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1. 发明申请

WO2013034611A1 HOLLOW FIBER MEMBRANE 审中-公开
标题翻译：中空纤维膜
公开(公告)号：WO2013034611A1
公开(公告)日：2013-03-14
申请号：PCT/EP2012/067353
申请日：2012-09-06
申请人： GAMBRO LUNDIA AB , KRAUSE, Bernd , ZWEIGART, Carina , HORNUNG, Markus , MENDA, Ralf
发明人： KRAUSE, Bernd , ZWEIGART, Carina , HORNUNG, Markus , MENDA, Ralf
IPC分类号： B01D71/68 , B01D67/00 , B01D69/08 , B01D71/78 , C08L81/06
CPC分类号： B01D67/0009 , B01D67/0011 , B01D69/08 , B01D69/087 , B01D71/44 , B01D71/68 , B01D71/78 , B01D2323/02 , B01D2323/38
摘要： The present invention relates to a semipermeable asymmetric hollow fiber membrane, the membrane material being a graft copolymer of at least one hydrophobic polymer and at least one hydrophilic polymer. The invention also relates to processes for the preparation of said membranes, devices comprising said membranes, and the use of said membranes in hemodialysis, hemodiafiltration or hemofiltration of blood as well as in bioprocessing, plasma fractionation and the preparation of protein solutions.
摘要翻译：本发明涉及半透非对称中空纤维膜，该膜材料是至少一种疏水性聚合物和至少一种亲水性聚合物的接枝共聚物。本发明还涉及制备所述膜的方法，包括所述膜的装置以及所述膜在血液透析，血液透析滤过或血液血液滤过以及生物处理，血浆分级分离和蛋白质溶液的制备中的用途。

2. 发明申请

WO2010133613A1 MEMBRANES HAVING IMPROVED PERFORMANCE 审中-公开
标题翻译：具有改进性能的膜
公开(公告)号：WO2010133613A1
公开(公告)日：2010-11-25
申请号：PCT/EP2010/056845
申请日：2010-05-19
申请人： GAMBRO LUNDIA AB , KRAUSE, Bernd , ZWEIGART, Carina , BEHR, Heinrich
发明人： KRAUSE, Bernd , ZWEIGART, Carina , BEHR, Heinrich
IPC分类号： B01D69/08 , B01D71/56 , B01D71/68 , D01F1/08
CPC分类号： B01D69/088 , A61M1/16 , A61M1/34 , A61M1/3403 , A61M1/341 , A61M1/3413 , A61M1/3496 , A61M2205/15 , B01D71/56 , B01D71/68
摘要： The present invention relates to permselective asymmetric membranes being suitable e.g. for hemodialysis, hemodiafiltration and hemofiltration of blood, and having improved performance, allowing for enhanced removal of middle molecular weight substances, e.g. inflammatory mediators having a molecular weight between 20 and 40 kDa. The improved sieving characteristics are due to a narrow pore size distribution of the membranes created in the production process. The invention also relates to processes for the preparation of said membranes, devices comprising said membranes, and the use of said membranes in hemodialysis, hemodiafiltration or hemofiltration of blood, as well as in bioprocessing, plasma fractionation and the preparation of protein solutions.
摘要翻译：本发明涉及选择性不对称膜，例如合适的。用于血液透析，血液透析过滤和血液的血液滤过，并且具有改善的性能，允许增强中等分子量物质的去除，例如，具有20至40kDa分子量的炎性介质。改进的筛分特性是由于在生产过程中产生的膜的孔径分布窄。本发明还涉及制备所述膜的方法，包括所述膜的装置，以及所述膜在血液透析，血液透析滤过或血液过滤中的用途，以及生物处理，血浆分级分离和蛋白质溶液的制备。

3. 发明申请

WO2010133612A1 MEMBRANES HAVING IMPROVED PERFORMANCE 审中-公开
标题翻译：具有改进性能的膜
公开(公告)号：WO2010133612A1
公开(公告)日：2010-11-25
申请号：PCT/EP2010/056844
申请日：2010-05-19
申请人： GAMBRO LUNDIA AB , KRAUSE, Bernd , ZWEIGART, Carina
发明人： KRAUSE, Bernd , ZWEIGART, Carina
IPC分类号： B01D69/08 , B01D71/40 , B01D71/68 , B01D67/00 , D01F1/08
CPC分类号： B01D69/08 , B01D67/0088 , B01D67/0093 , B01D71/40 , B01D71/68 , B01D71/76
摘要： The present invention relates to permselective asymmetric membranes being suitable e.g. for hemodialysis, hemodiafiltration and hemofiltration of blood, and having improved sieving characteristics allowing for enhanced removal of middle molecular weight substances, e.g. inflammatory mediators having a molecular weight between 20 and 40 kDa. The membranes comprise polyethersulfone and polyvinylpyrrolidone and are coated with hyaluronic acid or copolymers of 2-methacryloyloxyethyl phosphoryl choline and other vinyl polymerizable monomers. The invention also relates to processes for the preparation of said membranes, devices comprising said membranes, and the use of said membranes in hemodialysis, hemodiafiltration or hemofiltration of blood, as well as in bioprocessing, plasma fractionation and the preparation of protein solutions.
摘要翻译：本发明涉及选择性不对称膜，例如合适的。用于血液透析，血液透析过滤和血液的血液滤过，并且具有改善的筛分特性，允许增强中等分子量物质的去除。具有20至40kDa分子量的炎性介质。膜包含聚醚砜和聚乙烯吡咯烷酮，并用透明质酸或2-甲基丙烯酰氧基乙基磷酰胆碱和其它乙烯基可聚合单体的共聚物涂覆。本发明还涉及制备所述膜的方法，包括所述膜的装置，以及所述膜在血液透析，血液透析滤过或血液血液滤过以及生物处理，血浆分级分离和蛋白质溶液制备中的用途。

4. 发明申请

WO2010034468A1 MEMBRANE FOR CELL EXPANSION 审中-公开
标题翻译：细胞扩增膜
公开(公告)号：WO2010034468A1
公开(公告)日：2010-04-01
申请号：PCT/EP2009/006849
申请日：2009-09-23
申请人： GAMBRO LUNDIA AB , ZWEIGART, Carina , KRAUSE, Bernd , NEUBAUER, Markus , DEPPISCH, Doris
发明人： ZWEIGART, Carina , KRAUSE, Bernd , NEUBAUER, Markus
IPC分类号： B01D71/68 , B01D71/54 , A61L15/24
CPC分类号： C12N5/0068 , A61L27/26 , A61L27/38 , B01D67/009 , B01D67/0095 , B01D69/02 , B01D69/06 , B01D69/08 , B01D71/44 , B01D71/54 , B01D71/56 , B01D71/68 , B01D2323/34 , B01D2325/36 , C12N2533/30 , C08L81/06
摘要： The invention relates to a membrane which can be used for cultivating cells, in particular adherent cells, wherein said membrane allows for the adhesion and proliferation of the cells based on its specific composition comprising polyurethane and the resulting surface characteristics further allow the membrane to be used without any pre-treatment with surface modifying substances. The invention further relates to a method for preparing a membrane which can be used for cultivating cells, in particular adherent cells, and to methods of using such membrane for cultivating cells, in particular adherent cells.
摘要翻译：本发明涉及可用于培养细胞，特别是贴壁细胞的膜，其中所述膜基于其包含聚氨酯的特定组合物允许细胞的粘附和增殖，并且所得表面特征进一步允许使用膜没有任何表面改性物质的预处理。本发明还涉及可用于培养细胞，特别是贴壁细胞的膜的制备方法，以及使用这种膜来培养细胞，特别是贴壁细胞的方法。

5. 发明申请

WO2010133615A1 MEMBRANES HAVING IMPROVED PERFORMANCE 审中-公开
标题翻译：具有改进性能的膜
公开(公告)号：WO2010133615A1
公开(公告)日：2010-11-25
申请号：PCT/EP2010/056847
申请日：2010-05-19
申请人： GAMBRO LUNDIA AB , KRAUSE, Bernd , ZWEIGART, Carina
发明人： KRAUSE, Bernd , ZWEIGART, Carina
IPC分类号： B01D69/08 , B01D71/40 , B01D71/68 , B01D67/00 , D01F1/08
CPC分类号： B01D69/08 , B01D67/0088 , B01D67/0093 , B01D71/40 , B01D71/68
摘要： The present invention relates to permselective asymmetric membranes being suitable e.g. for hemodialysis, hemodiafiltration and hemofiltration of blood, and having improved performance, allowing for enhanced removal of middle molecular weight substances, e.g. inflammatory mediators having a molecular weight between 20 and 40 kDa. The membranes are modified with particular polysulf obetaines. The invention also relates to processes for the preparation of said membranes, devices comprising said membranes, and the use of said membranes in hemodialysis, hemodiafiltration or hemofiltration of blood, as well as in bioprocessing, plasma fractionation and the preparation of protein solutions.
摘要翻译：本发明涉及选择性不对称膜，例如合适的。用于血液透析，血液透析过滤和血液的血液滤过，并且具有改善的性能，允许增强中等分子量物质的去除，例如，具有20至40kDa分子量的炎性介质。膜被特定的聚磺酸酯改性。本发明还涉及制备所述膜的方法，包括所述膜的装置，以及所述膜在血液透析，血液透析滤过或血液血液滤过以及生物处理，血浆分级分离和蛋白质溶液制备中的用途。

6. 发明申请

WO2010133614A1 MEMBRANES HAVING IMPROVED PERFORMANCE 审中-公开
标题翻译：具有改进性能的膜
公开(公告)号：WO2010133614A1
公开(公告)日：2010-11-25
申请号：PCT/EP2010/056846
申请日：2010-05-19
申请人： GAMBRO LUNDIA AB , KRAUSE, Bernd , ZWEIGART, Carina
发明人： KRAUSE, Bernd , ZWEIGART, Carina
IPC分类号： B01D69/08 , B01D71/40 , B01D71/68 , B01D67/00 , D01F1/08
CPC分类号： B01D69/08 , B01D67/0088 , B01D67/0093 , B01D71/40 , B01D71/68
摘要： The present invention relates to permselective asymmetric membranes being suitable e.g. for hemodialysis, hemodiafiltration and hemofiltration of blood, and having improved sieving characteristics allowing for enhanced removal of middle molecular weight substances, e.g. inflammatory mediators having a molecular weight between 20 and 40 kDa. The membranes are modified with a polycarboxybetaine based on copolymers of vinylpyrrolidone and vinylimidazole. The invention also relates to processes for the preparation of said membranes, devices comprising said membranes, and the use of said membranes in hemodialysis, hemodiafiltration or hemofiltration of blood, as well as in bioprocessing, plasma fractionation and the preparation of protein solutions.
摘要翻译：本发明涉及选择性不对称膜，例如合适的。用于血液透析，血液透析过滤和血液的血液滤过，并且具有改善的筛分特性，允许增强中等分子量物质的去除。具有20至40kDa分子量的炎性介质。用基于乙烯基吡咯烷酮和乙烯基咪唑的共聚物的聚羧基甜菜碱修饰膜。本发明还涉及制备所述膜的方法，包括所述膜的装置，以及所述膜在血液透析，血液透析滤过或血液血液滤过以及生物处理，血浆分级分离和蛋白质溶液制备中的用途。

7. 发明申请

WO2013057161A1 PROCESS FOR CONTINUOUSLY WASHING A HOLLOW FIBRE MEMBRANE FOR DEPLETING RESIDUALS 审中-公开
标题翻译：连续清洗中空纤维膜用于清除残留物的方法
公开(公告)号：WO2013057161A1
公开(公告)日：2013-04-25
申请号：PCT/EP2012/070604
申请日：2012-10-18
申请人： GAMBRO LUNDIA AB
发明人： KRAUSE, Bernd , ZWEIGART, Carina , BECK, Christof , HERTZLER, Bernd , WAGNER, Steffen , LOERCHER, Joachim
IPC分类号： B01D67/00 , B01D69/08 , D01D5/24 , B01D65/02
CPC分类号： B01D65/02 , B01D67/003 , B01D67/0088 , B01D69/087 , B01D2321/00 , B01D2321/2066 , B01D2321/2075 , B01D2321/26 , B01D2321/30 , B01D2323/42
摘要： The present disclosure relates to continuous processes for depleting residuals in hollow fiber membranes comprising polysulfone or polyethersulfone and polyvinylpyrrolidone by means of rinsing the membranes while compressing them in a pinching device (20) comprising grooved rollers (22).
摘要翻译：本公开涉及通过在包括沟槽辊（22）的夹持装置（20）中压缩它们的同时冲洗膜来消耗包含聚砜或聚醚砜和聚乙烯吡咯烷酮的中空纤维膜中残留物的连续方法。

8. 发明申请

WO2019016246A1 FILTER MEMBRANE AND DEVICE 审中-公开
公开(公告)号：WO2019016246A1
公开(公告)日：2019-01-24
申请号：PCT/EP2018/069458
申请日：2018-07-18
申请人： GAMBRO LUNDIA AB
发明人： MENDA, Ralf , HARTMANN, Evelyn , ZWEIGART, Carina , BAUER, Bernd , SCHUSTER, Michael
IPC分类号： B01D67/00 , B01D69/02 , B01D71/44 , B01D71/68 , B01D71/82
摘要： The present disclosure relates to a microporous hollow fiber filter membrane having a large inner diameter and a thin wall. The fiber can be used for sterile filtration of liquids or removal of particles from liquids. The disclosure further relates to a method for producing the membrane and a filter device comprising the membrane.

9. 发明申请

WO2018188973A1 OPTIMIZED HEMODIALYZER FOR BLOOD PURIFICATION 审中-公开
公开(公告)号：WO2018188973A1
公开(公告)日：2018-10-18
申请号：PCT/EP2018/058216
申请日：2018-03-29
申请人： GAMBRO LUNDIA AB
发明人： DONATO, Danilo , ELOOT, Sunny , ZWEIGART, Carina , BOSCHETTI-DE-FIERRO, Adriana , KOLB, Michael , KRAUSE, Bernd , STORR, Markus
IPC分类号： B01D61/28 , B01D63/02 , B01D69/08 , A61M1/16 , B01D61/24 , B01D71/42
摘要： The present disclosure concerns a hemodialyzer for the purification of blood and use thereof. The hemodialyzer comprises a bundle of hollow fiber membranes, wherein the hollow fiber membranes have an inner diameter (d B ) within the range of 168-175 μιτι, a fiber wall thickness (δ m ) within the range of 25-26 μιτι, and an effective length (L) within the hemodialyzer within the range of 207-287 mm. The bundle of hollow fiber membranes has a packing density within the range of 57.5-60.0%, and a total membrane surface area (A tot ) within the range of from 1.64 to 1.73 m 2 .

10. 发明申请

WO2015118046A1 HEMODIALYZER FOR BLOOD PURIFICATION 审中-公开
标题翻译：血液透析器用于血液净化
公开(公告)号：WO2015118046A1
公开(公告)日：2015-08-13
申请号：PCT/EP2015/052365
申请日：2015-02-05
申请人： GAMBRO LUNDIA AB
发明人： HORNUNG, Markus , KRAUSE, Bernd , STORR, Markus , HERBST, Philipp , WOCHNER, Arnd , BOSCHETTI-DE-FIERRO, Adriana , VOIGT, Manuel , ZWEIGART, Carina , LOERCHER, Joachim , BUCK, Reinhold , BEHR, Heinrich , BECK, Werner
IPC分类号： B01D61/24 , B01D63/02 , B01D69/08 , B01D71/44 , B01D71/68
CPC分类号： B01D71/68 , A61M1/3479 , B01D61/243 , B01D63/021 , B01D69/084 , B01D69/087 , B01D71/38 , B01D71/44 , B01D2323/06 , B01D2323/12 , B01D2325/022 , B01D2325/20
摘要： The present disclosure relates to a dialyzer comprising a bundle of semipermeable hollow fiber membranes which is suitable for blood purification, wherein the dialyzer has an increased ability to remove larger molecules while at the same time it is able to effectively remove small uremic toxins and efficiently retain albumin and larger proteins. The invention also relates to using said dialyzer in hemodialysis.
摘要翻译：本公开涉及一种透析器，其包括适于血液净化的半透明中空纤维膜束，其中所述透析器具有增加去除较大分子的能力，同时能够有效去除小的尿毒症毒素并有效保留白蛋白和较大的蛋白质。本发明还涉及在血液透析中使用所述透析器。

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