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1. 发明申请

US20070280983A1 Medical devices having improved performance 有权
标题翻译：具有改进性能的医疗设备
公开(公告)号：US20070280983A1
公开(公告)日：2007-12-06
申请号：US11444804
申请日：2006-06-01
申请人： Frederick H. Strickler , Shrirang V. Ranade
发明人： Frederick H. Strickler , Shrirang V. Ranade
IPC分类号： A61F13/02
CPC分类号： A61L29/041 , A61L27/16 , A61L29/16 , A61L31/048 , A61L31/16 , A61L2300/00 , C08L53/005
摘要： According to an aspect of the present invention, medical devices are provided that contain at least one polymeric region which contains (a) at least one block copolymer that contains at least at least three polymer blocks that differ from one another and (b) at least one therapeutic agent.
摘要翻译：根据本发明的一个方面，提供了包含至少一个聚合物区域的医疗装置，所述至少一个聚合物区域包含（a）至少一种包含至少三个彼此不同的聚合物嵌段的嵌段共聚物，和（b）至少一种治疗代理商

2. 发明授权

US07914806B2 Medical devices having improved performance 有权
标题翻译：具有改进性能的医疗设备
公开(公告)号：US07914806B2
公开(公告)日：2011-03-29
申请号：US11444804
申请日：2006-06-01
申请人： Frederick H. Strickler , Shrirang V. Ranade
发明人： Frederick H. Strickler , Shrirang V. Ranade
IPC分类号： A61F13/00 , A61F2/00 , A61F2/01 , A61F2/24 , A61F2/82 , A61K47/30
CPC分类号： A61L29/041 , A61L27/16 , A61L29/16 , A61L31/048 , A61L31/16 , A61L2300/00 , C08L53/005
摘要： According to an aspect of the present invention, medical devices are provided that contain at least one polymeric region which contains (a) at least one block copolymer that contains at least at least three polymer blocks that differ from one another and (b) at least one therapeutic agent.
摘要翻译：根据本发明的一个方面，提供了包含至少一个聚合物区域的医疗装置，所述至少一个聚合物区域包含（a）至少一种包含至少三个彼此不同的聚合物嵌段的嵌段共聚物，和（b）至少一种治疗代理商

3. 发明授权

US08535702B2 Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility 有权
标题翻译：具有用于受控药物递送和调节的生物相容性的多孔聚合物区域的医疗装置
公开(公告)号：US08535702B2
公开(公告)日：2013-09-17
申请号：US11048616
申请日：2005-02-01
申请人： Robert E. Richard , Frederick H. Strickler , Marlene C. Schwarz , Rudolf Faust , Shrirang V. Ranade , Michael N. Helmus
发明人： Robert E. Richard , Frederick H. Strickler , Marlene C. Schwarz , Rudolf Faust , Shrirang V. Ranade , Michael N. Helmus
IPC分类号： A61F2/00
CPC分类号： A61L31/129 , A61L27/48 , A61N1/05
摘要： The present invention relates to phase separated polymeric regions and to their use in conjunction with implantable or insertable medical devices. In some aspects of the invention, phase separated polymeric regions are provided that include (a) at least one biostable polymeric phase and (b) at least one biodisintegrable polymeric phase, which is of nanoscale dimensions and which undergoes biodisintegration such that the phase separated polymeric region becomes a nanoporous polymeric region in vivo. Other aspects of the invention are directed to methods of making implantable or insertable medical devices having at least one nanoporous polymeric region. These methods include (a) providing a phase separated polymeric region comprising a stable polymeric phase and a disintegrable polymeric phase of nanoscale dimensions, (b) selectively removing the disintegrable polymeric phase thereby producing the nanoporous polymeric region. In still other aspects, implantable or insertable medical devices are provided which have phase separated polymeric regions that include (a) at least one block copolymer having at least one biostable polymer block and at least one biodisintegrable polymer block and (b) at least one therapeutic agent which is released in vivo upon implantation or insertion of the medical device.
摘要翻译：本发明涉及相分离的聚合物区域以及它们与可植入或可插入的医疗装置结合使用。在本发明的一些方面，提供了相分离的聚合物区域，其包括（a）至少一个生物稳定的聚合物相和（b）至少一个具有纳米级尺寸并且经历生物整合的生物分解聚合物相，并且经历相分离的聚合物区域在体内成为纳米孔聚合物区域。本发明的其它方面涉及制造具有至少一个纳米多孔聚合物区域的可植入或可插入医疗器械的方法。这些方法包括（a）提供包含稳定聚合物相和纳米尺度的可分解聚合物相的相分离聚合物区域，（b）选择性地除去可分解的聚合物相，从而制备纳米多孔聚合物区域。在另外的方面，提供了可植入或可插入的医疗装置，其具有相分离的聚合物区域，其包括（a）至少一种具有至少一种生物稳定聚合物嵌段和至少一种生物可分解聚合物嵌段的嵌段共聚物和（b）至少一种治疗在植入或插入医疗装置时在体内释放的药剂。

4. 发明申请

US20110150972A1 MEDICAL DEVICES HAVING IMPROVED PERFORMANCE 有权
标题翻译：具有改进性能的医疗器械
公开(公告)号：US20110150972A1
公开(公告)日：2011-06-23
申请号：US13036777
申请日：2011-02-28
申请人： Frederick H. Strickler , Shrirang V. Ranade
发明人： Frederick H. Strickler , Shrirang V. Ranade
IPC分类号： A61K47/32 , A61K9/70 , A61P31/00 , A61P29/00 , A61P35/00 , A61P7/02
CPC分类号： A61L29/041 , A61L27/16 , A61L29/16 , A61L31/048 , A61L31/16 , A61L2300/00 , C08L53/005
摘要： According to an aspect of the present invention, medical devices are provided that contain at least one polymeric region which contains (a) at least one block copolymer that contains at least at least three polymer blocks that differ from one another and (b) at least one therapeutic agent.
摘要翻译：根据本发明的一个方面，提供了包含至少一个聚合物区域的医疗装置，该聚合物区域含有（a）至少含有至少三个彼此不同的聚合物嵌段的嵌段共聚物，和（b）至少一种治疗剂。

5. 发明授权

US08034874B2 Medical devices having polymeric regions that contain fluorocarbon-containing block copolymers 有权
标题翻译：具有含有含氟烃嵌段共聚物的聚合物区域的医疗装置
公开(公告)号：US08034874B2
公开(公告)日：2011-10-11
申请号：US11285885
申请日：2005-11-23
申请人： Frederick H. Strickler , Ronald A. Sahatjian
发明人： Frederick H. Strickler , Ronald A. Sahatjian
IPC分类号： C08L53/00 , A61F2/06 , A61F2/24
CPC分类号： C08L53/00 , C08F293/00 , C08F293/005 , C09D153/00
摘要： In one aspect, the present invention provides implantable or insertable medical devices, which contain at least one polymeric region. The polymeric region contains at least one fluorocarbon-containing block copolymer, which, in turn, contains (a) at least one fluorocarbon-containing, low glass transition temperature (low Tg) copolymer chain and (b) at least one glass transition temperature (high Tg) polymer chain.
摘要翻译：在一个方面，本发明提供了可植入或可插入的医疗装置，其包含至少一个聚合物区域。聚合物区域含有至少一种含氟烃嵌段共聚物，其又包含（a）至少一种含碳氟化合物，低玻璃化转变温度（低Tg）共聚物链和（b）至少一个玻璃化转变温度高Tg）聚合物链。

6. 发明授权

US07897170B2 Medical devices having improved mechanical performance 有权
标题翻译：医疗器械具有改善的机械性能
公开(公告)号：US07897170B2
公开(公告)日：2011-03-01
申请号：US11809459
申请日：2007-06-01
申请人： Frederick H. Strickler , Mark Boden
发明人： Frederick H. Strickler , Mark Boden
IPC分类号： A61F13/00
CPC分类号： A61L27/16 , A61L29/041 , A61L31/048 , C08L53/00
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided that contain at least one covalently crosslinked polymeric region, which contains at least one block copolymer comprising at least one low Tg block and at least one high Tg block.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含至少一个共价交联的聚合物区域，其含有至少一个包含至少一个低Tg嵌段和至少一个高Tg嵌段的嵌段共聚物。

7. 发明申请

US20080145516A1 Processes for producing polymer coatings through surface polymerization 失效
标题翻译：通过表面聚合生产聚合物涂层的方法
公开(公告)号：US20080145516A1
公开(公告)日：2008-06-19
申请号：US12070275
申请日：2008-02-14
申请人： Robert A. Herrmann , Frederick H. Strickler , Wendy Naimark , Peter L. Dayton
发明人： Robert A. Herrmann , Frederick H. Strickler , Wendy Naimark , Peter L. Dayton
IPC分类号： B05D3/10 , A61F2/82
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/606
摘要： A medical device with a therapeutic agent-releasing polymer coating. The medical device is provided by a method that comprises: (a) attaching at least one reactive species to a medical device surface, which reactive species leads to chain growth polymerization in the presence of monomer; (b) contacting the reactive species with at least one monomer species, thereby forming a polymer coating on the surface of the medical device; and (c) providing at least one therapeutic agent within the polymer coating. The therapeutic agent may be incorporated during formation of the polymer coating or after formation of the polymer coating. The at least one reactive species can comprise, for example, a free radical species, a carbanion species. a carbocation species, a Ziegler-Natta polymerization complex, a metallocene complex, and/or an atom transfer radical polymerization initiator. Alternatively, the medical device is provided by a process comprising: (a) immobilizing least one polymerization catalyst at a medical device surface, which polymerization catalyst leads to polymerization in the presence of monomer; (b) contacting the medical device surface with at least one monomer species, thereby forming a polymer coating at the surface of the medical device; and (c) providing at least one therapeutic agent within the polymer coating.
摘要翻译：具有治疗剂释放聚合物涂层的医疗装置。该医疗装置由一种方法提供，该方法包括：（a）将至少一种反应性物质附着到医疗器械表面上，该反应性物质在单体存在下导致链增长聚合; （b）使反应性物质与至少一种单体物质接触，从而在医疗装置的表面上形成聚合物涂层; 和（c）在聚合物涂层内提供至少一种治疗剂。治疗剂可以在形成聚合物涂层期间或在形成聚合物涂层之后引入。至少一种反应性物质可以包含例如自由基物质，碳负离子物质。碳阳离子种类，齐格勒 - 纳塔聚合络合物，茂金属络合物和/或原子转移自由基聚合引发剂。或者，医疗装置由包括以下步骤的方法提供：（a）在医疗器械表面固定最少一种聚合催化剂，该聚合催化剂在单体存在下导致聚合; （b）使医疗器械表面与至少一种单体物质接触，从而在医疗装置的表面形成聚合物涂层; 和（c）在聚合物涂层内提供至少一种治疗剂。

8. 发明授权

US08870814B2 Implantable or insertable medical devices containing silicone copolymer for controlled delivery of therapeutic agent 有权
标题翻译：可植入或可插入的含有共聚物的硅氧烷共聚物，用于治疗剂的控制递送
公开(公告)号：US08870814B2
公开(公告)日：2014-10-28
申请号：US10632008
申请日：2003-07-31
申请人： Robert E. Richard , Marlene C. Schwarz , Frederick H. Strickler
发明人： Robert E. Richard , Marlene C. Schwarz , Frederick H. Strickler
IPC分类号： A61K9/22 , A61M37/00 , A61L33/00 , A61L31/10 , A61L31/06 , A61L29/06 , A61L29/08 , A61L31/16 , A61L29/16 , A61K9/00
CPC分类号： A61K9/0024 , A61L29/06 , A61L29/085 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/602 , C08L83/04
摘要： Implantable or insertable medical devices are described. The medical devices comprise (a) a therapeutic agent and (b) a polymeric release region, which controls the release of the therapeutic agent upon administration to a patient. The polymeric release region further comprises a silicone copolymer that contains a plurality of siloxane units and a plurality of non-siloxane units. Also described are methods for administering a therapeutic agent to a patient using the above implantable or insertable medical devices as well as methods of making the above devices.
摘要翻译：描述了可植入或可插入的医疗装置。医疗装置包括（a）治疗剂和（b）聚合物释放区域，其在施用于患者时控制治疗剂的释放。聚合物释放区域还包含含有多个硅氧烷单元和多个非硅氧烷单元的硅氧烷共聚物。还描述了使用上述可植入或可插入医疗装置向患者施用治疗剂的方法以及制备上述装置的方法。

9. 发明申请

US20110144276A1 MEDICAL DEVICES HAVING IMPROVED PERFORMANCE 有权
标题翻译：具有改进性能的医疗器械
公开(公告)号：US20110144276A1
公开(公告)日：2011-06-16
申请号：US13034249
申请日：2011-02-24
申请人： Shaina Brito , Frederick H. Strickler
发明人： Shaina Brito , Frederick H. Strickler
IPC分类号： C08F299/00 , C08F214/18 , C08F228/02
CPC分类号： A61L31/048 , A61L27/16 , A61L29/041 , C08F293/00 , C08L53/02
摘要： In accordance with various aspects of the invention, implantable and insertable medical devices are provided, which contain one or more polymeric regions. In one aspect, the polymeric regions comprise (a) a block copolymer that comprises a polyaromatic block and a polyalkene block admixed with (b) a sulfonated high Tg polymer. In another aspect, the polymeric regions comprise a block copolymer that comprises (a) a sulfonated polymer block and (b) fluorinated polymer block.
摘要翻译：根据本发明的各个方面，提供了可植入和可插入的医疗装置，其包含一个或多个聚合物区域。在一个方面，聚合物区域包含（a）嵌段共聚物，其包含与（b）磺化的高Tg聚合物混合的多芳族嵌段和聚烯烃嵌段。另一方面，聚合物区域包含嵌段共聚物，其包含（a）磺化聚合物嵌段和（b）氟化聚合物嵌段。

10. 发明授权

US07357940B2 Implantable or insertable medical devices containing graft copolymer for controlled delivery of therapeutic agents 有权
标题翻译：含有接受共聚物的植入式或可插入医疗器械用于治疗剂的控制递送
公开(公告)号：US07357940B2
公开(公告)日：2008-04-15
申请号：US10632413
申请日：2003-07-31
申请人： Robert E. Richard , Frederick H. Strickler
发明人： Robert E. Richard , Frederick H. Strickler
IPC分类号： A61F13/00
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/602 , C08L51/00
摘要： Implantable or insertable medical devices are described. The medical devices comprise (a) a therapeutic agent and (b) a polymeric release region that controls the release of the therapeutic agent upon administration to a patient. The polymer release region comprises a graft copolymer, which further comprises a main chain and a plurality of side chains. One of (a) the main chain and (b) the side chains corresponds to a rubbery phase within the release region at ambient temperatures, while the other corresponds to a hard phase within the release layer at ambient temperatures. Typically, the graft copolymer will comprise one glass transition temperature below ambient temperature and another second glass transition temperature above ambient temperature. Also described are methods for forming the above graft copolymers, methods for administering a therapeutic agent to a patient using the above implantable or insertable medical devices, as well as methods for making the above devices.
摘要翻译：描述了可植入或可插入的医疗装置。医疗装置包括（a）治疗剂和（b）控制治疗剂在给予患者时释放的聚合物释放区域。聚合物释放区域包括接枝共聚物，其还包含主链和多个侧链。（a）主链和（b）侧链对应于环境温度下释放区内的橡胶相，而另一个对应于在环境温度下释放层内的硬相。通常，接枝共聚物将包括低于环境温度的一个玻璃化转变温度和高于环境温度的另一个第二玻璃化转变温度。还描述了形成上述接枝共聚物的方法，使用上述可植入或可插入的医疗装置向患者施用治疗剂的方法，以及制备上述装置的方法。

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