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1. 发明授权

US06288054B1 Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment 失效
标题翻译：碳青霉烯抗菌化合物，含有这些化合物的组合物和治疗方法
公开(公告)号：US06288054B1
公开(公告)日：2001-09-11
申请号：US09317777
申请日：1999-05-24
申请人： Frank P. Dininno , Milton L. Hammond , Kevin D. Dykstra
发明人： Frank P. Dininno , Milton L. Hammond , Kevin D. Dykstra
IPC分类号： C07D47714
CPC分类号： C07D477/14
摘要： The present invention relates to tricyclic carbapenem antibacterial agents in which the carbapenem nucleus is fused to a 6 membered carbocyclic ring. The compound is further substituted with various substituent groups including at least one cationic group. The compounds are represented by formula I: Pharmaceutical compositions and methods of use are also included.
摘要翻译：本发明涉及三碳青霉烯类抗生素，其中碳青霉烯核与6元碳环稠合。该化合物被包括至少一个阳离子基团的各种取代基进一步取代。化合物由式I表示：还包括药物组合物和使用方法。

2. 发明授权

US06207823B1 Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment 失效
公开(公告)号：US06207823B1
公开(公告)日：2001-03-27
申请号：US09166506
申请日：1998-10-05
申请人： Frank P. Dininno , Milton L. Hammond
发明人： Frank P. Dininno , Milton L. Hammond
IPC分类号： C07D47714
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D477/00
摘要： The present invention relates to tricyclic carbapenem antibacterial agents in which the carbapenem nucleus is fused to a 6 membered carbocyclic ring. The compound is further substituted with various substituent groups including at least one cationic group. The compounds are represented by formula I: Pharmaceutical compositions and methods of use are also included.

3. 发明授权

US06310055B2 Halophenoxy substituted carbapenem antibacterial compounds 失效
标题翻译：卤代苯氧基取代的碳青霉烯类抗菌化合物
公开(公告)号：US06310055B2
公开(公告)日：2001-10-30
申请号：US09311519
申请日：1999-05-13
申请人： Frank P. Dininno , Kevin D. Dykstra
发明人： Frank P. Dininno , Kevin D. Dykstra
IPC分类号： A61K31407
CPC分类号： C07D477/14
摘要： The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2 -position with a iodophenoxy linked through a group —Z—CH2—; The compound is further substituted with various substituent groups including at least one cationic group. The compounds are represented by formula I: wherein Z represents trans-ethenediyl or ethynediyl. Pharmaceutical compositions and methods of use are also included.
摘要翻译：本发明涉及碳青霉烯类抗菌剂，其中碳青霉烯核在2-位被与通过基团-Z-CH2-基团连接的碘苯氧基取代; 该化合物进一步被包括至少一个阳离子基团的各种取代基取代。化合物由式I表示：其中Z代表反式 - 乙烯二基或乙炔二基。还包括药物组合物和使用方法。

4. 发明授权

US06284753B1 Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment 有权
公开(公告)号：US06284753B1
公开(公告)日：2001-09-04
申请号：US09317790
申请日：1999-05-24
申请人： Frank P. Dininno , Kevin D. Dykstra
发明人： Frank P. Dininno , Kevin D. Dykstra
IPC分类号： C07D47714
摘要： The present invention relates to tricyclic carbapenem antibacterial agents wherein X is CH2, CHRa, CHRb, C═CHRa, C═CHRb, O, S, SO, SO2, CO, COO

5. 发明授权

US06255300B1 Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment 失效
标题翻译：碳青霉烯抗菌化合物，含有这些化合物的组合物和治疗方法
公开(公告)号：US06255300B1
公开(公告)日：2001-07-03
申请号：US09455629
申请日：1999-12-07
申请人： Frank P. Dininno , Kevin D. Dykstra
发明人： Frank P. Dininno , Kevin D. Dykstra
IPC分类号： C07D47714
CPC分类号： C07D477/14
摘要： The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2-position with an iodo-substituted phenyl linked through a CH2—O— group. The compounds of the invention are represented by formula I: wherein A represent O, S or —CH2— attached at position 3, 4 or 6; Q is selected from the group consisting of: &agr; represents O, S or NRs; &bgr;, &dgr;, &ggr;, &mgr; and &sgr; represent CRt, N or N+Rs, provided that no more than one of &bgr;, &dgr;, &ggr;, &mgr; and &sgr; is N+Rs, balanced by L− or a carboxylate anion. Salts and hydrates thereof are included. The iodo-substituted phenyl ring is further substituted with various substituent groups including at least one cationic group. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译：本发明涉及碳青霉烯类抗菌剂，其中碳青霉烯核在2位被碘取代的苯基通过CH2-O-基团连接。本发明的化合物由式I表示：其中A表示在3,4或6位上连接的O，S或-CH 2; Q选自：α表示O，S或NR; β，δ，γ，μ和σ表示CRt，N或N + Rs，条件是β，δ，γ，μ和σ的不超过一个为N + Rs，由L-或羧酸根阴离子平衡。包括其盐和水合物。碘取代的苯环进一步被包括至少一个阳离子基团的各种取代基取代。还包括药物组合物和治疗方法。

6. 发明授权

US5994343A Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment 失效
标题翻译：碳青霉烯抗菌化合物，含有这些化合物的组合物和治疗方法
公开(公告)号：US5994343A
公开(公告)日：1999-11-30
申请号：US150569
申请日：1998-09-10
申请人： Frank P. Dininno , Kevin D. Dykstra
发明人： Frank P. Dininno , Kevin D. Dykstra
IPC分类号： C07D477/00 , A61K31/397 , A61K31/407 , A61K31/4995 , A61P31/04 , C07D477/14 , A61K31/425 , A61K31/395 , C07D487/04
CPC分类号： C07D477/14
摘要： The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2-position with a naphthosultam linked through a --Z--CH.sub.2 group. The naphthosultam is further substituted with various substituent groups including cationic groups. The compounds are represented by formula I: ##STR1## Pharmaceutical compositions and methods of use are also included.
摘要翻译：本发明涉及碳青霉烯类抗菌剂，其中碳青霉烯核在2-位被通过-Z-CH 2基团连接的萘磺酰胺代替。萘磺叠胺进一步被包括阳离子基团的各种取代基取代。化合物由式I表示：还包括药物组合物和使用方法。

7. 发明授权

US5182385A 2-biphenyl-carbapenems intermediates 失效
标题翻译： 2-联苯基 - 碳青霉烯中间体
公开(公告)号：US5182385A
公开(公告)日：1993-01-26
申请号：US594767
申请日：1990-10-09
申请人： Frank P. Dininno , Thomas N. Salzmann
发明人： Frank P. Dininno , Thomas N. Salzmann
IPC分类号： C07D477/14
CPC分类号： C07D477/14
摘要： Carbapenems of the formula: ##STR1## are useful intermediates to antibacterial agents.
摘要翻译：具有下式的碳青霉烯类：是抗菌剂的有用中间体。

8. 发明授权

US5132421A 2-naphthyl-carbapenem intermediates 失效
公开(公告)号：US5132421A
公开(公告)日：1992-07-21
申请号：US594213
申请日：1990-10-09
申请人： Frank P. Dininno , Mark L. Greenlee
发明人： Frank P. Dininno , Mark L. Greenlee
IPC分类号： C07D477/14
CPC分类号： C07D477/14
摘要： Carbapenems of the formula ##STR1## are useful intermediates to antibacterial agents.

9. 发明授权

US5128335A 2-heteroarylphenyl-carbapenem antibacterial agents 失效
标题翻译： 2-异丁基苯胺抗生素
公开(公告)号：US5128335A
公开(公告)日：1992-07-07
申请号：US597638
申请日：1990-10-15
申请人： Ravindra N. Guthikonda , Susan M. Schmitt , Frank P. Dininno
发明人： Ravindra N. Guthikonda , Susan M. Schmitt , Frank P. Dininno
IPC分类号： A61K31/40 , A61K31/397 , A61P31/04 , C07D477/00 , C07D477/14
CPC分类号： C07D477/14
摘要： Carbapenems of the formula ##STR1## are useful antibacterial agents.

10. 发明授权

US5004740A 2-phenanthrenyl-carbapenem antibacterial agents 失效
标题翻译： 2-菲基 - 碳青霉烯类抗菌剂
公开(公告)号：US5004740A
公开(公告)日：1991-04-02
申请号：US543990
申请日：1990-06-26
申请人： Frank P. Dininno , Thomas N. Salzmann , Mark L. Greenlee
发明人： Frank P. Dininno , Thomas N. Salzmann , Mark L. Greenlee
IPC分类号： C07D477/14
CPC分类号： C07D477/14
摘要： Carbapenems of the formula ##STR1## are useful antibacterial agents.
摘要翻译：配方的碳青霉烯类是有用的抗菌剂。

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