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1. 发明授权

EP3166032B1 BIOMETRIC SIMULATION DEVICE, METHOD FOR CONTROLLING BIOMETRIC SIMULATION DEVICE, AND PROGRAM FOR CONTROLLING BIOMETRIC SIMULATION DEVICE 有权
公开(公告)号：EP3166032B1
公开(公告)日：2018-10-03
申请号：EP14896780.5
申请日：2014-07-03
申请人： Fujitsu Limited , The University of Tokyo
发明人： HISADA, Toshiaki , SUGIURA, Seiryo , WASHIO, Takumi , OKADA, Junichi , NAGAI, Ryozo , KARIYA, Taro , WATANABE, Masahiro , HATANAKA, Kohei , NAKAGAWA, Machiko , KADOOKA, Yoshimasa
IPC分类号： G16H50/50
CPC分类号： G16H50/50 , G06F19/00
摘要： There is enabled an accurate fluid-structure interaction simulation on a biological organ having a deformable site that has an interface difficult to track. An operation unit (12) represents a structure domain in which tissues of a biological organ exist by using a structure mesh model (2) based on a Lagrange description method and a fluid domain in which fluid inside the biological organ exists by using an ALE fluid mesh model (3) based on an ALE description method. In addition, when performing a fluid-structure interaction simulation, the operation unit (12) deforms the structure mesh model (2) along with the progress of the simulation. Specifically, the operation unit (12) deforms the ALE fluid mesh model (3) in such a manner that no gap is formed on a first interface (4) located between a domain in which a site other than a certain site (2a) of the biological organ in the structure domain exists and the fluid domain or no overlap is formed with the structure domain, to track the first interface (4). The operation unit (12) captures a position of a second interface (5) located between a domain in which the certain site (2a) in the structure domain exists and the fluid domain by using the ALE fluid mesh model (3) as a reference.

2. 发明公开

EP3166032A1 BIOMETRIC SIMULATION DEVICE, METHOD FOR CONTROLLING BIOMETRIC SIMULATION DEVICE, AND PROGRAM FOR CONTROLLING BIOMETRIC SIMULATION DEVICE 有权
标题翻译： DEVICE生物识别模拟方法，用于控制生物体模拟并对器件进行编程控制用于生物识别仿真的器件
公开(公告)号：EP3166032A1
公开(公告)日：2017-05-10
申请号：EP14896780.5
申请日：2014-07-03
申请人： Fujitsu Limited , The University of Tokyo
发明人： HISADA, Toshiaki , SUGIURA, Seiryo , WASHIO, Takumi , OKADA, Junichi , NAGAI, Ryozo , KARIYA, Taro , WATANABE, Masahiro , HATANAKA, Kohei , NAKAGAWA, Machiko , KADOOKA, Yoshimasa
IPC分类号： G06F19/00
CPC分类号： G16H50/50 , G06F19/00
摘要： There is enabled an accurate fluid-structure interaction simulation on a biological organ having a deformable site that has an interface difficult to track.
An operation unit (12) represents a structure domain in which tissues of a biological organ exist by using a structure mesh model (2) based on a Lagrange description method and a fluid domain in which fluid inside the biological organ exists by using an ALE fluid mesh model (3) based on an ALE description method. In addition, when performing a fluid-structure interaction simulation, the operation unit (12) deforms the structure mesh model (2) along with the progress of the simulation. Specifically, the operation unit (12) deforms the ALE fluid mesh model (3) in such a manner that no gap is formed on a first interface (4) located between a domain in which a site other than a certain site (2a) of the biological organ in the structure domain exists and the fluid domain or no overlap is formed with the structure domain, to track the first interface (4). The operation unit (12) captures a position of a second interface (5) located between a domain in which the certain site (2a) in the structure domain exists and the fluid domain by using the ALE fluid mesh model (3) as a reference.
摘要翻译：有准确的流固耦合仿真启用了具有可变形部位做了一个生物器官具有接口难以追踪。运算单元（12）darstellt其中A生物器官的组织中通过使用结构网格模型存在的结构域（2）的基础上拉格朗日描述方法，并且其中流体中的生物器官内部的流体域中存在通过使用在ALE流体在ALE描述方法基于网格模型（3）。此外，当进行流体 - 结构交互模拟，运算单元（12）变形的结构网格模型（2）非常久远的模拟的进度。位于一个域之间具体地，操作单元（12）变形，ALE流体网格模型（3）求的方式并没有间隙形成在第一界面（4）上，其中除了有一定的位点（图2a）以外的部位在该结构域的生物器官存在和流体域或没有重叠形成为与结构域，以跟踪所述第一接口（4）。运算单元（12）通过使用ALE流体网格模型捕获位于其中在结构域中的某些部位（2a）中存在结构域和流体域之间的第二接口（5）的位置（3）为基准，

3. 发明授权

EP1733723B1 MEDICINE CAPABLE OF INHIBITING ACTIVATION OF TRANSCRIPTION FACTOR KLF5 有权
标题翻译：药物转录因子KLF5来抑制激活
公开(公告)号：EP1733723B1
公开(公告)日：2011-07-13
申请号：EP05710637.9
申请日：2005-02-24
申请人： The University of Tokyo , Kowa Company, Ltd.
发明人： NAGAI, Ryozo , SUZUKI, Toru
IPC分类号： A61K31/202 , A61K45/00 , A61P9/00 , A61P9/10 , A61P43/00
CPC分类号： A61K31/202
摘要： A medicine capable of inhibiting the activation of transcription factor KLF5 and thus capable of inhibiting blood vessel remodeling and arteriosclerosis, which medicine comprises as an active ingredient an acyclic polyprenyl compound (for example, polyprenylcarboxylic acids such as 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid).

4. 发明公开

EP1733723A1 MEDICINE CAPABLE OF INHIBITING ACTIVATION OF TRANSCRIPTION FACTOR KLF5 有权
标题翻译： MEDIKAMENT ZUR HEMMUNG DER AKTIVIERUNG DES TRANSKRIPTIONS FAKTORS KLF5
公开(公告)号：EP1733723A1
公开(公告)日：2006-12-20
申请号：EP05710637.9
申请日：2005-02-24
申请人： The University of Tokyo , Nikken Chemicals Company, Limited
发明人： NAGAI, Ryozo , SUZUKI, Toru
IPC分类号： A61K31/202 , A61K45/00 , A61P9/00 , A61P9/10 , A61P43/00
CPC分类号： A61K31/202
摘要： A medicament having an action of inhibiting activation of transcription factor KLF5 and thus inhibiting vascular remodeling and arteriosclerosis, which comprises an acyclic polyprenyl compound (e.g., polyprenylcarboxylic acid such as 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentanoic acid and the like) as an active ingredient.
摘要翻译：一种具有抑制转录因子KLF5活化并因此抑制血管重构和动脉硬化的作用的药物，其包含无环聚异戊二烯基化合物（例如聚异戊二烯基羧酸，例如3,7,11,15-四甲基-2,4,6,10 ，14-十六酸戊酯等）作为活性成分。

5. 发明公开

EP2626069A1 PROPHYLACTIC AND/OR THERAPEUTIC AGENT AGAINST LYMPHEDEMA 审中-公开
标题翻译： PROPHYLAKTISCHES UND / ODER THERAPEUTISCHES MITTEL GEGENLYMPHÖDEME
公开(公告)号：EP2626069A1
公开(公告)日：2013-08-14
申请号：EP11830704.0
申请日：2011-10-05
申请人： The University of Tokyo , Kowa Company, Ltd.
发明人： MANABE, Ichiro , NAGAI, Ryozo , OGATA, Fusa
IPC分类号： A61K31/22 , A61P7/10
CPC分类号： A61K31/22 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/44 , A61K31/47 , A61K31/505
摘要： Provided is a new prophylactic and/or therapeutic agent for lymphedema, for which until now there has been no effective means of treatment, and the prophylactic and/or therapeutic agent for lymphedema comprises, as an active ingredient, a compound represented by the following formula (1), a lactone derivative thereof, or a salt of the compound or lactone derivative:

wherein R 1 represents an organic group, X represents -CH 2 CH 2 - or -CH=CH-, and R 2 represents a hydrogen atom or an alkyl group.
摘要翻译：提供了一种用于淋巴水肿的新的预防和/或治疗剂，迄今为止，没有有效的治疗方法，并且用于淋巴水肿的预防和/或治疗剂包含作为活性成分的由下式表示的化合物（1）表示的内酯衍生物或其内酯衍生物的盐或其盐，其中R 1表示有机基团，X表示-CH 2 CH 2 - 或-CH = CH-，R 2表示氢原子或烷基。

6. 发明公开

EP2644734A1 NICKEL-FREE STAINLESS STEEL STENT 有权
标题翻译： NICKELFREIER EDELSTAHL-STENT
公开(公告)号：EP2644734A1
公开(公告)日：2013-10-02
申请号：EP11843581.7
申请日：2011-11-25
申请人： National Institute for Materials Science , The University of Tokyo
发明人： TAGUCHI, Tetsushi , KATADA, Yasuyuki , NAGAI, Ryozo , MANABE, Ichiro , FIJIU, Katsuhito
IPC分类号： C22C38/00 , A61L29/00 , C22C38/22 , C22C38/32
CPC分类号： A61F2/82 , A61L31/022 , C22C38/001 , C22C38/002 , C22C38/02 , C22C38/04 , C22C38/06 , C22C38/22 , C22C38/26 , C22C38/28 , C22C38/32 , C22C38/44
摘要： A nickel-free stainless steel stent using a stainless steel which does not substantially contain Ni in the stainless steel, has a metal allergy onset-preventing effect, and is excellent in terms of precision workability, strength, and ductility, is provided.
The nickel-free stainless steel stent is characterized by using a stainless steel containing, as a chemical composition, from 15 to 30 % by mass of Cr, from 1 to 10 % by mass of Mo, and from 0.5 to 1 % by mass of N, with the remainder being Fe, and optionally containing inevitable impurities.
摘要翻译：使用不锈钢中不含有Ni的不锈钢的不含镍的不锈钢支架具有金属过敏起效防止效果，并且在精度可加工性，强度和延展性方面优异。无镍不锈钢支架的特征在于，使用含有15〜30质量％的Cr，1〜10质量％的Mo和0.5〜1质量％的作为化学组成的不锈钢， N，其余为Fe，并且任选地含有不可避免的杂质。

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