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1. 发明申请

US20090011945A1 Method For Making Microsensor Arrays For Detecting Analytes 审中-公开
标题翻译：用于检测分析物的微传感器阵列的方法
公开(公告)号：US20090011945A1
公开(公告)日：2009-01-08
申请号：US11957915
申请日：2007-12-17
申请人： Frank V. Bright , Eun Jeong Cho
发明人： Frank V. Bright , Eun Jeong Cho
IPC分类号： C40B30/00
CPC分类号： C12Q1/54 , B01J2219/00387 , B01J2219/00527 , B01J2219/00605 , B01J2219/00612 , B01J2219/00637 , B01J2219/00641 , G01N21/6452 , G01N33/521 , G01N2021/6421
摘要： The present invention provides a method and a device for high-throughput, simultaneous, and continuous detection of one or more analytes using a pin-printed chemical sensor array. Chemical sensors comprising [Ru(4,7-diphenyl-1,10-phenanthroline)3]2+, glucose oxidase, and fluorescein sequestered in sol-gel-derived-glass have been used. Examples of analytes detected using the present method include O2, glucose, and protons. Gas-phase and liquid-phase analytes have been detected using the present method. In addition, analytes contained in an aerosol have been detected.
摘要翻译：本发明提供了一种使用针印刷化学传感器阵列高通量，同时和连续检测一种或多种分析物的方法和装置。已经使用包含[Ru（4,7-二苯基-1,10-菲咯啉）3] 2+，葡萄糖氧化酶和螯合在溶胶 - 凝胶衍生玻璃中的荧光素的化学传感器。使用本方法检测的分析物的实例包括O 2，葡萄糖和质子。已经使用本方法检测了气相和液相分析物。此外，已经检测到气溶胶中包含的分析物。

2. 发明申请

US20100233828A1 Site Selectively Tagged and Templated Molecularly Imprinted Polymers for Sensor Applications 有权
标题翻译：选择性标记和模板分子印迹聚合物用于传感器应用
公开(公告)号：US20100233828A1
公开(公告)日：2010-09-16
申请号：US12728783
申请日：2010-03-22
申请人： Frank V. Bright
发明人： Frank V. Bright
IPC分类号： G01N33/545 , C08G63/91 , C08F10/00 , C08F112/08 , C08L83/04
CPC分类号： G01N33/582 , B01J20/268 , B82Y5/00 , B82Y10/00 , G01N33/531 , G01N33/543 , G01N33/94 , G01N2600/00
摘要： This invention provides molecularly imprinted polymers (MIPs) for the detection of analytes, methods for forming the MIPs and detecting the analyte using the MIPs. The MIP comprises templated sites which are formed using a mimic of the analyte such that a reporter compound can be selectively attached at the templated sites, thus providing a site selectively tagged and templated MIP.
摘要翻译：本发明提供用于检测分析物的分子印迹聚合物（MIP），用于形成MIP的方法和使用MIP检测分析物。 MIP包括使用分析物的模拟物形成的模板位点，使得报告化合物可以在模板位点选择性连接，从而提供选择性标记和模板MIP的位点。

3. 发明授权

US07794795B2 Hybrid anti-fouling coating compositions and methods for preventing the fouling of surfaces subjected to a marine environment 有权
标题翻译：混合防污涂料组合物和防止经受海洋环境的表面结垢的方法
公开(公告)号：US07794795B2
公开(公告)日：2010-09-14
申请号：US11774437
申请日：2007-07-06
申请人： Michael R. Detty , Michael D. Drake , Ying Tang , Frank V. Bright
发明人： Michael R. Detty , Michael D. Drake , Ying Tang , Frank V. Bright
IPC分类号： B23B9/04
CPC分类号： C09D5/1675 , C09D5/1606 , C09D5/1625 , C09D5/1637 , C09D5/1662 , C09D201/005 , C23C18/1212 , C23C18/1233 , C23C18/1241 , C23C18/1245 , C23C18/1254 , Y10T428/31663
摘要： The present invention relates to a coating composition including a sol-gel matrix and a dendrimeric organochalcogeno derivative and a system including the coating composition and a substrate. The present invention also relates to a method of preventing fouling of surfaces subjected to a marine environment.
摘要翻译：本发明涉及包含溶胶 - 凝胶基质和树枝状大分子有机硫原子衍生物的涂料组合物和包括该涂料组合物和基材的体系。本发明还涉及防止经受海洋环境的表面结垢的方法。

4. 发明授权

US06492182B1 Microsensor arrays and method of using same for detecting analytes 有权
标题翻译：微传感器阵列及其使用方法用于检测分析物
公开(公告)号：US06492182B1
公开(公告)日：2002-12-10
申请号：US09628209
申请日：2000-07-28
申请人： Frank V. Bright , Brett R. Wenner , Meagan A. Doody , Gary A. Baker
发明人： Frank V. Bright , Brett R. Wenner , Meagan A. Doody , Gary A. Baker
IPC分类号： G01N2176
CPC分类号： G01N33/542 , G01N33/54373 , Y10T436/24
摘要： A device for detection of one or more analytes in a sample is disclosed. The device can simultaneously detect and quantitate multiple analytes in a sample. The device comprises an eletromagnetic radiation generator having one or more chemical sensors thereon. The chemical sensor interacts with or reacts with specific analytes in a sample. The presence of an analyte is detected by a comparison of the spectroscopic properties of the chemical sensor in the absence and presence of the analyte. A method is also disclosed for the detection and quantitation of analytes using the device of the present invention. In addition, a method of making the device of the present invention is also disclosed.
摘要翻译：公开了一种用于检测样品中一种或多种分析物的装置。该装置可以同时检测和定量样品中的多种分析物。该装置包括在其上具有一个或多个化学传感器的电磁辐射发生器。化学传感器与样品中的特定分析物相互作用或与其反应。通过在不存在和存在分析物的情况下比较化学传感器的光谱特性来检测分析物的存在。还公开了使用本发明的装置检测和定量分析物的方法。此外，还公开了制造本发明的装置的方法。

5. 发明授权

US08377717B2 Site selectively tagged and templated molecularly imprinted polymers for sensor applications 有权
标题翻译：选择性地标记和模板分子印迹聚合物用于传感器应用
公开(公告)号：US08377717B2
公开(公告)日：2013-02-19
申请号：US12728783
申请日：2010-03-22
申请人： Frank V. Bright
发明人： Frank V. Bright
IPC分类号： G01N21/00 , G01N21/77 , G01N33/48 , C08G63/91 , C08F10/00
CPC分类号： G01N33/582 , B01J20/268 , B82Y5/00 , B82Y10/00 , G01N33/531 , G01N33/543 , G01N33/94 , G01N2600/00
摘要： This invention provides molecularly imprinted polymers (MIPs) for the detection of analytes, methods for forming the MIPs and detecting the analyte using the MIPs. The MIP comprises templated sites which are formed using a mimic of the analyte such that a reporter compound can be selectively attached at the templated sites, thus providing a site selectively tagged and templated MIP.
摘要翻译：本发明提供用于检测分析物的分子印迹聚合物（MIP），用于形成MIP的方法和使用MIP检测分析物。 MIP包括使用分析物的模拟物形成的模板位点，使得报告化合物可以在模板位点选择性连接，从而提供选择性标记和模板MIP的位点。

6. 发明申请

US20120312192A1 Anti-Fouling Coating Compositions and Methods For Preventing the Fouling of Surfaces 有权
标题翻译：防污涂料组合物和防止表面结垢的方法
公开(公告)号：US20120312192A1
公开(公告)日：2012-12-13
申请号：US13493116
申请日：2012-06-11
申请人： Michael Ray Detty , Frank V. Bright , Stephanie Marie Bennett , Anastasiya Sokolova
发明人： Michael Ray Detty , Frank V. Bright , Stephanie Marie Bennett , Anastasiya Sokolova
IPC分类号： C09D5/16
CPC分类号： C01B33/145 , C01B33/16 , C09D5/1675 , C09D5/1681
摘要： A xerogel film exhibiting antifouling properties. The films are made using long-chain alkyltrialkoxysilanes, short-chain alkyltrialkoxysilanes, aminoalkyltrialkoxysilanes, alkylaminoalkyltrialkoxysilanes, dialkylaminoalkyltrialkoxysilanes, and perfluororalkyltrialkoxysilanes as sol-gel precursors. The films can be used as coatings on surfaces to reduce or eliminate fouling resulting from attachment and/or growth of biofoulants such as algae, diatoms, bacteria, barnacles, and biofilms.
摘要翻译：具有防污性能的干凝胶膜。作为溶胶 - 凝胶前体，使用长链烷基三烷氧基硅烷，短链烷基三烷氧基硅烷，氨基烷基三烷氧基硅烷，烷基氨基烷基三烷氧基硅烷，二烷基氨基烷基三烷氧基硅烷和全氟烷基三烷氧基硅烷制备薄膜。这些膜可以用作表面上的涂层，以减少或消除由生物物质如藻类，硅藻，细菌，藤壶和生物膜的附着和/或生长引起的结垢。

7. 发明授权

US06589438B2 Method for making microsensor arrays for detecting analytes 有权
标题翻译：制造用于检测分析物的微传感器阵列的方法
公开(公告)号：US06589438B2
公开(公告)日：2003-07-08
申请号：US10254254
申请日：2002-09-25
申请人： Frank V. Bright , Brett R. Wenner , Meagan A. Doody , Gary A. Baker
发明人： Frank V. Bright , Brett R. Wenner , Meagan A. Doody , Gary A. Baker
IPC分类号： C03C1500
CPC分类号： G01N33/542 , G01N33/54373 , Y10T436/24
摘要： A device for detection of one or more analytes in a sample is disclosed. The device can simultaneously detect and quantitate multiple analytes in a sample. The device comprises an eletromagnetic radiation generator having one or more chemical sensors thereon. The chemical sensor interacts with or reacts with specific analytes in a sample. The presence of an analyte is detected by a comparison of the spectroscopic properties of the chemical sensor in the absence and presence of the analyte. A method is also disclosed for the detection and quantitation of analytes using the device of the present invention. In addition, a method of making the device of the present invention is also disclosed.
摘要翻译：公开了一种用于检测样品中一种或多种分析物的装置。该装置可以同时检测和定量样品中的多种分析物。该装置包括在其上具有一个或多个化学传感器的电磁辐射发生器。化学传感器与样品中的特定分析物相互作用或与其反应。通过在不存在和存在分析物的情况下比较化学传感器的光谱特性来检测分析物的存在。还公开了使用本发明的装置检测和定量分析物的方法。此外，还公开了制造本发明的装置的方法。

8. 发明授权

US08501098B1 Temporally addressable detection array 失效
标题翻译：临时寻址检测阵列
公开(公告)号：US08501098B1
公开(公告)日：2013-08-06
申请号：US10945344
申请日：2004-09-20
申请人： Albert H. Titus , Frank V. Bright , Alexander N. Cartwright
发明人： Albert H. Titus , Frank V. Bright , Alexander N. Cartwright
IPC分类号： G01N21/00
CPC分类号： G01N21/1717 , G01N21/253 , G01N2021/1725 , G01N2021/1772
摘要： A detection device and a method of detection are disclosed. The device may have a sensor array, a detector array, and a sensor controller. The sensor array may have a plurality of sensors, each sensor being responsive to a different analyte of interest. Each sensor may also be able to emit electromagnetic energy. For example, one or more of the sensors may include an LED. One or more of the sensors may include a sensing compound within a xerogel, which is responsive to an analyte of interest. In the method, one of the sensors is turned on, and one or more of the detectors are activated to receive electromagnetic energy emitted from the sensor.
摘要翻译：公开了一种检测装置和检测方法。该装置可以具有传感器阵列，检测器阵列和传感器控制器。传感器阵列可以具有多个传感器，每个传感器响应不同的感兴趣的分析物。每个传感器也可能能够发射电磁能。例如，一个或多个传感器可以包括LED。一个或多个传感器可以包括在干凝胶内的感测化合物，其对感兴趣的分析物有反应。在该方法中，传感器中的一个被接通，并且一个或多个检测器被激活以接收从传感器发射的电磁能。

9. 发明授权

US07897108B1 Sensor and method of sensing having an energy source and detector on the same side of a sensor substance 有权
标题翻译：传感器和感测方法在传感器物质的同一侧具有能量源和检测器
公开(公告)号：US07897108B1
公开(公告)日：2011-03-01
申请号：US10957254
申请日：2004-10-01
申请人： Albert H. Titus , Frank V. Bright , Alexander N. Cartwright
发明人： Albert H. Titus , Frank V. Bright , Alexander N. Cartwright
IPC分类号： G01N21/77 , B32B5/02
CPC分类号： G01N21/77
摘要： A sensor has a sensor substance, an electromagnetic energy source, and a detector. The sensor substance may be able to emit electromagnetic energy different than that provided by the energy source when an analyte of interest is in contact with the sensor substance and electromagnetic energy is received by the sensor substance. The energy source and the detector may be provided on the same side of the sensor substance.In a method according to the invention, a determination may be made as to whether an analyte is present in a sample. Such a method may provide a sensor, such as that described above. Electromagnetic energy may be provided to the sensor substance using the energy source, and the sensor substance may be contacted with a sample. Electromagnetic energy may be emitted from the sensor substance and received at the detector. The detector may provide a signal indicating the type of electromagnetic energy emitted from the sensor substance. The signal from the detector may be analyzed to determine whether the analyte was detected.
摘要翻译：传感器具有传感器物质，电磁能源和检测器。当感兴趣的分析物与传感器物质接触并且电磁能量被传感器物质接收时，传感器物质可能能够发射不同于由能量源提供的电磁能量的电磁能量。能量源和检测器可以设置在传感器物质的同一侧。在根据本发明的方法中，可以确定样品中是否存在分析物。这种方法可以提供如上所述的传感器。可以使用能量源将电磁能量提供给传感器物质，并且传感器物质可以与样品接触。电磁能量可以从传感器物质发射并在检测器处接收。检测器可以提供指示从传感器物质发射的电磁能量的类型的信号。可以分析来自检测器的信号以确定是否检测到分析物。

10. 发明申请

US20100179397A1 Device And Method For Continuous Monitoring Of A Chemical Parameter Of An Individual 审中-公开
标题翻译：连续监测个体化学参数的装置和方法
公开(公告)号：US20100179397A1
公开(公告)日：2010-07-15
申请号：US12685480
申请日：2010-01-11
申请人： Frank V. Bright , Jerome J. Schentag , David T. D'Andrea
发明人： Frank V. Bright , Jerome J. Schentag , David T. D'Andrea
IPC分类号： A61B5/00
CPC分类号： A61B5/00 , A61B5/14514 , A61B5/14525 , A61B5/14528 , A61B5/15003 , A61B5/150229 , A61B5/151 , A61B5/154 , A61B5/412
摘要： A device according to an embodiment of the invention includes a microdialysis catheter having an inlet and an outlet, a pump, and a flow-through monitor. The monitor is configured to analyze dialysate present in perfusion fluid exiting the microdialysis catheter. A chemical parameter may thereby be continuously monitored.
摘要翻译：根据本发明实施例的装置包括具有入口和出口，泵和流通监测器的微透析导管。监测器被配置为分析离开微透析导管的灌注流体中存在的透析液。因此可以连续监测化学参数。

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