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    • 8. 发明申请
    • Protease enzyme inhibitors
    • 蛋白酶抑制剂
    • US20060003943A1
    • 2006-01-05
    • US11221445
    • 2005-09-08
    • Todd UnderinerRenae FossumJohn McIver
    • Todd UnderinerRenae FossumJohn McIver
    • A61K38/05C07K5/06
    • A61K47/60
    • The present invention relates to compounds having the general formula: [Poly]—[(L)z—[R—CHO]]y wherein [Poly] is a water-soluble, non-peptidic polymer component, L is an optionally present linking group, and RCHO is a substrate capable of interacting with one or more protease enzymes to reversibly inhibit said enzyme, and wherein said substrate comprises a peptide or peptide-like aldehyde. The index z is 0 when linking groups are absent and z is 1 when linking groups are present. The index y is at least 1. The inhibitors of the present invention are suitable for use in personal care compositions, inter alia, body washes, shampoos, and skin creams.
    • 本发明涉及具有以下通式的化合物:<?in-line-formula description =“In-line Formulas”end =“lead”?> [Poly] - [(L)z - [R-CHO]] <?in-line-formula description =“In-line Formulas”end =“tail”?>其中[Poly]是一种水溶性非肽聚合物 L是任选存在的连接基团,并且RCHO是能够与一种或多种蛋白酶相互作用以可逆地抑制所述酶的底物,并且其中所述底物包含肽或肽样醛。 当不存在连接基团时,索引z为0,当存在连接基团时,z为1。 指数y至少为1.本发明的抑制剂适用于个人护理组合物,特别是身体洗涤剂,洗发剂和护肤霜。