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1. 发明申请

US20160299164A1 REAGENT MANAGEMENT SYSTEM 审中-公开
标题翻译：试剂管理系统
公开(公告)号：US20160299164A1
公开(公告)日：2016-10-13
申请号：US15084663
申请日：2016-03-30
申请人： Friedrich Ackermann , Andreas Calatzis , Rik Harbers , Roland Hutter , Jean-Pierre Bolliger , Theresa Kitcoff , Patrick Sascha Labud
发明人： Friedrich Ackermann , Andreas Calatzis , Rik Harbers , Roland Hutter , Jean-Pierre Bolliger , Theresa Kitcoff , Patrick Sascha Labud
IPC分类号： G01N35/00 , B01L9/00 , G01N35/10
CPC分类号： G01N35/00663 , B01L9/00 , B01L2200/025 , G01N35/00693 , G01N35/00722 , G01N35/0092 , G01N35/04 , G01N35/1002 , G01N35/1009 , G01N35/1016 , G01N35/1079 , G01N2035/00425 , G01N2035/00673 , G01N2035/00891 , G01N2035/0094 , G01N2035/0406 , G01N2035/1025
摘要： A reagent management system is disclosed comprising a reagent container section for receiving reagent containers and a reagent reconstitution device for reconstituting dry, or lyophilized, reagents or concentrated reagents in reagent containers in order to carry out in-vitro diagnostic tests with the reconstituted reagents. A controller is programmed to instruct the reagent reconstitution device to automatically reconstitute an initial volume of a selected reagent type in reagent containers. The initial volume is calculated based on an open container stability time (OCS) of the reconstituted reagent type for each reagent container and on a number of tests to be carried out within the OCS of the reconstituted reagent type. A reagent container for use by the reagent management system and methods of automatically reconstituting a dry, or lyophilized reagent, or a concentrated liquid reagent in a reagent container to carry out an in-vitro diagnostic test with the reagent are disclosed.
摘要翻译：公开了一种试剂管理系统，其包括用于接收试剂容器的试剂容器部分和用于在试剂容器中重构干燥或冻干的试剂或浓缩试剂的试剂重构装置，以便用重构的试剂进行体外诊断试验。控制器被编程为指示试剂重构装置在试剂容器中自动重建所选试剂类型的初始体积。基于每个试剂容器的重构试剂类型的开放容器稳定时间（OCS）以及将在重构试剂类型的OCS内进行的许多试验来计算初始体积。公开了一种试剂管理系统使用的试剂容器和将试剂容器中的干燥试剂或冻干试剂或浓缩液体试剂自动重构的方法，对试剂进行体外诊断试验。

2. 发明授权

US08465978B2 Method for conducting platelete aggregation analysis by a cartridge device 有权
标题翻译：通过药筒装置进行血小板聚集分析的方法
公开(公告)号：US08465978B2
公开(公告)日：2013-06-18
申请号：US13029575
申请日：2011-02-17
申请人： Andreas Calatzis , Ben Krüger , Marc Wittwer
发明人： Andreas Calatzis , Ben Krüger , Marc Wittwer
IPC分类号： G01N33/86 , G01N33/48 , G01N27/02
CPC分类号： G01N33/86 , G01N27/07 , G01N33/4905
摘要： Methods and devices for conducting platelet aggregation analysis. A method for conducting platelet aggregation analysis by a cartridge device, including providing a blood sample in the cartridge device, stirring the blood sample within the cartridge device, measuring the electrical impedance between electrodes to obtain measured electrical impedance values, comparing measured electrical impedance values, discarding and repeating the measurements of the electrical impedance in case a variation of the measurements is outside a predetermined threshold range, or reporting the measured electrical impedance values in case the variation of the measurements is within the predetermined threshold range. Reported measured electrical impedance values indicate platelet aggregation in a blood sample.
摘要翻译：用于进行血小板聚集分析的方法和装置。一种用于通过盒装置进行血小板聚集分析的方法，包括在盒装置中提供血液样品，搅拌盒装置内的血样，测量电极之间的电阻抗，以获得测得的电阻抗值，比较测量的电阻抗值，在测量的变化超出预定阈值范围的情况下丢弃并重复电阻抗的测量，或者在测量的变化在预定阈值范围内的情况下报告所测量的电阻抗值。报告的测量电阻抗值表示血液样本中的血小板聚集。

3. 发明授权

US07901629B2 Cartridge device for blood analysis 有权
标题翻译：血液分析装置
公开(公告)号：US07901629B2
公开(公告)日：2011-03-08
申请号：US10583062
申请日：2003-12-16
申请人： Andreas Calatzis , Ben Krüger , Marc Wittwer
发明人： Andreas Calatzis , Ben Krüger , Marc Wittwer
IPC分类号： G01N33/48 , G01N33/86 , G01N27/02 , B01L3/00
CPC分类号： G01N33/86 , G01N27/07 , G01N33/4905
摘要： A cartridge device having a receiving portion for receiving a blood sample and a jack portion for receiving a plug; a stirring device for circulating the blood sample within the receiving portion; and an electrode holder having at least one incorporated electrode wire pair; wherein the electrode holder is attachable to the cell such that one end of the at least one electrode wire pair forms a sensor unit for measuring the electrical impedance between the two electrode wires of the at least one electrode wire pair within the blood sample and that the opposite end of the at least one electrode wire pair forms a plug portion being connectable directly to the plug for an electrical connection of the sensor unit to an analyser.
摘要翻译：具有用于接收血液样本的接收部分和用于接收插头的插座部分的盒装置; 搅拌装置，用于在接收部分内循环血液样品; 和具有至少一个结合的电极线对的电极保持器; 其中所述电极保持器可附接到所述电池，使得所述至少一个电极线对的一端形成传感器单元，用于测量所述血液样本内的所述至少一个电极线对的两个电极线之间的电阻抗，至少一个电极线对的相对端形成可直接连接到插头的插头部分，用于传感器单元与分析器的电连接。

4. 发明授权

US08591816B2 Cartridge device for blood analysis 有权
标题翻译：血液分析装置
公开(公告)号：US08591816B2
公开(公告)日：2013-11-26
申请号：US13029553
申请日：2011-02-17
申请人： Andreas Calatzis , Ben Krüger , Marc Wittwer
发明人： Andreas Calatzis , Ben Krüger , Marc Wittwer
IPC分类号： G01N33/86 , G01N33/48 , G01N27/02 , B01L3/00
CPC分类号： G01N33/86 , G01N27/07 , G01N33/4905
摘要： A cartridge device having a receiving portion for receiving a blood sample and a jack portion for receiving a plug; a stirring device for circulating the blood sample within the receiving portion; and an electrode holder having at least one incorporated electrode wire pair; wherein the electrode holder is attachable to the cell such that one end of the at least one electrode wire pair forms a sensor unit for measuring the electrical impedance between the two electrode wires of the at least one electrode wire pair within the blood sample and that the opposite end of the at least one electrode wire pair forms a plug portion being connectable directly to the plug for an electrical connection of the sensor unit to an analyzer.
摘要翻译：具有用于接收血液样本的接收部分和用于接收插头的插座部分的盒装置; 搅拌装置，用于在接收部分内循环血液样品; 和具有至少一个结合的电极线对的电极保持器; 其中所述电极保持器可附接到所述电池，使得所述至少一个电极线对的一端形成传感器单元，用于测量所述血液样本内的所述至少一个电极线对的两个电极线之间的电阻抗，至少一个电极线对的相对端形成可直接连接到插头的插头部分，用于传感器单元与分析器的电连接。

5. 发明申请

US20110136164A1 CARTRIDGE DEVICE FOR BLOOD ANALYSIS 有权
公开(公告)号：US20110136164A1
公开(公告)日：2011-06-09
申请号：US13029575
申请日：2011-02-17
申请人： Andreas Calatzis , Ben Krüger , Marc Wittwer
发明人： Andreas Calatzis , Ben Krüger , Marc Wittwer
IPC分类号： C12Q1/02
CPC分类号： G01N33/86 , G01N27/07 , G01N33/4905
摘要： A cartridge device having a receiving portion for receiving a blood sample and a jack portion for receiving a plug; a stirring device for circulating the blood sample within the receiving portion; and an electrode holder having at least one incorporated electrode wire pair; wherein the electrode holder is attachable to the cell such that one end of the at least one electrode wire pair forms a sensor unit for measuring the electrical impedance between the two electrode wires of the at least one electrode wire pair within the blood sample and that the opposite end of the at least one electrode wire pair forms a plug portion being connectable directly to the plug for an electrical connection of the sensor unit to an analyser.

6. 发明申请

US20110133762A1 CARTRIDGE DEVICE FOR BLOOD ANALYSIS 有权
标题翻译：用于血液分析的盒装置
公开(公告)号：US20110133762A1
公开(公告)日：2011-06-09
申请号：US13029553
申请日：2011-02-17
申请人： Andreas Calatzis , Ben Krüger , Marc Wittwer
发明人： Andreas Calatzis , Ben Krüger , Marc Wittwer
IPC分类号： G01R27/08
CPC分类号： G01N33/86 , G01N27/07 , G01N33/4905
摘要： A cartridge device having a receiving portion for receiving a blood sample and a jack portion for receiving a plug; a stirring device for circulating the blood sample within the receiving portion; and an electrode holder having at least one incorporated electrode wire pair; wherein the electrode holder is attachable to the cell such that one end of the at least one electrode wire pair forms a sensor unit for measuring the electrical impedance between the two electrode wires of the at least one electrode wire pair within the blood sample and that the opposite end of the at least one electrode wire pair forms a plug portion being connectable directly to the plug for an electrical connection of the sensor unit to an analyser.
摘要翻译：具有用于接收血液样本的接收部分和用于接收插头的插座部分的盒装置; 搅拌装置，用于在接收部分内循环血液样品; 和具有至少一个结合的电极线对的电极保持器; 其中所述电极保持器可附接到所述电池，使得所述至少一个电极线对的一端形成传感器单元，用于测量所述血液样本内的所述至少一个电极线对的两个电极线之间的电阻抗，至少一个电极线对的相对端形成可直接连接到插头的插头部分，用于传感器单元与分析器的电连接。

7. 发明授权

US07745223B2 Device with novel and improved surface properties 有权
标题翻译：具有新颖和改进的表面性能的装置
公开(公告)号：US07745223B2
公开(公告)日：2010-06-29
申请号：US11200494
申请日：2005-08-10
申请人： Axel Schubert , Stefan Wurlitzer , Andreas Calatzis , Martin Glauner
发明人： Axel Schubert , Stefan Wurlitzer , Andreas Calatzis , Martin Glauner
IPC分类号： G01N33/86
CPC分类号： B29C59/14 , B01L3/508 , G01N33/4905 , Y10T436/25
摘要： To increase the adhesion strength of coagulated blood on a surface by increasing the surface interaction of blood-inherent components like fibrin/fibrinogen and thrombocytes it is described to treat the surface by exposing it to ionized atoms or molecules. The surface treatment according to the invention is applied on plastic disposables used in blood diagnostics (e.g. hemostasis analysis) as well as medical implants like artery sealings. The improved blood clot adhesion results in higher diagnostic security due to reduced measurement failure (e.g., for patients with increased thrombocyte content) and in better significance of special tests (e.g., hyperfibrinolysis diagnosis).
摘要翻译：为了通过增加血液固有组分如纤维蛋白/纤维蛋白原和凝血细胞的表面相互作用来增加凝血血液在表面上的粘附强度，可以通过将其暴露于离子化的原子或分子来处理表面。根据本发明的表面处理应用于血液诊断（例如止血分析）中使用的塑料一次性物品以及诸如动脉密封的医疗植入物。由于减少的测量失败（例如，对于具有增加的血小板含量的患者）和特别测试（例如，超纤维蛋白溶解诊断）的更好的显着性，改善的血块粘附导致更高的诊断安全性。

8. 发明申请

US20060034734A1 Device with novel and improved surface properties 有权
标题翻译：具有新颖和改进的表面性能的装置
公开(公告)号：US20060034734A1
公开(公告)日：2006-02-16
申请号：US11200494
申请日：2005-08-10
申请人： Axel Schubert , Stefan Wurlitzer , Andreas Calatzis , Martin Glauner
发明人： Axel Schubert , Stefan Wurlitzer , Andreas Calatzis , Martin Glauner
IPC分类号： B01L11/00
CPC分类号： B29C59/14 , B01L3/508 , G01N33/4905 , Y10T436/25
摘要： To increase the adhesion strength of coagulated blood on a surface by increasing the surface interaction of blood-inherent components like fibrin/fibrinogen and thrombocytes it is described to treat the surface by exposing it to ionized atoms or molecules. The surface treatment according to the invention is applied on plastic disposables used in blood diagnostics (e.g. haemostasis analysis) as well as medical implants like artery sealings. The improved blood clot adhesion results in higher diagnostic security due to reduced measurement failure (e.g., for patients with increased thrombocyte content) and in better significance of special tests (e.g., hyperfibrinolysis diagnosis).
摘要翻译：为了通过增加血液固有组分如纤维蛋白/纤维蛋白原和凝血细胞的表面相互作用来增加凝血血液在表面上的粘附强度，可以通过将其暴露于离子化的原子或分子来处理表面。根据本发明的表面处理用于血液诊断（例如止血分析）中使用的塑料一次性物品以及诸如动脉密封的医疗植入物。由于减少的测量失败（例如，对于具有增加的血小板含量的患者）和特别测试（例如，超纤维蛋白溶解诊断）的更好的显着性，改善的血块粘附导致更高的诊断安全性。

9. 发明申请

US20100190193A1 DIAGNOSTIC COMPOSITION AND ITS USE IN THE DETERMINATION OF COAGULATION CHARACTERISTICS OF A TEST LIQUID 审中-公开
标题翻译：诊断组合物及其在测定液体凝集特性中的应用
公开(公告)号：US20100190193A1
公开(公告)日：2010-07-29
申请号：US12522364
申请日：2008-01-31
申请人： Andreas Calatzis , Martin Glauner , Axel Schubert , Max Kessler
发明人： Andreas Calatzis , Martin Glauner , Axel Schubert , Max Kessler
IPC分类号： C12Q1/56 , C12M1/34
CPC分类号： G01N33/86 , G01N2333/745
摘要： The present invention is directed to a diagnostic composition for use in the viscoelastic analysis of a test liquid, and to a container (1) comprising same. The composition comprises at least an activator of coagulation, and, optionally CaCl2 an optionally, one or more inhibitors and/or coagulation components, wherein the composition is present as an essentially dry mixture of all constituents and in an amount sufficient for performing one single viscoelastic analysis of a specified blood or plasma sample. The present invention is further directed to a method of performing a viscoelastic analysis on a test liquid, and to the use of the diagnostic composition in such a method.
摘要翻译：本发明涉及用于测试液体的粘弹性分析的诊断组合物，以及包含该液体的容器（1）。该组合物包含至少一种凝固活化剂，以及任选的CaCl 2，任选的一种或多种抑制剂和/或凝结组分，其中所述组合物作为所有组分的基本上干燥的混合物存在并且以足以实施单一粘弹性分析指定的血液或血浆样品。本发明还涉及对这种方法对测试液体进行粘弹性分析的方法和诊断组合物的用途。

10. 发明申请

US20070140902A1 Cartridge device for blood analysis 有权
标题翻译：血液分析装置
公开(公告)号：US20070140902A1
公开(公告)日：2007-06-21
申请号：US10583062
申请日：2003-12-16
申请人： Andreas Calatzis , Ben Kruger , Marc Wittwer
发明人： Andreas Calatzis , Ben Kruger , Marc Wittwer
IPC分类号： B01L3/00
CPC分类号： G01N33/86 , G01N27/07 , G01N33/4905
摘要： The present invention provides a cartridge device (20) comprising a receiving portion (10) for receiving a blood sample and a jack portion (18) for receiving a plug (22); a stirring device (19) for circulating said blood sample within said receiving portion (10); and an electrode holder (14) having at least one incorporated electrode wire pair (16; 24; 25; 26); wherein the electrode holder (14) is attachable to the cell (9) such that one end (16a; 24a; 25a; 26a) of the at least one electrode wire pair (16; 24; 25; 26) forms a sensor unit (17a; 17b; 17c; 17d) for measuring the electrical impedance between the two electrode wires of the at least one electrode wire pair (16; 24; 25; 26) within the blood sample and that the opposite end (16b; 24b; 25b; 26b) of the at least one electrode wire pair (16; 24; 25; 26) forms a plug portion (21a; 21b; 21c; 21d) being connectable directly to the plug (22) for an electrical connection of the sensor unit (17a; 17b; 17c; 17d) to an analyser.
摘要翻译：本发明提供了一种盒装置（20），其包括用于接收血液样本的接收部分（10）和用于接收插头（22）的插座部分（18）。用于在所述接收部分（10）内循环所述血液样品的搅拌装置（19）; 和具有至少一个并入电极线对（16; 24; 25; 26）的电极夹持器（14）; 其中所述电极保持器（14）可附接到所述电池（9），使得所述至少一个电极线对（16; 24; 25; 26）的一端（16a; 24a; 25a; 26a）形成用于测量所述血样中所述至少一个电极线对（16; 24; 25; 26）的两个电极线之间的电阻抗的传感器单元（17a; 17b; 17c; 17d），并且所述至少一个电极线对（16; 24; 25; 26）的相对端（16b; 24b; 25b; 26b）形成插塞部分（21a; 21b; 21c; 21d）可直接连接到插头（22），用于将传感器单元（17a; 17b; 17c; 17d）的电连接到分析器。

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