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1. 发明申请

WO2006051428A2 METHOD FOR THE USE OF [11C] CARBON MONOXIDE IN LABELING SYNTHESIS OF 11C-LABELLED AMIDES USING METAL AMIDES AND PHOTO-INDUCED FREE RADICAL CARBONYLATION 审中-公开
标题翻译：使用[11C]一氧化碳标记合成11C标记的氨基酸的方法，使用金属氨基和光致自由基自由基碳化
公开(公告)号：WO2006051428A2
公开(公告)日：2006-05-18
申请号：PCT/IB2005/004086
申请日：2005-11-07
申请人： GE HEALTHCARE LIMITED , LANGSTROM, Bengt , KIHLBERG, Tor , ITSENKO, Oleksiy
发明人： LANGSTROM, Bengt , KIHLBERG, Tor , ITSENKO, Oleksiy
CPC分类号： A61K51/0406 , C07B59/002
摘要： Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using weakly nucleophilic amines and alkyl/aryl iodides are provided. The resultant carbon-isotope labeled amides are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
摘要翻译：提供了使用弱亲核胺和烷基/芳基碘化物的碳同位素标记的一氧化碳进行光引发羰基化的方法和试剂。所得碳同位素标记的酰胺可用作放射性药物，特别用于正电子发射断层扫描（PET）。还提供了用于PET研究的相关工具包。

2. 发明申请

WO2006064349A1 METHOD FOR THE USE OF [11C] CARBON MONOXIDE INLABELING SYNTHESIS OF 11C-LABELLED ESTERS BY PHOTO-INDUCED FREE RADICAL CARBONYLATION 审中-公开
标题翻译：使用[11C]一氧化碳的方法通过光致自由基自由基羰化法合成11C标记的酯
公开(公告)号：WO2006064349A1
公开(公告)日：2006-06-22
申请号：PCT/IB2005/003783
申请日：2005-12-14
申请人： GE HEALTHCARE LIMITED , LANGSTROM, Bengt , KIHLBERG, Tor , ITSENKO, Oleksiy
发明人： LANGSTROM, Bengt , KIHLBERG, Tor , ITSENKO, Oleksiy
IPC分类号： C07B59/00 , C07C67/36
CPC分类号： C07C69/753 , C07B59/001 , C07B2200/05 , C07C67/36 , C07C2601/14 , C07C2603/74 , C07C69/34 , C07C69/63 , C07C69/75 , C07C69/007 , C07C69/612 , C07C69/24
摘要： Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with alcohols pretreated by a base are provided. The resultant carbon-isotope labeled esters are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
摘要翻译：提供了使用烷基/芳基碘化物与由碱预处理的醇的碳同位素标记的一氧化碳进行光引发羰基化的方法和试剂。所得的碳同位素标记的酯可用作放射性药物，特别是用于正电子发射断层扫描（PET）。还提供了用于PET研究的相关工具包。

3. 发明申请

WO2007026216A1 METHOD FOR THE USE OF [11C] CARBON MONOXIDE IN LABELING SYNTHESIS OF 11C-LABELLED KETONES BY PHOTO-INDUCED FREE RADICAL CARBONYLATION 审中-公开
标题翻译：使用[11C]一氧化碳通过光致自由放射性碳化合物标记11C标记的酮的合成方法
公开(公告)号：WO2007026216A1
公开(公告)日：2007-03-08
申请号：PCT/IB2006/002357
申请日：2006-08-29
申请人： GE HEALTHCARE LIMITED , LANGSTROM, Bengt , ITSENKO, Oleksiy , KIHLBERG, Tor
发明人： LANGSTROM, Bengt , ITSENKO, Oleksiy , KIHLBERG, Tor
IPC分类号： C07B59/00 , C07C45/49 , C07C49/792 , A61K51/04
CPC分类号： C07B59/001 , C07C45/49
摘要： Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with carbanion precursors pretreated by a base are provided. The resultant carbon-isotope labeled ketones, and pharmaceutical acceptable salts and solvates are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits and method for PET studies are also provided.
摘要翻译：提供了使用具有由碱预处理的碳负离子前体的烷基/芳基碘化物用碳同位素标记的一氧化碳进行光引发羰基化的方法和试剂。所得到的碳同位素标记酮和药学上可接受的盐和溶剂化物可用作放射性药物，特别是用于正电子发射断层扫描（PET）。还提供了关于PET研究的试剂盒和方法。

4. 发明申请

WO2006082497A1 METHOD FOR THE USE OF [11C] CARBON MONOXIDE IN LABELING SYNTHESIS OF 11C-LABELLED COMPOUNDS BY THERMALLY INDUCED FREE RADICAL CARBONYLATION 审中-公开
标题翻译：使用[11C]一氧化碳在11C标记化合物的标记合成方法中的方法，通过热诱导的自由基碳酸化
公开(公告)号：WO2006082497A1
公开(公告)日：2006-08-10
申请号：PCT/IB2006/000185
申请日：2006-02-01
申请人： GE HEALTHCARE LIMITED , LANGSTROM, Bengt , ITSENKO, Oleksiy , KIHLBERG, Tor
发明人： LANGSTROM, Bengt , ITSENKO, Oleksiy , KIHLBERG, Tor
IPC分类号： C07B59/00 , C07C233/11 , C07C57/30 , C07C69/612 , C07D295/182
CPC分类号： C07D295/185 , A61K51/04 , A61K51/0459 , C07B59/00 , C07B2200/05 , C07C51/10 , C07C67/36 , C07C69/612 , C07C233/11 , C07D295/182 , C07C57/30
摘要： Methods and reagents for thermally initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with nucleophiles are provided. The resultant carbon-isotope labeled compounds are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
摘要翻译：提供了使用具有亲核试剂的烷基/芳基碘与碳同位素标记的一氧化碳进行热引发羰基化的方法和试剂。所得碳同位素标记的化合物可用作放射性药物，特别用于正电子发射断层扫描（PET）。还提供了用于PET研究的相关工具包。

5. 发明申请

WO2005042441A1 METHOD AND APPARATUS FOR THE USE OF [11C] CARBON MONIXIDE IN LABELING SYNTHESIS BY PHOTO-INITIATED CARBONYLATION 审中-公开
标题翻译：使用[11C]二氧化碳在通过光引发碳化合物进行标记合成的方法和装置
公开(公告)号：WO2005042441A1
公开(公告)日：2005-05-12
申请号：PCT/IB2004/003488
申请日：2004-10-25
申请人： AMERSHAM PLC , KIHLBERG, Tor , ITSENKO, Oleksiy , FERM, Tommy , LANGSTROM, Bengt
发明人： KIHLBERG, Tor , ITSENKO, Oleksiy , FERM, Tommy , LANGSTROM, Bengt
IPC分类号： C07B59/00
CPC分类号： C07D295/185 , C01B32/40 , C07B59/00 , C07B2200/05 , C07C233/22 , C07C233/58
摘要： Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using amines and alkyl/aryl iodides are provided. The resultant carbon-isotope labeled amides are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
摘要翻译：提供了使用胺和烷基/芳基碘化物用碳同位素标记的一氧化碳进行光引发羰基化的方法和试剂。所得碳同位素标记的酰胺可用作放射性药物，特别用于正电子发射断层扫描（PET）。还提供了用于PET研究的相关工具包。

6. 发明申请

WO2009029633A1 SYNTHESIS OF [18F]-LABELLED ALKYL MESYLATES USING FLUOROUS SPE SEPARATION 审中-公开
标题翻译：使用荧光分离法合成[18 F] -LABELLED烷基甲酸酯
公开(公告)号：WO2009029633A1
公开(公告)日：2009-03-05
申请号：PCT/US2008/074363
申请日：2008-08-27
申请人： GE HEALTHCARE LIMITED , MEDI-PHYSICS, INC. , LANGSTROM, Bengt , KIHLBERG, Tor
发明人： LANGSTROM, Bengt , KIHLBERG, Tor
IPC分类号： C07B59/00 , C07C303/30 , C07C309/66
CPC分类号： C07C303/30 , C07B59/001 , C07C309/66
摘要： The invention relates to new processes for preparation of 18 F-labelled alkylation reagents that can be used in the alkylation of amines that are suitable for use in labelling of Positron Emission Tomography (PET) radiotracers. (I)
摘要翻译：本发明涉及用于制备18F标记的烷基化试剂的新方法，其可用于适用于标记正电子发射断层扫描（PET）放射性示踪剂的胺的烷基化。（一世）

7. 发明申请

WO2007072182A3 MINIATURIZED LIQUID SURFACE REACTIONS USING NANOMOLAR AMOUNTS OF CONCENTRATED [11C]CARBON DIOXIDE IN A STATIONARY GAS-PHASE 审中-公开
公开(公告)号：WO2007072182A3
公开(公告)日：2007-06-28
申请号：PCT/IB2006/003700
申请日：2006-12-19
申请人： GE HEALTHCARE LIMITED , KIHLBERG, Tor , LANGSTROM, Bengt
发明人： KIHLBERG, Tor , LANGSTROM, Bengt
IPC分类号： C01B31/20 , C07B59/00
摘要： Methods and reagents for miniaturized carboxylation with carbon-isotope labeled carbon dioxide using Grignard reagents or other organometallic reagents in a closable reaction loop or reactor are provided. The resultant carbon-isotope labeled compounds are useful as radiopharmaceuticals or precursors for radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.

8. 发明申请

WO2005054128A3 METHOD AND APPARATUS FOR SYNTHESIS OF [11C] PHOSGEN USING CONCENTRATED [11C] CARBON MONOXIDE WITH UV LIGHT 审中-公开
公开(公告)号：WO2005054128A3
公开(公告)日：2005-06-16
申请号：PCT/IB2004/003907
申请日：2004-11-29
申请人： GE HEALTHCARE LIMITED , KIHLBERG, Tor , FERM, Tommy , LANGSTROM, Bengt
发明人： KIHLBERG, Tor , FERM, Tommy , LANGSTROM, Bengt
IPC分类号： C01B31/28 , A61K51/00
摘要： Methods and systems for labeling synthesis of phosgen by UV light are provided. Methods of synthesizing labeled compounds useful as PET tracers from labeled phosgen are also provided. The resultant carbon-isotope labeled compounds are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography. Associated kits for PET studies are also provided.

9. 发明申请

WO2007069043A2 NON THERMAL PLASMA METHOD TO PREPARE [11C] METHYL IODIDE FROM [11C] METHANE AND IODINE 审中-公开
标题翻译：从[11C]甲烷和碘制备[11C]甲基碘的非热等离子体方法
公开(公告)号：WO2007069043A2
公开(公告)日：2007-06-21
申请号：PCT/IB2006/003588
申请日：2006-12-12
申请人： GE HEALTHCARE LIMITED , ERIKSSON, Jonas , KIHLBERG, Tor , LANGSTROM, Bengt , UHLIN, Johan
发明人： ERIKSSON, Jonas , KIHLBERG, Tor , LANGSTROM, Bengt , UHLIN, Johan
CPC分类号： C07B59/001 , C07B2200/05 , C07C17/10 , C07C19/07
摘要： A method and an apparatus for preparing [ 11 C]methyl iodide from [ 11 C]methane and iodine in a single pass through a non-thermal plasma reactor has been developed. The plasma was created by applying high voltage (400 V / 31 kHz) to electrodes in a stream of helium gas at reduced pressure. The [ 11 C]methane used in the experiments was produced from [ 11 C]carbon dioxide via reduction with hydrogen over nickel. [ 11 C]Methyl iodide was obtained with a specific radioactivity of 412 ± 32 GBq/ mol within 6 min from approximately 24 GBq of [ 11 C]carbon dioxide. The decay corrected radiochemical yield was 13 ± 3% based on [ 11 C]carbon dioxide at start of synthesis. [ 11 C]Flumazenil was synthesized via a N-alkylation with the prepared [ 11 C]methyl iodide. Kit claims for preparing [ 11 C] methyl iodide from a non thermal plasma reactor system are also provided. Methods of use and use of apparatus claims for preparing [ 11 C] methyl iodide from a non thermal plasma reactor system are provided as well.
摘要翻译：已经开发了通过非热等离子体反应器的单程中从[11 C]甲烷和碘制备[11 C]甲基碘的方法和装置。通过在减压下在氦气流中的电极施加高电压（400V / 31kHz）来产生等离子体。实验中使用的[11 C 11 C]甲烷是通过用氢气还原镍从而制备的。在约24GBq的[11 C]二氧化碳的6分钟内，得到特征放射性为412±32GBq / mol的甲基碘。在合成开始时，基于[11 C]二氧化碳的衰变校正放射化学产率为13±3％。通过N-烷基化与所制备的[11 C]甲基碘合成氟马西尼。还提供了用于从非热等离子体反应器系统制备[11 C 11]甲基碘的试剂盒。还提供了从非热等离子体反应器系统制备[11 C]甲基碘的设备权利要求的使用和使用方法。

10. 发明申请

WO2006008603A1 METHODS AND APPARATUS FOR PRODUCTION AND USE OF [11C] CARBON MONOXIDE IN LABELING SYNTHESIS 审中-公开
标题翻译： [11C]一氧化碳在标签合成中的生产和使用的方法和装置
公开(公告)号：WO2006008603A1
公开(公告)日：2006-01-26
申请号：PCT/IB2005/001939
申请日：2005-07-08
申请人： GE HEALTHCARE LIMITED , KIHLBERG, Tor , LANGSTROM, Bengt , FERM, Tommy , ERIKSSON, Jonas
发明人： KIHLBERG, Tor , LANGSTROM, Bengt , FERM, Tommy , ERIKSSON, Jonas
IPC分类号： C01B31/18
CPC分类号： C07B59/00 , B01J3/04 , B01J19/02 , B01J2219/00006 , B01J2219/0245
摘要： Methods and apparatus for production and use of carbon-isotope monoxide in labeling synthesis are provided. The resultant carbon-isotope labeled reagents are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided
摘要翻译：提供了碳标记合成中碳同位素一氧化碳生产和使用的方法和设备。所得碳同位素标记的试剂可用作放射性药物，特别用于正电子发射断层扫描（PET）。还提供了用于PET研究的相关工具包

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