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1. 发明申请

US20120070450A1 LEUKEMIA STEM CELL MARKERS 审中-公开
公开(公告)号：US20120070450A1
公开(公告)日：2012-03-22
申请号：US13258993
申请日：2010-03-24
申请人： Fumihiko Ishikawa , Osamu Ohara , Yoriko Saito , Hiroshi Kitamura , Atsushi Hijikata , Hidetoshi Ozawa , Leonard D. Shultz
发明人： Fumihiko Ishikawa , Osamu Ohara , Yoriko Saito , Hiroshi Kitamura , Atsushi Hijikata , Hidetoshi Ozawa , Leonard D. Shultz
IPC分类号： A61K39/395 , C12Q1/68 , G01N21/64 , A61P35/02 , C40B30/04 , A61K31/7088 , C07K16/18 , C07H21/00 , A61K35/12 , C12N5/078
CPC分类号： G01N33/57426 , A61K31/713 , A61K35/28 , C12Q1/6886 , C12Q2600/158
摘要： The invention provides a test method for predicting the initial onset or a recurrence of acute myeloid leukemia (AML) comprising (1) measuring the expression level of human leukemic stem cell (LSC) marker genes in a biological sample collected from a subject for a transcription product or translation product of the gene as an analyte and (2) comparing the expression level with a reference value; an LSC-targeting therapeutic agent for AML capable of suppressing the expression of a gene selected from among LSC marker genes or a substance capable of suppressing the activity of a translation product of the gene; a method for producing a sample containing hematopoietic cells for autologous transplantation or allogeneic transplantation for AML patients comprising obtaining an LSC-purged sample with at least 1 kind of LSC marker as an index; and a method of preventing or treating AML.
摘要翻译：本发明提供了一种用于预测急性骨髓性白血病（AML）的初始发作或复发的测试方法，其包括（1）测量从受试者收集的生物样品中人白血病干细胞（LSC）标记基因在转录中的表达水平作为分析物的基因的产物或翻译产物和（2）将表达水平与参考值进行比较; 用于抑制选自LSC标记基因或能够抑制该基因的翻译产物的活性的物质的表达的AML的LSC靶向治疗剂。一种用于产生含有用于AML患者的自体移植或同种异体移植的造血细胞的样品的方法，包括用至少1种LSC标记作为指标获得LSC清除的样品; 以及预防或治疗AML的方法。

2. 发明申请

US20140224041A1 LOAD MEASUREMENT SENSOR SUPPORT STRUCTURE 有权
标题翻译：负载测量传感器支持结构
公开(公告)号：US20140224041A1
公开(公告)日：2014-08-14
申请号：US14235301
申请日：2012-07-27
申请人： Hidetoshi Ozawa , Wataru Honda
发明人： Hidetoshi Ozawa , Wataru Honda
IPC分类号： G01D11/30 , G01L1/00
CPC分类号： G01D11/30 , B60N2/002 , B60N2/0732 , B60N2/682 , G01L1/00
摘要： A support structure stabilizes a position of a load measurement sensor by ensuring the rigidity of a support bracket supporting the sensor. The support structure supports the sensor, including an extension shaft portion extending from a sensor body, by each of attachment bracket and while the extension shaft portion is located at the lateral side of the sensor body, wherein each of the attachment brackets and includes an upright wall that is provided with an insertion hole into which the extension shaft portion is inserted when the sensor is supported, a bottom wall that intersects the upright wall and contacts the upright wall at one end in the seat width direction, and an upward protruding wall provided at a position contacting the bottom wall at the other end opposite the upright wall in the seat width direction of the bottom wall, intersecting the bottom wall, and facing the upright wall.
摘要翻译：支撑结构通过确保支撑传感器的支撑支架的刚度来稳定负载测量传感器的位置。所述支撑结构支撑所述传感器，所述传感器包括由传感器主体延伸的延伸轴部分，每个所述附接支架以及所述延伸轴部分位于所述传感器主体的侧面侧，其中每个所述附接支架包括直立所述壁设置有当所述传感器被支撑时所述延伸轴部分插入到其中的插入孔，与所述直立壁相交并在所述座椅宽度方向上的一端与所述直立壁相接触的底壁，在与底壁的座椅宽度方向相对的另一端的底壁处接触底壁的位置处，与底壁相交并且面向直立壁。

3. 发明授权

US09352666B2 Vehicle seat 有权
标题翻译：车座
公开(公告)号：US09352666B2
公开(公告)日：2016-05-31
申请号：US14238031
申请日：2012-08-02
申请人： Hiroyuki Kaku , Masaya Furuta , Hidetoshi Ozawa
发明人： Hiroyuki Kaku , Masaya Furuta , Hidetoshi Ozawa
IPC分类号： B60N2/16 , B60N2/42 , B60N2/00
CPC分类号： B60N2/16 , B60N2/002 , B60N2/1615 , B60N2/165 , B60N2/4228
摘要： A vehicle seat with a height adjustable seat bottom, includes left and right side frames each including a main body portion extending in a front-rear direction and a mount portion for a seat back frame protruding from a rear portion of the main body portion, which side frames constitute left and right frames of the seat bottom, a height adjustment mechanism configured to allow the left and right side frames to be lifted and lowered, and an operation unit including an operation knob configured to be operated by an occupant to cause the height adjustment mechanism to be actuated which operation unit is fixed to one of the left and right side frames. The operation unit is so disposed that at least a part thereof lies over the mount portion.
摘要翻译：具有高度可调节座椅底部的车辆座椅包括左右侧框架，每个框架包括从前后方向延伸的主体部分和用于从主体部分的后部突出的座椅靠背框架的安装部分，侧框架构成座椅底部的左右框架，配置为允许左右侧框架被提升和降低的高度调节机构，以及包括操作旋钮的操作单元，其被构造成由乘员操作以使高度调节机构被致动，哪个操作单元被固定到左侧框架和右侧框架中的一个。操作单元设置成使其至少一部分位于安装部分上方。

4. 发明授权

US09151644B2 Load measurement sensor support structure 有权
标题翻译：负载测量传感器支撑结构
公开(公告)号：US09151644B2
公开(公告)日：2015-10-06
申请号：US14235301
申请日：2012-07-27
申请人： Hidetoshi Ozawa , Wataru Honda
发明人： Hidetoshi Ozawa , Wataru Honda
IPC分类号： G01L1/00 , G01D11/30 , B60N2/00 , B60N2/07 , B60N2/68
CPC分类号： G01D11/30 , B60N2/002 , B60N2/0732 , B60N2/682 , G01L1/00
摘要： A support structure stabilizes a position of a load measurement sensor by ensuring the rigidity of a support bracket supporting the sensor. The support structure supports the sensor, including an extension shaft portion extending from a sensor body, by each of attachment bracket and while the extension shaft portion is located at the lateral side of the sensor body, wherein each of the attachment brackets and includes an upright wall that is provided with an insertion hole into which the extension shaft portion is inserted when the sensor is supported, a bottom wall that intersects the upright wall and contacts the upright wall at one end in the seat width direction, and an upward protruding wall provided at a position contacting the bottom wall at the other end opposite the upright wall in the seat width direction of the bottom wall, intersecting the bottom wall, and facing the upright wall.
摘要翻译：支撑结构通过确保支撑传感器的支撑支架的刚度来稳定负载测量传感器的位置。所述支撑结构支撑所述传感器，所述传感器包括由传感器主体延伸的延伸轴部分，每个所述附接支架以及所述延伸轴部分位于所述传感器主体的侧面侧，其中每个所述附接支架包括直立所述壁设置有当所述传感器被支撑时所述延伸轴部分插入到其中的插入孔，与所述直立壁相交并在所述座椅宽度方向上的一端与所述直立壁相接触的底壁，在与底壁的座椅宽度方向相对的另一端的底壁处接触底壁的位置处，与底壁相交并且面向直立壁。

5. 发明申请

US20140303004A1 METHOD FOR EXCLUSIVE SELECTION OF CIRCULARIZED DNA FROM MONOMOLECULAR DNA IN CIRCULARIZING DNA MOLECULES 有权
标题翻译：在单链DNA分子中从单分子DNA中独占选择循环DNA的方法
公开(公告)号：US20140303004A1
公开(公告)日：2014-10-09
申请号：US14240488
申请日：2012-08-24
申请人： Shinichi Mizuno , Hidetoshi Ozawa , Koji Nagafuji , Takashi Okamura
发明人： Shinichi Mizuno , Hidetoshi Ozawa , Koji Nagafuji , Takashi Okamura
IPC分类号： C12N15/10 , C12Q1/68
CPC分类号： C12N15/1065 , C07H21/04 , C12N9/93 , C12N15/10 , C12N15/1003 , C12N15/1096 , C12N15/64 , C12Q1/6806 , C12Q1/6809 , C12Q1/6883 , C12Q2521/301 , C12Q2525/307 , C12Q2525/191
摘要： The present invention provides a method for producing a circular DNA molecule having a specific structure that enables to distinguish circular DNA formed from a single DNA molecule (single-molecule circular DNA), from circular DNA formed from multiple DNA molecules (multiple-molecule circular DNA) and also from single-molecule circular DNA derived from the circular DNA formed from multiple DNA molecules. According to the present invention, only single-molecule circular DNA that is not derived from multiple-molecule circular DNA can be selected in the production of circular DNA.
摘要翻译：本发明提供一种具有特定结构的环状DNA分子的制造方法，该方法能够区分由单个DNA分子形成的环状DNA（单分子环状DNA）与由多个DNA分子形成的环状DNA（多分子环状DNA ）以及衍生自由多个DNA分子形成的环状DNA的单分子环状DNA。根据本发明，在循环DNA的制备中，只能选择不是来自多分子环状DNA的单分子环状DNA。

6. 发明申请

US20140183918A1 VEHICLE SEAT 有权
标题翻译：车辆座椅
公开(公告)号：US20140183918A1
公开(公告)日：2014-07-03
申请号：US14238031
申请日：2012-08-02
申请人： Hiroyuki Kaku , Masaya Furuta , Hidetoshi Ozawa
发明人： Hiroyuki Kaku , Masaya Furuta , Hidetoshi Ozawa
IPC分类号： B60N2/16
CPC分类号： B60N2/16 , B60N2/002 , B60N2/1615 , B60N2/165 , B60N2/4228
摘要： A vehicle seat with a height adjustable seat bottom, includes left and right side frames each including a main body portion extending in a front-rear direction and a mount portion for a seat back frame protruding from a rear portion of the main body portion, which side frames constitute left and right frames of the seat bottom, a height adjustment mechanism configured to allow the left and right side frames to be lifted and lowered, and an operation unit including an operation knob configured to be operated by an occupant to cause the height adjustment mechanism to be actuated which operation unit is fixed to one of the left and right side frames. The operation unit is so disposed that at least a part thereof lies over the mount portion.
摘要翻译：具有高度可调节座椅底部的车辆座椅包括左右侧框架，每个框架包括从前后方向延伸的主体部分和用于从主体部分的后部突出的座椅靠背框架的安装部分，侧框架构成座椅底部的左右框架，配置为允许左右侧框架被提升和降低的高度调节机构，以及包括操作旋钮的操作单元，其被构造成由乘员操作以使高度调节机构被致动，哪个操作单元被固定到左侧框架和右侧框架中的一个。操作单元设置成使其至少一部分位于安装部分上方。

7. 发明授权

US6059993A Record display medium and use thereof 失效
标题翻译：记录显示介质及其用途
公开(公告)号：US6059993A
公开(公告)日：2000-05-09
申请号：US992633
申请日：1997-12-18
申请人： Atsushi Baba , Hidetoshi Ozawa , Yoshinori Kinase
发明人： Atsushi Baba , Hidetoshi Ozawa , Yoshinori Kinase
IPC分类号： G02F1/13 , C08K5/105 , C08K5/315 , C08L101/00 , C09K19/46 , C09K19/54 , C09K19/60 , G02F1/1333 , G02F1/137 , C09K19/00 , C09K19/12 , C09K19/32
CPC分类号： C09K19/601 , C09K19/46 , C09K19/544 , G02F1/133365
摘要： A record display medium that can display a high contrast image and is less likely to cause a lowering of contrast or disappearance of the displayed image even in low temperature and high temperature regions. The record display medium has a conductive substrate and a liquid crystal/polymer composite film provided on the conductive substrate. The liquid crystal/polymer composite film includes a smectic liquid and a dichroic dye dispersed in a polymer matrix. The liquid crystal contains a liquid crystal mixture having a specific composition and the dichroic dye is a black dichroic dye formed of a mixture of dichroic azo dyes.
摘要翻译：可以显示高对比度图像的记录显示介质，并且即使在低温和高温区域中也不太可能导致显示图像的对比度或消失。记录显示介质具有导电基板和设置在导电基板上的液晶/聚合物复合膜。液晶/聚合物复合膜包括分散在聚合物基质中的近晶液体和二色性染料。液晶含有具有特定组成的液晶混合物，二色性染料是由二色性偶氮染料混合物形成的黑色二色性染料。

8. 发明授权

US09416358B2 Method for exclusive selection of circularized DNA from monomolecular DNA in circularizing DNA molecules 有权
标题翻译：在循环DNA分子中从单分子DNA中独占选择环化DNA的方法
公开(公告)号：US09416358B2
公开(公告)日：2016-08-16
申请号：US14240488
申请日：2012-08-24
申请人： Shinichi Mizuno , Hidetoshi Ozawa , Koji Nagafuji , Takashi Okamura
发明人： Shinichi Mizuno , Hidetoshi Ozawa , Koji Nagafuji , Takashi Okamura
IPC分类号： C12N15/10 , C07H21/04 , C12Q1/68 , C12N15/64 , C12N9/00
CPC分类号： C12N15/1065 , C07H21/04 , C12N9/93 , C12N15/10 , C12N15/1003 , C12N15/1096 , C12N15/64 , C12Q1/6806 , C12Q1/6809 , C12Q1/6883 , C12Q2521/301 , C12Q2525/307 , C12Q2525/191
摘要： The present invention provides a method for producing a circular DNA molecule having a specific structure that enables to distinguish circular DNA formed from a single DNA molecule (single-molecule circular DNA), from circular DNA formed from multiple DNA molecules (multiple-molecule circular DNA) and also from single-molecule circular DNA derived from the circular DNA formed from multiple DNA molecules. According to the present invention, only single-molecule circular DNA that is not derived from multiple-molecule circular DNA can be selected in the production of circular DNA.
摘要翻译：本发明提供一种具有特定结构的环状DNA分子的制造方法，该方法能够区分由单个DNA分子形成的环状DNA（单分子环状DNA）与由多个DNA分子形成的环状DNA（多分子环状DNA ）以及衍生自由多个DNA分子形成的环状DNA的单分子环状DNA。根据本发明，在循环DNA的制备中，只能选择不是来自多分子环状DNA的单分子环状DNA。

9. 发明申请

US20140224553A1 LOAD MEASUREMENT SENSOR SUPPORT STRUCTURE 审中-公开
标题翻译：负载测量传感器支持结构
公开(公告)号：US20140224553A1
公开(公告)日：2014-08-14
申请号：US14237739
申请日：2012-08-09
申请人： Hidetoshi Ozawa
发明人： Hidetoshi Ozawa
IPC分类号： G01G19/08
CPC分类号： G01G19/08 , B60N2/002 , B60N2/1615 , B60N2/165 , B60N2/682
摘要： In a case where a load measurement sensor is supported so that an extension shaft portion is located at the lateral side of a sensor body, the load measurement sensor is stably disposed without interference with the other members and an increase in the size of a seat is suppressed. In a support structure that supports a load measurement sensor by a height adjustment mechanism so that an extension shaft portion of the load measurement sensor is located at the lateral side of a sensor body, the height adjustment mechanism is a mechanism that displaces the height of a side frame with respect to an attachment member through the link mechanism including link members connecting the side frame to the attachment member, and the load measurement sensor is disposed so that at least a part of a load receiving portion of the sensor body is disposed in the link mechanism.
摘要翻译：在负载测量传感器被支撑以使得延伸轴部分位于传感器主体的侧面的情况下，负载测量传感器被稳定地布置而不与其它构件的干涉，并且座椅的尺寸的增加是被压制在通过高度调节机构支撑负载测量传感器的支撑结构中，负载测量传感器的延伸轴部分位于传感器主体的侧面，高度调节机构是将所述连结机构包括将所述侧架与所述安装部件连接的连杆部件，所述负载测量传感器配置成使得所述传感器主体的承载部的至少一部分配置在所述连接机构链接机制。

10. 发明申请

US20130025378A1 SUPPORT STRUCTURE FOR LOAD MEASUREMENT SENSOR 有权
标题翻译：负载测量传感器支撑结构
公开(公告)号：US20130025378A1
公开(公告)日：2013-01-31
申请号：US13558514
申请日：2012-07-26
申请人： Hidetoshi Ozawa , Wataru Honda
发明人： Hidetoshi Ozawa , Wataru Honda
IPC分类号： G01L1/04
CPC分类号： G01G19/4142 , B60N2/002
摘要： Provided is a support structure for a load measurement sensor having sufficient durability without adding a large load to a portion transmitting a load to the load measurement sensor. In a support structure for a load measurement sensor, including a sensor body detecting a load generated from a seat having a seat frame and an extension shaft portion extending from the sensor body, by way of attachment brackets in the state where the extension shaft portion follows the horizontal direction, the support structure includes a load input portion which comes into contact with the sensor body and inputs a load to the sensor body, the sensor body includes a load receiving surface which contacts the load input portion and receives the load, and the load input portion is formed to be movable in the axial direction of the extension shaft portion with respect to the load receiving surface.
摘要翻译：提供一种用于负载测量传感器的支撑结构，其具有足够的耐久性，而不向负载测量传感器传输负载的部分增加大的负载。在用于负载测量传感器的支撑结构中，包括传感器主体，其检测从具有座椅框架的座椅产生的负载和从传感器主体延伸的延伸轴部分，在延伸轴部分跟随的状态下，通过附接支架在水平方向上，支撑结构包括与传感器主体接触并将负载输入到传感器主体的负载输入部，传感器主体包括与负载输入部接触并接收负载的负载接收面，负载输入部形成为能够相对于负载接收面在延伸轴部的轴向上移动。

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