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1. 发明申请

WO2014199316A1 MODIFIED RELEASE FORMULATION 审中-公开
标题翻译：修改释放公式
公开(公告)号：WO2014199316A1
公开(公告)日：2014-12-18
申请号：PCT/IB2014/062136
申请日：2014-06-11
申请人： GALLI, Bruno , THOMA, Hubert , GRANDEURY, Arnaud , SPICKERMANN, Dirk , PUTZBACH, Karsten , MOLL, Klaus-Peter , UFER, Mike , GLANTZMANN, Jean-Marie , MUELLER-ZSIGMONDY, Martin , NOVARTIS AG
发明人： GALLI, Bruno , THOMA, Hubert , GRANDEURY, Arnaud , SPICKERMANN, Dirk , PUTZBACH, Karsten , MOLL, Klaus-Peter , UFER, Mike , GLANTZMANN, Jean-Marie , MUELLER-ZSIGMONDY, Martin
IPC分类号： A61K9/20 , A61K31/4439
CPC分类号： A61K31/404 , A61J3/02 , A61J3/10 , A61K9/1652 , A61K9/1682 , A61K9/2004 , A61K9/2072 , A61K9/28 , A61K9/50 , A61K9/5089 , A61K31/4045 , A61K47/38
摘要： Drug products in the form of modified release formulations comprising the drug substance (-)-(3aR,4S,7aR)-4-Hydroxy-4m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester (AFQ056), as well as processes for making such drug products are 5 provided. The drug products are useful in treating patients with Parkinson's disease and exhibiting L-dopa induced dyskinesia.
摘要翻译：包含药物（ - ） - （3aR，4S，7aR）-4-羟基-4m-甲苯乙炔基 - 八氢 - 吲哚-1-甲酸甲酯（AFQ056）的改性释放制剂形式的药物产品，以及提供制备这些药物的方法是5。该药物可用于治疗帕金森病患者，并表现出左旋多巴引起的运动障碍。

2. 发明申请

WO2003075895A1 TASTED MASKED VETERINARY SOLID COMPOSITIONS 审中-公开
标题翻译：被烘烤的兽用固体组合物
公开(公告)号：WO2003075895A1
公开(公告)日：2003-09-18
申请号：PCT/EP2003/002446
申请日：2003-03-10
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , THOMA, Hubert , SCHOTE, Uwe, Thomas , ISELE, Ute
发明人： THOMA, Hubert , SCHOTE, Uwe, Thomas , ISELE, Ute
IPC分类号： A61K9/26
CPC分类号： A61K9/5026 , A61K9/2081
摘要： The present invention relates to the supply and production of an animal medicine consisting of a substrate in pellet or tablet form, which is attractive to livestock and domestic animals, in which fine-grained particles of a neutral-tasting, physiologically compatible, solid carrier material are embedded, which is characterised in that said fine-grained particles of carrier material have an average diameter of 0.09 to 0.8 mm and are coated with an active substance from veterinary medicine, and said active substance layer is covered with a protective layer of a physiologically compatible polymer matrix, and to the production of this animal medicine. It also relates to the usage of said double-coated, fine-grained particles of carrier material in the production of a preparation for veterinary medicine.
摘要翻译：本发明涉及一种动物药物的供应和生产，该药物由颗粒或片剂形式的基质组成，其对家畜和家畜具有吸引力，其中中性品味，生理上相容的固体载体材料的细粒颗粒其特征在于，所述载体材料的细粒颗粒的平均直径为0.09至0.8mm，并且由兽医药物涂覆活性物质，并且所述活性物质层被生理学上的保护层覆盖相容的聚合物基质，以及该动物药物的生产。它还涉及在制备兽药制剂中使用载体材料的所述双重涂层细粒颗粒。

3. 发明申请

WO2021009695A1 FORMULATIONS OF (S)-3-AMINO-6-METHOXY-N-(3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPYL)-5-(TRIFLUOROMETHYL)PICOLINAMIDE 审中-公开
公开(公告)号：WO2021009695A1
公开(公告)日：2021-01-21
申请号：PCT/IB2020/056661
申请日：2020-07-15
申请人： NOVARTIS AG
发明人： DUBEY, Vivek , LOWALEKAR, Rohit , SANTOS, Paulo , THOMA, Hubert , TIAN, Xianbin
IPC分类号： A61K31/44 , A61K9/20 , A61K9/16 , A61P11/00 , A61K9/28 , A61K9/00 , A61P43/00 , A61P11/06
摘要： A pharmaceutical composition comprising a. (S)-3-amino-6-methoxy-N-(3,3,3-trifluoro-2-hydroxy-2-methylpropyl) -5-(trifluoromethyl)picolinamide or a pharmaceutically acceptable salt, polymorph, or co-crystal thereof, b. sodium starch glycolate, and c. sodium stearyl fumarate. A pharmaceutical composition comprising a. (S)-3-amino-6-methoxy-N-(3,3,3-trifluoro-2-hydroxy-2-methylpropyl) -5-(trifluoromethyl)picolinamide or a pharmaceutically acceptable salt, polymorph, or co-crystal thereof, b. crospovidone, and c. sodium stearyl fumarate. Said compositions for use in the treatment of bronchiectasis, chronic obstructive pulmonary disorder, cystic fibrosis, chronic bronchitis or asthma. A process for the manufacture of said compositions, comprising the steps of: (a) blending (S)-3-amino-6-methoxy-N-(3,3,3-trifluoro-2- hydroxy-2-methylpropyl)-5-(trifluoromethyl)picolinamide together with sodium starch glycolate to form a material, (b) wet milling the material to form a plurality of granules, (c) blending the granules with sodium stearyl fumarate and sodium starch glycolate to form a final blend, and (d) compressing the final blend into a tablet. A process for the manufacture of said compositions, comprising the steps of: (a) blending (S)-3-amino-6-methoxy-N-(3,3,3-trifluoro-2- hydroxy-2-methylpropyl)-5-(trifluoromethyl)picolinamide together with sodium starch glycolate to form a material, (b) wet milling the material to form a plurality of granules, (c) blending the granules with sodium stearyl fumarate and crospovidone to form a final blend, and (d) compressing the final blend into a tablet.

4. 发明授权

EP1490037B1 TASTE MASKED VETERINARY SOLID COMPOSITIONS 无效
标题翻译： TASTE不包括固体药物剂型动物协会
公开(公告)号：EP1490037B1
公开(公告)日：2008-03-26
申请号：EP03711962.5
申请日：2003-03-10
申请人： Novartis AG , Novartis Pharma GmbH
发明人： THOMA, Hubert , SCHOTE, Uwe, Thomas , ISELE, Ute
IPC分类号： A61K9/26 , A61K9/00
CPC分类号： A61K9/5026 , A61K9/2081
摘要： The present invention relates to the supply and production of an animal medicine consisting of a substrate in pellet or tablet form, which is attractive to livestock and domestic animals, in which fine-grained particles of a neutral-tasting, physiologically compatible, solid carrier material are embedded, which is characterised in that said fine-grained particles of carrier material have an average diameter of 0.09 to 0.8 mm and are coated with an active substance from veterinary medicine, and said active substance layer is covered with a protective layer of a physiologically compatible polymer matrix, and to the production of this animal medicine. It also relates to the usage of said double-coated, fine-grained particles of carrier material in the production of a preparation for veterinary medicine.

5. 发明公开

EP3007682A1 MODIFIED RELEASE FORMULATION 无效
标题翻译：缓释制剂
公开(公告)号：EP3007682A1
公开(公告)日：2016-04-20
申请号：EP14741382.7
申请日：2014-06-11
申请人： Novartis AG
发明人： GALLI, Bruno , THOMA, Hubert , GRANDEURY, Arnaud , SPICKERMANN, Dirk , PUTZBACH, Karsten , MOLL, Klaus-Peter , UFER, Mike , GLANTZMANN, Jean-Marie , MUELLER-ZSIGMONDY, Martin
IPC分类号： A61K9/20 , A61K31/4439
CPC分类号： A61K31/404 , A61J3/02 , A61J3/10 , A61K9/1652 , A61K9/1682 , A61K9/2004 , A61K9/2072 , A61K9/28 , A61K9/50 , A61K9/5089 , A61K31/4045 , A61K47/38
摘要： Drug products in the form of modified release formulations comprising the drug substance (-)-(3aR,4S,7aR)-4-Hydroxy-4m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester (AFQ056), as well as processes for making such drug products are 5 provided. The drug products are useful in treating patients with Parkinson's disease and exhibiting L-dopa induced dyskinesia.

6. 发明公开

EP1490037A1 TASTE MASKED VETERINARY SOLID COMPOSITIONS 无效
标题翻译： TASTE不包括固体药物剂型动物协会
公开(公告)号：EP1490037A1
公开(公告)日：2004-12-29
申请号：EP03711962.5
申请日：2003-03-10
申请人： Novartis AG , Novartis Pharma GmbH
发明人： THOMA, Hubert , SCHOTE, Uwe, Thomas , ISELE, Ute
IPC分类号： A61K9/26 , A61K9/00
CPC分类号： A61K9/5026 , A61K9/2081
摘要： The present invention relates to the supply and production of an animal medicine consisting of a substrate in pellet or tablet form, which is attractive to livestock and domestic animals, in which fine-grained particles of a neutral-tasting, physiologically compatible, solid carrier material are embedded, which is characterised in that said fine-grained particles of carrier material have an average diameter of 0.09 to 0.8 mm and are coated with an active substance from veterinary medicine, and said active substance layer is covered with a protective layer of a physiologically compatible polymer matrix, and to the production of this animal medicine. It also relates to the usage of said double-coated, fine-grained particles of carrier material in the production of a preparation for veterinary medicine.

7. 发明公开

EP3999063A1 FORMULATIONS OF (S)-3-AMINO-6-METHOXY-N-(3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPYL)-5-(TRIFLUOROMETHYL)PICOLINAMIDE 审中-实审
公开(公告)号：EP3999063A1
公开(公告)日：2022-05-25
申请号：EP20743848.2
申请日：2020-07-15
申请人： Novartis AG
发明人： DUBEY, Vivek , LOWALEKAR, Rohit , SANTOS, Paulo , THOMA, Hubert , TIAN, Xianbin
IPC分类号： A61K31/44 , A61K9/20 , A61K9/16 , A61P11/00 , A61K9/28 , A61K9/00 , A61P43/00 , A61P11/06

8. 发明授权

EP3007682B1 MODIFIED RELEASE FORMULATION 无效
标题翻译：修改释放制剂
公开(公告)号：EP3007682B1
公开(公告)日：2017-07-26
申请号：EP14741382.7
申请日：2014-06-11
申请人： Novartis AG
发明人： GALLI, Bruno , THOMA, Hubert , GRANDEURY, Arnaud , SPICKERMANN, Dirk , PUTZBACH, Karsten , MOLL, Klaus-Peter , UFER, Mike , GLANTZMANN, Jean-Marie , MUELLER-ZSIGMONDY, Martin
IPC分类号： A61J3/02 , A61J3/10 , A61K47/38 , A61K9/16 , A61K9/28 , A61K9/50 , A61K31/404 , A61K31/4045 , A61K9/20
CPC分类号： A61K31/404 , A61J3/02 , A61J3/10 , A61K9/1652 , A61K9/1682 , A61K9/2004 , A61K9/2072 , A61K9/28 , A61K9/50 , A61K9/5089 , A61K31/4045 , A61K47/38

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