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1. 发明申请

WO2015091082A1 AN APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT AND A CONTROL METHOD THEREFOR 审中-公开
标题翻译：用于提取血液治疗的装置及其控制方法
公开(公告)号：WO2015091082A1
公开(公告)日：2015-06-25
申请号：PCT/EP2014/076956
申请日：2014-12-09
申请人： GAMBRO LUNDIA AB
发明人： SOLEM, Kristian , STEFANI, David , HOBRO, Sture , OLDE, Bo
IPC分类号： A61M1/36 , G01F23/14
CPC分类号： A61M1/3627 , A61M1/3624 , A61M1/3626 , A61M1/367 , A61M2205/123 , A61M2205/3331 , A61M2205/3386 , A61M2205/3389 , G01F23/14 , G01F23/18
摘要： An apparatus (1) is described for extracorporeal blood treatment, comprising a treatment unit (2), an extracorporeal blood circuit (8) and a fluid evacuation line (10). A venous chamber (12) is placed in a blood return line (7) and isarranged in use to contain a gas in an upper portion (120) and blood at a predetermined level in a lower portion. The apparatus (1) comprises a control unit (21) connected to a first pressure sensor (14) and configured to: receive from the first pressure sensor (14) a first signal (P1(t)) relating to a time variable pressure (P(t)) of the blood flow; calculate a phase shift (θ) between the first signal (P1(t)) and a reference signal (P2(t)) correlated to the time variable pressure (P(t)) detected at a location distinct from the upper portion (120) of the chamber (12); monitorthe volume (V) of gas in the upper portion (120) of the chamber (12)through the phase shift (θ).
摘要翻译：一种用于体外血液处理的装置（1），其包括处理单元（2），体外血液回路（8）和排液管线（10）。静脉腔室（12）被放置在血液回流管线（7）中，并且在使用中被排列成在上部（120）中容纳气体，并在下部含有预定水平的血液。装置（1）包括连接到第一压力传感器（14）并被配置为：从第一压力传感器（14）接收与时间可变压力相关的第一信号（P1（t））的控制单元（21） P（t））; 计算第一信号（P1（t））和与在与上部不同的位置处检测到的时间可变压力（P（t））相关的参考信号（P2（t））之间的相移（θ））; 通过相移（θ）在腔室（12）的上部（120）中的气体的单调体积（V）。

2. 发明申请

WO2021053201A1 NON-INVASIVE SENSOR FOR DETERMINING A HEARTBEAT AND/OR HEART RATE IN A SEGMENT OF AN EXTRACORPOREAL BLOOD CIRCUIT 审中-公开
公开(公告)号：WO2021053201A1
公开(公告)日：2021-03-25
申请号：PCT/EP2020/076200
申请日：2020-09-18
申请人： GAMBRO LUNDIA AB
发明人： ROVATTI, Paolo , RUFFO, Mariano , STEFANI, David
IPC分类号： A61M1/36 , A61B5/024 , A61B5/00
摘要： Non-invasive heartbeat sensor for determining a heart rate in a conduit of an extracorporeal blood treatment apparatus, comprising one source for directing an optical signal towards the blood flowing in the segment; one detector for receiving an optical informative signal comprising the signal emitted by said source after passing the blood, and emitting respective output signal; a controller receiving the respective output signal and retrieving a heartbeat frequency and a heart rate value, based on the output signal, wherein the informative signal is altered by flow perturbation of the blood partially generated by the flow impulses originated by the heart.

3. 发明申请

WO2015004030A1 AN APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT AND A RELATED CONTROL METHOD 审中-公开
标题翻译：用于超临界血液治疗的装置和相关控制方法
公开(公告)号：WO2015004030A1
公开(公告)日：2015-01-15
申请号：PCT/EP2014/064357
申请日：2014-07-04
申请人： GAMBRO LUNDIA AB
发明人： STEFANI, David , RUFFO, Mariano
IPC分类号： A61M1/36 , A61B5/00 , A61B5/021
CPC分类号： A61M1/3639 , A61B5/02141 , A61B5/08 , A61B5/4836 , A61B5/6866 , A61M1/16 , A61M1/267 , A61M1/36 , A61M1/3607 , A61M1/3653 , A61M1/3656 , A61M2205/3331 , A61M2205/3344 , A61M2205/3365 , A61M2205/52
摘要： An apparatus for extracorporeal blood treatment (1) is described, comprising a treatment unit (3) having at least a first chamber (4) and at least a second chamber (5) separated from one another by a semi-permeable membrane (6); at least a blood removal line (7) connected to an inlet port (4a) of the first chamber (4) and predisposed to remove blood from a patient (P); at least a blood return line (8) connected to an outlet port (4b) from the first chamber (4) and predisposed to return treated blood to the patient (P), wherein the blood removal line (7), the blood return line (8) and the first chamber (4) are part of an extracorporeal blood circuit (2); at least a peristaltic pump (9) operating at the extracorporeal blood circuit (2) for moving the blood in the circuit; at least a pressure sensor (13, 14) associated to the extracorporeal blood circuit (2) and configured to enable determining pressure values in the extracorporeal blood circuit (2); at least a fluid drainage line (23) connected to an outlet port of the second chamber (5); a control unit (CU) connected to the at least a pressure sensor (13, 14) and to the peristaltic pump (9) and configured to: move the peristaltic pump (9) with a cyclic motion to generate a blood flow; receive from the at least a pressure sensor (13, 14) a signal (Ps) indicating the pressure of the blood in the extracorporeal blood circuit (2). The signal (Ps) indicating the blood pressure is detected with a time domain frequency depending on the velocity (ω) of the peristaltic pump (9), when the peristaltic pump (9) is in a plurality of predefined positions (pp 1 -pp y ). The pressure signal (Ps) is therefore sampled with a constant frequency in the spatial domain (constant at each pump cycle) and independent of the velocity of the pump (9).
摘要翻译：一种体外血液处理装置（1），其特征在于，包括具有至少第一室（4）的处理单元（3）和至少通过半透膜（6）彼此分离的第二室（5） ; 至少一个连接到第一腔室（4）的入口（4a）并且易于从患者（P）去除血液的排血管线（7）; 至少一个血液回流管线（8）从第一腔室（4）连接到出口（4b）并且倾向于将经处理的血液返回给患者（P），其中除血管线（7），血液回流管线（8）和第一腔室（4）是体外血液回路（2）的一部分; 至少一个在体外血液循环（2）上操作以使电路中的血液移动的蠕动泵（9）; 至少一个与体外血液回路（2）相关联的压力传感器（13,14），并被配置为能够确定体外血液回路（2）中的压力值。至少连接到所述第二室（5）的出口的流体排放管线（23）。连接到所述至少一个压力传感器（13,14）和所述蠕动泵（9）的控制单元（CU），并且构造成：以循环运动移动所述蠕动泵（9）以产生血流; 从所述至少一个压力传感器（13,14）接收指示体外血液回路（2）中的血液压力的信号（Ps）。当蠕动泵（9）处于多个预定位置（pp1-ppy）时，根据蠕动泵（9）的速度（ω）以时域频率检测指示血压的信号（Ps）。因此，压力信号（Ps）在空间域中以恒定频率进行采样（在每个泵循环中为常数），而与泵（9）的速度无关。

4. 发明申请

WO2009122229A9 AN APPARATUS AND A METHOD FOR MONITORING A VASCULAR ACCESS 审中-公开
公开(公告)号：WO2009122229A9
公开(公告)日：2009-10-08
申请号：PCT/IB2008/000768
申请日：2008-04-01
申请人： GAMBRO LUNDIA AB , STEFANI, David , LODI, Carlo Alberto , SANNA, Salvatore
发明人： STEFANI, David , LODI, Carlo Alberto , SANNA, Salvatore
IPC分类号： A61M5/168
摘要： An apparatus for monitoring a vascular access comprises a dialysis circuit having a venous needle (18) and a blood pump (14) of a peristaltic type which generates oscillatory perturbations in the circuit. An optical sensor (19), arranged on a patient's body by the venous needle, perceives the perturbations transmitted through the needle and sends a pulsating signal to an analysis device (20), absence of which pulsating signal provides an indication of a detachment of the needle.

5. 发明申请

WO2019122348A1 INFUSION SET FOR MEASURING VITAL SIGNALS OF A PATIENT COMPRISING A COMPLIANCE ELEMENT AND A REFLECTIVE ELEMENT 审中-公开
公开(公告)号：WO2019122348A1
公开(公告)日：2019-06-27
申请号：PCT/EP2018/086627
申请日：2018-12-21
申请人： GAMBRO LUNDIA AB
发明人： ROVATTI, Paolo , RUFFO, Mariano , STEFANI, David , GRANDI, Elena
IPC分类号： A61M5/142 , A61M5/172
CPC分类号： A61M5/142 , A61M5/1407 , A61M5/141 , A61M5/1411 , A61M5/14228 , A61M2005/1726 , A61M2205/3341 , A61M2206/22 , A61M2230/04 , A61M2230/30
摘要： There is provided an IV infusion set comprising a patient access configured to connect to a vascular system of a patient, a source of medical fluid, an infusion line having one first end configured to connect to the source of medical fluid and one opposite second end configured to deliver the medical fluid towards the patient access, an infusion apparatus arranged on the infusion line, a sensor configured to emit a pressure signal indicative of a pressure of a medical fluid in the infusion line, and a control unit configured to receive the pressure signal and to determine a patient signal indicative of a vital signal of the patient based on the pressure signal. The IV infusion set further comprises a compliance element configured to attenuate pressure variations of medical fluid the infusion line, and a resistance element configured to reflect pressure waves moving along the infusion line. The sensor is arranged on the infusion line at a position downstream from the resistance element with respect to a direction of fluid flow along the infusion line from the medical fluid source towards the patient access. The infusion line may include a main infusion line and/or one or more auxiliary infusion lines connected to a main infusion line.

6. 发明公开

EP3501571A1 INFUSION SET FOR MEASURING VITAL SIGNALS OF A PATIENT COMPRISING A COMPLIANCE ELEMENT AND A REFLECTIVE ELEMENT 有权转让
公开(公告)号：EP3501571A1
公开(公告)日：2019-06-26
申请号：EP17210526.4
申请日：2017-12-22
申请人： Gambro Lundia AB
发明人： ROVATTI, Paolo , RUFFO, Mariano , STEFANI, David , GRANDI, Elena
IPC分类号： A61M5/142 , A61M5/172
摘要： There is provided an IV infusion set comprising a patient access configured to connect to a vascular system of a patient, a source of medical fluid, an infusion line having one first end configured to connect to the source of medical fluid and one opposite second end configured to deliver the medical fluid towards the patient access, an infusion apparatus arranged on the infusion line, a sensor configured to emit a pressure signal indicative of a pressure of a medical fluid in the infusion line, and a control unit configured to receive the pressure signal and to determine a patient signal indicative of a vital signal of the patient based on the pressure signal. The IV infusion set further comprises a compliance element configured to attenuate pressure variations of medical fluid the infusion line, and a resistance element configured to reflect pressure waves moving along the infusion line. The sensor is arranged on the infusion line at a position downstream from the resistance element with respect to a direction of fluid flow along the infusion line from the medical fluid source towards the patient access. The infusion line may include a main infusion line and/or one or more auxiliary infusion lines connected to a main infusion line.

7. 发明公开

EP4031207A1 NON-INVASIVE SENSOR FOR DETERMINING A HEARTBEAT AND/OR HEART RATE IN A SEGMENT OF AN EXTRACORPOREAL BLOOD CIRCUIT 有权
公开(公告)号：EP4031207A1
公开(公告)日：2022-07-27
申请号：EP20772070.7
申请日：2020-09-18
申请人： Gambro Lundia AB
发明人： ROVATTI, Paolo , RUFFO, Mariano , STEFANI, David
IPC分类号： A61M1/36 , A61B5/024 , A61B5/00

8. 发明授权

EP2288397B1 AN APPARATUS AND A METHOD FOR MONITORING A VASCULAR ACCESS 有权
公开(公告)号：EP2288397B1
公开(公告)日：2019-03-13
申请号：EP08737366.8
申请日：2008-04-01
申请人： Gambro Lundia AB
发明人： STEFANI, David , LODI, Carlo Alberto , SANNA, Salvatore
IPC分类号： A61M5/168

9. 发明公开

EP2288397A1 AN APPARATUS AND A METHOD FOR MONITORING A VASCULAR ACCESS 有权
标题翻译：装置和用于监控血管通路
公开(公告)号：EP2288397A1
公开(公告)日：2011-03-02
申请号：EP08737366.8
申请日：2008-04-01
申请人： Gambro Lundia AB
发明人： STEFANI, David , LODI, Carlo Alberto , SANNA, Salvatore
IPC分类号： A61M5/168
CPC分类号： A61M5/16836 , A61M1/3653 , A61M1/3656 , A61M1/3669 , A61M5/16859 , A61M2205/15 , A61M2205/3306 , A61M2205/3375
摘要： An apparatus for monitoring a vascular access includes a dialysis circuit having a venous needle and a blood pump of a peristaltic type which generates oscillatory perturbations in the circuit. An optical sensor, arranged on a patient's body by the venous needle, perceives the perturbations transmitted through the needle and sends a pulsating signal to an analysis device. The absence of a pulsating signal indicates a detachment of the needle.

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