 , C12P21/02 , C12R1/91 , G01N33/566 , G01N33/74 , C12N15/85 , A61K38/17
摘要： The present invention provides mutated proteins of steroid hormone receptors. These mutated proteins are useful as gene medicines. In particular, these mutated proteins are useful for regulating expression of genes in gene therapy. In addition, the present invention provides plasmids encoding for the desired mutated steroid hormone receptor proteins, as well as cells transfected with those plasmids.

5. 发明专利

AT371736T 未知
公开(公告)号：AT371736T
公开(公告)日：2007-09-15
申请号：AT97949348
申请日：1997-10-28
申请人： BAYLOR COLLEGE MEDICINE
发明人： O'MALLEY BERT , TSAI MING-JER , TSAI SOPHIA , WANG YAOLIN
IPC分类号： A01K67/027 , C12N15/12 , A61K38/00 , A61K38/17 , A61K48/00 , A61P11/06 , A61P19/02 , A61P25/28 , C07K14/72 , C12N5/10 , C12N15/09 , C12N15/62 , C12N15/63 , C12N15/82 , G01N33/566 , G01N33/74
摘要： The present invention provides mutant proteins of steroid hormone receptors. These mutant proteins are useful in methods of distinguishing a steroid hormone receptor antagonist from a steroid hormone receptor agonist. The present invention also provides plasmids containing mutated steroid hormone receptor proteins and cells transfected with those plasmids. In addition, the present invention provides methods for determining whether a compound is a steroid hormone receptor antagonist or agonist. Also, the present invention provides methods of determining endogenous ligands for steroid hormone receptors. The invention further provides a molecular switch protein for regulating expression in gene therapy.

6. 发明专利

AU685054C Mutated steroid hormone receptors, methods for their use and molecular switch for gene therapy 未知
公开(公告)号：AU685054C
公开(公告)日：2003-02-27
申请号：AU4241793
申请日：1993-05-11
申请人： BAYLOR COLLEGE MEDICINE
发明人： VEGETO ELISABETTA , MCDONNELL DONALD P , O'MALLEY BERT W , SCHRADER WILLIAM T , TSAI MING-JER
IPC分类号： A61K31/70 , A61K38/00 , A61K48/00 , C07H15/12 , C07H17/00 , C07H21/04 , C07K14/705 , C07K14/72 , C12N5/00 , C12N5/10 , C12N7/01 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/82 , C12P21/02 , C12R1/91 , G01N33/566 , G01N33/68 , G01N33/74 , C07K15/06 , C07K13/00
摘要： The present invention provides mutant proteins of steroid hormone receptors. These mutant proteins are useful in methods of distinguishing a steroid hormone receptor antagonist from a steroid hormone receptor agonist. The present invention also provides plasmids containing mutated steroid hormone receptor proteins and cells transfected with those plasmids. In addition, the present invention provides methods for determining whether a compound is a steroid hormone receptor antagonist or agonist. Also, the present invention provides methods of determining endogenous ligands for steroid hormone receptors. The invention further provides a molecular switch for regulating expression in gene therapy and methods of employing the molecular switch in humans, animals, transgenic animals and plants.

8. 发明专利

AU5312890A ASSAYS OF COUP-TRANSCRIPTION FACTOR INTERACTIONS IN MAMMALIAN SYSTEMS 未知
公开(公告)号：AU5312890A
公开(公告)日：1990-10-11
申请号：AU5312890
申请日：1990-04-10
申请人： BAYLOR COLLEGE MEDICINE
发明人： O'MALLEY BERT W , TSAI MING-JER , WANG LEE-HO , TSAI SOPHIA YANG
IPC分类号： G01N33/53 , C07K14/00 , C07K14/47 , C07K16/00 , C07K16/18 , C12N15/85 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/564 , G01N33/577 , G01N33/68 , G01N33/74 , C12N15/12 , C07K15/12
摘要： Multiple methods for measuring the COUP-TF system, including: a method to measure the level of COUP-TF by combining antibodies with biological samples and measuring the resultant antibody/COUP-TF complex; the binding of COUP-TF to promoters by combining biological samples with COUP-TF binding oligonucleotides and measuring the resultant complex or gene synthesis; and a method to measure COUP-TF inducable promoters by combining native COUP-TF with nuclear extracts of biological samples and measuring the resultant complexes. The methods when applied to human biological samples can detect diabetes due to COUP-TF or promoter defects. In addition to the methods for measuring the COUP-TF system and associated diseases, there are also the polyclonal and monoclonal antibodies necessary for the methods. These bind to at least one immunoreactive site on COUP-TF. Furthermore, there is a DNA clone containing the genetic coding regions of the COUP-TF protein.

9. 发明申请

WO0025800A9 STEROID RECEPTOR RNA ACTIVATOR 审中-公开
标题翻译：甾类受体RNA激活剂
公开(公告)号：WO0025800A9
公开(公告)日：2000-09-21
申请号：PCT/US9925684
申请日：1999-11-02
申请人： BAYLOR COLLEGE MEDICINE
发明人： O'MALLEY BERT W , TSAI MING-JER , TSAI SOPHIA Y , LANZ RAINER
IPC分类号： A61K31/00 , C12N15/10 , C12N15/11 , A61K31/7088 , C07H21/02 , C12N5/00 , C12N15/86 , C12P19/34 , C12P21/00 , C12Q1/68
CPC分类号： C12N15/11 , A01K2217/075 , A61K31/00 , C07K2319/00 , C12N15/1034
摘要： The invention relates to a Steroid Receptor RNA Activator (termed SRA) which acts as a steroid hormone receptor coactivator and to the detection of RNA transcripts capable of transactivation of a DNA sequence. The use of SRA to detect protein/RNA interactions including the specific situation of RNA/protein interactions for transactivation of heterologous promoters is described. Methods to evaluate or modulate type I or "classical" nuclear receptors are also described. Furthermore, SRA and its expression levels can facilitate design and evaluation of agents capable of modulating its levels or interactions with other proteins. It also relates to the levels of SRA expression facilitating detection, prognosis or treatment of steroid-dependent tumors or to the detection of prenatal or postnatal cortisol resistance. Finally, SRA expression patterns can be utilized to detect steroid receptor expression patterns.
摘要翻译：本发明涉及作为类固醇激素受体共激活剂的类固醇受体RNA激活剂（称为SRA），并涉及能够反式激活DNA序列的RNA转录物的检测。描述了使用SRA检测蛋白质/ RNA相互作用，包括用于反式激活异源启动子的RNA /蛋白质相互作用的特定情况。还描述了评估或调节I型或“经典”核受体的方法。此外，SRA及其表达水平可以促进设计和评估能够调节其水平或与其他蛋白质相互作用的试剂。它还涉及促进检测，预后或治疗类固醇依赖性肿瘤或检测出生前或产后皮质醇抗性的SRA表达水平。最后，可以利用SRA表达模式来检测类固醇受体表达模式。

10. 发明专利

DE69334150T2 未知
公开(公告)号：DE69334150T2
公开(公告)日：2008-03-13
申请号：DE69334150
申请日：1993-05-11
申请人： BAYLOR COLLEGE MEDICINE
发明人： VEGETO ELISABETTA , MCDONNELL DONALD P , O'MALLEY BERT W , SCHRADER WILLIAM T , TSAI MING-JER
IPC分类号： C12N15/00 , A61K31/70 , A61K38/00 , A61K48/00 , C07H15/12 , C07H17/00 , C07H21/04 , C07K14/00 , C07K14/705 , C07K14/72 , C12N5/00 , C12N5/10 , C12N7/01 , C12N15/09 , C12N15/63 , C12N15/82 , C12P21/02 , C12R1/91 , G01N33/566 , G01N33/68 , G01N33/74
摘要： The present invention provides mutant proteins of steroid hormone receptors. These mutant proteins are useful in methods of distinguishing a steroid hormone receptor antagonist from a steroid hormone receptor agonist. The present invention also provides plasmids containing mutated steroid hormone receptor proteins and cells transfected with those plasmids. In addition, the present invention provides methods for determining whether a compound is a steroid hormone receptor antagonist or agonist. Also, the present invention provides methods of determining endogenous ligands for steroid hormone receptors. The invention further provides a molecular switch for regulating expression in gene therapy and methods of employing the molecular switch in humans, animals, transgenic animals and plants.

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