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1. 发明申请

WO2008127732A3 BIOMIMETIC VASCULAR NETWORK AND DEVICES USING THE SAME 审中-公开
标题翻译：生物体血管网络及使用该装置的装置
公开(公告)号：WO2008127732A3
公开(公告)日：2008-12-24
申请号：PCT/US2008004872
申请日：2008-04-14
申请人： GEN HOSPITAL CORP , HOGANSON DAVID M , VACANTI JOSEPH P , PRYOR HOWARD , SPOOL IRA
发明人： HOGANSON DAVID M , VACANTI JOSEPH P , PRYOR HOWARD , SPOOL IRA
IPC分类号： A01N1/00 , A61F2/06
CPC分类号： A61F2/06 , A61F2/022 , A61F2/04 , A61F2/062 , A61F2002/068 , G01N33/5008
摘要： The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of. (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a charactepstic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity withm the network of channels; (d) measuring the sheer stress and the velocity and compapng the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b) - (e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits.
摘要翻译：本发明提供制造包括流体网络的支架的方法，包括以下步骤。（a）产生用于封闭所述腔室并向细胞提供流体的初始血管层，所述初始血管层具有用于流体的通道网络; （b）将初始血管层转化为用于流体动力学分析的模型; （c）基于选自特定流体的特征，输入压力，输出压力，总体流量及其组合的所需参数来分析初始血管层，以确定网络的简单应力和速度渠道; （d）测量纯粹的应力和速度，并将所获得的值与预定值进行比较; （e）确定剪切应力或速度是否大于或小于预定值，和（f）任选地修饰初始血管层并重复步骤（b） - （e）。本发明还提供包含用于组织层的血管层的组合物以及具有血管层和试剂盒的医疗装置。

2. 发明申请

WO2009102751A3 SYSTEM AND METHOD FOR IN VITRO BLOOD VESSEL MODELING 审中-公开
标题翻译：血管内血管造影的系统与方法
公开(公告)号：WO2009102751A3
公开(公告)日：2009-11-12
申请号：PCT/US2009033736
申请日：2009-02-11
申请人： GEN HOSPITAL CORP , HOGANSON DAVID M , VACANTI JOSEPH P
发明人： HOGANSON DAVID M , VACANTI JOSEPH P
IPC分类号： G09B23/28 , A61F2/06 , A61L27/14 , A61L27/24
CPC分类号： G01N33/5088 , A61L27/18 , A61L27/38 , A61L27/507 , A61L27/56 , B01L3/5027 , B01L3/502707 , B01L2200/027 , B01L2300/0681 , C12M21/08 , C12M23/34 , C12M25/02 , C12M35/08 , G09B23/28 , C08L69/00
摘要： The present invention provides an in vitro blood vessel model for investigation of drug induced vascular injury and other vascular pathologies. The in vitro blood vessel model provides two channels separated by a porous membrane that is coated on one side by an endothelial cell layer and is coated on the other side by a smooth muscle cell layer, wherein said model is susceptible to the extravasation of red blood cells across said porous membrane due to drug induced vascular injury.
摘要翻译：本发明提供了用于研究药物诱导的血管损伤和其它血管病变的体外血管模型。体外血管模型提供了由多孔膜分离的两个通道，其通过内皮细胞层在一侧被涂覆并且被另一侧涂覆在平滑肌细胞层上，其中所述模型易于血液外渗由于药物引起的血管损伤，穿过所述多孔膜的细胞。

3. 发明申请

WO2010014949A3 COMPOSITIONS COMPRISING HEPATOCYTE-LIKE CELLS AND USES THEREOF 审中-公开
标题翻译：包含肝细胞样细胞的组合物及其用途
公开(公告)号：WO2010014949A3
公开(公告)日：2010-05-06
申请号：PCT/US2009052482
申请日：2009-07-31
申请人： GEN HOSPITAL CORP , PRYOR HOWARD I , VACANTI JOSEPH P , LUM DAVID H , AHFELDT TIM D , COWAN CHAD
发明人： PRYOR HOWARD I , VACANTI JOSEPH P , LUM DAVID H , AHFELDT TIM D , COWAN CHAD
IPC分类号： C12N5/077 , A61K35/12 , C12N5/02 , C12N5/10 , C12N15/12
CPC分类号： C12N5/067 , A61K38/00 , C12N5/0667 , C12N2501/115 , C12N2501/12 , C12N2501/60 , C12N2506/1384
摘要： The invention generally features methods for generating hepatocytes from a variety of pluripotent stem cells, including adipose mesenchymal stem cells, therapeutic compositions featuring such cells, and methods of using them for the treatment of subjects.
摘要翻译：本发明总体上涉及用于从各种多能干细胞（包括脂肪间充质干细胞）产生肝细胞的方法，以这些细胞为特征的治疗组合物，以及使用它们治疗受试者的方法。

4. 发明申请

WO0155212A3 DELIVERY OF THERAPEUTIC BIOLOGICAL FROM IMPLANTABLE TISSUE MATRICES 审中-公开
标题翻译：从可植入的组织矩阵中提取治疗性生物学
公开(公告)号：WO0155212A3
公开(公告)日：2002-01-24
申请号：PCT/US0102694
申请日：2001-01-26
申请人： GEN HOSPITAL CORP
发明人： VACANTI JOSEPH P , DONAHOE PATRICIA K , MACLAUGHLIN DAVID T , MASIAKOS PETER T
IPC分类号： A61K35/12 , A61K38/22 , A61K48/00 , C12N5/077 , C12N5/10 , A61K9/00 , C07K14/575
CPC分类号： C12N5/0656 , A61K38/22 , A61K48/00 , B33Y10/00 , B33Y30/00 , B33Y70/00 , B33Y80/00 , C12N2510/02
摘要： Normal cells, such as fibroblasts or other tissue or organ cell types, are genetically engineered to express biologically active, therapeutic agents, such as proteins that are normally produced in small amounts, for example, MIS, or other members of the TGF-beta family Herceptin , interferons, andantiangiogenic factors. These cells are seeded into a matrix for implantation into the patient to be treated. Cells may also be engineered to include a lethal gene, so that implanted cells can be destroyed once treatment is completed. Cells can be implanted in a variety of different matrices. In a preferred embodiment, these matrices are implantable and biodegradable over a period of time equal to or less than the expected period of treatment, when cells engraft to form a functional tissue producing the desired biologically active agent.
摘要翻译：正常细胞如成纤维细胞或其它组织或器官细胞类型被遗传工程化以表达生物活性的治疗剂，例如通常少量产生的蛋白质，例如MIS或TGF-β家族的其他成员赫赛汀，干扰素和促血管生成因子。将这些细胞接种到基质中以便植入待治疗的患者中。细胞还可以被设计成包括致死基因，使得植入的细胞一旦完成就可以被破坏。细胞可以植入各种不同的基质中。在优选的实施方案中，当细胞移植以形成产生所需生物活性剂的功能组织时，这些基质可植入和生物降解的时间等于或小于预期的治疗期。

5. 发明申请

WO2006052551A3 MICROMACHINED BILAYER UNIT OF ENGINEERED TISSUES 审中-公开
标题翻译：工程组织MICROMACHINED BILAYER单位
公开(公告)号：WO2006052551A3
公开(公告)日：2009-06-11
申请号：PCT/US2005039503
申请日：2005-11-01
申请人： GEN HOSPITAL CORP , MASSACHUSETTS INST TECHNOLOGY , DRAPER LAB CHARLES S , BORENSTEIN JEFFREY T , WEINBERG ELI , ORRICK BRIAN K , PRITCHARD ELEANOR M , BARNARD EDWARD J , KREBS NICHOLAS J , MARENTIS THEODORE , VACANTI JOSEPH P , KAAZEMPUR-MOFRAD MOHAMMAD REZA
发明人： BORENSTEIN JEFFREY T , WEINBERG ELI , ORRICK BRIAN K , PRITCHARD ELEANOR M , BARNARD EDWARD J , KREBS NICHOLAS J , MARENTIS THEODORE , VACANTI JOSEPH P , KAAZEMPUR-MOFRAD MOHAMMAD REZA
IPC分类号： A01N1/00 , A01N1/02 , C12M1/12 , C12M1/34 , C12M3/06 , C12N5/08
CPC分类号： A61M1/1678 , Y10T436/25375 , Y10T436/255
摘要： Methods and materials for making an apparatus which duplicates the functionality of a physiological system is provided.
摘要翻译：提供了用于制造复制生理系统的功能的装置的方法和材料。

6. 发明申请

WO2005034624A3 MICROFABRICATED COMPOSITIONS AND PROCESSES FOR ENGINEERING TISSUES CONTAINING MULTIPLE CELL TYPES 审中-公开
标题翻译：含多种细胞类型工程组织的微晶组合物和方法
公开(公告)号：WO2005034624A3
公开(公告)日：2005-08-25
申请号：PCT/US2004016059
申请日：2004-05-21
申请人： GEN HOSPITAL CORP , DRAPER LAB CHARLES S , VACANTI JOSEPH P , BORENSTEIN JEFFREY , WEINBERG ELI
发明人： VACANTI JOSEPH P , BORENSTEIN JEFFREY , WEINBERG ELI
IPC分类号： A01N20060101 , A61F2/00 , C12N5/00 , C12N5/071 , C12N11/04 , C12N11/08 , C12N11/14 , C12N5/06
CPC分类号： C12N5/0068 , B33Y80/00 , C12N5/0062 , C12N5/0697 , C12N2533/40
摘要： The present invention relates to a three-dimensional system, and compositions obtained therefrom, wherein individual layers of the system comprise channels divided longitudinally into two compartments by a centrally positioned membrane, and wherein each compartment can comprise a different cell type (Figure 5).
摘要翻译：本发明涉及三维系统及其组合物，其中系统的各层包括通过中心定位的膜纵向分成两个隔间的通道，并且其中每个隔间可以包括不同的电池类型（图5）。

7. 发明申请

WO2010037130A3 COMPOSITIONS AND METHODS OF GENERATING REPROGRAMMED ADIPOCYTE CELLS AND METHODS OF USE THEREFORE 审中-公开
标题翻译：产生重编程的脂肪细胞的组合物和方法及其使用方法
公开(公告)号：WO2010037130A3
公开(公告)日：2010-05-27
申请号：PCT/US2009058869
申请日：2009-09-29
申请人： GEN HOSPITAL CORP , VACANTI JOSEPH P , PRYOR HOWARD I , LUM DAVID H , AHFELDT TIM D , COWAN CHAD
发明人： VACANTI JOSEPH P , PRYOR HOWARD I , LUM DAVID H , AHFELDT TIM D , COWAN CHAD
IPC分类号： C12N15/00 , C12N5/00 , C12N5/02
CPC分类号： C12N5/0653 , C12N2501/385 , C12N2503/02 , C12N2506/02 , C12N2510/00
摘要： The invention provides therapeutic compositions comprising reprogrammed adipocyte cells for use as disease models, therapeutic compositions comprising reprogrammed adipocyte cells for the treatment of conditions characterized by a reduction in cell number or tissue mass, and methods of generating such cells.
摘要翻译：本发明提供包含用作疾病模型的重编程脂肪细胞细胞的治疗组合物，包含用于治疗特征在于细胞数量或组织质量减少的病症的重编程的脂肪细胞的治疗组合物，以及产生此类细胞的方法。

8. 发明申请

WO2009103057A3 POLYGLYCEROL SEBECATE PERITONEAL ADHESION PREVENTION BARRIER 审中-公开
标题翻译： POLYGLYCEROL SEBECATE PERTIONE粘合防护栏
公开(公告)号：WO2009103057A3
公开(公告)日：2009-11-12
申请号：PCT/US2009034276
申请日：2009-02-17
申请人： GEN HOSPITAL CORP , PRYOR II HOWARD I , SUNDBACK CATHRYN A , VACANTI JOSEPH P
发明人： PRYOR II HOWARD I , SUNDBACK CATHRYN A , VACANTI JOSEPH P
IPC分类号： A61K31/74 , A61B19/00 , A61L31/00
CPC分类号： A61K31/74 , A61B90/00 , A61B2090/0816 , A61L31/06 , C08L67/02
摘要： The present invention is directed to a method of preventing adhesions between two tissue surfaces. The method includes providing a film comprising a condensation polymer of glycerol and a diacid, wherein the film does not contain anti-inflammatory drugs and positioning the film between a first tissue surface and a second tissue surface under conditions effective to prevent adhesion between said first tissue surface and said second tissue surface.
摘要翻译：本发明涉及一种防止两个组织表面之间粘连的方法。该方法包括提供包含甘油和二酸的缩聚物的膜，其中所述膜不含有抗炎药物，并且在有效防止所述第一组织表面和所述第二组织表面。

9. 发明申请

WO2008100559A2 MEDICAL DEVICES HAVING A MICRO-FLUIDIC CHANNELED VASCULATURE 审中-公开
标题翻译：具有微流体通道血管的医疗装置
公开(公告)号：WO2008100559A2
公开(公告)日：2008-08-21
申请号：PCT/US2008001942
申请日：2008-02-14
申请人： BIOENGINE INC , ALITO SCIENT INC , GEN HOSPITAL CORP , ORRICK BRIAN K , WOOLF GARY , VACANTI JOSEPH P
发明人： ORRICK BRIAN K , WOOLF GARY , VACANTI JOSEPH P
IPC分类号： A61F2/02
CPC分类号： A61F2/022 , A61M1/1678 , A61M1/1698 , B01D61/18
摘要： The present invention provides medical devices containing a micro-fluidic channeled vasculature capable of attaining fluid and gas flow there through, which are capable of augmenting or supplanting one or more physiological functions of an organ. The medical devices may be adapted to be exogenously seeded with at least organ specific cells. Methods of making and using the medical devices to supplant or augment one or more physiological functions of an organ are also provided.
摘要翻译：本发明提供了包含能够获得通过的流体和气体流动的微流体通道脉管系统的医疗装置，其能够增强或取代器官的一种或多种生理功能。医疗装置可以适于至少外来种子至少器官特异性细胞。还提供了制造和使用医疗装置取代或增加器官的一种或多种生理功能的方法。

10. 发明申请

WO03076564A2 TISSUE-ENGINEERED ORGANS 审中-公开
标题翻译：组织工程机械
公开(公告)号：WO03076564A2
公开(公告)日：2003-09-18
申请号：PCT/US0215813
申请日：2002-05-16
申请人： GEN HOSPITAL CORP , GRIKSCHEIT TRACY C , VACANTI JOSEPH P , OGILIVIE JENNIFER
发明人： GRIKSCHEIT TRACY C , VACANTI JOSEPH P , OGILIVIE JENNIFER
IPC分类号： A61K35/12 , A61L27/36 , C12N5/00 , C12N5/071 , C12N5/077 , C12N
CPC分类号： A61L27/3683 , A61K35/12 , A61L27/3641 , C12N5/0062 , C12N5/0648 , C12N5/0657 , C12N5/0677 , C12N5/0679 , C12N5/0686 , C12N2533/40
摘要： The present invention relates to a method for producing a tissue-engineered organ or organ portion or specific section thereof comprising the steps of loading organoid units into a biocompatible polymer scaffold and implanting the polymer scaffold into a subject. Organs produced by this method are also encompassed by the invention. Organoid units can be derived from tissues including, but not limited to, spleen, lung, liver, kidney, pancreas, endocrine tissue, heart, esophagus, colon, stomach, gall bladder and uterus. The resulting engineered tissue can comprise spleen, lung, liver, kidney, pancreas, endocrine, cardiac muscle, esophagus, colon, stomach, gall bladder or uterus. The invention further relates to a tissue-engineered organ or organ portion or specific section thereof comprising compact tissue grown in a biocompatible polymer scaffold, wherein the tissue is derived from spleen, lung, liver, kidney, pancreas, endocrine, heart, esophagus, colon, stomach, gall bladder or uterus.
摘要翻译：本发明涉及一种用于生产组织工程化器官或器官部分或其特定部分的方法，其包括以下步骤：将有机体单元装入生物相容性聚合物支架并将聚合物支架植入受试者中。通过该方法生产的器官也包括在本发明中。组织单位可以衍生自包括但不限于脾，肺，肝，肾，胰腺，内分泌组织，心脏，食管，结肠，胃，胆囊和子宫的组织。所得到的工程组织可以包括脾，肺，肝，肾，胰腺，内分泌，心肌，食道，结肠，胃，胆囊或子宫。本发明还涉及组织工程化的器官或器官部分或其特定部分，其包含在生物相容性聚合物支架中生长的紧密组织，其中所述组织衍生自脾，肺，肝，肾，胰腺，内分泌，心脏，食道，结肠，胃，胆囊或子宫。

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