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1. 发明授权

US08076285B2 Lysobactin amides 失效
标题翻译：溶血磷脂酰胺
公开(公告)号：US08076285B2
公开(公告)日：2011-12-13
申请号：US12249888
申请日：2008-10-10
申请人： Franz Von Nussbaum , Hartmut Beck , Nina Brunner , Rainer Endermann , Johannes Koebberling , Jacques Ragot , Joachim Telser , Joachim Schuhmacher , Sonja Anlauf , Yolanda Cancho-Grande , Susanne Greschat , Hans-Christian Militzer , Guido Schiffer
发明人： Franz Von Nussbaum , Hartmut Beck , Nina Brunner , Rainer Endermann , Johannes Koebberling , Jacques Ragot , Joachim Telser , Joachim Schuhmacher , Sonja Anlauf , Yolanda Cancho-Grande , Susanne Greschat , Hans-Christian Militzer , Guido Schiffer
IPC分类号： A61K38/12 , C07K7/54
CPC分类号： C07K7/06 , A61K38/00 , C07K7/56
摘要： The invention relates to lysobactin amides and methods for their preparation, as well as their use for manufacturing medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases.
摘要翻译：本发明涉及溶血酶蛋白酰胺及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是细菌感染性疾病的药物的用途。

2. 发明申请

US20090203582A1 LYSOBACTIN AMIDES 失效
公开(公告)号：US20090203582A1
公开(公告)日：2009-08-13
申请号：US12249888
申请日：2008-10-10
申请人： Franz VON NUSSBAUM , Hartmut Beck , Nina Brunner , Rainer Endermann , Johannes Koebberling , Jacques Ragot , Joachim Telser , Joachim Schuhmacher , Sonja Anlauf , Yolanda Cancho-Grande , Susanne Greschat , Hans-Christian Militzer , Guido Schiffer
发明人： Franz VON NUSSBAUM , Hartmut Beck , Nina Brunner , Rainer Endermann , Johannes Koebberling , Jacques Ragot , Joachim Telser , Joachim Schuhmacher , Sonja Anlauf , Yolanda Cancho-Grande , Susanne Greschat , Hans-Christian Militzer , Guido Schiffer
IPC分类号： A61K38/12 , C07K14/00 , A61P31/04
CPC分类号： C07K7/06 , A61K38/00 , C07K7/56
摘要： The invention relates to lysobactin amides and methods for their preparation, as well as their use for manufacturing medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases.
摘要翻译：本发明涉及溶血酶蛋白酰胺及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是细菌感染性疾病的药物的用途。

3. 发明授权

US5770622A Method of preserving materials using 4-methylene-2-amino-cyclopentane-1-carboxylic acids 失效
标题翻译：使用4-亚甲基-2-氨基 - 环戊烷-1-羧酸保存材料的方法
公开(公告)号：US5770622A
公开(公告)日：1998-06-23
申请号：US709073
申请日：1996-09-06
申请人： Joachim Mittendorf , Franz Kunisch , Michael Matzke , Hans-Christian Militzer , Rainer Endermann , Karl Georg Metzger , Klaus-Dieter Bremm , Manfred Plempel
发明人： Joachim Mittendorf , Franz Kunisch , Michael Matzke , Hans-Christian Militzer , Rainer Endermann , Karl Georg Metzger , Klaus-Dieter Bremm , Manfred Plempel
IPC分类号： C07C61/15 , C07C61/20 , C07C61/35 , C07C61/39 , C07C61/40 , C07C69/74 , C07C69/753 , C07C69/757 , C07C229/48 , C07C237/04 , C07C251/42 , C07C271/22 , C07C271/24 , C07C271/34 , C07C271/36 , C07D265/12 , C07D307/93 , A01N37/00
CPC分类号： C07C251/42 , C07C229/48 , C07C237/04 , C07C271/22 , C07C271/24 , C07C271/34 , C07C271/36 , C07C61/15 , C07C61/20 , C07C61/35 , C07C61/39 , C07C61/40 , C07C69/74 , C07C69/753 , C07C69/757 , C07D265/12 , C07D307/93 , C07C2101/08 , C07C2101/10 , C07C2103/18
摘要： The invention relates to cyclopentane- and -pentene-.beta.-amino acids, processes for their preparation and their use as medicaments, and to prevent contamination of materials such as wood and leather.
摘要翻译：本发明涉及环戊烷和戊烯-β-氨基酸，其制备方法及其作为药物的用途，并且防止木材和皮革等材料的污染。

4. 发明授权

US5739160A Cyclopentane- and -pentene-.beta.-amino acids 失效
标题翻译：环戊烷和β-戊烯-β-氨基酸
公开(公告)号：US5739160A
公开(公告)日：1998-04-14
申请号：US308873
申请日：1994-09-19
申请人： Joachim Mittendorf , Franz Kunisch , Michael Matzke , Hans-Christian Militzer , Rainer Endermann , Karl Georg Metzger , Klaus-Dieter Bremm , Manfred Plempel
发明人： Joachim Mittendorf , Franz Kunisch , Michael Matzke , Hans-Christian Militzer , Rainer Endermann , Karl Georg Metzger , Klaus-Dieter Bremm , Manfred Plempel
IPC分类号： A61K31/16 , A61K31/19 , A61K31/195 , A61K31/196 , A61K31/215 , A61K31/275 , A61P31/00 , A61P31/04 , A61P31/10 , A61P43/00 , C07C61/15 , C07C61/20 , C07C61/35 , C07C61/39 , C07C61/40 , C07C69/74 , C07C69/753 , C07C69/757 , C07C229/48 , C07C237/04 , C07C239/18 , C07C251/42 , C07C271/20 , C07C271/22 , C07C271/24 , C07C271/34 , C07C271/36 , C07D265/12 , C07D307/93 , A61K31/21
CPC分类号： C07C61/35 , C07C229/48 , C07C237/04 , C07C251/42 , C07C271/22 , C07C271/24 , C07C271/34 , C07C271/36 , C07C61/15 , C07C61/20 , C07C61/39 , C07C61/40 , C07C69/74 , C07C69/753 , C07C69/757 , C07D265/12 , C07D307/93 , C07C2101/08 , C07C2101/10 , C07C2103/18 , Y02P20/55
摘要： New Cyclopentane- or cyclopentene-beta-aminoacid derivatives and their isomers, acid additional salts and metal salt complexes have strong antimicrobial and broad-spectrum antimycotic acitivity. As antimycotics they are especially active against dermatophyte, and biphasic fungi. The new compounds are also low toxicity antibacterial agents, effective against Gram positive bacteria, including antibiotic-resistant strains. The new Cyclopentane- or cyclopentene-beta-aminoacid derivatives are useful in human or veterinary medicine for combating dermatomycosis or systemic mycosis or local or systemic bacterial infections. In addition, the new compounds can also be used as preservatives, especially for water, foods, or organic materials such as polymers, lubricants, paints, fibers, leather, paper or wood.
摘要翻译：新的环戊烷或环戊烯-β-氨基酸衍生物及其异构体，酸加成盐和金属盐络合物具有强抗微生物和广谱抗真菌活性。作为抗霉菌剂，它们对皮肤癣菌和双相真菌特别有活性。新化合物也是低毒抗菌剂，对革兰氏阳性菌有效，包括抗生素抗性菌株。新的环戊烷或环戊烯-β-氨基酸衍生物可用于人或兽医学中用于对抗皮肤真菌病或全身性真菌病或局部或全身性细菌感染。此外，新化合物也可用作防腐剂，特别是用于水，食品或有机材料如聚合物，润滑剂，油漆，纤维，皮革，纸或木材的防腐剂。

5. 发明授权

US5631291A Cyclopentane- and -pentene-.beta.-amino acids 失效
标题翻译：环戊烷和β-戊烯-β-氨基酸
公开(公告)号：US5631291A
公开(公告)日：1997-05-20
申请号：US336584
申请日：1994-11-09
申请人： Joachim Mittendorf , Franz Kunisch , Michael Matzke , Hans-Christian Militzer , Rainer Endermann , Karl G. Metzger , Klaus-Dieter Bremm , Manfred Plempel
发明人： Joachim Mittendorf , Franz Kunisch , Michael Matzke , Hans-Christian Militzer , Rainer Endermann , Karl G. Metzger , Klaus-Dieter Bremm , Manfred Plempel
IPC分类号： C07C61/15 , C07C61/20 , C07C61/35 , C07C61/39 , C07C61/40 , C07C69/74 , C07C69/753 , C07C69/757 , C07C229/48 , C07C237/04 , C07C251/42 , C07C271/22 , C07C271/24 , C07C271/34 , C07C271/36 , C07D265/12 , C07D307/93 , A61K31/195
CPC分类号： C07C251/42 , C07C229/48 , C07C237/04 , C07C271/22 , C07C271/24 , C07C271/34 , C07C271/36 , C07C61/15 , C07C61/20 , C07C61/35 , C07C61/39 , C07C61/40 , C07C69/74 , C07C69/753 , C07C69/757 , C07D265/12 , C07D307/93 , C07C2101/08 , C07C2101/10 , C07C2103/18
摘要： The invention relates to cyclopentane- and -pentene-.beta.-amino acids, processes for their preparation and their use as medicaments.
摘要翻译：本发明涉及环戊烷和戊烯-β-氨基酸，其制备方法及其作为药物的用途。

6. 发明申请

US20130310381A1 SUBSTITUTED SODIUM-1H-PYRAZOLE-5-OLATE 有权
标题翻译：取代的钠-1H-吡唑-5-醇
公开(公告)号：US20130310381A1
公开(公告)日：2013-11-21
申请号：US13988141
申请日：2011-11-15
申请人： Hans-Christian Militzer , Jörg Gries , Stefan Koep
发明人： Hans-Christian Militzer , Jörg Gries , Stefan Koep
IPC分类号： C07D403/14 , A61K45/06 , A61K31/5377
CPC分类号： C07D403/14 , A61K31/5377 , A61K45/06
摘要： The present application relates to sodium 1-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-5-olate, to processes for its preparation, to its use for the treatment and/or prophylaxis of diseases and to its use for the preparation of medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and haematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译：本申请涉及1- [6-（吗啉-4-基）嘧啶-4-基] -4-（1H-1,2,3-三唑-1-基）-1H-吡唑-5-醇酸钠，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液病和肾脏疾病的药物的用途，以及用于促进伤口愈合。

7. 发明授权

US07208447B2 Polyamino acid-catalyzed process for the enantioselective epoxidation of α,β-unsaturated enones and α,β-unsaturated sulfones 失效
标题翻译：用于α，β-不饱和烯酮和α，β-不饱和砜的对映选择性环氧化的聚氨基酸催化方法
公开(公告)号：US07208447B2
公开(公告)日：2007-04-24
申请号：US10926458
申请日：2004-08-25
申请人： Thomas Geller , Christa Maria Krüger , Hans-Christian Militzer
发明人： Thomas Geller , Christa Maria Krüger , Hans-Christian Militzer
IPC分类号： B01J20/26 , C07D301/12 , C07D303/32 , C08L77/00
CPC分类号： C07D303/32 , C07B2200/07 , C07D303/48
摘要： The invention relates to a novel process that makes it possible to epoxidize α,β-unsaturated enones or α,β-unsaturated sulfones with high conversions and enantiomeric excesses in a two-phase system without addition of water in the presence of an organic solvent, a base, an oxidant, a diastereomer- and enantiomer-enriched homo-polyamino acid that has not been separately preactivated as catalyst, and a specific phase-transfer catalyst as cocatalyst.
摘要翻译：本发明涉及一种新的方法，其可以在有机溶剂的存在下在不加水的情况下在两相体系中以高转化率和对映体过量进行环氧化的α，β-不饱和烯酮或α，β-不饱和砜，没有单独预活化作为催化剂的碱，氧化剂，非对映异构体和对映体富集的均聚氨基酸，以及作为助催化剂的特定相转移催化剂。

8. 发明授权

US07193092B2 Chiral diphosphorus compounds and their transition metal complexes 失效
标题翻译：手性二磷化合物及其过渡金属络合物
公开(公告)号：US07193092B2
公开(公告)日：2007-03-20
申请号：US10643552
申请日：2003-08-19
申请人： Benjamin Meseguer , Hans-Christian Militzer , Sergio Castillon , Carmen Claver , Yolanda Diaz , Mohamed Aghmiz , Ester Guiu , Ali Aghmiz , Anna Masdeu
发明人： Benjamin Meseguer , Hans-Christian Militzer , Sergio Castillon , Carmen Claver , Yolanda Diaz , Mohamed Aghmiz , Ester Guiu , Ali Aghmiz , Anna Masdeu
IPC分类号： C07F7/08 , C07F7/18 , C07F9/6553
CPC分类号： C07D497/04 , C07B2200/07 , C07C209/52 , C07C231/18 , C07F9/65515 , C07C211/48 , C07C233/05
摘要： The present invention relates to chiral diphosphorus compounds and their transition metal complexes, to a process for preparing chiral diphosphorus compounds and their transition metal complexes and also to their use in asymmetric syntheses.
摘要翻译：本发明涉及手性二磷化合物及其过渡金属络合物，涉及制备手性二磷化合物及其过渡金属配合物的方法，以及它们在不对称合成中的用途。

9. 发明授权

US07057061B2 Chiral monophosphorus compounds 失效
公开(公告)号：US07057061B2
公开(公告)日：2006-06-06
申请号：US10256700
申请日：2002-09-27
申请人： Claus Dreisbach , Benjamin Meseguer , Thomas Prinz , Ulrich Scholz , Hans-Christian Militzer , Friederike Agel , Birgit Drieβen-Hölscher
发明人： Claus Dreisbach , Benjamin Meseguer , Thomas Prinz , Ulrich Scholz , Hans-Christian Militzer , Friederike Agel , Birgit Drieβen-Hölscher
IPC分类号： C07F9/655
CPC分类号： C07F9/65744 , B01J31/185 , B01J2231/4261 , B01J2231/643 , B01J2231/645 , B01J2531/822 , C07B53/00 , C07B2200/07 , C07C45/505 , C07C67/303 , C07C231/12 , C07C231/18 , C07F9/6571 , C07F9/657154 , C07F9/65719 , C07C69/34 , C07C233/47
摘要： The present invention relates to catalysts comprising chiral monophosphorus compounds and their use, the chiral monophosphorus compounds themselves and also their precursors.

10. 发明申请

US20140072529A1 SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE SALTS 审中-公开
标题翻译：取代的2,3-二氢吲哚并[1,2-C]喹唑啉盐
公开(公告)号：US20140072529A1
公开(公告)日：2014-03-13
申请号：US14009599
申请日：2012-03-29
申请人： Jan-Georg Peters , Hans-Christian Militzer , Hartwig Müller
发明人： Jan-Georg Peters , Hans-Christian Militzer , Hartwig Müller
IPC分类号： C07D487/04 , A61K45/06 , A61K31/5377
CPC分类号： A61K31/5377 , A61K45/06 , C07D487/04
摘要： The present invention relates:—to 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo-[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide dihydrochloride salt of formula (II): or a tautomer, solvate or hydrate thereof;—to methods of preparing said dihydrochloride salt;—to said dihydrochloride salt for the treatment and/or prophylaxis of a disease;—to the use of said dihydrochloride salt for the preparation of a medicament for the treatment and/or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, more particularly for the treatment or prophylaxis of a cancer, particularly lung cancer, in particular non-small cell lung carcinoma, colorectal cancer, melanoma, pancreatic cancer, hepatocyte carcinoma, pancreatic cancer, hepatocyte carcinoma or breast cancer;—to a pharmaceutical composition comprising said dihydrochloride salt; and to a pharmaceutical combination comprising said dihydrochloride salt in combination with one or more further pharmaceutical agents.
摘要翻译：本发明涉及2-氨基-N-〔7-甲氧基-8-（3-吗啉-4-基丙氧基）-2,3-二氢咪唑并〔1,2-c〕喹唑啉-5-基〕嘧啶式（II）的5-甲酰胺二盐酸盐：或其互变异构体，溶剂化物或水合物; - 制备所述二盐酸盐的方法; - 用于治疗和/或预防疾病的所述二盐酸盐; - 使用的所述二盐酸盐用于制备用于治疗和/或预防疾病，特别是高增殖和/或血管生成障碍的药物，更特别是用于治疗或预防癌症，特别是肺癌，特定的非小细胞肺癌，结肠直肠癌，黑素瘤，胰腺癌，肝细胞癌，胰腺癌，肝细胞癌或乳腺癌; - 包含所述二盐酸盐的药物组合物; 以及包含所述二盐酸盐与一种或多种其它药剂组合的药物组合。

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