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1. 发明授权

US06296095B1 Coupling assembly with double shear channel 失效
标题翻译：双重剪切通道联轴器组件
公开(公告)号：US06296095B1
公开(公告)日：2001-10-02
申请号：US09347617
申请日：1999-07-02
申请人： Frank Böttger , Theodor Gassmann
发明人： Frank Böttger , Theodor Gassmann
IPC分类号： F16D43284
CPC分类号： F16D35/005 , F16D43/284
摘要： A coupling assembly comprising a friction coupling a pressure-generating device comprising a pump body member, an axially-displaceable piston loading the friction coupling, and a pressure chamber formed by the pump body and by the piston and filled with a highly-viscous fluid, and with at least one conveying plate being provided in the pressure chamber; and a shear channel with a control member in the pressure chamber, the control member cooperating with at least one conveying plate. In a first embodiment, the shear channel with a control member forms two circumferential grooves of limited length and each covered by one of the two radial surfaces of the conveying plate, thereby forming two shear channels. Passages through the conveying plate connect the two shear channels. In a second embodiment, the shear channel with a control member forms a circumferential groove of limited length which is covered by one of the two radial surfaces of the conveying plate to form a first shear channel. In the shear channel with a control member, there is a circumferential slot of limited length which is covered by the other one of the two radial surfaces of the conveying plate and by a second conveying plate, the latter being designed to form a second shear channel. The first conveying plate includes fluid passages extending therethrough and connecting both shear channels to one another.
摘要翻译：一种联接组件，包括摩擦联接器，压力产生装置包括泵主体构件，装载摩擦联接器的可轴向移动的活塞和由泵主体和活塞形成并且填充有高粘度流体的压力室，并且至少一个传送板设置在压力室中; 以及在所述压力室中具有控制构件的剪切通道，所述控制构件与至少一个输送板协作。在第一实施例中，具有控制构件的剪切通道形成有限长度的两个周向槽，并且每个由传送板的两个径向表面中的一个覆盖，从而形成两个剪切通道。通过输送板连接两个剪切通道。在第二实施例中，具有控制构件的剪切通道形成有限长度的周向凹槽，其被输送板的两个径向表面之一覆盖以形成第一剪切通道。在具有控制构件的剪切通道中，存在有限长度的周向槽，其被输送板的两个径向表面中的另一个覆盖，并且由第二输送板覆盖，第二输送板被设计成形成第二剪切通道。第一输送板包括延伸穿过其中并将两个剪切通道彼此连接的流体通道。

2. 发明申请

US20110099836A1 LARGE-SCALE LYOPHILIZATION DEVICE 有权
标题翻译：大规模LYOPHILIZING设备
公开(公告)号：US20110099836A1
公开(公告)日：2011-05-05
申请号：US12999021
申请日：2009-06-16
申请人： Frank Böttger , Martin Häuptle
发明人： Frank Böttger , Martin Häuptle
IPC分类号： F26B5/06
CPC分类号： G03B15/00 , F26B5/06
摘要： A device for large-scale lyophilization of pharmaceutical solutions in medical hollow bodies, includes a lyophilization device and at least one camera. Images of at least one pharmaceutical solution to be lyophilized are recorded by the at least one camera. The images may be used for controlling and/or monitoring the lyophilization process.
摘要翻译：用于药物溶液在医用空心体中大规模冷冻干燥的装置包括冻干装置和至少一个照相机。由至少一个照相机记录要冻干的至少一种药物溶液的图像。图像可用于控制和/或监测冻干过程。

3. 发明授权

US08813955B2 Container for medical products and method for production of said container 有权
标题翻译：用于医疗产品的容器和用于生产所述容器的方法
公开(公告)号：US08813955B2
公开(公告)日：2014-08-26
申请号：US12999241
申请日：2009-06-18
申请人： Frank Böttger , Benjamin Böbst , Patricia Koch
发明人： Frank Böttger , Benjamin Böbst , Patricia Koch
IPC分类号： B65D25/08 , F26B5/06 , A61J1/00
CPC分类号： A61J1/00 , F26B5/06
摘要： A container for medical products has at least one chamber. At least two lyophilized active substances and/or auxiliary substances are jointly present in the at least one chamber.
摘要翻译：医疗产品的容器至少有一个腔室。在至少一个室中共同存在至少两种冻干的活性物质和/或辅助物质。

4. 发明申请

US20110094188A1 METHOD FOR FILLING DUAL-CHAMBER SYSTEMS IN PRE-STERILIZABLE CARRIER SYSTEMS AND PRE-STERILIZABLE CARRIER SYSTEM 有权
标题翻译：在不可消毒的载体系统和预先无菌载体系统中填充双室系统的方法
公开(公告)号：US20110094188A1
公开(公告)日：2011-04-28
申请号：US12997218
申请日：2009-06-16
申请人： Frank Böttger , Benjamin Böbst
发明人： Frank Böttger , Benjamin Böbst
IPC分类号： B65B55/02 , B65D85/00
CPC分类号： B65D21/02 , A61J1/062 , A61J1/2041 , A61J1/2093 , B65B3/003 , B65B7/2821 , B65B55/027
摘要： A method for filling dual-chamber systems in pre-sterilizable carrier systems includes providing at least one washed, siliconized and sterilized dual-chamber system in a magazine. The dual-chamber system includes respective separating elements separating the two chambers from each other. The magazine accommodates at least one dual-chamber system and is arranged in a container that is sealed with a closing element. The method additionally includes introducing the container into a clean room; opening the container and filling a first chamber of the at least one dual-chamber system; and closing the first chamber. The method further includes filling a second chamber of the at least one dual-chamber system; closing the second chamber; and removing the system from the clean room.
摘要翻译：用于在预消毒的载体系统中填充双室系统的方法包括在盒中提供至少一个洗涤的，硅化的和灭菌的双室系统。双室系统包括将两个室彼此分开的各自的分离元件。该杂志容纳至少一个双室系统，并且布置在用闭合元件密封的容器中。该方法还包括将容器引入洁净室; 打开容器并填充至少一个双室系统的第一室; 并关闭第一个房间。该方法还包括填充至少一个双室系统的第二室; 关闭第二个房间; 并从洁净室中取出系统。

5. 发明申请

US20110089065A1 CONTAINER FOR MEDICAL PRODUCTS AND METHOD FOR PRODUCTION OF SAID CONTAINER 有权
标题翻译：医疗产品用容器及生产集装箱的方法
公开(公告)号：US20110089065A1
公开(公告)日：2011-04-21
申请号：US12999241
申请日：2009-06-18
申请人： Frank Böttger , Benjamin Böbst
发明人： Frank Böttger , Benjamin Böbst
IPC分类号： A61B19/02 , B65B63/08
CPC分类号： A61J1/00 , F26B5/06
摘要： A container for medical products has at least one chamber. At least two lyophilized active substances and/or auxiliary substances are jointly present in the at least one chamber.
摘要翻译：医疗产品的容器至少有一个腔室。在至少一个室中共同存在至少两种冻干的活性物质和/或辅助物质。

6. 发明申请

US20110092906A1 DEVICE WITH AT LEAST ONE CHAMBER FOR RECEIVING A MEDICAMENT OR A SAMPLE VOLUME 审中-公开
标题翻译：具有至少一个房间用于接收药物或样品量的装置
公开(公告)号：US20110092906A1
公开(公告)日：2011-04-21
申请号：US12999593
申请日：2009-06-18
申请人： Frank Böttger , Benjamin Böbst
发明人： Frank Böttger , Benjamin Böbst
IPC分类号： A61M5/20
CPC分类号： A61M5/2046 , A61M5/19 , A61M5/24 , A61M5/2466 , A61M5/28 , A61M5/3135 , A61M2005/3121 , A61M2205/8218 , A61M2205/8231
摘要： A device has at least one chamber for accommodating a medicament or a sample volume, and has a plunger element which is displaceable in the device. The device includes a syringe or carpule, a multi- or dual-chamber system, an autoinjector, or a pen. Pressure forces resulting from a chemical reaction may be introduced into the plunger element, thereby causing displacement of the plunger element.
摘要翻译：装置具有用于容纳药物或样品体积的至少一个腔室，并且具有可在装置中移位的柱塞元件。该装置包括注射器或小心丸，多室或双室系统，自动注射器或笔。由化学反应产生的压力可以引入柱塞元件，从而引起柱塞元件的位移。

7. 发明申请

US20110088617A1 COATING APPARATUS 有权
标题翻译：涂装装置
公开(公告)号：US20110088617A1
公开(公告)日：2011-04-21
申请号：US12999258
申请日：2009-06-18
申请人： Frank Böttger , Günther Späth
发明人： Frank Böttger , Günther Späth
IPC分类号： B05B13/06
CPC分类号： B05B7/0416 , A61M5/3129 , B05B7/04 , B05B7/0458 , B05B7/0475 , B05B7/064 , B05B13/0235 , B05B13/0436 , B05B13/06 , B05B13/0627 , B05C7/08 , B05D1/02 , B05D7/22
摘要： A coating device for coating an inside of a hollow body with an atomized fluid has at least one atomizing tube enclosing an atomizing channel. A pressurized propellant gas for atomizing an unatomized fluid can be introduced into the atomizing tube. The atomizing tube has at least one outlet opening and further has at least one hollow needle having a discharge opening for the unatomized fluid. The at least one hollow needle interacts with the atomizing channel and is arranged essentially coaxially thereto. The atomizing tube and the hollow needle form a Venturi arrangement.
摘要翻译：用雾化流体涂覆中空体的内部的涂覆装置具有包围雾化通道的至少一个雾化管。用于雾化未溶解流体的加压推进剂气体可以被引入到雾化管中。雾化管具有至少一个出口，并且还具有至少一个具有用于未溶解流体的排放口的空心针。至少一个中空针与雾化通道相互作用并且基本上与其同轴布置。雾化管和中空针形成文丘里排列。

8. 发明授权

US09108205B2 Coating apparatus for coating an inside of a hollow body with an atomized fluid 有权
标题翻译：用雾化液涂覆中空体的内部的涂布装置
公开(公告)号：US09108205B2
公开(公告)日：2015-08-18
申请号：US12999258
申请日：2009-06-18
申请人： Frank Böttger , Günther Späth
发明人： Frank Böttger , Günther Späth
IPC分类号： B05B7/04 , B05B13/06 , B05D7/22 , A61M5/31 , B05C7/08 , B05B7/06
CPC分类号： B05B7/0416 , A61M5/3129 , B05B7/04 , B05B7/0458 , B05B7/0475 , B05B7/064 , B05B13/0235 , B05B13/0436 , B05B13/06 , B05B13/0627 , B05C7/08 , B05D1/02 , B05D7/22
摘要： A coating device for coating an inside of a hollow body with an atomized fluid has at least one atomizing tube enclosing an atomizing channel. A pressurized propellant gas for atomizing an unatomized fluid can be introduced into the atomizing tube. The atomizing tube has at least one outlet opening and further has at least one hollow needle having a discharge opening for the unatomized fluid. The at least one hollow needle interacts with the atomizing channel and is arranged essentially coaxially thereto. The atomizing tube and the hollow needle form a Venturi arrangement.
摘要翻译：用雾化流体涂覆中空体的内部的涂覆装置具有包围雾化通道的至少一个雾化管。用于雾化未溶解流体的加压推进剂气体可以被引入到雾化管中。雾化管具有至少一个出口，并且还具有至少一个具有用于未溶解流体的排放口的空心针。至少一个中空针与雾化通道相互作用并且基本上与其同轴布置。雾化管和中空针形成文丘里排列。

9. 发明授权

US08677723B2 Method for filling dual-chamber systems in pre-sterilizable carrier systems and pre-sterilizable carrier system 有权
标题翻译：在预消毒的载体系统和预消毒的载体系统中填充双室系统的方法
公开(公告)号：US08677723B2
公开(公告)日：2014-03-25
申请号：US12997218
申请日：2009-06-16
申请人： Frank Böttger , Benjamin Böbst
发明人： Frank Böttger , Benjamin Böbst
IPC分类号： B65B55/02 , B65B7/00
CPC分类号： B65D21/02 , A61J1/062 , A61J1/2041 , A61J1/2093 , B65B3/003 , B65B7/2821 , B65B55/027
摘要： A method for filling dual-chamber systems in pre-sterilizable carrier systems includes providing at least one washed, siliconized and sterilized dual-chamber system in a magazine. The dual-chamber system includes respective separating elements separating the two chambers from each other. The magazine accommodates at least one dual-chamber system and is arranged in a container that is sealed with a closing element. The method additionally includes introducing the container into a clean room; opening the container and filling a first chamber of the at least one dual-chamber system; and closing the first chamber. The method further includes filling a second chamber of the at least one dual-chamber system; closing the second chamber; and removing the system from the clean room.
摘要翻译：用于在预消毒的载体系统中填充双室系统的方法包括在盒中提供至少一个洗涤的，硅化的和灭菌的双室系统。双室系统包括将两个室彼此分开的各自的分离元件。该杂志容纳至少一个双室系统，并且布置在用闭合元件密封的容器中。该方法还包括将容器引入洁净室; 打开容器并填充至少一个双室系统的第一室; 并关闭第一个房间。该方法还包括填充至少一个双室系统的第二室; 关闭第二个房间; 并从洁净室中取出系统。

10. 发明申请

US20110094189A1 METHOD FOR FILLING DUAL-CHAMBER SYSTEMS IN PRE-STERILIZABLE CARRIER SYSTEMS AND PRE-STERILIZABLE CARRIER SYSTEM 失效
标题翻译：在不可消毒的载体系统和预先无菌载体系统中填充双室系统的方法
公开(公告)号：US20110094189A1
公开(公告)日：2011-04-28
申请号：US12999039
申请日：2009-06-16
申请人： Frank Böttger , Benjamin Böbst
发明人： Frank Böttger , Benjamin Böbst
IPC分类号： B65B55/02 , B65D85/84
CPC分类号： B65B3/003 , A61J1/2093 , A61M5/284 , B65B7/2821 , B65B55/00
摘要： A method for filling dual-chamber systems in pre-sterilizable carrier systems includes providing at least one washed, siliconized and sterilized dual-chamber system with respectively one separating element separating the two chambers from one another in a magazine, which accommodates the at least one dual-chamber system. The magazine is arranged in a container sealed with a closure element. The method additionally includes feeding the container into a clean room; opening the container and filling a first chamber of the at least one dual-chamber system; closing the first chamber with a gas-permeable closure element; and freeze drying the solution contained in the first chamber. The method further includes closing the first chamber with a closure element; filling a second chamber of the at least one dual-chamber system; closing the second chamber; and discharging the container from the clean room.
摘要翻译：一种用于在预消毒的载体系统中填充双室系统的方法包括提供至少一个经洗涤的，硅化的和灭菌的双室系统，分别具有一个分离元件，其将两个室彼此分离在盒中，所述盒容纳至少一个双室系统。该杂志被布置在用闭合元件密封的容器中。该方法还包括将容器进料到洁净室中; 打开容器并填充至少一个双室系统的第一室; 用气体可渗透的封闭元件封闭第一腔室; 并冷冻干燥包含在第一室中的溶液。该方法还包括用闭合元件关闭第一腔室; 填充所述至少一个双室系统的第二室; 关闭第二个房间; 并从洁净室排出容器。

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