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1. 发明申请

WO2013011115A1 PRECURSOR COMPOUNDS AND METHODS FOR MAKING SAME 审中-公开
标题翻译：前体化合物及其制备方法
公开(公告)号：WO2013011115A1
公开(公告)日：2013-01-24
申请号：PCT/EP2012/064254
申请日：2012-07-20
申请人： GE HEALTHCARE LIMITED , ACHANATH, Radha , BALAJI, Srinath , KADAVILPPARAMPU MOHAMED, Afsal, Mohammed , NILSEN, Sondre , FAIRWAY, Steven, Michael
发明人： ACHANATH, Radha , BALAJI, Srinath , KADAVILPPARAMPU MOHAMED, Afsal, Mohammed , NILSEN, Sondre , FAIRWAY, Steven, Michael
IPC分类号： C07C41/44 , C07C43/174 , C07C45/42 , C07C49/757
CPC分类号： C07C45/78 , C07C41/44 , C07C43/174 , C07C45/42 , C07C49/757 , C07C319/20 , C07C2601/04 , C07C49/753 , C07C323/65
摘要： The present invention relates to a method of obtaining radiopharmaceutical precursors, and in particular precursors to protected amino acid derivatives, which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging procedures, such as positron emission tomography (PET).
摘要翻译：本发明涉及一种获得放射性药物前体的方法，特别是被保护的氨基酸衍生物的前体，其用作用于生物体内成像过程如正电子发射断层摄影（PET）的放射性标记氨基酸的前体。

2. 发明申请

WO2011117421A1 TRICYCLIC INDOLE DERIVATIVES AS PBR LIGANDS 审中-公开
标题翻译：作为PBR配比的三聚吲哚类衍生物
公开(公告)号：WO2011117421A1
公开(公告)日：2011-09-29
申请号：PCT/EP2011/054744
申请日：2011-03-28
申请人： GE HEALTHCARE LIMITED , ACHANATH, Radha , BALAJI, Srinath , FAIRWAY, Steven, Michael , MANTZILAS, Dimitrios , MOKKAPATI, Umamaheshwar , O'SHEA, Dennis , PASSMORE, Joanna, Marie , SHAN, Bo , TRIGG, William, John , WADSWORTH, Harry, John , KADAVILPPARAMPU MOHAMED, Afsal, Mohammed
发明人： ACHANATH, Radha , BALAJI, Srinath , FAIRWAY, Steven, Michael , MANTZILAS, Dimitrios , MOKKAPATI, Umamaheshwar , O'SHEA, Dennis , PASSMORE, Joanna, Marie , SHAN, Bo , TRIGG, William, John , WADSWORTH, Harry, John , KADAVILPPARAMPU MOHAMED, Afsal, Mohammed
IPC分类号： C07D209/80 , C07D495/04 , A61K51/04
CPC分类号： C07D209/88 , A61K51/0446
摘要： The present invention provides a PET tracer that has improved properties for imaging the peripheral benzodiazepine receptor (PBR) as compared with known such PET tracers. The present invention also provides a precursor compound useful in the preparation of the PET tracer of the invention and methods for the preparation of said precursor compound and said PET tracer. Also provided by the present invention is a radiopharmaceutical composition comprising the PET tracer of the invention. Methods for using the PET tracer and the radiopharmaceutical composition are also provided.
摘要翻译：本发明提供了与已知的这种PET示踪剂相比具有改进的外周苯并二氮杂受体（PBR）成像的特性的PET示踪剂。本发明还提供了可用于制备本发明的PET示踪剂的前体化合物和用于制备所述前体化合物和所述PET示踪剂的方法。本发明还提供了包含本发明的PET示踪剂的放射性药物组合物。还提供了使用PET示踪剂和放射性药物组合物的方法。

3. 发明申请

WO2012001050A1 DYE COMPOSITIONS AND DYE SYNTHESES 审中-公开
标题翻译： DYE组合物和染料合成
公开(公告)号：WO2012001050A1
公开(公告)日：2012-01-05
申请号：PCT/EP2011/060919
申请日：2011-06-29
申请人： GE HEALTHCARE AS , ACHANATH, Radha , BALAJI, Srinath , JOHANSEN, John, Henrik
发明人： ACHANATH, Radha , BALAJI, Srinath , JOHANSEN, John, Henrik
IPC分类号： C09B67/22 , G01N33/533 , G01N33/58
CPC分类号： C09B23/086 , C07D209/14 , C09B67/0034 , G01N33/583
摘要： The present invention relates to sulfonated optical dye compositions, especially dyes suitable for biological applications in vitro , and for in vivo imaging. Improved dye compositions and intermediates are provided, which enable the suppression of undesirable newly-identified impurities. Also provided is the use of the improved dye compositions in the preparation of conjugates with biological targeting molecules.
摘要翻译：本发明涉及磺化光学染料组合物，特别是适用于体外生物应用的染料和用于体内成像的染料。提供改进的染料组合物和中间体，其能够抑制不期望的新鉴定的杂质。还提供了改进的染料组合物在与生物靶向分子的共轭物的制备中的用途。

4. 发明申请

WO2008062436A4 ANTIMICROBIAL DERIVATIVES OF ANACARDIC ACID AND PROCESS FOR PREPARING THE SAME 审中-公开
公开(公告)号：WO2008062436A4
公开(公告)日：2008-05-29
申请号：PCT/IN2007/000386
申请日：2007-08-24
申请人： UNICHEM LABORATORIES LTD. , ACHANATH, Radha , SRINIVAS, Malladi , RAMADOSS, Candadai Seshadri
发明人： ACHANATH, Radha , SRINIVAS, Malladi , RAMADOSS, Candadai Seshadri
IPC分类号： A61K38/00
摘要： Derivatives of anacardic acid having antimicrobial properties and method for preparing said derivatives. The antimicrobial properties include bacteriostatic and bacteriocidal activity.

5. 发明申请

WO2014001538A1 IMAGING FIBROSIS 审中-公开
标题翻译：成像纤维
公开(公告)号：WO2014001538A1
公开(公告)日：2014-01-03
申请号：PCT/EP2013/063702
申请日：2013-06-28
申请人： GE HEALTHCARE LIMITED
发明人： OLSSON, Andreas , ACHANATH, Radha , IVESON, Peter, Brian , TUCH, David
IPC分类号： A61K51/04
CPC分类号： A61K51/0478 , A61K2123/00 , C07F5/025
摘要： The present invention provides a labelled compound suitable for use as an in vivo imaging agent. The in vivo imaging agent of the invention is useful in the in vivo diagnosis and imaging of fibrosis and in particular fibrosis in the liver. Also provided by the present invention is a method for the preparation of the labelled compound of the invention and a precursor compound useful in said method and a kit useful for carrying out said method. In addition, the present invention provides a pharmaceutical composition comprising the labelled compound of the invention as well as a method of in vivo imaging using the labelled compound of the invention, preferably as the pharmaceutical composition of the invention.
摘要翻译：本发明提供了适合用作体内显像剂的标记化合物。本发明的体内显像剂可用于肝纤维化，特别是纤维化的体内诊断和成像。本发明还提供了制备本发明的标记化合物的方法和可用于所述方法的前体化合物和用于实施所述方法的试剂盒。此外，本发明提供包含本发明的标记化合物的药物组合物以及优选作为本发明的药物组合物的本发明的标记化合物的体内成像方法。

6. 发明申请

WO2013041682A1 NOVEL SYNTHESIS METHOD 审中-公开
标题翻译：新的合成方法
公开(公告)号：WO2013041682A1
公开(公告)日：2013-03-28
申请号：PCT/EP2012/068662
申请日：2012-09-21
申请人： GE HEALTHCARE LIMITED
发明人： ACHANATH, Radha , JOSE, Jinto , RANGASWAMY, Chitralekha , MANDAL, Subrata , BALAJI, Srinath , KADAVILPPARAMPU MOHAMED, Afsal, Mohammed , NEWINGTON, Ian, Martin
IPC分类号： C07D401/12
CPC分类号： C07D213/75 , C07D401/12
摘要： The present invention relates to a method of making compounds having affinity for the 1 A subtype of the serotonin receptor, i.e. 5HT 1A . The method of the present invention provides advantages over the known methods of synthesis. The compounds obtained by the method of the invention have use in therapeutic methods. The compounds of the invention may also optionally compose a moiety suitable for detection by an in vivo imaging procedure and as such these compounds have use in in vivo imaging methods. The compounds have particular use in the treatment and diagnosis of various neurological and/or psychiatric disorders.
摘要翻译：本发明涉及制备对5-羟色胺受体的1A亚型（即5HT1A）具有亲和性的化合物的方法。本发明的方法提供了优于已知的合成方法的优点。通过本发明方法获得的化合物可用于治疗方法。本发明的化合物还可以任选地构成适于通过体内成像程序检测的部分，因此这些化合物可用于体内成像方法。该化合物特别用于治疗和诊断各种神经和/或精神疾病。

7. 发明授权

EP2734494B1 PRECURSOR COMPOUNDS AND METHODS FOR MAKING SAME 有权
公开(公告)号：EP2734494B1
公开(公告)日：2019-01-02
申请号：EP12737563.2
申请日：2012-07-20
申请人： GE Healthcare Limited
发明人： ACHANATH, Radha , BALAJI, Srinath , KADAVILPPARAMPU MOHAMED, Afsal, Mohammed , NILSEN, Sondre , FAIRWAY, Steven, Michael
IPC分类号： C07C41/44 , C07C43/174 , C07C45/42 , C07C49/757

8. 发明公开

EP2866842A1 IMAGING FIBROSIS 审中-公开
标题翻译： BILDGEBUNG VON FIBROSE
公开(公告)号：EP2866842A1
公开(公告)日：2015-05-06
申请号：EP13732924.9
申请日：2013-06-28
申请人： GE Healthcare Limited
发明人： OLSSON, Andreas , ACHANATH, Radha , IVESON, Peter, Brian , TUCH, David
IPC分类号： A61K51/04
CPC分类号： A61K51/0478 , A61K2123/00 , C07F5/025
摘要： The present invention provides a labelled compound suitable for use as an
in vivo imaging agent. The
in vivo imaging agent of the invention is useful in the
in vivo diagnosis and imaging of fibrosis and in particular fibrosis in the liver. Also provided by the present invention is a method for the preparation of the labelled compound of the invention and a precursor compound useful in said method and a kit useful for carrying out said method. In addition, the present invention provides a pharmaceutical composition comprising the labelled compound of the invention as well as a method of
in vivo imaging using the labelled compound of the invention, preferably as the pharmaceutical composition of the invention.
摘要翻译：本发明提供了适合用作体内显像剂的标记化合物。本发明的体内显像剂可用于肝纤维化，特别是纤维化的体内诊断和成像。本发明还提供了制备本发明的标记化合物的方法和可用于所述方法的前体化合物和用于实施所述方法的试剂盒。此外，本发明提供了包含本发明的标记化合物的药物组合物以及优选作为本发明的药物组合物的本发明的标记化合物的体内成像方法。

9. 发明公开

EP2758390A1 NOVEL SYNTHESIS METHOD 审中-公开
标题翻译：新合成方法
公开(公告)号：EP2758390A1
公开(公告)日：2014-07-30
申请号：EP12766422.5
申请日：2012-09-21
申请人： GE Healthcare Limited
发明人： ACHANATH, Radha , JOSE, Jinto , RANGASWAMY, Chitralekha , MANDAL, Subrata , BALAJI, Srinath , KADAVILPPARAMPU MOHAMED, Afsal, Mohammed , NEWINGTON, Ian, Martin
IPC分类号： C07D401/12
CPC分类号： C07D213/75 , C07D401/12
摘要： The present invention relates to a method of making compounds having affinity for the 1 A subtype of the serotonin receptor, i.e. 5HT
1A . The method of the present invention provides advantages over the known methods of synthesis. The compounds obtained by the method of the invention have use in therapeutic methods. The compounds of the invention may also optionally compose a moiety suitable for detection by an in vivo imaging procedure and as such these compounds have use in in vivo imaging methods. The compounds have particular use in the treatment and diagnosis of various neurological and/or psychiatric disorders.

10. 发明授权

EP2552891B1 TRICYCLIC INDOLE DERIVATIVES AS PBR LIGANDS 有权
公开(公告)号：EP2552891B1
公开(公告)日：2018-08-08
申请号：EP11710228.5
申请日：2011-03-28
申请人： GE Healthcare Limited
发明人： ACHANATH, Radha , BALAJI, Srinath , FAIRWAY, Steven, Michael , MANTZILAS, Dimitrios , MOKKAPATI, Umamaheshwar , O'SHEA, Dennis , PASSMORE, Joanna, Marie , SHAN, Bo , TRIGG, William, John , WADSWORTH, Harry, John , KADAVILPPARAMPU MOHAMED, Afsal, Mohammed
IPC分类号： A61K51/04 , C07D209/88 , C07D495/04 , A61K101/02
CPC分类号： C07D209/88 , A61K51/0446
摘要： The present invention provides a PET tracer that has improved properties for imaging the peripheral benzodiazepine receptor (PBR) as compared with known such PET tracers. The present invention also provides a precursor compound useful in the preparation of the PET tracer of the invention and methods for the preparation of said precursor compound and said PET tracer. Also provided by the present invention is a radiopharmaceutical composition comprising the PET tracer of the invention. Methods for using the PET tracer and the radiopharmaceutical composition are also provided.

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