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1. 发明申请

WO1996006134A1 RESPONSIVE GELS FOR SELECTIVE REMOVAL OF A TARGET FROM AN ENVIRONMENT AND METHODS THEREFOR 审中-公开
标题翻译：从环境中选择性去除目标的反应性凝胶及其方法
公开(公告)号：WO1996006134A1
公开(公告)日：1996-02-29
申请号：PCT/US1995010636
申请日：1995-08-21
申请人： GEL SCIENCES, INC.
发明人： GEL SCIENCES, INC. , GOLD, Harris , TANAKA, Toyoichi , ENGLISH, Anthony, E. , KING, Kathleen, Rose , LEVY, Rhonda, Dulmage , MASAMUNE, Satoru , WANG, Changnan
IPC分类号： C08L33/24
CPC分类号： B01J20/26 , C02F1/285
摘要： Responsive polymer gels that selectively remove a target from an environment are described. A three-dimensional, reversibly responsive polymer gel comprises at least two binding moieties for the target, capable of binding the target when they come into proximity to each other to form a binding site. The binding moieties are combined with a responsive polymer component that is adapted to undergo reversible volumetric collapse and expansion in response to a change in an environmental condition. The polymer gel component has a phase-transition threshold for volumetric collapse different from the phase-transition threshold for volumetric expansion. The responsive gel is constructed so that as the polymer gel collapses to a collapsed position at a phase-transition threshold, the binding moieties are placed in sufficient proximity to each other and to the target to allow the binding site to bind the target. As the polymer expands to an expanded position at a phase-transition threshold, the binding moieties are disengaged from each other. Method of removing a target from an environment is also described and includes the steps of contacting the polymer gel of the invention with the target, the target having binding affinity for the binding site and allowing the gel to move to a collapsed position, so that the binding moieties come into sufficient proximity to each other and to the target to bind the target at the binding site. Methods of selectively removing a chosen target from a solution of the target and another target are also described. In preferred embodiments, the step of altering an environmental condition comprises altering temperature of the gel.
摘要翻译：描述了从环境中选择性地去除靶的响应性聚合物凝胶。三维，可逆响应的聚合物凝胶包含靶的至少两个结合部分，当它们彼此接近以形成结合位点时，能够结合靶。结合部分与响应性聚合物组分组合，其适于响应于环境条件的变化而经历可逆的体积塌陷和膨胀。聚合物凝胶组分具有不同于体积膨胀的相变阈值的体积塌陷的相变阈值。构建响应性凝胶，使得当聚合物凝胶在相变阈值下塌陷至收缩位置时，将结合部分置于彼此足够接近并且与靶标相接合以允许结合位点结合靶标。当聚合物在相变阈值下膨胀到扩展位置时，结合部分彼此脱离。还描述了从环境中除去靶的方法，并且包括使本发明的聚合物凝胶与靶标接触的步骤，所述靶对结合位点具有结合亲合力，并允许凝胶移动到折叠位置，使得结合部分彼此充分接近并且与靶标在结合位点处结合。还描述了从目标和另一目标的解决方案中选择性地去除所选择的目标的方法。在优选实施方案中，改变环境条件的步骤包括改变凝胶的温度。

2. 发明申请

WO1996002276A2 NOVEL POLYMER GEL NETWORKS AND METHODS OF USE 审中-公开
标题翻译：新型聚合物凝胶网络和使用方法
公开(公告)号：WO1996002276A2
公开(公告)日：1996-02-01
申请号：PCT/US1995009815
申请日：1995-07-18
申请人： GEL SCIENCES, INC.
发明人： GEL SCIENCES, INC. , SCHILLER, Matthew, E. , GEHRKE, Stevin, Henry , LUPTON, Elmer, C. , TANAKA, Toyoichi , YU, Xiaohong
IPC分类号： A61K47/38
CPC分类号： A61K8/042 , A61K8/731 , A61K8/732 , A61K9/0004 , A61K9/0009 , A61K9/0014 , A61K9/2054 , A61K38/47 , A61K47/38 , A61K2800/54 , A61L15/60 , A61L26/008 , A61L27/52 , A61L27/54 , A61L29/145 , A61L31/145 , A61L2300/252 , A61L2300/404 , A61L2300/408 , A61L2300/43 , A61L2300/452 , A61L2300/602 , A61Q13/00 , A61Q19/00 , C08B15/005 , C08B31/003 , C08B31/006 , C12N5/0068 , C12N2533/30 , C12N2533/78
摘要： A cross-linked, responsive polymer gel network comprising polymer chains interconnected by way of a multifunctional cross-linker is described. The polymer chains and cross-linker have a known acceptable toxicological profile (KATP). Pathways for determining if a particular material has a KATP are provided. The polymer chains should be a component part of a product that is considered in compliance with applicable governmental agency regulations as acceptable for a use selected from the group consisting of a food use, a cosmetic use, and an animal drug delivery use. Moreover, the cross-linker also should be a component part of a product that is considered in compliance with applicable governmental agency regulations as acceptable for a use selected from the group consisting of a food use, a cosmetic use, and an animal drug delivery use.
摘要翻译：描述了包括通过多功能交联剂互连的聚合物链的交联的响应性聚合物凝胶网络。聚合物链和交联剂具有已知的可接受的毒理学特性（KATP）。提供了确定特定材料是否具有KATP的途径。聚合物链应该是符合适用的政府机构法规的产品的组成部分，对于从食品用途，化妆品用途和动物药物输送用途中选择的用途可以接受。此外，交联剂也应该是符合适用的政府机构规定的产品的组成部分，对于从食品用途，化妆品用途和动物药物输送用途中选择的用途可以接受。

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