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1. 发明授权

US07971429B2 Procedure for the regeneration of a particle filter and for the desulphurization of an NOx storage catalytic converter 有权
标题翻译：用于再生颗粒过滤器和用于NOx储存催化转化器的脱硫的方法
公开(公告)号：US07971429B2
公开(公告)日：2011-07-05
申请号：US11827627
申请日：2007-07-12
申请人： Stefan Forthmann , Frank Schweizer , Stefan Scherer
发明人： Stefan Forthmann , Frank Schweizer , Stefan Scherer
IPC分类号： F01N3/00 , F01N3/10 , F01N3/02
CPC分类号： F02D41/029 , F01N3/0234 , F01N3/0885 , F01N9/002 , F02D41/028
摘要： The disclosure concerns a procedure for the regeneration of a particle filter and the desulfurization of a NOx storage catalytic converter in an exhaust gas aftertreatment system of an internal combustion engine. The disclosed procedure allows for the necessary heating energy and fuel consumption required to completely or partially regenerating the particle filter to be significantly reduced. Furthermore, an increase in efficiency of the NOx storage catalytic converter results, because the process reduces the average sulfur absorption on account of a greater frequency of desulfurization phases. In so doing, the NOx emissions after the NOx storage catalytic converter can further be reduced.
摘要翻译：本公开涉及在内燃机的废气后处理系统中的颗粒过滤器的再生和NOx储存催化转化器的脱硫的过程。所公开的方法允许完全或部分再生颗粒过滤器所需的必要的加热能量和燃料消耗量显着降低。此外，由于该方法由于更高的脱硫阶段的频率而使平均硫吸收降低，因此导致NOx储存催化转化器的效率的提高。这样做可以进一步降低NOx吸收催化转化器之后的NOx排放。

2. 发明申请

US20080053077A1 Procedure and control unit to operate a diesel engine 有权
标题翻译：操作柴油机的程序和控制单元
公开(公告)号：US20080053077A1
公开(公告)日：2008-03-06
申请号：US11899108
申请日：2007-09-04
申请人： Andreas Pfaeffle , Wolfgang Klenk , Frank Schweizer , Stefan Scherer , Andreas Schaffrath
发明人： Andreas Pfaeffle , Wolfgang Klenk , Frank Schweizer , Stefan Scherer , Andreas Schaffrath
IPC分类号： F01N3/10
CPC分类号： F02D41/10 , F01N3/0814 , F01N3/0842 , F01N3/0871 , F01N13/009 , F02D41/1475 , F02D2250/32
摘要： A procedure is introduced to operate a diesel engine (10), which has a catalytic converter (24; 26) with three-way conversion characteristics. The procedure is characterized thereby, in that if the engine rotational speed (n) increases without in the process exceeding an engine rotational speed threshold value (n_S) and the engine's load (mk) is greater than a load threshold value (mk_S), the diesel engine (10) is operated in such a manner that the diesel engine (10) alternately generates an oxidizing and a reductive exhaust gas atmosphere before the catalytic converter (24; 26). Additionally a control unit (14) is introduced, which controls the sequence of the procedure.
摘要翻译：引入了具有三相转换特性的催化转化器（24; 26）的柴油发动机（10）的操作程序。其特征在于，如果发动机转速（n）不超过发动机转速阈值（n_S）并且发动机负载（mk）大于负载阈值（mk_S）的情况下增加，那么，柴油发动机（10）以使得柴油发动机（10）在催化转化器（24; 26）之前交替地产生氧化还原废气气氛的方式操作。此外，引入控制单元（14），其控制过程的顺序。

3. 发明授权

US08567181B2 Procedure for metering a reagent and device for implementing the procedure 有权
标题翻译：计量用于实施该程序的试剂和装置的步骤
公开(公告)号：US08567181B2
公开(公告)日：2013-10-29
申请号：US12432375
申请日：2009-04-29
申请人： Frank Schweizer
发明人： Frank Schweizer
IPC分类号： F01N3/00
CPC分类号： F01N3/208 , F01N2610/02 , F01N2900/0408 , Y02T10/24
摘要： A procedure for metering a reagent into an exhaust duct of a combustion engine, which is required for a catalytic conversion of NOx in a SCR-catalyzer and a device for implementing the procedure are suggested. Determined is the difference between a calculated and a measured NOx-concentration each downstream after the SCR-catalyzer. The difference is compared to a difference threshold. After an exceeding of the difference threshold a lowering of the metering rate on to a sinking metering rate is undertaken, which is higher than zero. After a waiting time, a comparison of the calculated and the measured NOx-concentration is provided each downstream after the SCR-catalyzer. If the measured NOx-concentration is above the calculated NOx-concentration the metering rate is increased. If the measured NOx-concentration is below the calculated NOx-concentration the metering rate is lowered. The approach according to the invention enables an adaptation of the metering, at which it is ensured that a NOx-conversion can always take place.
摘要翻译：提出了将催化转化SCR催化剂中的NOx所需的内燃机的排气管中的试剂计量的程序和用于实施该方法的装置。确定了SCR催化剂之后每个下游的计算值和测量的NOx浓度之间的差异。将差异与差异阈值进行比较。超过差异阈值后，进行计量率下降到下沉计量率，该值高于零。在等待时间之后，在SCR催化器之后每下游提供计算的和测量的NOx浓度的比较。如果测量的NOx浓度高于计算的NOx浓度，则计量率增加。如果测量的NOx浓度低于计算的NOx浓度，则计量率降低。根据本发明的方法使得可以适应计量，在该计量下，可以始终发生NOx转换。

4. 发明申请

US20120115774A1 ANTIMICROBIAL CATIONIC LIPO-BETA-PEPTIDES 审中-公开
标题翻译：抗真菌阳离子型LIPO-BETA-PEPTIDES
公开(公告)号：US20120115774A1
公开(公告)日：2012-05-10
申请号：US13260670
申请日：2010-02-23
申请人： George Zhanel , Frank Schweizer
发明人： George Zhanel , Frank Schweizer
IPC分类号： A61K38/07 , A61P31/04 , C07K5/11
CPC分类号： C07C237/22 , A61K38/00 , C07K5/0202 , Y02A50/473
摘要： In some aspects, the present invention provides ultrashort lipopeptides which feature β-amino acids or β-peptides and demonstrate antimicrobial activity. Accordingly, some aspects of the present invention provide lipopeptide compositions and methods of making and using the compositions as antimicrobial agents.
摘要翻译：在一些方面，本发明提供了具有β-氨基酸或β-葡聚糖并具有抗微生物活性的超短脂肽。因此，本发明的一些方面提供脂肽组合物和制备和使用该组合物作为抗微生物剂的方法。

5. 发明授权

US08028519B2 Method and device for regenerating an emission control system 有权
标题翻译：再生排放控制系统的方法和装置
公开(公告)号：US08028519B2
公开(公告)日：2011-10-04
申请号：US12158899
申请日：2006-12-13
申请人： Frank Schweizer , Stefan Scherer , Gerd Hartmann
发明人： Frank Schweizer , Stefan Scherer , Gerd Hartmann
IPC分类号： F01N3/10
CPC分类号： F01N3/0871 , B01D53/9481 , B01D53/9495 , B01D2255/91 , F01N3/0842 , F01N2430/06 , F01N2610/03 , F02D41/0275 , F02D41/1441
摘要： The invention relates to a method for regenerating an emission control system of an internal combustion engine, comprising a storage catalytic converter, a first exhaust gas probe being situated in an exhaust gas tract upstream of the storage catalytic converter and a second exhaust gas probe being situated in a second exhaust gas tract downstream of the storage catalytic converter. A first output signal of a first exhaust gas probe and a second output signal of a second exhaust gas probe are supplied to an engine management system and the storage catalytic converter is regenerated by being exposed to a reductant in a regeneration phase. If the quantity of reductant is controlled by the engine management system during the regeneration phase, whereby said system detects the quantity of reductant that is present downstream of the storage catalytic converter by means of the second output signal of the second exhaust gas probe situated downstream of said converter, the charging of reductant can be significantly reduced with respect to an optimised dosage. Excess consumption of fuel or reductant as a result of the regeneration of the storage catalytic converter is minimised. In addition, the method improves the emission values, thus significantly contributing to the maintenance of emission limits.
摘要翻译：本发明涉及一种用于再生内燃机的排放控制系统的方法，包括：存储催化转化器，位于所述储存催化转化器上游的废气道中的第一排气探针和位于在存储催化转化器的下游的第二废气道中。第一排气探针的第一输出信号和第二排气探头的第二输出信号被提供给发动机管理系统，并且通过在再生阶段暴露于还原剂来再生储存催化转化器。如果还原剂的量在再生阶段由发动机管理系统控制，则所述系统通过位于下游的第二废气探针的第二输出信号来检测存在于催化转化器下游的还原剂的量所述转化器，相对于优化的剂量，还原剂的充电可以显着降低。由于储存催化转化器的再生，燃料或还原剂的过量消耗被最小化。此外，该方法提高了排放值，从而大大有助于维护排放限值。

6. 发明申请

US20090094962A1 METHOD AND DEVICE FOR REGENERATING AN EMISSION CONTROL SYSTEM 有权
标题翻译：用于再现排放控制系统的方法和装置
公开(公告)号：US20090094962A1
公开(公告)日：2009-04-16
申请号：US12158899
申请日：2006-12-13
申请人： Frank Schweizer , Stefan Scherer , Gerd Hartmann
发明人： Frank Schweizer , Stefan Scherer , Gerd Hartmann
IPC分类号： F01N9/00
CPC分类号： F01N3/0871 , B01D53/9481 , B01D53/9495 , B01D2255/91 , F01N3/0842 , F01N2430/06 , F01N2610/03 , F02D41/0275 , F02D41/1441
摘要： The invention relates to a method for regenerating an emission control system of an internal combustion engine, comprising a storage catalytic converter, a first exhaust gas probe being situated in an exhaust gas tract upstream of the storage catalytic converter and a second exhaust gas probe being situated in a second exhaust gas tract downstream of the storage catalytic converter. A first output signal of a first exhaust gas probe and a second output signal of a second exhaust gas probe are supplied to an engine management system and the storage catalytic converter is regenerated by being exposed to a reductant in a regeneration phase. If the quantity of reductant is controlled by the engine management system during the regeneration phase, whereby said system detects the quantity of reductant that is present downstream of the storage catalytic converter by means of the second output signal of the second exhaust gas probe situated downstream of said converter, the charging of reductant can be significantly reduced with respect to an optimised dosage. Excess consumption of fuel or reductant as a result of the regeneration of the storage catalytic converter is minimised. In addition, the method improves the emission values, thus significantly contributing to the maintenance of emission limits.
摘要翻译：本发明涉及一种用于再生内燃机的排放控制系统的方法，包括：存储催化转化器，位于所述储存催化转化器上游的废气道中的第一排气探针和位于在存储催化转化器的下游的第二废气道中。第一排气探针的第一输出信号和第二排气探头的第二输出信号被提供给发动机管理系统，并且通过在再生阶段暴露于还原剂来再生储存催化转化器。如果还原剂的量在再生阶段由发动机管理系统控制，则所述系统通过位于下游的第二排气探针的第二输出信号来检测存在于催化转化器下游的还原剂的量所述转化器，相对于优化的剂量，还原剂的充电可以显着降低。由于储存催化转化器的再生，燃料或还原剂的过量消耗被最小化。此外，该方法提高了排放值，从而大大有助于维护排放限值。

7. 发明申请

US20080275213A1 Synthesis of Carbohydrate-Templated Amino Acids and Methods of Using Same 有权
标题翻译：碳水化合物 - 模板化氨基酸的合成及其使用方法
公开(公告)号：US20080275213A1
公开(公告)日：2008-11-06
申请号：US11857367
申请日：2007-09-18
申请人： Frank Schweizer , Kaidong Zhang , Neil Owens , George Zhanel
发明人： Frank Schweizer , Kaidong Zhang , Neil Owens , George Zhanel
IPC分类号： C07H7/00 , C07H7/02 , C07H1/00 , C07K1/107 , C07K2/00
CPC分类号： C07K5/06139 , C07K9/00
摘要： The present invention generally relates to tetrahydropyranyl-derivatized amino acids, their syntheses and their incorporation into peptides and peptidomimetics. The tetrahydropyran moiety constrains the side chain of an amino acid, thereby providing a molecule that may act as a sugar- or amino acid-mimetic as well as a scaffold for combinatorial synthesis.
摘要翻译：本发明一般涉及四氢吡喃基衍生的氨基酸，它们的合成及其掺入肽和肽模拟物。四氢吡喃部分限制氨基酸的侧链，从而提供可以作为糖或氨基酸模拟物以及用于组合合成的支架的分子。

8. 发明授权

US08999942B2 Polyol modified aminoglycoside-lipid conjugates 有权
标题翻译：多元醇修饰的氨基糖苷 - 脂质缀合物
公开(公告)号：US08999942B2
公开(公告)日：2015-04-07
申请号：US13639223
申请日：2011-04-05
申请人： Frank Schweizer , Smritilekha Bera , George Zhanel
发明人： Frank Schweizer , Smritilekha Bera , George Zhanel
IPC分类号： A61K31/7036 , A61K31/7008 , A61K31/702 , A61K31/7028 , C07H15/234 , C07H15/232 , C07H5/06 , C07H15/224 , C07H17/04
CPC分类号： C07H15/224 , C07H17/04
摘要： In some aspects, the present invention provides aminoglycoside derivatives thereof that exhibit antibacterial activity. In some aspects, the aminoglycoside derivatives comprise compounds consisting of (a) an ammoglycoside group and (b) at least one hydrophobic carbamate and alkoxy group to the primary or secondary hydroxy position of the aminolvcoside group and salts thereof. Additionally, methods of treating and preventing bacterial infections using the aminoglycoside derivatives are also provided.
摘要翻译：在某些方面，本发明提供具有抗菌活性的氨基糖苷衍生物。在一些方面，氨基糖苷衍生物包含由（a）氨基甙基和（b）氨基甙基的伯或仲羟基位置的至少一个疏水氨基甲酸酯和烷氧基及其盐组成的化合物。此外，还提供了使用氨基糖苷衍生物治疗和预防细菌感染的方法。

9. 发明申请

US20130157969A1 POLYOL MODIFIED AMINOGLYCOSIDE-LIPID CONJUGATES 有权
标题翻译：多元醇改性氨基丁糖 - 脂质结合物
公开(公告)号：US20130157969A1
公开(公告)日：2013-06-20
申请号：US13639223
申请日：2011-04-05
申请人： Frank Schweizer , Smritilekha Bera , George Zhanel
发明人： Frank Schweizer , Smritilekha Bera , George Zhanel
IPC分类号： C07H15/224
CPC分类号： C07H15/224 , C07H17/04
摘要： In some aspects, the present invention provides aminoglycoside derivatives thereof that exhibit antibacterial activity. In some aspects, the aminoglycoside derivatives comprise compounds consisting of (a) an ammoglycoside group and (b) at least one hydrophobic carbamate and alkoxy group to the primary or secondary hydroxy position of the aminolvcoside group and salts thereof. Additionally, methods of treating and preventing bacterial infections using the aminoglycoside derivatives are also provided
摘要翻译：在某些方面，本发明提供具有抗菌活性的氨基糖苷衍生物。在一些方面，氨基糖苷衍生物包含由（a）氨基甙基和（b）氨基甙基的伯或仲羟基位置的至少一个疏水氨基甲酸酯和烷氧基及其盐组成的化合物。此外，还提供了使用氨基糖苷衍生物治疗和预防细菌感染的方法

10. 发明授权

US07951905B2 Synthesis of carbohydrate-templated amino acids and methods of using same 有权
标题翻译：碳水化合物模板化氨基酸的合成及其使用方法
公开(公告)号：US07951905B2
公开(公告)日：2011-05-31
申请号：US11857367
申请日：2007-09-18
申请人： Frank Schweizer , Kaidong Zhang , Neil Owens , George Zhanel
发明人： Frank Schweizer , Kaidong Zhang , Neil Owens , George Zhanel
IPC分类号： C07K2/00
CPC分类号： C07K5/06139 , C07K9/00
摘要： The present invention generally relates to tetrahydropyranyl-derivatized amino acids, their syntheses and their incorporation into peptides and peptidomimetics. The tetrahydropyran moiety constrains the side chain of an amino acid, thereby providing a molecule that may act as a sugar- or amino acid-mimetic as well as a scaffold for combinatorial synthesis.
摘要翻译：本发明一般涉及四氢吡喃基衍生的氨基酸，它们的合成及其掺入肽和肽模拟物。四氢吡喃部分限制氨基酸的侧链，从而提供可以作为糖或氨基酸模拟物以及用于组合合成的支架的分子。

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