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1. 发明申请

WO2006015789A2 METHOD FOR MODULATING GENE EXPRESSION BY MODIFYING THE CPG CONTENT 审中-公开
标题翻译：调制基因表达的方法通过修改CpG含量
公开(公告)号：WO2006015789A2
公开(公告)日：2006-02-16
申请号：PCT/EP2005008423
申请日：2005-08-03
申请人： GENEART GMBH , NOTKA FRANK , GRAF MARCUS , LEIKAM DORIS , WAGNER RALF , RAAB DAVID
发明人： NOTKA FRANK , GRAF MARCUS , LEIKAM DORIS , WAGNER RALF , RAAB DAVID
IPC分类号： C12N15/63
CPC分类号： C12N15/63 , C07K14/43595 , C12N2830/46
摘要： The invention relates to nucleic acid modifications for a directed expression modulation by the targeted insertion or removal of CpG dinucleotides. The invention also relates to modified nucleic acids and expression vectors.
摘要翻译：本发明涉及核酸用于通过CpG二核苷酸的靶向插入或移除的表达的定向调制氨基酸修饰。此外，本发明涉及modifzierte核酸和表达载体。

2. 发明申请

WO2004059556A3 METHOD AND DEVICE FOR OPTIMIZING A NUCLEOTIDE SEQUENCE FOR THE PURPOSE OF EXPRESSION OF A PROTEIN 审中-公开
标题翻译： VERFAREN和用于表达蛋白质优化的核苷酸序列装置
公开(公告)号：WO2004059556A3
公开(公告)日：2005-12-01
申请号：PCT/EP0314850
申请日：2003-12-23
申请人： GENEART GMBH , RAAB DAVID , GRAF MARCUS , NOTKA FRANK , WAGNER RALF
发明人： RAAB DAVID , GRAF MARCUS , NOTKA FRANK , WAGNER RALF
IPC分类号： C07H21/00 , C12M1/36 , C12N15/11 , C12N15/12 , C12N15/19 , C12N15/24 , C12N15/27 , C12N15/29 , C12N15/31 , C12N15/52 , C12P21/00 , G06F19/18 , G06F19/22 , G06F19/00
CPC分类号： G06F19/20 , C07K14/43595 , C07K14/535 , C07K14/5443 , G06F19/18 , G06F19/22
摘要： The invention relates to a method for optimizing a nucleotide sequence for the purpose of expression of a protein on the basis of the amino acid sequence of said protein. According to the inventive method, a test sequence with m optimization positions is determined for a defined region, in which positions the codon usage is varied. The optimum codon usage on said optimization positions is determined by means of a power function and one or more codons of said optimum usage are determined as the codons of the optimized nucleotide sequence. These steps are iterated, while the codons of the optimized nucleotide sequence determined in the preceding steps remain unchanged during the subsequent iteration steps. The invention further relates to a device for carrying out said method.
摘要翻译：本发明涉及一种方法，用于该蛋白质的氨基酸序列，其中对于给定的范围内，其中m优化位置的测试序列来确定在其上的密码子职业多种多样，通过一个质量函数，最佳密码子占领上的装置的基础上表达蛋白质优化的核苷酸序列这种优化的位置被确定，并且一个或多个密码子优化本职业被定义为密码子优化的核苷酸序列。这些步骤被重复，从而在前面的步骤密码子的组优化的核苷酸序列保持在随后的迭代步骤不变。本发明还涉及一种用于执行这种方法。

3. 发明申请

WO2006013103A3 INDUCIBLE GENE EXPRESSION 审中-公开
标题翻译：诱导的基因表达
公开(公告)号：WO2006013103A3
公开(公告)日：2006-06-01
申请号：PCT/EP2005008427
申请日：2005-08-03
申请人： GENEART GMBH , NOTKA FRANK , WAGNER RALF , HAMMER DIANA
发明人： NOTKA FRANK , WAGNER RALF , HAMMER DIANA
IPC分类号： C12N15/867 , A61K48/00 , C12Q1/68
CPC分类号： C07K14/005 , A61K48/00 , C12N2740/16322
摘要： The invention relates to vector constructs for an HIV-specific gene therapy. The expression of transgenes is coupled with an infection of the cell with HIV while the transcription of the transgene is controlled by a transcription control region derived from HIV. In addition, the transgene is improved with regard to RNA stability and expression efficiency by modifying the nucleotide sequence.
摘要翻译：本发明涉及一种载体构建体用于HIV特异性基因治疗。所述转基因的表达被耦合到与HIV细胞的感染，由该转基因由来自HIV的转录控制区域衍生的基团控制的转录。转基因也通过在RNAStabilität和表达效率的核苷酸序列的修饰改善。

4. 发明申请

WO9630523A3 ANTIGEN PRESENTATION SYSTEM BASED ON RETROVIRUS-LIANTIGEN PRESENTATION SYSTEM BASED ON RETROVIRUS-LIKE PARTICLES KE PARTICLES 审中-公开
标题翻译：基于逆转录病毒颗粒的替罗非鱼联合显示系统的抗原呈递系统
公开(公告)号：WO9630523A3
公开(公告)日：1997-04-17
申请号：PCT/EP9601433
申请日：1996-04-01
申请人： WOLF HANS , WAGNER RALF , DEML LUDWIG , OSTERRIEDER KLAUS , NOTKA FRANK
发明人： WOLF HANS , WAGNER RALF , DEML LUDWIG , OSTERRIEDER KLAUS , NOTKA FRANK
IPC分类号： A61K38/00 , A61K39/00 , A61K39/21 , A61K39/245 , C07K14/03 , C07K14/16 , C07K19/00 , C12N7/04 , C12N15/49 , C12N15/62 , C12N15/86 , C12N15/866
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N7/00 , C12N15/86 , C12N2710/14143 , C12N2710/16722 , C12N2710/16734 , C12N2740/16023 , C12N2740/16122 , C12N2740/16222
摘要： The present invention relates to the provision of an antigen presentation system on the basis of a DNA sequence encoding a protein capable of self assembly into particles without a lipid membrane, preferably a retroviral group-specific antigen (gag) that can be used, e.g., for the preventive and therapeutic immunization of mammals against infectious diseases or neoplasias.

5. 发明专利

HK1247233A1 高效小體積核酸合成未知
公开(公告)号：HK1247233A1
公开(公告)日：2018-09-21
申请号：HK18106686
申请日：2018-05-23
申请人： LIFE TECHNOLOGIES CORP , THERMO FISHER SCIENT GENEART GMBH , LIFE TECH AS
发明人： POEHMERER THOMAS , KUHN PHILLIP , NOTKA FRANK , ZEIDLER ANDREAS , HEIL KORBINIAN , TREFZER AXEL , FONNUM GEIR , KATZEN FEDERICO , ANDERSSON KRISTIAN , LIANG XIQUAN
IPC分类号： C25B3/29

6. 发明专利

DE102004037611A1 未知
公开(公告)号：DE102004037611A1
公开(公告)日：2006-03-16
申请号：DE102004037611
申请日：2004-08-03
申请人： GENEART GMBH
发明人： NOTKA FRANK , HAMMER DIANA , WAGNER RALF
IPC分类号： C12N15/867 , A61K48/00

7. 发明专利

CA3147259A1 HIGH EFFICIENCY, SMALL VOLUME NUCLEIC ACID SYNTHESIS 未知
公开(公告)号：CA3147259A1
公开(公告)日：2016-06-16
申请号：CA3147259
申请日：2015-12-09
申请人： LIFE TECHNOLOGIES CORP , THERMO FISHER SCIENT GENEART GMBH , LIFE TECH AS
发明人： POEHMERER THOMAS , KUHN PHILLIP , NOTKA FRANK , ZEIDLER ANDREAS , HEIL KORBINIAN , TREFZER AXEL , FONNUM GEIR , KATZEN FEDERICO , ANDERSSON KRISTIAN , LIANG XIQUAN
IPC分类号： C25B3/29
摘要： The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).

8. 发明专利

CA2970477C HIGH EFFICIENCY, SMALL VOLUME NUCLEIC ACID SYNTHESIS 未知
公开(公告)号：CA2970477C
公开(公告)日：2022-03-15
申请号：CA2970477
申请日：2015-12-09
申请人： LIFE TECHNOLOGIES CORP , THERMO FISHER SCIENT GENEART GMBH , LIFE TECH AS
发明人： POEHMERER THOMAS , KUHN PHILLIP , NOTKA FRANK , ZEIDLER ANDREAS , HEIL KORBINIAN , TREFZER AXEL , FONNUM GEIR , KATZEN FEDERICO , ANDERSSON KRISTIAN , LIANG XIQUAN
IPC分类号： C07H21/00 , B01L3/00 , B03C5/02 , C12M1/42 , C12N15/10 , C12P19/34
摘要： The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).

9. 发明专利

CA2970477A1 HIGH EFFICIENCY, SMALL VOLUME NUCLEIC ACID SYNTHESIS 未知
公开(公告)号：CA2970477A1
公开(公告)日：2016-06-16
申请号：CA2970477
申请日：2015-12-09
申请人： LIFE TECHNOLOGIES CORP , THERMO FISHER SCIENT GENEART GMBH , LIFE TECH AS
发明人： POEHMERER THOMAS , KUHN PHILLIP , NOTKA FRANK , ZEIDLER ANDREAS , HEIL KORBINIAN , TREFZER AXEL , FONNUM GEIR , KATZEN FEDERICO , ANDERSSON KRISTIAN , LIANG XIQUAN
IPC分类号： C07H21/00 , B01L3/00 , B03C5/02 , C12M1/42 , C12N15/10 , C12P19/34 , C25B3/29 , G01N35/00
摘要： The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).

10. 发明专利

AU2003294953A1 METHOD AND DEVICE FOR OPTIMIZING A NUCLEOTIDE SEQUENCE FOR THE PURPOSE OF EXPRESSION OF A PROTEIN 未知
公开(公告)号：AU2003294953A1
公开(公告)日：2004-07-22
申请号：AU2003294953
申请日：2003-12-23
申请人： GENEART GMBH
发明人： GRAF MARCUS , NOTKA FRANK , WAGNER RALF , RAAB DAVID
IPC分类号： C07H21/00 , C12M1/36 , C12N15/11 , C12N15/12 , C12N15/19 , C12N15/24 , C12N15/27 , C12N15/29 , C12N15/31 , C12N15/52 , C12P21/00 , G06F19/18 , G06F19/22 , G06F19/00
摘要： Computer optimization of a nucleotide sequence for a protein comprises generating a test sequence; establishing positions corresponding to codons to be optimized; generating further test sequences by replacing one or more of these codons with another codon for the same amino acid; evaluating the test sequences with a quality function to determine the optimum sequence; establishing codons of the optimum sequence as success codons; and iterating the above steps without changing the success codons. Computer optimization of a nucleotide sequence for expression of a protein comprising N amino acids comprises generating a test sequence of n codons corresponding to n contiguous amino acids of the protein sequence, where n is =N; establishing m positions corresponding to codons to be optimized, where m is = n and less than N; generating one or more further test sequences by replacing one or more of the m codons with another codon encoding the same amino acid; evaluating the test sequences with a quality function to determine the optimum sequence; establishing p codons of the optimum sequence as success codons, where p is =m; and iterating the above steps without changing the success codons. Independent claims are also included for: (1) computer apparatus for optimization of a nucleotide sequence for expression of a protein, comprising means for performing the above steps; (2) computer program for performing the above method; (3) data carrier on which the above program is stored in computer-readable form; (4) nucleic acid (I) comprising a protein-encoding nucleotide sequence produced by synthesizing the sequence optimized as above; (5) nucleic acid (II) comprising one of four defined nucleotide sequences; (6) vector containing (I) or (II); (7) cells containing the vector or (I) or (II); (8) organism comprising at least one cell as above.

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