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1. 发明授权

US08735122B2 Method for the purification of heat shock proteins 有权
标题翻译：热休克蛋白纯化方法
公开(公告)号：US08735122B2
公开(公告)日：2014-05-27
申请号：US12311755
申请日：2007-10-12
申请人： Frederic Henot , Thierry Legon , Sabine Pirotton , Gael Placier
发明人： Frederic Henot , Thierry Legon , Sabine Pirotton , Gael Placier
IPC分类号： C12N9/14 , A23J1/00 , A61K38/43
CPC分类号： C07K14/47
摘要： Recombinant purified DnaK—having a ATPase activity without the addition of an other chaperone protein—essentially free of T-cell stimulating impurities.
摘要翻译：重组纯化的DnaK-具有ATP酶活性而不添加其它伴侣蛋白 - 基本上不含T细胞刺激杂质。

2. 发明申请

US20100278880A1 PHARMACEUTICAL FORMULATION FOR ALLERGEN PREPARATION 审中-公开
标题翻译：用于过敏制剂的药物制剂
公开(公告)号：US20100278880A1
公开(公告)日：2010-11-04
申请号：US12810536
申请日：2008-12-30
申请人： Thierry Legon , Sabine Pirotton , Gael Placier , Gilles Kergoat
发明人： Thierry Legon , Sabine Pirotton , Gael Placier , Gilles Kergoat
IPC分类号： A61K9/00 , A61K39/35
CPC分类号： A61K39/35 , A61K39/36 , A61K2039/542 , A61K2039/6087
摘要： Method for the production of a purified extract of natural allergens comprising the steps of extracting a natural source of allergens comprising allergenic proteins, purifying of said extract to remove non-protein components denaturating said purified extract, said purified denaturated extract comprising proteins, wherein the most abundant (w/w) proteins, forming together at least 60% (w/w) of all proteins, are at least two proteins, and all proteins represent at least 60% (w/w) of the dry weight of the purified denaturated extract or a method for the production of a purified extract of natural allergens comprising the steps of hydrolysing a denaturated allergen purifying said allergen hydrolysate to remove peptides with a molecular weight above 10,000 Da and below 1,000 Da in order to obtain a purified hydrolysate where 70%, more preferably 80% of the peptides are between 10,000 Da and 1,000 Da, in the form of an starch based pellet.
摘要翻译：用于生产天然过敏原纯化提取物的方法，包括以下步骤：提取包含过敏原蛋白质的天然过敏原来源，纯化所述提取物以除去使所述纯化提取物变性的非蛋白质组分，所述纯化的变性提取物包含蛋白质，其中最多含有至少60％（w / w）的所有蛋白质的丰富的（w / w）蛋白质是至少两种蛋白质，所有蛋白质代表纯化变性干重的至少60％（w / w）提取物或生产天然过敏原纯化提取物的方法，包括以下步骤：将纯化所述变应原水解产物的变性过敏原水解除去分子量高于10,000Da且低于1,000Da的肽，以获得纯化的水解产物，其中70％更优选80％的肽在10,000Da和1,000Da之间，以淀粉基丸的形式。

3. 发明申请

US20090324650A1 Method for The Production of Hydrolyzed Allergen 审中-公开
标题翻译：水解过敏原生产方法
公开(公告)号：US20090324650A1
公开(公告)日：2009-12-31
申请号：US12308859
申请日：2007-06-28
申请人： Thierry Legon , Sabine Pirotton , Gael Placier , Gilles Kergoat
发明人： Thierry Legon , Sabine Pirotton , Gael Placier , Gilles Kergoat
IPC分类号： A61K39/35 , C07K1/00 , C07K1/14 , C07K1/16 , C07K1/18 , C07K1/22 , C07K1/30 , C07K14/00 , C07K1/20 , A61P37/08
CPC分类号： A61K39/35 , A61K39/36 , A61K2039/542 , C07K14/415 , C12P21/06
摘要： A method for the production of a purified extract of natural allergens comprising the steps of a) extracting a natural source of allergens comprising allergenic proteins to form an extract, b) purifying of said extract to remove non-protein components to form a purified extract c) denaturating said purified extract to form a purified denaturated extract, said purified denaturated extract comprising proteins, wherein the most abundant (w/w) proteins, forming together at least 60% (w/w) of all proteins, are at least two proteins, and all proteins represent at least 60% (w/w) of the dry weight of the purified denaturated extract and a method for the production of a purified extract of natural allergens comprising the steps of a) hydrolysing a denaturated allergen to form an allergen hydrolysate, b) purifying said allergen hydrolysate to remove peptides with a molecular weight above 10,000 Da and below 1,000 Da in order to obtain a purified hydrolysate where 70%, more preferably 80% of the peptides are between 10,000 Da and 1,000 Da.
摘要翻译：一种用于生产天然过敏原纯化提取物的方法，包括以下步骤：a）提取包含过敏原蛋白质的天然过敏原来源以形成提取物，b）纯化所述提取物以除去非蛋白质组分以形成纯化的提取物c ）使所述纯化的提取物变性以形成纯化的变性提取物，所述纯化的变性提取物包含蛋白质，其中形成所有蛋白质至少60％（w / w）的最丰富的（w / w）蛋白质是至少两种蛋白质，并且所有蛋白质代表纯化的变性提取物的干重的至少60％（w / w），以及用于生产纯化的天然过敏原提取物的方法，包括以下步骤：a）水解变性变应原以形成变应原水解物，b）纯化所述变应原水解产物以除去分子量高于10,000Da且低于1,000Da的肽，以获得纯化的水解产物，其中70％，更优选80％肽在10,000Da和1,000Da之间。

4. 发明授权

US10195276B2 Method for the production of hydrolyzed allergens 有权
公开(公告)号：US10195276B2
公开(公告)日：2019-02-05
申请号：US14125036
申请日：2012-06-15
申请人： Gael Placier , Laetitia Frisch , Thierry Legon , Marie-Ange Benoit
发明人： Gael Placier , Laetitia Frisch , Thierry Legon , Marie-Ange Benoit
IPC分类号： A21D2/26 , A61K45/06 , A61K39/00 , A61K39/35 , C07K14/415 , C12P21/06 , C07K14/435
摘要： A method for the production of hydrolyzed allergens from allergens comprising the steps of: a) extracting a source of allergens comprising allergenic proteins to form an extract, b) purifying the extract to remove non-protein components to form a purified extract, c) denaturing the purified extract with a first denaturing agent to form a purified denatured extract, d) refining the purified denatured extract to remove impurities to form a refined denatured extract, e) denaturing the refined denatured extract with a second denaturing agent to form denatured allergen mixture, and f) hydrolyzing the denatured allergen mixture to form the hydrolyzed allergens.

5. 发明申请

US20140220044A1 METHOD FOR THE PRODUCTION OF HYDROLYZED ALLERGENS 审中-公开
标题翻译：生产水解过敏原的方法
公开(公告)号：US20140220044A1
公开(公告)日：2014-08-07
申请号：US14125036
申请日：2012-06-15
申请人： Gael Placier , Laetitia Frisch , Thierry Legon , Marie-Ange Benoit
发明人： Gael Placier , Laetitia Frisch , Thierry Legon , Marie-Ange Benoit
IPC分类号： A61K39/35 , A61K45/06
CPC分类号： A61K45/06 , A61K39/00 , A61K39/35 , C07K14/415 , C07K14/43531 , C12P21/06
摘要： A method for the production of hydrolyzed allergens from allergens comprising the steps of: a) extracting a source of allergens comprising allergenic proteins to form an extract, b) purifying the extract to remove non-protein components to form a purified extract, c) denaturing the purified extract with a first denaturing agent to form a purified denatured extract, d) refining the purified denatured extract to remove impurities to form a refined denatured extract, e) denaturing the refined denatured extract with a second denaturing agent to form denatured allergen mixture, and f) hydrolyzing the denatured allergen mixture to form the hydrolyzed allergens.
摘要翻译：一种用于从变应原产生水解过敏原的方法，包括以下步骤：a）提取包含过敏原蛋白的变应原源以形成提取物，b）纯化提取物以除去非蛋白质组分以形成纯化的提取物，c）变性所述纯化的提取物用第一变性剂形成纯化的变性提取物，d）精制所述纯化的变性提取物以除去杂质以形成精制变性提取物，e）用第二变性剂变性所述精制变性提取物以形成变性过敏原混合物，和f）水解变性过敏原混合物以形成水解的变应原。

6. 发明申请

US20140255449A1 DOSAGE OF DNAK 审中-公开
标题翻译： DNAK的剂量
公开(公告)号：US20140255449A1
公开(公告)日：2014-09-11
申请号：US14233584
申请日：2012-07-19
申请人： Thierry Legon , Sabine Pirotton , Jean Duchateau
发明人： Thierry Legon , Sabine Pirotton , Jean Duchateau
IPC分类号： A61K39/36 , A61K39/39
CPC分类号： A61K39/36 , A61K39/0008 , A61K39/35 , A61K39/39 , A61K2039/545 , A61K2039/55516 , A61K2039/6043
摘要： A pharmaceutical preparation for subcutaneous injection comprising between 0.5 ng and 200 μg of HSP70 between 0.5 and 100 μg of fragments of an antigenic structure.
摘要翻译：一种用于皮下注射的药物制剂，其包含0.5至200μg的抗原结构片段的0.5至100μg之间的HSP70。

7. 发明授权

US08436136B2 Peptide complex 有权
标题翻译：肽复合物
公开(公告)号：US08436136B2
公开(公告)日：2013-05-07
申请号：US10557334
申请日：2004-05-18
申请人： Frederic Henot , Thierry Legon , Isabelle Galy-Fauroux , Jean Duchateau
发明人： Frederic Henot , Thierry Legon , Isabelle Galy-Fauroux , Jean Duchateau
IPC分类号： A61K38/28 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , A61P5/50
CPC分类号： C07K14/47 , C07K14/245 , C07K14/43531 , C07K2319/00
摘要： A complex comprising at least one heat shock protein (HSP) and at least one peptide selected from the group consisting of R1-QXRAA-R2 with R1=peptide with 1-10 amino acids R2=peptide with 1-10 amino acids X=K or R GFFYTPK (insulin 23-29) SEQ ID No 1 GFFYTPKT (insulin 23-30) SEQ ID No 2 IYPPNANK (DER p1) SEQ ID No 3 GIEYIQHNGVVQESYYR (DER P1) SEQ ID No 4 ASTTTNYT (gp120 of HIV) SEQ ID No 5 DYEYLINVIHAFQYV (PLP 56-70) SEQ ID No 6 EKLIETYFSKNYQDYEYLINVI (PLP 43-64) SEQ ID No 7 KTTICGKGLSATVT (PLP 104-117) SEQ ID No 8 HSLGKWLGHPDKF (PLP 139-151 C140 ô S140) SEQ ID No 9 PRHPIRVELPCRISP (MOG 8-22) SEQ ID No 10 DEGGYTCFFRDHSYQ (MOG 92-106) SEQ ID No 11 Ac-ASQKRPSQRHG (MBP ac1-11) SEQ ID No 12 TGILDSIGRFFSG (MBP 35-47) SEQ ID No 13 VHFFKNIVTPRTP (MBP 89-101) SEQ ID No 14 HCLGKWLGHPDKF (PLP 139-151) SEQ ID No 15 MEVGWYRSPFSRVVHLYRNGK (MOG) SEQ ID No 16 QKRAAYDQYGHAAFE (E. Coli DnaJ) SEQ ID No. 17 QKRAAVDTYCRHNYG (HLA DRB1*0401) SEQ ID No. 18 QRRAAYDQYGHAAFE SEQ ID No. 19 and QRRAAVDTYCRHNYG SEQ ID No. 20.
摘要翻译：包含至少一种热休克蛋白（HSP）和至少一种选自下组的复合物：R1-QXRAA-R2，R1 =具有1-10个氨基酸的肽R2 =具有1-10个氨基酸的肽X = K 或R GFFYTPK（胰岛素23-29）SEQ ID No 1 GFFYTPKT（胰岛素23-30）SEQ ID No 2 IYPPNANK（DER p1）SEQ ID No 3 GIEYIQHNGVVQESYYR（DER P1）SEQ ID No 4 ASTTTNYT（HIV的gp120）SEQ ID No 5 DYEYLINVIHAFQYV（PLP 56-70）SEQ ID No 6 EKLIETYFSKNYQDYEYLINVI（PLP 43-64）SEQ ID No 7 KTTICGKGLSATVT（PLP 104-117）SEQ ID No 8 HSLGKWLGHPDKF（PLP 139-151 C140ôS140）SEQ ID No 9 PRHPIRVELPCRISP （MOG8-22）SEQ ID No 10 DEGGYTCFFRDHSYQ（MOG 92-106）SEQ ID No 11 Ac-ASQKRPSQRHG（MBP ac1-11）SEQ ID No 12 TGILDSIGRFFSG（MBP 35-47）SEQ ID No.13 VHFFKNIVTPRTP（MBP 89- SEQ ID No 14 HCLGKWLGHPDKF（PLP 139-151）SEQ ID No 15 MEVGWYRSPFSRVVHLYRNGK（MOG）SEQ ID No 16 QKRAAYDQYGHAAFE（E.coli DnaJ）SEQ ID No.17 QKRAAVDTYCRHNYG（HLA DRB1 * 0401）SEQ ID No.18 QRRAAYDQYGHAAFE SEQ ID No.19和QRRAAVDTYCRHNYG SE 问题编号20。

8. 发明申请

US20060008483A1 Dispersions of lipids for use as therapeutic and cosmetic agents and intracellular delivery vehicles 审中-公开
标题翻译：用作治疗和美容剂和细胞内递送载体的脂质分散体
公开(公告)号：US20060008483A1
公开(公告)日：2006-01-12
申请号：US10513736
申请日：2003-05-06
申请人： Frederic Henot , Roland Frebillot , Sebastien Baudart , Thierry Legon
发明人： Frederic Henot , Roland Frebillot , Sebastien Baudart , Thierry Legon
IPC分类号： A61K8/37 , A61K9/127
CPC分类号： A61K9/1272
摘要： In a dispersion of lipids in a dispersing medium, the said lipids comprising an amino-amidine compound A, the amidine function of the said compound A is titrated substantially in water by means of an acid HX, wherein X is an anion, in a manner such that the pH of the said lipid dispersion is between about 6.5 and 7.8 within a temperature range from about 2° C. to 40° C. The so titrated dispersion is useful inter alia as a component of a synthetic vector for therapeutic molecules or macromolecules.
摘要翻译：在脂质在分散介质中的分散体中，所述脂质包含氨基脒化合物A，所述化合物A的脒功能基本上在水中通过酸HX（其中X为阴离子）以使得所述脂质分散体的pH在约2℃至40℃的温度范围内为约6.5至7.8之间。所述滴定的分散体尤其可用作治疗分子或大分子的合成载体的组分。

9. 发明申请

US20080075735A1 Demethylated and/or oxidized membrane DNA 有权
标题翻译：去甲基化和/或氧化膜DNA
公开(公告)号：US20080075735A1
公开(公告)日：2008-03-27
申请号：US11878800
申请日：2007-07-26
申请人： Frederic Henot , Thierry Legon , Nadine Questiaux
发明人： Frederic Henot , Thierry Legon , Nadine Questiaux
IPC分类号： A61K31/70 , A61K39/00 , A61P37/04 , C07H21/00 , C07K14/00 , C12N13/00 , C12N5/06 , C12P19/34 , C12Q1/68
CPC分类号： G01N33/564 , C07H21/04 , C12N15/01 , C12N15/1003 , C12N15/11 , C12P19/34
摘要： A process for the preparation of oxidized and/or demethylated antigens comprising the steps of treating a cell with a stress factor selected from the group consisting of UV-radiation, oxidizing reagents, heavy metal salts, drugs, nucleoside and nucleotide analogs, and enzyme inhibitors lyses of the cell to give a cell lysate purification of oxidized and/or demethylated antigens from the cell lysate.
摘要翻译：一种制备氧化和/或脱甲基抗原的方法，包括以下步骤：用选自紫外线辐射，氧化剂，重金属盐，药物，核苷和核苷酸类似物的组合物和酶抑制剂细胞的裂解以产生细胞裂解物从细胞裂解物纯化氧化和/或去甲基化的抗原。

10. 发明申请

US20060270833A1 Peptide complex 有权
标题翻译：肽复合物
公开(公告)号：US20060270833A1
公开(公告)日：2006-11-30
申请号：US10557334
申请日：2004-05-18
申请人： Frederic Henot , Thierry Legon , Isabelle Galy-Fauroux , Jean Duchateau
发明人： Frederic Henot , Thierry Legon , Isabelle Galy-Fauroux , Jean Duchateau
IPC分类号： C07K14/47 , C07K16/18 , C07H21/04 , C12P21/06
CPC分类号： C07K14/47 , C07K14/245 , C07K14/43531 , C07K2319/00
摘要： A complex comprising at least one heat shock protein (HSP) and at least one peptide selected from the group consisting of R1-QXRAA-R2 with R1=peptide with 1-10 amino acids R2=peptide with 1-10 amino acids X=K or R GFFYTPK (insulin 23-29) SEQ ID No 1 GFFYTPKT (insulin 23-30) SEQ ID No 2 IYPPNANK (DER p1) SEQ ID No 3 GIEYIQHNGVVQESYYR (DER P1) SEQ ID No 4 ASTTTNYT (gp120 of HIV) SEQ ID No 5 DYEYLINVIHAFQYV (PLP 56-70) SEQ ID No 6 EKLIETYFSKNYQDYEYLINVI (PLP 43-64) SEQ ID No 7 KTTICGKGLSATVT (PLP 104-117) SEQ ID No 8 HSLGKWLGHPDKF (PLP 139-151 C140 ô S140) SEQ ID No 9 PRHPIRVELPCRISP (MOG 8-22) SEQ ID No 10 DEGGYTCFFRDHSYQ (MOG 92-106) SEQ ID No 11 Ac-ASQKRPSQRHG (MBP ac1-11) SEQ ID No 12 TGILDSIGRFFSG (MBP 35-47) SEQ ID No 13 VHFFKNIVTPRTP (MBP 89-101) SEQ ID No 14 HCLGKWLGHPDKF (PLP 139-151) SEQ ID No 15 MEVGWYRSPFSRVVHLYRNGK (MOG) SEQ ID No 16 QKRAAYDQYGHAAFE (E. Coli DnaJ) SEQ ID No. 17 QKRAAVDTYCRHNYG (HLA DRB1*0401) SEQ ID No. 18 QRRAAYDQYGHAAFE SEQ ID No. 19 and QRRAAVDTYCRHNYG SEQ ID No. 20.
摘要翻译：一种复合物，其包含至少一种热休克蛋白（HSP）和至少一种选自R 1 -QXRAA-R 2和R 1的肽 =具有1-10个氨基酸的肽R 2 =具有1-10个氨基酸的肽X = K或R GFFYTPK（胰岛素23-29）SEQ ID NO 1 GFFYTPKT（胰岛素23- 30）SEQ ID No 2 IYPPNANK（DER p1）SEQ ID No 3 GIEYIQHNGVVQESYYR（DER P1）SEQ ID No 4 ASTTTNYT（HIV的gp120）SEQ ID No 5 DYEYLINVIHAFQYV（PLP 56-70）SEQ ID No 6 EKLIETYFSKNYQDYEYLINVI（PLP 43- SEQ ID No 7 KTTICGKGLSATVT（PLP 104-117）SEQ ID No 8 HSLGKWLGHPDKF（PLP 139-151 C140ôS140）SEQ ID No 9 PRHPIRVELPCRISP（MOG 8-22）SEQ ID NO 10 DEGGYTCFFRDHSYQ（MOG 92-106）SEQ ID No 11 Ac-ASQKRPSQRHG（MBP ac1-11）SEQ ID No 12 TGILDSIGRFFSG（MBP 35-47）SEQ ID No 13 VHFFKNIVTPRTP（MBP 89-101）SEQ ID No 14 HCLGKWLGHPDKF（PLP 139-151）SEQ ID No 15 MEVGWYRSPFSRVVLYRNGK （MOG）SEQ ID No 16 QKRAAYDQYGHAAFE（大肠杆菌DnaJ）SEQ ID No.17 QKRAAVDTYCRHNYG（HLA DRB1 * 0401）SEQ ID No.18 QRRAAYDQ YGHAAFE SEQ ID No.19和QRRAAVDTYCRHNYG SEQ ID No.20。

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