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1. 发明授权

US06180007B2 Membrane formed by an acrylonitrile-based polymer 失效
标题翻译：由丙烯腈基聚合物形成的膜
公开(公告)号：US06180007B2
公开(公告)日：2001-01-30
申请号：US09016518
申请日：1998-01-31
申请人： Frank Gentile , Molly Shoichet , Milton Harris
发明人： Frank Gentile , Molly Shoichet , Milton Harris
IPC分类号： C08L2044
CPC分类号： C08L71/02 , C08F8/12 , C08G81/025 , C08J5/2268 , C08J2327/06 , C08J2371/02 , C08F20/44 , C08L2666/24 , C08L2666/04
摘要： A permselective graft polymer is disclosed that is formed by converting into intermediate reactive sites a portion of the cyano groups of a backbone polymer containing —CH2—CH(—C≡N)— units, and grafting polyalkylene oxide polymer chains to the backbone polymer through the reactive sites. Either the backbone polymer of a polymer resin or a permselective polymer membrane can be grafted. When a resin is used, it is formed into a permselective polymer membrane using known methods. The resulting permselective membrane can be formed into hollow fibers or flat sheets for the encapsulation of living cells. The encapsulated cells are then implanted into a patient in need of the biologically active factors produced by the cells. The permselective graft polymer membrane exhibits good molecular diffusion with minimal protein adsorption.
摘要翻译：公开了通过将包含-CH 2 -CH（-C = N） - 单元的主链聚合物的一部分氰基转化为中间反应性位点而形成的选择性接枝聚合物，并且将聚环氧烷聚合物链通过反应场地。聚合物树脂或选择性聚合物膜的主链聚合物可以被接枝。当使用树脂时，使用已知的方法将其形成为选择性选择性聚合物膜。所得到的选择性渗透膜可以形成用于活细胞包封的中空纤维或平板。然后将包封的细胞植入需要由细胞产生的生物活性因子的患者体内。选择性接枝聚合物膜表现出良好的分子扩散和最小的蛋白质吸附。

2. 发明授权

US5720969A Membrane formed by an acrylonitrile-based polymer 失效
标题翻译：由丙烯腈基聚合物形成的膜
公开(公告)号：US5720969A
公开(公告)日：1998-02-24
申请号：US535213
申请日：1996-01-16
申请人： Frank Gentile , Molly Shoichet , Milton Harris
发明人： Frank Gentile , Molly Shoichet , Milton Harris
IPC分类号： B01D71/42 , C08F8/00 , C08F8/12 , C08G69/00 , C08G69/04 , C08G81/02 , C08J5/18 , C08J5/22 , C08L71/02 , C08L20/44 , C08L81/02 , C12N11/04 , C12N11/08
CPC分类号： C08L71/02 , C08F8/12 , C08G81/025 , C08J5/2268 , C08J2327/06 , C08J2371/02
摘要： A permselective graft polymer is disclosed that is formed by converting into intermediate reactive sites a portion of the cyano groups of a backbone polymer and grafting polyalkylene oxide polymer chains to the backbone polymer through the reactive sites. Either the backbone polymer of a polymer resin or a permselective polymer membrane can be grafted. When a resin is used, it is formed into a permselective polymer membrane using known methods. The resulting permselective membrane can be formed into hollow fibers or flat sheets for the encapsulation of living cells. The encapsulated cells are then implanted into a patient in need of the biologically-active factors produced by the cells. The permselective graft polymer membrane exhibits good molecular diffusion with minimal protein adsorption.
摘要翻译：公开了通过将主链聚合物的一部分氰基转化为中间反应性位点并通过反应性位点将聚环氧烷聚合物链接枝到主链聚合物而形成的选择性选择性接枝聚合物。聚合物树脂或选择性聚合物膜的主链聚合物可以被接枝。当使用树脂时，使用已知的方法将其形成为选择性选择性聚合物膜。所得到的选择性渗透膜可以形成用于活细胞包封的中空纤维或平板。然后将包封的细胞植入需要由细胞产生的生物活性因子的患者体内。选择性接枝聚合物膜表现出良好的分子扩散和最小的蛋白质吸附。

3. 发明授权

US06638500B1 Polyol-IFN-&bgr;conjugates modified at Cys-17 and composition containing same 有权
标题翻译：在Cys-17修饰的多元醇-β-IFN-betaconjugates和含有它的组合物
公开(公告)号：US06638500B1
公开(公告)日：2003-10-28
申请号：US09698133
申请日：2000-10-30
申请人： Nabil El-Tayar , Michael J. Roberts , Milton Harris , Wayne Sawlivich
发明人： Nabil El-Tayar , Michael J. Roberts , Milton Harris , Wayne Sawlivich
IPC分类号： A61K3821
CPC分类号： A61K47/60 , Y10S514/825 , Y10S514/903
摘要： PEG-IFN-&bgr; conjugates, where a PEG moiety is covalently bound to Cys17 of human IFN-&bgr;, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-&bgr;.
摘要翻译：其中PEG部分与人IFN-β的Cys 17共价结合的PEG-IFN-β缀合物通过用硫醇反应性聚乙二醇化剂进行位点特异性PEG化的方法产生。还提供了用于治疗感染，肿瘤和自身免疫性和炎性疾病的药物组合物和方法。本发明还涉及将PEG部分逐步连接到多肽，更具体地说涉及IFN-β的方法。

4. 发明授权

US07700314B2 Method for producing polyol-IFN-β conjugate 有权
标题翻译：生产多元醇-IFF-的方法缀合物
公开(公告)号：US07700314B2
公开(公告)日：2010-04-20
申请号：US11674476
申请日：2007-02-13
申请人： Nabil El-Tayar , Michael J. Roberts , Milton Harris , Wayne Sawlivich
发明人： Nabil El-Tayar , Michael J. Roberts , Milton Harris , Wayne Sawlivich
IPC分类号： C12P21/00 , C08G65/08 , C07K14/52
CPC分类号： A61K47/60 , Y10S514/825 , Y10S514/903
摘要： PEG-IFN-β conjugates, where a PEG moiety is covalently bound to Cys17 of human IFN-β, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-β.
摘要翻译： PEG-IFN- 通过用硫醇反应性聚乙二醇化剂进行位点特异性PEG化的方法，其中PEG部分共价结合人IFN-和bgr的Cys17。还提供了用于治疗感染，肿瘤和自身免疫性和炎性疾病的药物组合物和方法。本发明还涉及一种将PEG部分逐步连接到多肽，更具体地涉及IFN-α的方法。

5. 发明授权

US07357925B2 Method for treating disorders and diseases treatable with human fibroblast interferon 有权
标题翻译：治疗可用人成纤维细胞干扰素治疗的疾病和疾病的方法
公开(公告)号：US07357925B2
公开(公告)日：2008-04-15
申请号：US10649609
申请日：2003-08-28
申请人： Nabil El-Tayar , Michael J. Roberts , Milton Harris , Wayne Sawlivich
发明人： Nabil El-Tayar , Michael J. Roberts , Milton Harris , Wayne Sawlivich
IPC分类号： A61K38/21
CPC分类号： A61K47/60 , Y10S514/825 , Y10S514/903
摘要： PEG-IFN-β conjugates, where a PEG moiety is covalently bound to Cys17 of human IFN-β, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-β.
摘要翻译：其中PEG部分共价结合人IFN-β的Cys 17的PEG-IFN-β缀合物通过用硫醇反应性聚乙二醇化剂进行位点特异性PEG化的方法产生。还提供了用于治疗感染，肿瘤和自身免疫性和炎性疾病的药物组合物和方法。本发明还涉及将PEG部分逐步连接到多肽，更具体地说涉及IFN-β的方法。

6. 发明申请

US20070141620A1 POLYOL-IFN-BETA CONJUGATE AND COMPOSITION CONTAINING SAME 有权
标题翻译：多聚-γ-氨基-β-共聚物和包含它们的组合物
公开(公告)号：US20070141620A1
公开(公告)日：2007-06-21
申请号：US11674476
申请日：2007-02-13
申请人： Nabil El-Tayar , Michael Roberts , Milton Harris , Wayne Sawlivich
发明人： Nabil El-Tayar , Michael Roberts , Milton Harris , Wayne Sawlivich
IPC分类号： C12Q1/68
CPC分类号： A61K47/60 , Y10S514/825 , Y10S514/903
摘要： PEG-IFN-β conjugates, where a PEG moiety is covalently bound to Cys17 of human IFN-β, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-β.
摘要翻译：其中PEG部分共价结合人IFN-β的Cys 17的PEG-IFN-β缀合物通过用硫醇反应性聚乙二醇化剂进行位点特异性PEG化的方法产生。还提供了用于治疗感染，肿瘤和自身免疫性和炎性疾病的药物组合物和方法。本发明还涉及将PEG部分逐步连接到多肽，更具体地说涉及IFN-β的方法。

7. 发明授权

US5463808A Discrete pallet deck board remover machine 失效
标题翻译：离散式托盘甲板去除机
公开(公告)号：US5463808A
公开(公告)日：1995-11-07
申请号：US340280
申请日：1994-11-15
申请人： Milton Harris
发明人： Milton Harris
IPC分类号： B23P19/04 , B23P19/00
CPC分类号： B23P19/041 , Y10T29/49822 , Y10T29/53543 , Y10T29/53683 , Y10T29/53796 , Y10T29/53835
摘要： A discrete deck board remover apparatus comprises a pallet pusher assembly for pushing a pallet into a position in which a selected deck board can be removed by a deck board plow assembly. Once the defective deck board is removed, the pallet can be optionally removed from further operation or moved to a second position in which the pallet can be turned over and returned to the position with the opposite side up whereupon further defective deck boards can be removed by the deck board plow assembly.
摘要翻译：独立的甲板板移除装置包括托盘推动器组件，用于将托盘推动到通过甲板板犁组件可以移除所选择的甲板板的位置。一旦有缺陷的甲板板被移除，托盘可以可选地从进一步的操作中移除或移动到第二位置，在该第二位置托盘可以翻转并返回到相对侧的位置，由此可以通过甲板板犁组件。

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