专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09115200B2 Pharmaceutical composition for treating cancer using a monoclonal antibody having immunological reactivity with CAPRIN-1 有权
标题翻译：使用具有与CAPRIN-1具有免疫反应性的单克隆抗体治疗癌症的药物组合物
公开(公告)号：US09115200B2
公开(公告)日：2015-08-25
申请号：US13576969
申请日：2011-02-04
申请人： Fumiyoshi Okano , Takanori Saito , Shinichi Kobayashi , Takayoshi Ido , Yoshinori Narita
发明人： Fumiyoshi Okano , Takanori Saito , Shinichi Kobayashi , Takayoshi Ido , Yoshinori Narita
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , C07K16/30 , A61K39/00
CPC分类号： C07K16/3053 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K2317/34
摘要： According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody or a fragment thereof as an active ingredient having immunological reactivity to a partial polypeptide of CAPRIN-1, which is represented by any of even-numbered sequences of SEQ ID NOS: 2 to 30, wherein the polypeptide has the amino acid sequence represented by SEQ ID NO: 37 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence.
摘要翻译：根据本发明，鉴定在癌细胞表面特异性表达的癌抗原蛋白，因此提供了靶向癌抗原蛋白的抗体作为治疗和/或预防癌症的药剂的用途。具体地说，本发明提供了一种用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为对CAPRIN-1的部分多肽具有免疫反应性的活性成分， SEQ ID NO：2至30的编号序列，其中所述多肽具有由SEQ ID NO：37表示的氨基酸序列或与氨基酸序列具有80％或更高序列同一性的氨基酸序列。

2. 发明申请

US20120301476A1 PHARMACEUTICAL COMPOSITION FOR TREATING AND/OR PREVENTING CANCER 有权
标题翻译：用于治疗和/或预防癌症的药物组合物
公开(公告)号：US20120301476A1
公开(公告)日：2012-11-29
申请号：US13576969
申请日：2011-02-04
申请人： Fumiyoshi Okano , Takanori Saito , Shinichi Kobayashi , Takayoshi Ido , Yoshinori Narita
发明人： Fumiyoshi Okano , Takanori Saito , Shinichi Kobayashi , Takayoshi Ido , Yoshinori Narita
IPC分类号： A61K39/395 , A61P35/00 , C07K16/30
CPC分类号： C07K16/3053 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K2317/34
摘要： According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody or a fragment thereof as an active ingredient having immunological reactivity to a partial polypeptide of CAPRIN-1, which is represented by any of even-numbered sequences of SEQ ID NOS: 2 to 30, wherein the polypeptide has the amino acid sequence represented by SEQ ID NO: 37 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence.
摘要翻译：根据本发明，鉴定在癌细胞表面特异性表达的癌抗原蛋白，因此提供了靶向癌抗原蛋白的抗体作为治疗和/或预防癌症的药剂的用途。具体地说，本发明提供了一种用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为对CAPRIN-1的部分多肽具有免疫反应性的活性成分， SEQ ID NO：2至30的编号序列，其中所述多肽具有由SEQ ID NO：37表示的氨基酸序列或与氨基酸序列具有80％或更高序列同一性的氨基酸序列。

3. 发明授权

US09180187B2 Medicament for treating and/or preventing cancer 有权
标题翻译：用于治疗和/或预防癌症的药物
公开(公告)号：US09180187B2
公开(公告)日：2015-11-10
申请号：US13576950
申请日：2011-02-04
申请人： Takayoshi Ido , Fumiyoshi Okano , Yoshinori Narita
发明人： Takayoshi Ido , Fumiyoshi Okano , Yoshinori Narita
IPC分类号： A61K39/395
CPC分类号： A61K39/39558 , A61K2300/00
摘要： This invention relates to a medicament for treating and/or preventing a cancer, comprising a combination of an antibody against a cancer antigen CAPRIN-1 protein that is specifically expressed on the surface of the cancer cell, and an antitumor agent, wherein the antibody and the antitumor agent are combined together or separately, and to a use of the medicament.
摘要翻译：本发明涉及用于治疗和/或预防癌症的药物，其包含抗癌细胞表面上特异性表达的癌抗原CAPRIN-1蛋白的抗体与抗肿瘤剂的组合，其中抗体和将抗肿瘤药物组合在一起或分开，以及药物的用途。

4. 发明申请

US20120294860A1 MEDICAMENT FOR TREATING AND/OR PREVENTING CANCER 有权
标题翻译：用于治疗和/或预防癌症的药物
公开(公告)号：US20120294860A1
公开(公告)日：2012-11-22
申请号：US13576950
申请日：2011-02-04
申请人： Takayoshi Ido , Fumiyoshi Okano , Yoshinori Narita
发明人： Takayoshi Ido , Fumiyoshi Okano , Yoshinori Narita
IPC分类号： A61K39/395 , A61P35/02 , A61P35/00
CPC分类号： A61K39/39558 , A61K2300/00
摘要： This invention relates to a medicament for treating and/or preventing a cancer, comprising a combination of an antibody against a cancer antigen CAPRIN-1 protein that is specifically expressed on the surface of the cancer cell, and an antitumor agent, wherein the antibody and the antitumor agent are combined together or separately, and to a use of the medicament.
摘要翻译：本发明涉及用于治疗和/或预防癌症的药物，其包含抗癌细胞表面上特异性表达的癌抗原CAPRIN-1蛋白的抗体与抗肿瘤剂的组合，其中抗体和将抗肿瘤药物组合在一起或分开，以及药物的用途。

5. 发明授权

US08138258B2 Clear coating composition for an automobile and method of forming a multi-layer coating film using the same 有权
标题翻译：用于汽车的透明涂料组合物和使用其形成多层涂膜的方法
公开(公告)号：US08138258B2
公开(公告)日：2012-03-20
申请号：US11313786
申请日：2005-12-22
申请人： Hideaki Tsujioka , Junji Shimada , Hisaki Tanabe , Mirei Kato , Yoshinori Narita
发明人： Hideaki Tsujioka , Junji Shimada , Hisaki Tanabe , Mirei Kato , Yoshinori Narita
IPC分类号： C08L75/00
CPC分类号： C08G18/791 , C08G18/6233 , C08G18/7831 , C09D133/14 , C09D175/04
摘要： An automotive clear coating composition includes a hydroxyl group-containing acrylic resin obtained using hydroxyalkyl(meth)acrylate having a hydroxyalkyl group having 4-9 carbon atoms as at least a part of its monomer; and a polyfunctional isocyanate compound in which at least a part thereof is an isocyanurate type isocyanate compound. The prepared composition has 25 to 50 mass % of a soft segment part with respect to a total solid content of such acrylic resin and the polyfunctional isocyanate compound, and a ratio of a soft segment part derived from a lactone-containing monomer with respect to the total solid content of such acrylic resin and the polyfunctional isocyanate compound of not more than 4.5 mass %. A cured coating film has a dynamic glass transition temperature within a range of 30 to 60° C. The soft segment part is represented by —CH2)n— wherein n represents an integer of 4 or more.
摘要翻译：汽车透明涂料组合物包括使用具有4-9个碳原子的羟基烷基的（甲基）丙烯酸羟烷基酯作为其单体的至少一部分获得的含羟基的丙烯酸树脂; 和其中至少一部分为异氰脲酸酯型异氰酸酯化合物的多官能异氰酸酯化合物。所制备的组合物相对于丙烯酸树脂和多官能异氰酸酯化合物的总固体含量为25〜50质量％的软链段部分，来自含内酯的单体的软链段的比例相对于这种丙烯酸树脂和多官能异氰酸酯化合物的总固体含量不超过4.5质量％。固化涂膜的动态玻璃化转变温度在30〜60℃的范围内。软链段部分由-CH 2）n表示，其中n表示4以上的整数。

6. 发明授权

US4828009A Method of manufacturing a complex body of sintered ceramic material and metal 失效
标题翻译：烧结陶瓷材料和金属复合体的制造方法
公开(公告)号：US4828009A
公开(公告)日：1989-05-09
申请号：US73173
申请日：1987-07-14
申请人： Masato Taniguchi , Yoshinori Narita
发明人： Masato Taniguchi , Yoshinori Narita
IPC分类号： C04B37/02 , B22D19/00 , F02B19/16 , F02F1/42
CPC分类号： B22D19/00
摘要： A method of forming a complex body of a sintered ceramic material and a metal. A through-hole is provided in the sintered ceramic material before it is cast-embedded in the metal. The through-hole provides for the release of gas to prevent the formation of a cavity between the sintered ceramic material and the metal.
摘要翻译：一种形成烧结陶瓷材料和金属的复合体的方法。在烧结陶瓷材料中嵌入金属之前，提供通孔。通孔提供了释放气体以防止在烧结的陶瓷材料和金属之间形成空腔。

7. 发明授权

US06720837B2 Surface mounting crystal oscillator 失效
标题翻译：表面贴装晶体振荡器
公开(公告)号：US06720837B2
公开(公告)日：2004-04-13
申请号：US10254620
申请日：2002-09-25
申请人： Kouichi Moriya , Kuichi Kubo , Katsuyuki Sato , Yoshinori Narita
发明人： Kouichi Moriya , Kuichi Kubo , Katsuyuki Sato , Yoshinori Narita
IPC分类号： H03B532
CPC分类号： H03B5/368 , H01L2924/16195
摘要： A surface mounting quartz crystal oscillator has an IC chip containing an oscillator circuit, and a quartz crystal unit which are sealed in a container body by a metal cover, wherein stray capacitances C1, C2 are equivalently in parallel with oscillation capacitors Ca, Cb connected to one and the other ends of the crystal unit, respectively. A gap between the IC chip and a crystal blank of the crystal unit, and a gap between the crystal blank and metal cover are set in accordance with a changing amount of the oscillation frequency due to a change in the stray capacitances C1, C2 in a direction in which a change in equivalent series capacitance is reduced, as viewed from the crystal unit, while maintaining a spacing between the IC chip and metal cover.
摘要翻译：表面安装石英晶体振荡器具有含有振荡电路的IC芯片和通过金属盖密封在容器主体中的石英晶体单元，其中杂散电容C1，C2等效地与连接到分别是晶体单元的一端和另一端。根据由于杂散电容C1，C2的变化引起的振荡频率的变化量，设定晶体单元的IC芯片和晶体坯料之间的间隙以及晶体坯料与金属盖板之间的间隙在从晶体单元观察时，等效串联电容的变化减小的方向，同时保持IC芯片和金属盖之间的间隔。

8. 发明授权

US5020319A Hollow heat-resisting body assembly for internal combustion engine 失效
标题翻译：用于内燃机的中空耐热体组件
公开(公告)号：US5020319A
公开(公告)日：1991-06-04
申请号：US559409
申请日：1990-07-26
申请人： Tooru Matsuura , Mitsuyoshi Kawamura , Yoshinori Narita
发明人： Tooru Matsuura , Mitsuyoshi Kawamura , Yoshinori Narita
IPC分类号： F01N3/04 , F01N13/10 , F01N13/14 , F01N13/16 , F01P3/12 , F02B37/02 , F02B39/00 , F02B77/11 , F16L53/00 , F28D7/02 , F28F13/00
CPC分类号： F01N13/16 , F01N13/102 , F01N13/14 , F01N3/046 , F01P3/12 , F02B37/02 , F02B39/005 , F02B77/11 , F16L53/00 , F28D7/024 , F28F13/00 , F01N2310/00 , F01N2530/06 , F01N2530/26 , F01P2060/16 , Y02T10/144 , Y02T10/20
摘要： A heat-resistant casing for an internal combustion engine comprises an outer wall member made of an aluminum alloy by casting and an inner wall member made of ceramic and embedded in the outer wall member at the time of casting of the outer wall member. A coolant jacket is formed in the outer wall member and is communicated with a source of cooling medium so that cooling medium circulates through the coolant jacket.
摘要翻译：用于内燃机的耐热壳体包括通过铸造由铝合金制成的外壁构件和在外壁构件浇铸时嵌入外壁构件中的由陶瓷制成的内壁构件。在外壁构件中形成冷却剂套，并且与冷却介质源连通，使得冷却介质循环通过冷却剂套。

9. 发明授权

US4873952A Engine cylinder head with precombustion chambers using porous ceramics insert 失效
标题翻译：使用多孔陶瓷刀片的预燃室的发动机气缸盖
公开(公告)号：US4873952A
公开(公告)日：1989-10-17
申请号：US161013
申请日：1988-02-26
申请人： Yoshinori Narita , Mitsuyoshi Kawamura
发明人： Yoshinori Narita , Mitsuyoshi Kawamura
IPC分类号： F02B19/16
CPC分类号： F02B19/165 , Y02T10/125 , Y10T29/49272
摘要： The invention relates to a cylinder head for an internal combustion engine in which each combustion chamber has a prechamber. A cast metal body of the cylinder head has recesses each of which provides a prechamber, and a hollow and, for example, bell-shaped member of a porous ceramics is cast-inserted in the inner surface defining each recess. Use is made of a ceramics low in thermal expansion coefficient and heat conductivity, such as aluminum titanate or cordierite, and the porosity of the ceramics is 5 to 50%. Because of its porousness the cast-inserted ceramics member is easily machine-finished. After that, for enhancement of strength and durability, the cast-inserted member of the porous ceramics is impregnated with an inorganic refractory material by using either a solution of, for example, sodium silicate or aluminum phosphate or an aqueous suspension of a ceramics powder, or a mixture of the solution and the suspension.
摘要翻译：本发明涉及一种用于内燃机的气缸盖，其中每个燃烧室都具有预燃室。气缸盖的铸造金属体具有各自提供预制室的凹部，并且多孔陶瓷的中空的，例如钟形的构件被铸造插入到限定每个凹部的内表面中。使用的陶瓷的热膨胀系数和导热系数低，如钛酸铝或堇青石，陶瓷的孔隙率为5〜50％。由于其多孔性，铸造陶瓷构件容易机加工。之后，为了提高强度和耐久性，通过使用例如硅酸钠或磷酸铝的溶液或陶瓷粉末的水性悬浮液，多孔陶瓷的铸造插入构件用无机耐火材料浸渍，或溶液和悬浮液的混合物。

10. 发明授权

US4180538A Method of making ceramic shaped article from inorganic raw material powder by extrusion molding 失效
标题翻译：通过挤出成型从无机原料粉末制造陶瓷制品的方法
公开(公告)号：US4180538A
公开(公告)日：1979-12-25
申请号：US759812
申请日：1977-01-17
申请人： Akira Morikawa , Yoshinori Narita , Junichi Mizutani
发明人： Akira Morikawa , Yoshinori Narita , Junichi Mizutani
IPC分类号： B28B3/20 , C04B33/13 , C04B35/195 , C04B35/634 , C04B35/64
CPC分类号： C04B35/63416 , B28B3/269 , C04B33/13 , C04B35/195 , C04B35/634 , C04B35/6342 , C04B35/63456
摘要： A method of making a ceramic shaped article from an inorganic raw material powder by extrusion molding is disclosed. The method comprises the steps of kneading an inorganic raw material powder with a plasticizer to obtain a kneaded body which is then molded by extrusion into a fluid having a high humidity to obtain a ceramic shaped article having no deformation and strain. The plasticizer is selected from the group consisting of mono-liquid type resin which is a water insoluble synthetic resin dissolved in a water soluble solvent and a hydraulic setting resin mainly consisting of polyurethane isocyanate prepolymer.
摘要翻译：公开了一种通过挤出成型从无机原料粉末制造陶瓷成型制品的方法。该方法包括以下步骤：将无机原料粉末与增塑剂捏合，得到捏合体，然后通过挤出成型为具有高湿度的流体，得到不变形和变形的陶瓷成型制品。增塑剂选自溶解在水溶性溶剂中的水溶性合成树脂的单液型树脂和主要由聚氨酯异氰酸酯预聚物组成的水硬性固化树脂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式