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1. 发明授权

US06316473B1 Two surfactant-containing medicinal composition 失效
标题翻译：两种含表面活性剂的药物组合物
公开(公告)号：US06316473B1
公开(公告)日：2001-11-13
申请号：US09402469
申请日：1999-10-12
申请人： Fumio Shimojo , Sumihisa Kimura , Takeo Hirose , Satoshi Ueda , Rinta Ibuki , Norio Ohnishi
发明人： Fumio Shimojo , Sumihisa Kimura , Takeo Hirose , Satoshi Ueda , Rinta Ibuki , Norio Ohnishi
IPC分类号： A61K3140
CPC分类号： A61K31/436 , A61K9/4866 , A61K47/14 , A61K47/44
摘要： Provided is a medicinal composition having a very satisfactory drug release profile and a very satisfactory drug absorption profile after oral administration characterized by its comprising an insoluble drug and two or more surfactants, at least one of the surfactants having as dissolved therein the insoluble drug and the other surfactant or surfactants.
摘要翻译：本发明提供一种具有非常令人满意的药物释放特性和口服给药后非常令人满意的药物吸收曲线的药物组合物，其特征在于其包含不溶性药物和两种或更多种表面活性剂，至少一种表面活性剂溶解有不溶性药物和其他表面活性剂或表面活性剂。

2. 发明授权

US06387918B1 Pharmaceutical composition 有权
标题翻译：药物组成
公开(公告)号：US06387918B1
公开(公告)日：2002-05-14
申请号：US09367698
申请日：1999-08-20
申请人： Masayuki Yamanaka , Fumio Shimojo , Satoshi Ueda , Toshihiko Toyoda , Rinta Ibuki , Norio Ohnishi
发明人： Masayuki Yamanaka , Fumio Shimojo , Satoshi Ueda , Toshihiko Toyoda , Rinta Ibuki , Norio Ohnishi
IPC分类号： A61K3144
CPC分类号： A61K9/0014 , A61K31/407 , A61K31/436 , A61K47/10 , A61K47/14 , A61K47/32
摘要： A pharmaceutical composition comprising a tricyclic compound (I) or its pharmaceutically acceptable salt, an oil substance, a surfactant, a hydrophilic substance, water, and optionally a pH control agent, with enhanced stability, absorbability and/or a low irritation potential, is provided.
摘要翻译：具有增强的稳定性，吸收性和/或低刺激潜力的三环化合物（I）或其药学上可接受的盐，油性物质，表面活性剂，亲水性物质，水和任选的pH控制剂的药物组合物是提供。

3. 发明授权

US4390694A Method for preparing stable crystals of salt of Ceftizoxime 失效
标题翻译：头孢唑肟盐稳定晶体的制备方法
公开(公告)号：US4390694A
公开(公告)日：1983-06-28
申请号：US283805
申请日：1981-07-16
申请人： Norio Ohnishi , Rinta Ibuki
发明人： Norio Ohnishi , Rinta Ibuki
IPC分类号： C07D501/00 , A61K9/14 , A61K31/545 , A61K31/546 , A61P31/04 , C07D501/04 , C07D501/12 , C07D501/20
CPC分类号： C07D501/20
摘要： A method for preparing stable crystals of a salt of Ceftizoxime which comprises mixing an aqueous solution of a salt of Ceftizoxime and isopropyl alcohol and collecting the precipitating crystals. Crystals obtained in this manner are more stable than the crystals obtained from prior art methods involving mixed solvents of water and ethanol.
摘要翻译：一种制备头孢唑肟盐稳定晶体的方法，其包括将头孢唑肟盐和异丙醇的盐水溶液混合并收集析出的晶体。以这种方式获得的晶体比从现有技术中涉及水和乙醇混合溶剂的方法得到的晶体更稳定。

4. 发明授权

US07094899B2 Vitreous form of known bradykinin antagonist 失效
标题翻译：已知缓激肽拮抗剂的玻璃体形式
公开(公告)号：US07094899B2
公开(公告)日：2006-08-22
申请号：US10301614
申请日：2002-11-22
申请人： Norio Ohnishi , Osamu Aoki , Atsuo Ohike , Kazuto Okimoto , Hiroshi Ishikuro
发明人： Norio Ohnishi , Osamu Aoki , Atsuo Ohike , Kazuto Okimoto , Hiroshi Ishikuro
IPC分类号： C07D215/38 , A61K31/47
CPC分类号： C07D401/12
摘要： This invention relates to a vitreous form of 8-[3-[N-[(E)-3-(6-acetamidopyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-methylquinoline (FR173657). This vitreous form has good solid stability and, therefor, is useful for producing and supplying FR173657 products whose quality is stable enough to be suitable for medicines.
摘要翻译：本发明涉及玻璃体形式的8- [3- [N - [（E）-3-（6-乙酰氨基吡啶-3-基）丙烯酰基甘氨酰] -N-甲基氨基] -2,6-二氯苄氧基] -2-甲基喹啉（FR173657）。这种玻璃体形式具有良好的固体稳定性，因此可用于生产和供应质量稳定至适合药物的FR173657产品。

5. 发明授权

US5236127A Humidifier 失效
标题翻译：加湿器
公开(公告)号：US5236127A
公开(公告)日：1993-08-17
申请号：US867603
申请日：1992-06-12
申请人： Norio Ohnishi , Satoru Tanaka , Akio Shimizu
发明人： Norio Ohnishi , Satoru Tanaka , Akio Shimizu
IPC分类号： F24F6/00 , F24F6/14
CPC分类号： F24F6/14 , Y02B30/545
摘要： A humidifier comprises a liquid storing chamber provided in the lower portion of the casing. A nozzle is provided in the upper portion of the casing. An adaptor, provided in the upper portion of the casing, introduces compressed air and liquid into the nozzle. A liquid sucking pipe communicates with a liquid sucking opening of the adaptor and extends vertically downward to the vicinity of the bottom surface of the liquid storing chamber. A float is provided in the liquid storing chamber and is movable along the inner surface of the liquid storing chamber, depending on the amount of the liquid stored therein. A liquid cutoff lever is provided above the float and contacts the upper surface thereof. A liquid cutoff valve, of a liquid cutoff device mounted on the casing is operated by the liquid cutoff lever so that the capacity of the liquid to be controlled by the liquid cutoff valve is small, for example 30 cc.

6. 发明授权

US06509468B1 Vitreous form of known bradykinin antagonist 失效
标题翻译：已知缓激肽拮抗剂的玻璃体形式
公开(公告)号：US06509468B1
公开(公告)日：2003-01-21
申请号：US09807421
申请日：2001-04-20
申请人： Norio Ohnishi , Osamu Aoki , Atsuo Ohike , Kazuto Okimoto , Hiroshi Ishikuro
发明人： Norio Ohnishi , Osamu Aoki , Atsuo Ohike , Kazuto Okimoto , Hiroshi Ishikuro
IPC分类号： C07D40112
CPC分类号： C07D401/12
摘要： The invention relates to a vitreous form of the compound, FR 173657, having the structure of formula (I). This vitreous form has good solid stability and is therefore useful for producing and supplying FR 173657 products whose quality is stable enough to be suitable for medicine.
摘要翻译：本发明涉及具有式（I）结构的化合物FR 173657的玻璃体形式。这种玻璃体形式具有良好的固体稳定性，因此可用于生产和供应质量足够稳定以适合于医药的FR 173657产品。

7. 发明授权

US5046668A Two-fluid nozzle 失效
标题翻译：双流体喷嘴
公开(公告)号：US5046668A
公开(公告)日：1991-09-10
申请号：US487248
申请日：1990-03-02
申请人： Hiroshi Ikeuchi , Norio Ohnishi
发明人： Hiroshi Ikeuchi , Norio Ohnishi
IPC分类号： B05B7/06 , B05B1/02 , B05B7/04
CPC分类号： B05B7/0416
摘要： A two-fluid nozzle, constituted by a gas inlet and a liquid inlet; a first mixing chamber having a gas feed element connected to the gas inlet for feeding a gas along an axial center line in a direction toward a discharge end of the nozzle and having a liquid feed element for feeding a liquid into the outer periphery of the gas at the downstream end of the gas inlet; a substantially uniform diameter rectifying chamber opening out of the first mixing chamber and extending along the axial center line toward the discharge end for receiving the mixture of gas and liquid and conveying it therealong; a second mixing chamber having a larger diameter than the rectifying chamber and into which the downstream end of the rectifying chamber opens, the second mixing chamber having a wall face at the downstream end thereof spaced from and opposed to the downstream end of the rectifying chamber and against which the outer peripheral portion of the mixture of gas and liquid discharged into the second mixing chamber from the rectifying chamber collides; and a nozzle tip on the downstream end of the second mixing chamber having a discharge opening at a discharge end thereof and a jetting chamber extending along the axial center line from the second mixing chamber to the discharge opening, the nozzle tip having an end face portion in which the discharge opening is located having a hemispherical shape and a cylindrical peripheral wall around the base of the hemisphere, the discharge opening being a uniform width slit extending across the hemispherical shape end face portion and into the cylindrical peripheral wall in a diametrically extending plane, the ends of the slit having a circular arc or a V-shape.

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