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1. 发明申请

US20120283665A1 METHOD FOR COATING INNER SURFACE OF MEDICAL TUBE MADE FROM VINYL CHLORIDE WITH ANTI-THROMBOTIC MATERIAL 有权
标题翻译：从氯乙烯与抗静电材料涂覆医用管内表面的方法
公开(公告)号：US20120283665A1
公开(公告)日：2012-11-08
申请号：US13520414
申请日：2011-01-06
申请人： Fumihiko Kajii , Hidenori Tanaka , Susumu Kashiwabara
发明人： Fumihiko Kajii , Hidenori Tanaka , Susumu Kashiwabara
IPC分类号： B05D7/22 , A61M25/00
CPC分类号： A61L27/502 , A61L27/34 , A61L29/085 , A61L29/141 , A61L31/10 , A61L31/141 , A61L33/0052 , A61L33/068 , C08L33/06
摘要： The present invention provides a method for coating an inner surface of a polyvinyl chloride medical tube containing a plasticizer with an antithrombogenic material composed of a specific (meth)acrylate copolymer. The simple method of the present invention is capable of evenly and efficiently coating an inner surface of a polyvinyl chloride medical tube with a sufficient amount of an antithrombogenic material without causing appearance deterioration or uneven coating due to elution of the plasticizer. The method is performed by passing through a tube a solution that is prepared by dissolving an antithrombogenic material in a solvent composed of water and at least one alcohol that is adjusted to dissolve the copolymer of the antithrombogenic material but does not dissolve the plasticizer, then subsequently passing water through the tube, and finally drying the tube.
摘要翻译：本发明提供一种包含具有由特定（甲基）丙烯酸酯共聚物构成的抗血栓形成材料的增塑剂的聚氯乙烯医用管的内表面的方法。本发明的简单方法能够均匀有效地涂覆聚氯乙烯医用管的内表面，其量足够量的抗血栓形成材料，而不引起外观恶化或由于增塑剂的洗脱引起的不均匀涂覆。该方法通过将管子溶解在由水和至少一种醇组成的溶剂中制备的溶液来进行，所述溶剂被调节以溶解抗凝血物质的共聚物但不溶解增塑剂，然后随后将水通过管子，最后干燥管子。

2. 发明申请

US20100249811A1 METHOD FOR THE MANUFACTURE OF NERVE REGENERATION-INDUCING TUBE 有权
标题翻译：神经再生诱导管制造方法
公开(公告)号：US20100249811A1
公开(公告)日：2010-09-30
申请号：US12744179
申请日：2008-12-04
申请人： Fumihiko Kajii , Hidenori Tanaka , Yuta Kawakatsu , Susumu Kashiwabara , Masaki Sato
发明人： Fumihiko Kajii , Hidenori Tanaka , Yuta Kawakatsu , Susumu Kashiwabara , Masaki Sato
IPC分类号： A61B17/03 , B05D3/00
CPC分类号： A61L31/044 , A61B17/1128 , A61B2017/00526 , A61L27/34 , A61L27/58 , A61L2430/32 , C08L89/06
摘要： To provide a method for the manufacture of a nerve regeneration-inducing tube being excellent in pressure resistance, shape recovery property, anti-kink property, film exfoliation resistance, property of prevention of invasion of outer tissues and leakage resistance.The present invention is a method for the manufacture of a nerve regeneration-inducting tube in which the outer surface of the tubular body knitted with a plurality of ultrafine fibers comprising biodegradable polymer is coated by application of a collagen solution for plural times to coat and then collagen is filled in the inner area of the above tubular body, characterized in that, viscosity of the collagen solution which is firstly applied on the outer surface of the tubular body is made 2 cps to 800 cps or, preferably, 5 cps to 200 cps.Preferably, viscosity of a collagen solution to be applied later is made high as compared with that of the firstly-applied one.
摘要翻译：提供一种制造耐压性，形状恢复性，抗扭结性，耐剥离性，防止外侧组织的侵入性和耐漏出性的神经再生诱导管的制造方法。本发明是一种制造神经再生感应管的方法，其中用多个包含可生物降解的聚合物的超细纤维编织的管状体的外表面通过涂覆胶原溶液多次涂覆，然后胶原填充在上述管状体的内部区域中，其特征在于，首先施加在管状体的外表面上的胶原溶液的粘度为2cps〜800cps，优选为5cps〜200cps 。优选与以后施用的胶原溶液的粘度相比较好。

3. 发明授权

US09017714B2 Nerve regeneration-inducing tube 有权
标题翻译：神经再生诱导管
公开(公告)号：US09017714B2
公开(公告)日：2015-04-28
申请号：US12744609
申请日：2008-12-25
申请人： Fumihiko Kajii , Hidenori Tanaka , Susumu Kashiwabara , Yuta Kawakatsu
发明人： Fumihiko Kajii , Hidenori Tanaka , Susumu Kashiwabara , Yuta Kawakatsu
IPC分类号： A61F2/00 , A61L27/50 , A61L27/34 , A61L27/58
CPC分类号： A61L27/50 , A61L27/34 , A61L27/58 , A61L2430/32 , C08L89/06
摘要： A nerve regeneration-inducing tube is provided which is excellent in cell growth property, resistance to pressure, shape recovery property, and anti-kink property in a nerve regeneration-inducing tube where a collagen solution is applied on the outer surface of a tubular body woven with ultrafine fiber comprising biodegradable and bioabsorbable polymer while collagen is filled in the inner area of the tubular body. The nerve regeneration-inducing tube has a degradation speed which is adjusted so as to make it suitable for the connection of nerve gaps of more than 40 mm. The nerve regeneration-inducing tube includes collagen coated on the outer surface of a tubular body woven with fiber bundles where plural ultrafine fibers comprising a biodegradable and bioabsorbable polymer are bundled. The tubular body mostly comprises a first polymer which is biodegradable and bioabsorbable and a second polymer which has higher biodegradability and bioabsorbability than those of the first polymer.
摘要翻译：提供了神经再生诱导管，其在胶原溶液施加在管状体的外表面上的神经再生诱导管中具有优异的细胞生长性，耐压性，形状恢复性和抗扭结性用包含可生物降解和生物可吸收聚合物的超细纤维编织，而胶原蛋白填充在管状体的内部区域中。神经再生诱导管具有降解速度，其被调节以使其适合于连接超过40mm的神经间隙。神经再生诱导管包括涂覆在由纤维束编织的管状体的外表面上的胶原，其中包含可生物降解和生物可吸收的聚合物的多个超细纤维捆扎在一起。管状体主要包含可生物降解和生物可吸收的第一聚合物和与第一聚合物相比具有更高生物降解性和生物吸收性的第二聚合物。

4. 发明申请

US20100255060A1 NERVE REGENERATION-INDUCING TUBE 有权
标题翻译：神经再生诱导管
公开(公告)号：US20100255060A1
公开(公告)日：2010-10-07
申请号：US12744609
申请日：2008-12-25
申请人： Fumihiko Kajii , Hidenori Tanaka , Susumu Kashiwabara , Yuta Kawakatsu
发明人： Fumihiko Kajii , Hidenori Tanaka , Susumu Kashiwabara , Yuta Kawakatsu
IPC分类号： A61F2/00
CPC分类号： A61L27/50 , A61L27/34 , A61L27/58 , A61L2430/32 , C08L89/06
摘要： To provide a nerve regeneration-inducing tube being excellent in cell growth property, resistance to pressure, shape recovery property, and anti-kink property in a nerve regeneration-inducing tube where a collagen solution is applied on the outer surface of a tubular body knitted with ultrafine fiber comprising biodegradable and bioabsorbable polymer while collagen is filled in the inner area of the tubular body. Specifically, to provide a nerve regeneration-inducing tube where a degradation speed is adjusted so as to make it suitable for the connection of nerve gaps of more than 40 mm.The present invention is a nerve regeneration-inducing tube where collagen is coated on the outer surface of a tubular body knitted with fiber bundles where plural ultrafine fibers comprising a biodegradable and bioabsorbable polymer are bundled, characterized in that, said tubular body mostly comprises a first polymer which is biodegradable and bioabsorbable and a second polymer which has higher biodegradability and bioabsorbability than those of the first polymer.
摘要翻译：为了提供神经再生诱导管，其神经再生诱导管中的细胞生长性，耐受力，形状恢复性和抗扭结性优异，其中胶原溶液被施加在针织的管状体的外表面上其中包含可生物降解和生物吸收性聚合物的超细纤维，而胶原蛋白填充在管状体的内部区域中。具体而言，为了提供神经再生诱导管，其中调节降解速度以使其适合于超过40mm的神经间隙的连接。本发明是一种神经再生诱导管，其中胶原被涂覆在用纤维束编织的管状体的外表面上，其中包含可生物降解和生物可吸收的聚合物的多个超细纤维捆扎在一起，其特征在于，所述管状主体包括第一可生物降解和生物可吸收的聚合物和具有比第一聚合物更高的生物降解性和生物吸收性的第二聚合物。

5. 发明授权

US08916225B2 Method for coating inner surface of medical tube made from vinyl chloride with anti-thrombotic material 有权
标题翻译：用抗血栓形成材料涂覆由氯乙烯制成的医用管内表面的方法
公开(公告)号：US08916225B2
公开(公告)日：2014-12-23
申请号：US13520414
申请日：2011-01-06
申请人： Fumihiko Kajii , Hidenori Tanaka , Susumu Kashiwabara
发明人： Fumihiko Kajii , Hidenori Tanaka , Susumu Kashiwabara
IPC分类号： A61L33/00 , A61L27/50 , A61L27/34 , A61L29/08 , A61L29/14 , A61L31/10 , A61L31/14 , A61L33/06
CPC分类号： A61L27/502 , A61L27/34 , A61L29/085 , A61L29/141 , A61L31/10 , A61L31/141 , A61L33/0052 , A61L33/068 , C08L33/06
摘要： The present invention provides a method for coating an inner surface of a polyvinyl chloride medical tube containing a plasticizer with an antithrombogenic material composed of a specific (meth)acrylate copolymer. The simple method of the present invention is capable of evenly and efficiently coating an inner surface of a polyvinyl chloride medical tube with a sufficient amount of an antithrombogenic material without causing appearance deterioration or uneven coating due to elution of the plasticizer. The method is performed by passing through a tube a solution that is prepared by dissolving an antithrombogenic material in a solvent composed of water and at least one alcohol that is adjusted to dissolve the copolymer of the antithrombogenic material but does not dissolve the plasticizer, then subsequently passing water through the tube, and finally drying the tube.
摘要翻译：本发明提供一种包含具有由特定（甲基）丙烯酸酯共聚物构成的抗血栓形成材料的增塑剂的聚氯乙烯医用管的内表面的方法。本发明的简单方法能够均匀有效地涂覆聚氯乙烯医用管的内表面，其量足够量的抗血栓形成材料，而不引起外观恶化或由于增塑剂的洗脱引起的不均匀涂覆。该方法通过将管子溶解在由水和至少一种醇组成的溶剂中制备的溶液来进行，所述溶剂被调节以溶解抗凝血物质的共聚物但不溶解增塑剂，然后随后将水通过管子，最后干燥管子。

6. 发明授权

US08741328B2 Nerve regeneration-inducing tube 有权
标题翻译：神经再生诱导管
公开(公告)号：US08741328B2
公开(公告)日：2014-06-03
申请号：US13147234
申请日：2009-02-02
申请人： Michiko Suzuki , Fumihiko Kajii , Hidenori Tanaka , Susumu Kashiwabara
发明人： Michiko Suzuki , Fumihiko Kajii , Hidenori Tanaka , Susumu Kashiwabara
IPC分类号： A61F2/04 , A61K33/14
CPC分类号： A61L27/24 , A61L2430/32
摘要： The present invention provides a nerve regeneration-inducing tube in which collagen having excellent adhesive property, cell growth property and differentiation inducing property to nerve cells is used as a scaffold for the nerve regeneration. The nerve regeneration-inducing tube is characterized in using the collagen which is made the concentration of sodium chloride contained therein not more than 2.0% by weight or, preferably, 0.1 to 1.5% by weight in a dry state. Purification of collagen is carried out by means of an isoelectric precipitation where the pH is 6.0 or higher and is lower than 10.0.
摘要翻译：本发明提供一种神经再生诱导管，其中使用具有优异的粘附性，细胞生长性和对神经细胞的分化诱导性的胶原作为神经再生的支架。神经再生诱导管的特征在于使用使干燥状态下所含氯化钠浓度不超过2.0重量％，优选为0.1〜1.5重量％的胶原。胶原蛋白的纯化是通过pH为6.0以上且低于10.0的等电沉淀进行的。

7. 发明授权

US08632844B2 Method for the manufacture of nerve regeneration-inducing tube 有权
标题翻译：制造神经再生诱导管的方法
公开(公告)号：US08632844B2
公开(公告)日：2014-01-21
申请号：US12744179
申请日：2008-12-04
申请人： Fumihiko Kajii , Hidenori Tanaka , Yuta Kawakatsu , Susumu Kashiwabara , Masaki Sato
发明人： Fumihiko Kajii , Hidenori Tanaka , Yuta Kawakatsu , Susumu Kashiwabara , Masaki Sato
IPC分类号： A61K9/00 , A61L33/00 , B05D3/00 , B01J13/22
CPC分类号： A61L31/044 , A61B17/1128 , A61B2017/00526 , A61L27/34 , A61L27/58 , A61L2430/32 , C08L89/06
摘要： A method for manufacturing a nerve regeneration-inducing tube with excellent pressure resistance, shape recovery property, anti-kink property, film exfoliation resistance, resistance to invasion of outer tissues, and leakage resistance. The tubular body is formed by weaving together fibers made up of biodegradable polymer. The outer surface of the tubular body is coated multiple times with a collagen solution. The lumen of the tubular body is filled with collagen. Viscosity of the collagen solution that is first applied to the outer surface of the tubular body is between 2 to 800 cps. Viscosity of the collagen solution that is subsequently applied is higher than viscosity of the first applied collagen solution.
摘要翻译：制造神经再生诱导管的方法，具有优异的耐压性，形状恢复性，抗扭结性，抗剥落性，外部组织的侵入性和耐渗漏性。管状体通过将由可生物降解的聚合物构成的纤维编织在一起而形成。用胶原溶液涂覆管状体的外表面多次。管状体的内腔充满胶原蛋白。首先施加到管状体的外表面的胶原溶液的粘度为2至800cps。随后施用的胶原溶液的粘度高于第一次施加的胶原溶液的粘度。

8. 发明申请

US20110288569A1 NERVE REGENERATION-INDUCING TUBE 有权
标题翻译：神经再生诱导管
公开(公告)号：US20110288569A1
公开(公告)日：2011-11-24
申请号：US13147234
申请日：2009-02-02
申请人： Michiko Suzuki , Fumihiko Kajii , Hidenori Tanaka , Susumu Kashiwabara
发明人： Michiko Suzuki , Fumihiko Kajii , Hidenori Tanaka , Susumu Kashiwabara
IPC分类号： A61B17/00
CPC分类号： A61L27/24 , A61L2430/32
摘要： The present invention provides a nerve regeneration-inducing tube in which collagen having excellent adhesive property, cell growth property and differentiation inducing property to nerve cells is used as a scaffold for the nerve regeneration. The nerve regeneration-inducing tube is characterized in using the collagen which is made the concentration of sodium chloride contained therein not more than 2.0% by weight or, preferably, 0.1 to 1.5% by weight in a dry state. Purification of collagen is carried out by means of an isoelectric precipitation where the pH is 6.0 or higher and is lower than 10.0.
摘要翻译：本发明提供一种神经再生诱导管，其中使用具有优异的粘附性，细胞生长性和对神经细胞的分化诱导性的胶原作为神经再生的支架。神经再生诱导管的特征在于使用使干燥状态下所含氯化钠浓度不超过2.0重量％，优选为0.1〜1.5重量％的胶原。胶原蛋白的纯化是通过pH为6.0以上且低于10.0的等电沉淀进行的。

9. 发明申请

US20100135852A1 OXYGENATOR OF A HOLLOW FIBER MEMBRANE TYPE 有权
标题翻译：中空纤维膜类型的氧化剂
公开(公告)号：US20100135852A1
公开(公告)日：2010-06-03
申请号：US12596384
申请日：2008-04-21
申请人： Yuta Kawakatsu , Hidenori Tanaka , Susumu Kashiwabara
发明人： Yuta Kawakatsu , Hidenori Tanaka , Susumu Kashiwabara
IPC分类号： A61M1/18 , A61L27/00
CPC分类号： B01D63/02 , A61M1/1698 , B01D53/22 , B01D53/228 , B01D67/0088 , B01D69/08 , B01D71/40 , B01D71/76 , B01D2256/12 , B01D2257/504 , B01D2325/38 , B01D2325/40 , Y02C10/10
摘要： The invention provides an oxygenator of a hollow fiber membrane type where a plurality of hollow fiber membranes are received in a housing, wherein at least a part of the regions of the hollow fiber membranes to contact blood during use is coated with a water-insoluble (meth)acrylate copolymer in which a hydrophobic (meth)acrylate is copolymerized with a hydrophilic (meth)acrylate at a molar ratio of (50 to 90):(50 to 10).
摘要翻译：本发明提供了一种中空纤维膜类型的充氧器，其中多个中空纤维膜被容纳在壳体中，其中使用过程中与血液接触的中空纤维膜的至少一部分区域涂覆有不溶于水的（（甲基）丙烯酸酯共聚物，其中疏水性（甲基）丙烯酸酯与亲水性（甲基）丙烯酸酯以摩尔比（50〜90）:( 50〜10）共聚。

10. 发明授权

US06967003B2 Artificial lung of membrane type 失效
标题翻译：人造肺膜型
公开(公告)号：US06967003B2
公开(公告)日：2005-11-22
申请号：US09964894
申请日：2001-09-28
申请人： Toru Takehisa , Kazunari Sakai , Susumu Kashiwabara , Hidenori Tanaka , Masaki Satoh , Hisateru Takano , Yoshiyuki Taenaka , Eisuke Tatsumi , Tomohiro Nishinaka
发明人： Toru Takehisa , Kazunari Sakai , Susumu Kashiwabara , Hidenori Tanaka , Masaki Satoh , Hisateru Takano , Yoshiyuki Taenaka , Eisuke Tatsumi , Tomohiro Nishinaka
IPC分类号： A61M1/16 , A61M1/36 , B01D67/00 , B01D69/02 , B01D69/08 , B01D71/26 , A61M37/00 , A61M1/14 , B01D63/00
CPC分类号： B01D67/0088 , A61M1/1698 , A61M1/3672 , A61M1/3673 , B01D69/02 , B01D69/08 , B01D71/26 , Y10S261/28
摘要： A membrane artificial lung performs gas exchange between blood and a gas via the membrane by flowing the blood in one side of the membrane and flowing oxygen or an oxygen-containing gas in the other side of the membrane. The membrane has a hollow fiber membrane of poly-4-methylpentene-1 and an oxygen permeation rate Q(O2) at 25° C. of from 1×10−6 to 3×10−3 (cm3(STP)/cm2·sec·cmHg) and an ethanol flux of from 0.1 to 100 ml/min·m2. The membrane has, in the side of the blood flow, a surface having an ionic complex derived from: quaternary aliphatic alkylammonium salts; and heparin or a heparin derivative. The quaternary alkylammonium salts are a quaternary aliphatic alkylammonium salt having from 22 to 26 carbon atoms in total and a quaternary aliphatic alkylammonium salt having from 37 to 40 carbon atoms in total.
摘要翻译：膜人造肺通过使血液在膜的一侧流动并在膜的另一侧流动氧气或含氧气体，通过膜进行血液和气体之间的气体交换。该膜具有聚-4-甲基戊烯-1的中空纤维膜和25℃下的氧渗透速率Q（O 2 O 2），为1×10 -6以上至 3×10 -3（cm 3）（STP）/ cm 2·sec·secHg），乙醇流量为0.1〜100ml / min .m ^{2 。膜在血流侧具有一个具有衍生自：季脂族烷基铵盐的离子络合物的表面; 和肝素或肝素衍生物。季烷基铵盐是总共具有22至26个碳原子的季脂族烷基铵盐和总共具有37至40个碳原子的季脂族烷基铵盐。}

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