会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 1. 发明授权
    • Process for making perhydroindole-2-carbonxylic acid
    • 制备全氢吲哚-2-甲酸的方法
    • US4879392A
    • 1989-11-07
    • US111982
    • 1987-10-21
    • Francis BrionJean BuendiaChristian Marie
    • Francis BrionJean BuendiaChristian Marie
    • C07C61/09C07C69/75C07C233/12C07D209/18C07D209/42C12P7/62
    • C07C255/00C07C61/09C07D209/42
    • A process for the asymmetric preparation of a compound of the formula ##STR1## wherein the hydrogen at 3a and 7a are of cis or trans configuration and their non-toxic, pharmaceutically acceptable acid addition salts comprising submitting a compound of the formula ##STR2## to a Hoffman reaction and reacting the resulting product with formaldehyde in the presence of cyanide ions and acid halide of benzoic acid or an aliphatic carboxylic acid of 1 to 5 carbon atoms to obtain a compound of the formula ##STR3## wherein R is acyl of benzoic acid or aliphatic carboxylic acid of 1 to 5 carbon atoms, cyclizing the latter to form a compound of the formula ##STR4## selectively hydrolyzing the latter with a dilute aqueous mineral acid to obtain a compound of the formula ##STR5## subjecting the latter to hydrolysis with a concentrated aqueous mineral acid to form the acid addition salt of a compound of claim 1 and optionally forming the free base.
    • 用于不对称制备式Ia化合物的方法,其中3a和7a上的氢是顺式或反式构型及其无毒的药学上可接受的酸加成盐,包括将下式化合物 II化合物进行霍夫曼反应,并在氰化物离子和苯甲酸或1至5个碳原子的脂族羧酸的酰卤存在下,使所得产物与甲醛反应,得到式III化合物,其中R是酰基 的苯甲酸或1至5个碳原子的脂族羧酸,使后者环化以形成式IV的化合物,用稀的无机酸水溶液选择性地水解后者,得到下式的化合物: 使后者用浓缩的无机酸水溶液水解,形成权利要求1的化合物的酸加成盐,并任选地形成游离碱。