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    • 6. 发明申请
    • USE OF GELATIN AND A CROSS-LINKING AGENT FOR PRODUCING A CROSS-LINKING THERAPEUTIC COMPOSITION
    • 明胶和交联剂用于生产含有交联的治疗组合物
    • WO2008006544A2
    • 2008-01-17
    • PCT/EP2007006104
    • 2007-07-10
    • GELITA AGTETEC TISSUE ENGINEERING TECHNGAISSMAIER CHRISTOPHAHLERS MICHAEL
    • GAISSMAIER CHRISTOPHAHLERS MICHAEL
    • A61K47/42A61K38/43A61L27/22
    • A61K38/45A61K35/12A61K35/28A61K35/32A61K47/42A61L27/222
    • The aim of the invention is to provide a therapeutic composition for use in biological regenerative methods, which composition can be administered to a target area of the body while ensuring that the suspended cells and/or the growth factors remain in the target area of the body and at the same time eliminating the need for the patient to maintain the treated body area immobilized for unreasonable periods. For this purpose, the invention relates to a novel of use gelatin and a cross-linking agent for producing a cross-linking therapeutic composition which forms a cross-linked gelatin gel as the cell matrix in a target area of the human or animal body. In particular, the invention relates to the use of said therapeutic composition for treating damages to the intervertebral disks, the cartilage, the menisci, the tendons or the bones in humans or animals. According to said method, (i) the gelatin and the cross-linking agent are mixed with each other to form the cross-linking therapeutic composition which is then administered to the target area; or (ii) the gelatin and the cross-linking agent are made available in separate form and are administered, simultaneously or one after the other, to the target area while forming the cross-linking therapeutic composition.
    • 以提供用于生物再生方法,其可被施用于身体的目标区域中的治疗组合物,它确保了悬浮的细胞和/或生长因子在体内的目标区域保持,没有患者需要的过长的处理的主体部分的固定化 必须是,是一种新型的使用明胶和用于制备交联的治疗组合物,其形成交联的明胶凝胶在人体或动物体的目标区域中的单元矩阵,且特别是使用这样的治疗性组合物用于椎间盘损伤的治疗中的交联剂, 软骨,半月板,和弦提出了人或动物骨,其中(i)明胶和交联剂的或以形成交联的治疗组合物 然后将其施用到目标区域克混合在一起; 是,或(ii)的明胶和在分开的形式交联剂和同时或相继施用,以形成交联的治疗组合物进入目标区域。